New perspectives in cancer biology from a study of canonical and non-canonical functions of base excision repair proteins with a focus on early steps.

abstract：:The mechanistic/mammalian target of rapamycin (mTOR) is a conserved protein kinase that controls several anabolic processes required for cell growth and proliferation. As such, mTOR has been implicated in an increasing number of pathological conditions, including cancer, obesity, type 2 diabetes and neurodegeneration....

journal_title：Mutagenesis

authors： Cargnello M,Tcherkezian J,Roux PP

更新日期：2015-03-01 00:00:00

abstract：:Vitamins with antioxidant properties have the ability to act as pro-oxidants, inducing oxidative damage and oxidative stress as opposed to preventing it. While vitamin supplements are commonly consumed, the scientific evidence for their health beneficial effects is inconclusive. In fact, even harmful effects have been...

journal_title：Mutagenesis

authors： Bergström T,Ersson C,Bergman J,Möller L

更新日期：2012-07-01 00:00:00

abstract：:Recombinant lambda phage DNA containing segments of human O6-methylguanine-DNA transferase gene was employed to localize this gene among the human chromosomes using non-radioactive in situ hybridization technique. This gene was found to be present at the telomeric end, 26q, of the long arm of the chromosome 10. ...

journal_title：Mutagenesis

authors： Natarajan AT,Vermeulen S,Darroudi F,Valentine MB,Brent TP,Mitra S,Tano K

更新日期：1992-01-01 00:00:00

abstract：:Nitro-polycyclic aromatic hydrocarbons (nitro-PAHs) are mutagenic and carcinogenic environmental pollutants found in diesel exhaust and on urban air pollution particles. In the present study, human bronchial epithelial BEAS-2B cells were exposed to 2-nitrobenzanthrone (2-NBA) and 3-nitrobenzanthrone (3-NBA). DNA damag...

journal_title：Mutagenesis

authors： Oya E,Ovrevik J,Arlt VM,Nagy E,Phillips DH,Holme JA

更新日期：2011-11-01 00:00:00

abstract：UNLABELLED:Gastric cancer is the second leading cause of cancer-related death worldwide with a low 5-year survival (S5y) after initial diagnosis. Although aberrant Wnt/β-catenin (CTNNB1) signaling has been observed in multiple human cancers, there is no information on the role of CTNNB1 polymorphisms in gastric cancer ...

journal_title：Mutagenesis

authors： Wang S,Tian Y,Wu D,Zhu H,Luo D,Gong W,Zhou Y,Zhou J,Zhang Z

更新日期：2012-11-01 00:00:00

abstract：:Ground chicken breast and ground beef with either endogenous or a 10-fold increase in the concentration of creatine were fried at 220 degrees C for 10 min per side. One patty (100 g) of chicken meat yielded 120,000 Salmonella (TA1538) revertants following metabolic activation. The pan residues had 39% of the total act...

journal_title：Mutagenesis

authors： Knize MG,Shen NH,Felton JS

更新日期：1988-11-01 00:00:00

abstract：:There are several reports demonstrating that aneugens may preferentially affect segregation of particular chromosomes in somatic cells. Much less is known on specific susceptibility of individual chromosomes to non-disjunction in mammalian meiosis in response to chemical exposures. To explore possible chromosome-speci...

journal_title：Mutagenesis

authors： Sun F,Yin H,Eichenlaub-Ritter U

更新日期：2001-09-01 00:00:00

abstract：:A collaborative study of interlaboratory variability in bacterial mutagenicity induced by mitomycin C (MMC) and bleomycin (BLM) was performed using the four strains Salmonella typhimurium TA102 and TA2638 and Escherichia coli WP2/pKM101 and WP2 uvrA/pKM101. Thirteen laboratories participated in this study. The four st...

journal_title：Mutagenesis

authors： Watanabe K,Sakamoto K,Sasaki T

更新日期：1995-05-01 00:00:00

abstract：:The accumulation of mitochondrial DNA (mtDNA) mutations has been proposed as an underlying cause of the ageing process and mutations have been associated with cancer in many tissues, including human skin. This involvement is linked to the key roles of mitochondrial function and mtDNA in oxidative stress production and...

journal_title：Mutagenesis

authors： Birch-Machin MA,Swalwell H

更新日期：2010-03-01 00:00:00

abstract：:In order to validate the in vivo micronucleus test in mouse splenocytes using the cytokinesis block method, 14 compounds with various mechanisms of action were tested: three direct alkylating agents (mitomycin C, ethylnitrosourea, beta-propiolactone), seven indirect alkylating agents (cyclophosphamide, benzo[a]pyrene,...

journal_title：Mutagenesis

authors： Benning V,Brault D,Duvinage C,Thybaud V,Melcion C

更新日期：1994-05-01 00:00:00

abstract：:3 beta-Hydroxy-13 alpha-amino-13,17-seco-5 alpha-androstan-17-oic-13,17-lactam-p-bis(2-chloroethyl) aminophenoxyacetate (NSC 294859) is a new modified steroidal alkylating agent. This compound was given by i.p. administration to mice bearing different types of tumour. It was found to exhibit good activity in L1210 and...

