Abstract：
PURPOSE:To investigate cataract risk associated with the use of atypical antipsychotics. DESIGN:Retrospective, nested case-control study. METHODS:A large health claims database (The British Columbia Ministry of Health Databases) from British Columbia, Canada, was used from January 2000 through December 2007. Cases were defined as clinically significant cataracts requiring surgery and were identified using cataract surgery procedure codes. For each case, 4 to 10 controls were selected randomly using a density-based sampling approach and were matched to cases by age and calendar time. Rate ratios were calculated for users of atypical and typical antipsychotics adjusting for known cataractogenic factors. RESULTS:One hundred sixty-two thousand five hundred one cases of cataract surgery and 650 004 controls were included. The adjusted rate ratio for current users of atypical antipsychotics was 0.84 (95% confidence interval, 0.80 to 0.89) compared with nonusers. A greater number of prescriptions filled in the year before cataract surgery compared with the median number of filled prescriptions was associated with a lower cataract surgery rate (adjusted rate ratio, 0.70; 95% confidence interval, 0.65 to 0.75) than those with fewer prescriptions filled (adjusted rate ratio, 0.85; 95% confidence interval, 0.79 to 0.91). CONCLUSIONS:A protective association between the use of atypical antipsychotics and risk of clinically significant cataracts requiring surgery was established. Potential biochemical and neurochemical mechanisms for this protective effect are discussed.
journal_name
Am J Ophthalmoljournal_title
American journal of ophthalmologyauthors
Pakzad-Vaezi KL,Etminan M,Mikelberg FSdoi
10.1016/j.ajo.2013.07.012subject
Has Abstractpub_date
2013-12-01 00:00:00pages
1141-1146.e1issue
6eissn
0002-9394issn
1879-1891pii
S0002-9394(13)00503-5journal_volume
156pub_type
杂志文章abstract：:Dipivalyl epinephrine, 0.1%, though slightly less effective in decreasing intraocular pressure, showed significantly fewer side effects than epinephrine hydrochloride, 2%. Seventeen patients with symmetrically increased intraocular pressures who completed a six-month double-masked crossover study showed a significant ...
journal_title：American journal of ophthalmology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0002-9394(79)90142-9
更新日期：1979-02-01 00:00:00
abstract：:We used scanning electron microscopy to study the surfaces of five coated soft contact lenses from subjects with giant papillary conjunctivitis. Findings were compared to the surfaces of five coated lenses from normal, asymptomatic wearers and five new, nerver-worn lenses. Lenses were from various manufacturers. All w...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(79)90416-1
更新日期：1979-12-01 00:00:00
abstract：PURPOSE:To establish the medium-term repeatability of the iPad perimetry app Melbourne Rapid Fields (MRF) compared to Humphrey Field Analyzer (HFA) 24-2 SITA-standard and SITA-fast programs. DESIGN:Multicenter longitudinal observational clinical study. METHODS:Sixty patients (stable glaucoma/ocular hypertension/glauc...
journal_title：American journal of ophthalmology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.ajo.2018.03.009
更新日期：2018-06-01 00:00:00
abstract：PURPOSE:To critically evaluate the potential impact of the coronavirus disease (COVID-19) pandemic on global ophthalmology and VISION 2020. DESIGN:Perspective supplemented with epidemiologic insights from available online databases. METHODS:We extracted data from the Global Vision Database (2017) and Global Burden of...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2020.11.016
更新日期：2020-12-09 00:00:00
abstract：:Because determination of the differential light threshold of a visual field is a psychophysiologic test, the results can be subject to variation. This scatter measured during a single examination is usually called the short-term fluctuation. Increases of the short-term fluctuation were thought to occur primarily in ab...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(89)90667-3
更新日期：1989-04-15 00:00:00
abstract：PURPOSE:To evaluate the mechanism of spontaneous resolution of foveal detachments and idiopathic macular breaks. METHODS:We reviewed the records of 139 consecutive eyes (94 patients) with either a foveal detachment or a macular break in patients who were examined between 1989 and 1992. There were 26 men and 68 women (...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)72730-8
更新日期：1995-12-01 00:00:00
abstract：PURPOSE:To compare the long-term efficacy and safety of 2 operation methods for late in-the-bag intraocular lens (IOL) dislocation. DESIGN:Prospective, randomized, parallel group surgical clinical trial. METHODS:During a 3-year period, 104 patients (104 eyes) were assigned one group for IOL repositioning by scleral s...
journal_title：American journal of ophthalmology
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.ajo.2019.05.030
更新日期：2019-11-01 00:00:00
abstract：PURPOSE:To investigate the efficacy of ciliary body endophotocoagulation during pars plana vitrectomy in eyes of pediatric patients with medically uncontrolled glaucoma. METHOD:We compared preoperative and postoperative intraocular pressure and visual acuity in five eyes of five patients aged between 10 months and 14....
