Subcortical dementia: a neurobehavioral approach.

Abstract:

:The subcortical dementias are a heterogeneous group of disorders in which the predominant pathological lesions occur in subcortical structures such as basal ganglia, brainstem nuclei, and the cerebellum. When the cerebral cortex is involved, the lesions are most often in the frontal lobes. These pathologic lesions are associated with cognitive changes that include bradyphrenia, personality change (apathy, depression, irritability), memory impairment, and impaired manipulation of acquired knowledge (calculation, abstraction). Aphasia, apraxia, and agnosia are commonly seen in the cortical dementias, but are absent in the subcortical dementias. Progress in research on the anatomy and connectivity of cortical-subcortical structures has led to refinement in our understanding of the cortical dementias. Despite the connectivity between the cortical and subcortical structures, patterns of cognitive impairment in subcortical dementias remain distinct.

journal_name

Brain Cogn

journal_title

Brain and cognition

authors

Darvesh S,Freedman M

doi

10.1006/brcg.1996.0043

subject

Has Abstract

pub_date

1996-07-01 00:00:00

pages

230-49

issue

2

eissn

0278-2626

issn

1090-2147

pii

S0278-2626(96)90043-3

journal_volume

31

pub_type

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