Abstract：
:Post-traumatic stress disorder (PTSD) is a syndrome resulting from exposure to a severe traumatic event that poses threatened death or injury and produces intense fear and helplessness. The neural structures implicated in PTSD development belong to the limbic system, an important region for emotional processing. Brain-derived neurotrophic factor (BDNF) is a neurotrophin that serves as survival factor for selected populations of central nervous system (CNS) neurons and plays a role in the limbic system by regulating synaptic plasticity, memory processes and behavior. Impaired BDNF production in the brain can lead to a variety of CNS dysfunctions including symptoms associated with PTSD. However, so far fewer studies have investigated this neurotrophin in patients with PTSD. Furthermore, given the multiple role of BDNF in various CNS disorders, it cannot be excluded that traumatic events per se may influence neurotrophin levels, without a direct association to the PTSD syndrome. To elucidate these issues, in this study we analyzed BDNF serum levels in two groups of subjects: patients with trauma exposure who developed PTSD, and subjects with trauma exposure who did not develop PTSD. We found that BDNF serum levels were lower in PTSD patients as compared to related control subjects. Thus, these data suggest that BDNF might be involved in pathophysiology of PTSD and consequently therapeutic approaches aimed at restoring BDNF serum levels may be beneficial to this pathology.
journal_name
Brain Cognjournal_title
Brain and cognitionauthors
Angelucci F,Ricci V,Gelfo F,Martinotti G,Brunetti M,Sepede G,Signorelli M,Aguglia E,Pettorruso M,Vellante F,Di Giannantonio M,Caltagirone Cdoi
10.1016/j.bandc.2013.11.012subject
Has Abstractpub_date
2014-02-01 00:00:00pages
118-22issue
1eissn
0278-2626issn
1090-2147pii
S0278-2626(13)00175-9journal_volume
84pub_type
杂志文章abstract：BACKGROUND:Diffusion tensor imaging (DTI) has revealed microstructural aspects of adolescent brain development, the cognitive correlates of which remain relatively uncharacterized. METHODS:DTI was used to assess white matter microstructure in 18 typically developing adolescents (ages 16-18). Fractional anisotropy (FA)...
journal_title：Brain and cognition
pub_type： 杂志文章
doi：10.1016/j.bandc.2008.01.009
更新日期：2008-07-01 00:00:00
abstract：:There is considerable variability among epilepsy centers in the methods and interpretations of the intracarotid amobarbital procedure. Prominent among these differences is the determination of language representation and assessment of language functions. Some centers rely on speech arrest following amobarbital injecti...
journal_title：Brain and cognition
pub_type： 杂志文章
doi：10.1006/brcg.1997.0889
更新日期：1997-03-01 00:00:00
abstract：:Motor overflow refers to involuntary movement or muscle activity coinciding with voluntary movement. We examined whether 16 young adults (18-30 years) and 16 older adults (50-80 years) could voluntarily inhibit overflow. Participants performed a finger pressing task, exerting 50% of their maximal force. Overflow was c...
journal_title：Brain and cognition
pub_type： 杂志文章
doi：10.1016/j.bandc.2010.10.001
更新日期：2010-12-01 00:00:00
abstract：:Comparisons between backward and forward translation (BT, FT) have long illuminated the organization of bilingual memory, with neuroscientific evidence indicating that FT would involve greater linguistic and attentional demands. However, no study has directly assessed the functional interaction between relevant mechan...
journal_title：Brain and cognition
pub_type： 杂志文章
doi：10.1016/j.bandc.2020.105584
更新日期：2020-08-01 00:00:00
abstract：:An issue of continued debate in the visuomotor control literature surrounds whether a 2D object serves as a representative proxy for a 3D object in understanding the nature of the visual information supporting grasping control. In an effort to reconcile this issue, we examined the extent to which aperture profiles for...
journal_title：Brain and cognition
pub_type： 杂志文章
doi：10.1016/j.bandc.2013.02.005
更新日期：2013-06-01 00:00:00
abstract：:Investigations of concurrent task and modality switching effects have to date been studied under conditions of uni-modal stimulus presentation. As such, it is difficult to directly compare resultant task and modality switching effects, as the stimuli afford both tasks on each trial, but only one modality. The current ...
journal_title：Brain and cognition
pub_type： 杂志文章
doi：10.1016/j.bandc.2013.02.011
更新日期：2013-06-01 00:00:00
abstract：:Thirteen nondemented patients with Parkinson's disease (PD) were compared with age-matched controls on two standard tests of implicit learning. A verbal version of the Serial Reaction Time (SRT) task was used to assess sequence learning and an artificial grammar (AG) task assessed perceptual learning. It was predicted...