journal_title：Mutagenesis

authors： Tselepi MR,Demopoulos NA,Catsoulacos P

更新日期：1989-09-01 00:00:00

abstract：:Transgenic B6C3F1 and C57BL/6 mice containing a lambda shuttle vector that carries a lacI target and an alpha lacZ reporter gene have been constructed for use in in vivo mutagenesis assays. After chemical treatment of mice carrying the lacI target gene, genomic DNA is isolated and the shuttle vector is recovered by ex...

journal_title：Mutagenesis

authors： Mirsalis JC,Provost GS,Matthews CD,Hamner RT,Schindler JE,O'Loughlin KG,MacGregor JT,Short JM

更新日期：1993-05-01 00:00:00

abstract：:Quantitative and qualitative aspects of the in vivo micronucleus-inducing potential of five chemicals were studied using flow cytometric enumeration of micronucleated polychromatic peripheral blood erythrocytes in mice. The chemicals were hydroquinone, vinblastine sulphate, chloral hydrate (tested in two different mou...

journal_title：Mutagenesis

authors： Grawé J,Nüsse M,Adler ID

更新日期：1997-01-01 00:00:00

abstract：:Comparative investigations of sister-chromatid exchange (SCE) and micronucleus induction in the bone marrow of rats, mice and Chinese hamsters with the cytostatic alkylating mutagen cyclophosphamide (CP) revealed remarkable species differences in their mutagenic responses. With both test systems the sensitivities of t...

journal_title：Mutagenesis

authors： Madle E,Korte A,Beek B

更新日期：1986-11-01 00:00:00

abstract：:In the present study we evaluated campthotecin (CPT)-induced chromosomal damage in human lymphocytes in the G0 phase of the cell cycle as revealed by the premature chromosome condensation technique. The results obtained here indicate that CPT was able to induce chromosome fragments in the G0 phase of the cell cycle of...

journal_title：Mutagenesis

authors： Mosesso P,Fonti E,Bassi L,Lorenti Garcia C,Palitti F

更新日期：1999-01-01 00:00:00

abstract：:Tobacco farming is an important economic income in Brazil, although it has been challenged as regard the occupational exposure to both pesticides and nicotine endured by farmers. Chronic occupational exposure to complex mixtures can lead to health hazardous. We examined genomic instability and epigenetic changes in to...

journal_title：Mutagenesis

authors： Kahl VFS,Dhillon VS,Simon D,da Silva FR,Salvador M,Branco CDS,Cappetta M,Martínez-López W,Thiesen FV,Dias JF,Souza CT,Fenech M,da Silva J

更新日期：2018-04-13 00:00:00

abstract：:Hepatic microsomes from rats pretreated with PCB were found to metabolize the food mutagen 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine (PhIP) to two major metabolites, one of which was identified as the N-hydroxy derivative, 2-hydroxy-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine (N-OH-PhIP). This identification w...

journal_title：Mutagenesis

authors： Frandsen H,Rasmussen ES,Nielsen PA,Farmer P,Dragsted L,Larsen JC

更新日期：1991-01-01 00:00:00

abstract：:Adducts of 1,2-epoxy-3-butene (EB) with haemoglobin were monitored in 17 workers from the 1,3-butadiene (BD) production unit of a petrochemical plant and in nine referents employed at the same factory but not exposed to BD. The air concentrations of BD were determined using stationary and personal monitoring. The ambi...

journal_title：Mutagenesis

authors： Osterman-Golkar S,Peltonen K,Anttinen-Klemetti T,Landin HH,Zorcec V,Sorsa M

更新日期：1996-03-01 00:00:00

abstract：:The lines irs1, irs2 and irs3, derived from V79-4 hamster cells, are sensitive to DNA-damaging agents including ionizing radiations. However, unlike some other radiosensitive lines, the irs lines show no apparent defect in the repair of DNA strand breaks. We have now assessed the mis-repair of DNA damage in the irs li...

journal_title：Mutagenesis

authors： Thacker J,Ganesh AN,Stretch A,Benjamin DM,Zahalsky AJ,Hendrickson EA

更新日期：1994-03-01 00:00:00

abstract：:The genotoxicity of atenolol, a beta-blocker antihypertensive drug, both in vitro and in vivo, was cytogenetically tested for its ability to induce sister chromatid exchange (SCE) and micronuclei (MN) in cultured peripheral lymphocytes. Also, fluorescence in situ hybridization (FISH) with a centromeric probe was perfo...

journal_title：Mutagenesis

authors： Télez M,Martínez B,Criado B,Lostao CM,Penagarikano O,Ortega B,Flores P,Ortiz-Lastra E,Alonso RM,Jiménez RM,Arrieta I

