Abstract：
:Working memory is devoted to the temporary storage and on-line manipulation of information. Recently, an integrative system termed the episodic buffer has been proposed to integrate and hold information being entered or retrieved from episodic memory. Although the brain system supporting such an integrative buffer is still in debate, the medial temporal lobe appears to be a promising candidate for the maintenance of bound information. In the current work, binding was assessed by comparing two conditions in which participants had to retain three letters and three spatial locations presented either bound or separate. At the behavioral level, lower performance was found for bound information than for separate information. When contrasting the two conditions, activation in the right parahippocampal gyrus was greater for the encoding and maintenance of bound information. No activation was observed in the medial temporal lobe during the retrieval of bound information. Together, our results suggest that the parahippocampal gyrus may underlie the integrative and maintenance functions of the episodic buffer.
journal_name
Brain Cognjournal_title
Brain and cognitionauthors
Luck D,Danion JM,Marrer C,Pham BT,Gounot D,Foucher Jdoi
10.1016/j.bandc.2009.09.009subject
Has Abstractpub_date
2010-03-01 00:00:00pages
255-63issue
2eissn
0278-2626issn
1090-2147pii
S0278-2626(09)00180-8journal_volume
72pub_type
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