journal_title：Brain and cognition
pub_type： 杂志文章
doi：10.1006/brcg.2001.1286
更新日期：2001-04-01 00:00:00
abstract：:Three experiments were conducted to examine effects of speech on concurrent unimanual tapping. Experiments 1 and 2 involved the manual tapping of a short burst of preprogrammed responses with or without concurrent articulation. Results of these experiments showed no effects of speech articulation on the concurrent exe...
journal_title：Brain and cognition
pub_type： 杂志文章
doi：10.1016/0278-2626(90)90040-u
更新日期：1990-05-01 00:00:00
abstract：:Actions have been proposed to follow hierarchical principles similar to those hypothesized for language syntax. These structural similarities are claimed to be reflected in the common involvement of certain neural populations of Broca's area, in the Inferior Frontal Gyrus (IFG). In this position paper, we follow an in...
journal_title：Brain and cognition
pub_type： 杂志文章
doi：10.1016/j.bandc.2020.105651
更新日期：2020-11-28 00:00:00
abstract：:Several methodological factors associated with the concurrent activities (finger-tapping) paradigm were considered in a cross-sectional study investigating cerebral patterns of asymmetry in three groups of English-speaking non-Hispanic dextral males at three levels of second language (Spanish) acquisition and one cont...
journal_title：Brain and cognition
pub_type： 杂志文章
doi：10.1016/0278-2626(86)90048-5
更新日期：1986-10-01 00:00:00
abstract：:We performed an event-related potential study to investigate the self-relevance effect in object recognition. Three stimulus categories were prepared: SELF (participant's own objects), FAMILIAR (disposable and public objects, defined as objects with less-self-relevant familiarity), and UNFAMILIAR (others' objects). Th...
journal_title：Brain and cognition
pub_type： 杂志文章
doi：10.1016/j.bandc.2006.12.001
更新日期：2007-03-01 00:00:00
abstract：:In later editions of his two major works, Isaac Newton proposed an electrical hypothesis of nervous transmission. According to this hypothesis, an electrical aether permeates the nerve and transmits vibrations along it. This implies that the nerve is a communication line, and potentially, an extension of the mind. The...
journal_title：Brain and cognition
pub_type： 传,历史文章,杂志文章
doi：10.1016/s0278-2626(02)00513-4
更新日期：2003-02-01 00:00:00
abstract：:The purpose of the present study was to address the issue of laterality of familiar face recognition. Seventy-two participants judged familiar faces presented laterally or centrally for their "faceness," familiarity, occupation, and name (which represent four stages of familiar face processing) using one of three resp...
journal_title：Brain and cognition
pub_type： 杂志文章
doi：10.1016/s0278-2626(02)00008-8
更新日期：2002-10-01 00:00:00
abstract：:Perceptual asymmetries have been explained by structural, attentional bias and attentional advantage models. Structural models focus on asymmetries in the physical access information has to the hemispheres, whereas attentional models focus on asymmetries in the operation of attentional processes. A series of experimen...
journal_title：Brain and cognition
pub_type： 杂志文章
doi：10.1006/brcg.1998.1052
更新日期：1998-12-01 00:00:00
abstract：:People can discriminate cheaters from cooperators by their appearance. However, successful cheater detection can be thwarted by a posed smile, which cheaters display with greater emotional intensity than cooperators. The present study investigated the underlying neural and cognitive mechanisms of a posed smile, which ...
journal_title：Brain and cognition
pub_type： 杂志文章
doi：10.1016/j.bandc.2013.04.004
更新日期：2013-07-01 00:00:00
abstract：:We studied the spoken language of 49 children who had undergone hemispherectomy as part of the UCLA Pediatric Epilepsy Surgery Research Program and analyzed, among a number of clinical factors, the relation between acquired vs developmental pathology and spoken language outcomes. In this paper we will briefly review t...
journal_title：Brain and cognition
pub_type： 杂志文章
doi：10.1006/brcg.1999.1134
更新日期：2000-06-01 00:00:00
abstract：:The subcortical dementias are a heterogeneous group of disorders in which the predominant pathological lesions occur in subcortical structures such as basal ganglia, brainstem nuclei, and the cerebellum. When the cerebral cortex is involved, the lesions are most often in the frontal lobes. These pathologic lesions are...
journal_title：Brain and cognition
pub_type： 杂志文章,评审
doi：10.1006/brcg.1996.0043
更新日期：1996-07-01 00:00:00
abstract：:Facial expression and direction of gaze are two important sources of social information, and what message each conveys may ultimately depend on how the respective information interacts in the eye of the perceiver. Direct gaze signals an interaction with the observer but averted gaze amounts to "pointing with the eyes"...
journal_title：Brain and cognition
pub_type： 临床试验,杂志文章
doi：10.1016/j.bandc.2008.01.008
更新日期：2008-10-01 00:00:00
abstract：:Brain imaging studies have identified two cortical areas, the parahippocampal place area (PPA) and the retrosplenial complex (RSC), that respond preferentially to the viewing of scenes. Contrary to the PPA, little is known about the functional maturation and cognitive control of the RSC. Here we used functional magnet...