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(98)00184-6
更新日期：1998-11-01 00:00:00
abstract：PURPOSE:To evaluate postoperative corneal deturgescence after Descemet stripping endothelial keratoplasty (DSAEK) using the Visante anterior segment optical coherence tomography (OCT) system (Carl Zeiss Meditec Inc, Dublin, California, USA). DESIGN:Retrospective case series. METHODS:We included 21 eyes (9 males and 1...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2009.01.016
更新日期：2009-07-01 00:00:00
abstract：:A 1:2000 solution of a radiomimetic alkylating agent-triethylene thiophosphoramide (thio-tepa, Lederle Laboratories) with a proven inhibitory action on proliferating vascular endothelium, was used topically as an adjunct to pterygium surgery in an attempt to decrease the incidence of recurrence. A bare-sclera techniqu...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(66)90931-7
更新日期：1966-05-01 00:00:00
abstract：PURPOSE:To assess the clinical outcomes of conventional and wavefront-guided myopic laser in situ keratomileusis (LASIK) retreatment. DESIGN:Retrospective, nonrandomized case series. METHODS:The study comprised a cohort of 97 eyes having LASIK retreatment for residual myopia after primary LASIK. The eyes were divided...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2005.11.011
更新日期：2006-04-01 00:00:00
abstract：PURPOSE:To report the clinicopathologic findings in patient with optic nerve sheath hemangiopericytoma. DESIGN:Clinicopathologic report. METHODS:The clinical, histologic, and immunohistochemical findings of a patient with optic nerve sheath hemangiopericytoma were reviewed. RESULTS:An excisional biopsy of an optic n...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2006.11.046
更新日期：2007-05-01 00:00:00
abstract：:We conducted a prospective randomized clinical trial on the use of 2% hydroxypropyl methylcellulose and 1% sodium hyaluronate in the anterior chamber during anterior capsulotomy and nuclear expression in extracapsular cataract extraction with posterior chamber lens implantation in 70 patients. Both viscoelastic substa...
journal_title：American journal of ophthalmology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0002-9394(86)90399-5
更新日期：1986-12-15 00:00:00
abstract：:Twenty-nine suture removals from 20 eyes (21 patients) on which penetrating keratoplasty had been performed were analyzed in a nonrandomized consecutive study to evaluate the role of computer-assisted corneal topography in selective suture removal to reduce astigmatism. Topographic guidance for suture removal resulted...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)77271-x
更新日期：1991-12-15 00:00:00
abstract：PURPOSE:To evaluate the behavior and attitudes among ophthalmology trainees toward pharmaceutical promotions. DESIGN:Questionnaire survey. METHODS:A questionnaire on behavior and attitudes toward interactions with pharmaceutical representatives was distributed to 110 ophthalmology residency programs in the United Sta...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2009.05.011
更新日期：2009-10-01 00:00:00
abstract：PURPOSE:To report the clinical outcome and complications of intravitreal injections of crystalline cortisone in patients undergoing pars plana vitrectomy for treatment of proliferative diabetic retinopathy. METHODS:The prospective, interventional case series study included 29 consecutive patients (29 eyes) who underwe...
journal_title：American journal of ophthalmology
pub_type： 临床试验,杂志文章
doi：10.1016/s0002-9394(00)00882-5
更新日期：2001-04-01 00:00:00
abstract：PURPOSE:To provide insight into the course of retinal detachment in eyes with aggressive posterior retinopathy of prematurity (APROP). DESIGN:Prospective, multicenter, masked clinical trial. METHODS:Multicenter trial based on serial digital photographic imaging detailing five infants (in the Photographic Screening fo...
