Microstructural integrity of the corpus callosum linked with neuropsychological performance in adolescents.

Abstract:

BACKGROUND:Diffusion tensor imaging (DTI) has revealed microstructural aspects of adolescent brain development, the cognitive correlates of which remain relatively uncharacterized. METHODS:DTI was used to assess white matter microstructure in 18 typically developing adolescents (ages 16-18). Fractional anisotropy (FA) and mean diffusion (MD) were evaluated within the splenium and body of the corpus callosum in relation to cognitive performance. RESULTS:Visuospatial construction abilities were associated with white matter integrity in both the splenium and body of the corpus callosum, while only splenium integrity was associated with language and psychomotor function. CONCLUSION:Results suggest that, for typically developing adolescents, white matter coherence positively relates to visuospatial, psychomotor, and language skills. These findings may have implications for the cognitive functioning of clinical populations in which typical white matter development is altered.

journal_name

Brain Cogn

journal_title

Brain and cognition

authors

Fryer SL,Frank LR,Spadoni AD,Theilmann RJ,Nagel BJ,Schweinsburg AD,Tapert SF

doi

10.1016/j.bandc.2008.01.009

subject

Has Abstract

pub_date

2008-07-01 00:00:00

pages

225-33

issue

2

eissn

0278-2626

issn

1090-2147

pii

S0278-2626(08)00023-7

journal_volume

67

pub_type

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