更新日期：2000-05-01 00:00:00

abstract：:Detailed dose-response data for two reference aneugens, vincristine and nocodazole, have been derived for the mouse bone marrow micronucleus assay. Positive data have also been described for six other micronucleus-inducing agents: cyclophosphamide; aniline; urethane; 1,2-dimethylhydrazine; 7,12-dimethylbenzanthracene ...

journal_title：Mutagenesis

authors： Tinwell H,Ashby J

更新日期：1991-05-01 00:00:00

abstract：:The mechanism responsible for the modification of mutagenicity by chlorophyllin has been investigated using mutagenic compounds with different mechanisms of action, including the monofunctional alkylating agents, N-methyl-N'-nitrosourea (MNU) and ethylmethanesulphonate (EMS); nitrosamines related to tobacco products, ...

journal_title：Mutagenesis

authors： Romert L,Curvall M,Jenssen D

更新日期：1992-09-01 00:00:00

abstract：:Cell transformation assays (CTAs) have long been proposed as in vitro methods for the identification of potential chemical carcinogens. Despite showing good correlation with rodent bioassay data, concerns over the subjective nature of using morphological criteria for identifying transformed cells and a lack of underst...

journal_title：Mutagenesis

authors： Creton S,Aardema MJ,Carmichael PL,Harvey JS,Martin FL,Newbold RF,O'Donovan MR,Pant K,Poth A,Sakai A,Sasaki K,Scott AD,Schechtman LM,Shen RR,Tanaka N,Yasaei H

更新日期：2012-01-01 00:00:00

abstract：:Radiation-induced bystander effects have been evaluated extensively, including the involvement of the mitogen-activated protein kinase (MAPK) pathways. However, few studies have examined the ability of chemicals to induce bystander effects, and the molecular mechanisms involved in chemical bystander effects have not b...

journal_title：Mutagenesis

authors： Asur R,Balasubramaniam M,Marples B,Thomas RA,Tucker JD

更新日期：2010-05-01 00:00:00

abstract：:The restriction site mutation method described by Parry et al. (1990) for isolating mutant sequences directly from DNA is discussed and an additional enrichment step proposed using magnetic beads. ...

journal_title：Mutagenesis

authors： Bridges BA,Carr AM,Lehmann AR

更新日期：1990-11-01 00:00:00

abstract：:Nanoremediation of soil, ground and surface water using nanoscale zerovalent iron particles (nZVI) has facilitated their direct environmental exposure posing ecotoxicological concerns. Numerous studies elucidate their phytotoxicity in terms of growth and their fate within the plant system. However, their potential gen...

journal_title：Mutagenesis

authors： Ghosh I,Mukherjee A,Mukherjee A

更新日期：2017-05-01 00:00:00

abstract：:The tetrahydrofuran-type abasic site analog (THF) induces large deletion mutations in human cells. To compare the large deletions induced by THF on leading and lagging strand templates, plasmid DNAs bearing the analog at a specific position outside the supF gene were introduced into human U2OS cells. The replicated DN...

journal_title：Mutagenesis

authors： Suzuki T,Katayama Y,Komatsu Y,Kamiya H

更新日期：2019-12-19 00:00:00

abstract：:The effects of deficiency in the DNA mismatch repair (MMR) protein Pms2 were investigated using the endogenous mouse Hprt and Tk genes as reporters of intragenic mutation and loss of heterozygosity (LOH). Pms2(-/-)Tk(+/-), Pms2(+/+)Tk(+/-), Pms2(+/-)Tk(+/-) and Pms2(-/-)Tk(-/-) mice were bred from Pms2(+/-)Tk(+/-) mic...

journal_title：Mutagenesis

authors： Dobrovolsky VN,McKinzie PB,Shaddock JG,Mittelstaedt RA,Heflich RH,Parsons BL

更新日期：2003-07-01 00:00:00

abstract：:The over-production of reactive oxygen species (ROS) can cause oxidative damage to a large number of molecules, including DNA, and has been associated with the pathogenesis of several disorders, such as diabetes mellitus (DM), dyslipidemia and periodontitis (PD). We hypothesise that the presence of these diseases coul...

journal_title：Mutagenesis

authors： Corbi SC,Bastos AS,Orrico SR,Secolin R,Dos Santos RA,Takahashi CS,Scarel-Caminaga RM

更新日期：2014-11-01 00:00:00

abstract：:As part of the third UKEMS collaborative trial, ICI Central Toxicology Laboratory (CTL) tested the three study chemicals ethylmethanesulphonate (EMS), benzo[a]pyrene (B[a]P) and benzidine (BZD) in a microwell adaptation of the L5178Y gene mutation assay using the thymidine kinase (tk) locus. Cofactors for metabolic ac...

journal_title：Mutagenesis

authors： Clay P,Cross MF

更新日期：1990-01-01 00:00:00