journal_title：American journal of ophthalmology
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.ajo.2007.10.027
更新日期：2008-03-01 00:00:00
abstract：:The original (1969) classification of the Eye Changes of Graves' Disease has been retained except for Classes 1 and 3. Class 1 has been limited so that proptosis of 23 mm or greater is placed in Class 3, even if the patient is asymptomatic. Grading of Classes 1 and 2 has been left to the individual physician or clinic...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(77)90140-4
更新日期：1977-05-01 00:00:00
abstract：:Amyloid was identified by light and electron microscopy within corneal grafts of two male siblings from a family with lattice corneal dystrophy type 1. These deposits indicate a recurrent disease within the donor tissue, and we believe this reflects an infiltration of the grafts by genetically abnormal host corneal fi...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(82)90251-3
更新日期：1982-10-01 00:00:00
abstract：PURPOSE:To report a case of Diffuse Subretinal Fibrosis (DSF) syndrome refractory to immunosuppressive therapy who was successfully treated with anti-tumor necrosis factor-alpha (TNF)-alpha monoclonal antibodies infliximab. DESIGN:Interventional case report. METHODS:A 23-year-old male with bilateral choroiditis prese...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2006.10.047
更新日期：2007-03-01 00:00:00
abstract：:Graft edema developed after removal of continuous monofilament sutures in six eyes of six patients in whom no wound dehiscence occurred. All sutures were removed at least one year after penetrating keratoplasty, and graft edema was noted one day after suture removal. In all cases, partial or total resolution of graft ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(79)90461-6
更新日期：1979-08-01 00:00:00
abstract：:Exposure to organic isocyanates in the atmosphere of a polyurethane-foam-producing company resulted in microcystic corneal epithelial edema and conjunctival injection localized primarily in the palpebral fissure. The degree of microcystic edema and decreased visual acuity appeared to be related to location, length of ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)75137-2
更新日期：1980-11-01 00:00:00
abstract：:We compared the intraocular pressure-decreasing effect of timolol maleate alone, acetazolamide alone, and combined timolol and acetazolamide therapy in nine patients with bilateral chronic open-angle glaucoma. Timolol decreased intraocular pressure at least as effectively as acetazolamide. The two medications together...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)75631-4
更新日期：1981-12-01 00:00:00
abstract：PURPOSE:compare the results of vitrectomy with or without arteriovenous (AV) crossing sheathotomy for macular edema associated with branch retinal vein occlusion (BRVO). DESIGN:Interventional case series. METHODS:A retrospective study of 36 eyes with BRVO-associated macular edema. Twenty eyes underwent AV sheathotomy...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2004.06.061
更新日期：2004-12-01 00:00:00
abstract：PURPOSE:To evaluate whether cost, insurance prior authorization, pregnancy considerations, and subspecialty practice lead to changes in therapeutic decisions among uveitis and retina specialists in the treatment of intermediate and posterior uveitis. DESIGN:Prospective cross-sectional study. METHODS:A total of 934 uv...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2014.10.015
更新日期：2015-02-01 00:00:00
abstract：PURPOSE:To analyze factors influencing corneal graft re-epithelialization after penetrating keratoplasty (PK) and evaluate the effect of topical autologous serum in promoting graft re-epithelialization. DESIGN:Prospective interventional study. METHODS:We analyzed 165 eyes of 165 patients who underwent PK between Janu...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2010.03.024
更新日期：2010-09-01 00:00:00
abstract：PURPOSE:To examine the development and management of glaucoma in patients with ocular chemical burns. DESIGN:Retrospective, observational case series. METHODS:setting: University of Washington Eye Clinics. patient population: Twenty-nine eyes (18 patients) with ocular chemical burns seen between 1997 and 2010 with a ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2012.03.026
更新日期：2012-09-01 00:00:00
abstract：:A white male infant was born with multiple hemangiomas of the skin and mucous membrane. At 7 months of age he exhibited the signs and symptoms of infantile glaucoma in each eye, but goniotomy was not possible because of vascularity in the angles. Cyclocryotherapy was used on multiple occasions to control intraocular p...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(76)90733-9
更新日期：1976-02-01 00:00:00
abstract：:We obtained serial electroretinograms in four patients aged between 6 months and 5 years with Alström's syndrome and studied the early stages of the severe retinopathy that is characteristic of that disease. The weak electroretinographic signals found at age 6 months demonstrate a severe early cone dysfunction; one ye...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)71466-7
更新日期：1993-05-15 00:00:00
abstract：:In three cases infarction in the inferotemporal prelaminar portion of the optic disk resulted in shallow cupping and arcuate visual field defects. Such changes occurred acutely, were not progressive, and required no treatment. ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)77720-7
更新日期：1978-03-01 00:00:00