journal_title：Brain and cognition
pub_type： 杂志文章
doi：10.1016/j.bandc.2014.10.005
更新日期：2014-12-01 00:00:00
abstract：:Slowness in obsessive-compulsive disorder (OCD) has been attributed to intrusive thoughts or meticulousness. Recent research suggests that slowness in OCD may be particularly evident on tests of executive function subserved by frontostriatal circuitry. In the present study, the speed and accuracy of responding on neur...
journal_title：Brain and cognition
pub_type： 杂志文章
doi：10.1016/j.bandc.2004.02.053
更新日期：2004-04-01 00:00:00
abstract：:Individuals with autism demonstrate impairments on measures of executive function (EF) relative to typically developing comparison participants. EF is comprised of several processes including inhibition, working memory and set shifting that develop throughout the lifespan. Impairments in EF may appear early in develop...
journal_title：Brain and cognition
pub_type： 杂志文章,评审
doi：10.1016/j.bandc.2006.04.007
更新日期：2007-10-01 00:00:00
abstract：:The double-dependency hypothesis (DDH, Mauner et al., 1993) holds that where two dependencies of a certain kind are present, comprehension in Broca's aphasia will be random, but that where there is only one dependency, comprehension will be intact. We tested this hypothesis by examining the performance of Broca's apha...
journal_title：Brain and cognition
pub_type： 杂志文章
doi：10.1016/s0278-2626(01)80030-0
更新日期：2001-06-01 00:00:00
abstract：BACKGROUND:Pseudoneglect is a normal left sided spatial bias observed with attempted bisections of horizontal lines and a normal upward bias observed with attempted bisections of vertical lines. Horizontal pseudoneglect has been attributed to right hemispheric dominance for the allocation of attention. The goal of this...
journal_title：Brain and cognition
pub_type： 杂志文章
doi：10.1016/j.bandc.2012.03.003
更新日期：2012-08-01 00:00:00
abstract：:Interference between concurrent tasks was used to investigate the brain basis of capacity limitations apparent when children encode information. Seventy-three right-handed children in Grades 1-4 engaged in speeded unilateral finger tapping while encoding a variable number of faces or numbers for subsequent recognition...
journal_title：Brain and cognition
pub_type： 杂志文章
doi：10.1016/0278-2626(87)90044-3
更新日期：1987-01-01 00:00:00
abstract：:Working memory is devoted to the temporary storage and on-line manipulation of information. Recently, an integrative system termed the episodic buffer has been proposed to integrate and hold information being entered or retrieved from episodic memory. Although the brain system supporting such an integrative buffer is ...
journal_title：Brain and cognition
pub_type： 杂志文章
doi：10.1016/j.bandc.2009.09.009
更新日期：2010-03-01 00:00:00
abstract：:Two experiments are reported which investigate hemispheric processing in an object decision task. Experiment 1 used 40 pictures of objects, and 40 pictures of nonobjects, and subjects decided manually whether each lateralized stimulus represented an object. Results indicated an interaction between visual field and res...
journal_title：Brain and cognition
pub_type： 杂志文章
doi：10.1016/0278-2626(92)90045-n
更新日期：1992-07-01 00:00:00
abstract：:Many studies have shown that infants prefer infant-directed (ID) speech to adult-directed (AD) speech. ID speech functions to aid language learning, obtain and/or maintain an infant's attention, and create emotional communication between the infant and caregiver. We examined psychophysiological responses to ID speech ...
journal_title：Brain and cognition
pub_type： 杂志文章
doi：10.1016/j.bandc.2007.02.008
更新日期：2007-10-01 00:00:00
abstract：:The predictive relations of peer victimization, depressive symptoms, and salivary cortisol on memory in 168 children aged 12 at Time 1 (T1) were examined using a longitudinal design in which data were collected on four occasions over a 2-year period. Results indicated that: (1) peer victimization, depressive symptoms,...
journal_title：Brain and cognition
pub_type： 杂志文章
doi：10.1016/j.bandc.2011.06.012
更新日期：2011-11-01 00:00:00
abstract：:We studied aspects of clock cognition that might underlie the sensitivity of the CDT in screening for dementia of the Alzheimer type (DAT). Two groups, 15 patients with mild-moderate DAT and 15 controls, were assessed with the CDT and specially designed tests of clock-related cognition. Patients were impaired on the C...
journal_title：Brain and cognition
pub_type： 临床试验,杂志文章
doi：
更新日期：2002-07-01 00:00:00
abstract：:Theories of category-specific effects on visual object identification predict easier identification of non-living than living objects. The Sensory-Functional theory credits greater representational weighting of the visual properties of living objects independent of greater weighting of the functional properties of non...
journal_title：Brain and cognition
pub_type： 杂志文章
doi：10.1016/j.bandc.2006.06.002
更新日期：2006-12-01 00:00:00
