Abstract:
BACKGROUND:Tension-type headache is the most common form of headache and its chronic form, chronic tension-type headache (CTTH), is one of the most difficult to treat. The etiology of CTTH is not well understood, but is believed to be multifactorial and to vary among individuals. In the present study, the authors sought to identify common mechanisms of CTTH pathology. Empirical studies have implicated various immunomodulatory cytokines as mediators of chronic pain disorders, including CTTH. OBJECTIVES:To determine the role of peripheral cytokines and genetic factors in the development of CTTH. METHODS:A panel of cytokines hypothesized to play a role in the pathogenesis of CTTH was measured using cytometric bead arrays and ELISAs in 56 individuals with CTTH and 42 healthy control participants between 18 and 65 years of age. RESULTS:Levels of interleukin (IL)-1β were significantly elevated in participants diagnosed with CTTH relative to healthy controls, while IL-18 levels were found to be significantly elevated in men with CTTH. Because the levels of these immune mediators were increased in the apparent absence of injury or infection, the authors sought to determine whether genetic changes were responsible for fluctuations in cytokine levels. Polymerase chain reaction and restriction fragment length polymorphism analyses were used to determine individual genotypes at key single nucleotide polymorphism positions in the IL-1B gene. No association was observed between CTTH and single nucleotide polymorphisms in the IL-1β gene. CONCLUSIONS:These findings suggest that increases in key proinflammatory cytokine levels are associated with CTTH and the pathology of the disorder involves sterile neurovascular inflammation.
journal_name
Pain Res Managjournal_title
Pain research & managementauthors
Della Vedova C,Cathcart S,Dohnalek A,Lee V,Hutchinson MR,Immink MA,Hayball Jdoi
10.1155/2013/796161subject
Has Abstractpub_date
2013-11-01 00:00:00pages
301-6issue
6eissn
1203-6765issn
1918-1523pii
15249journal_volume
18pub_type
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journal_title:Pain research & management
pub_type: 杂志文章
doi:10.1155/2014/623830
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journal_title:Pain research & management
pub_type: 杂志文章
doi:10.1155/2013/740379
更新日期:2013-03-01 00:00:00
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journal_title:Pain research & management
pub_type: 杂志文章
doi:10.1155/2016/8617182
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journal_title:Pain research & management
pub_type: 杂志文章
doi:10.1155/2020/7125060
更新日期:2020-01-20 00:00:00
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journal_title:Pain research & management
pub_type: 杂志文章
doi:10.1155/2020/3428587
更新日期:2020-10-22 00:00:00
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journal_title:Pain research & management
pub_type: 杂志文章
doi:10.1155/2019/9292617
更新日期:2019-06-03 00:00:00
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journal_title:Pain research & management
pub_type: 杂志文章,随机对照试验
doi:10.1155/2016/4261949
更新日期:2016-01-01 00:00:00
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journal_title:Pain research & management
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2019-08-21 00:00:00
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journal_title:Pain research & management
pub_type: 临床试验,杂志文章
doi:10.1155/2009/497217
更新日期:2009-03-01 00:00:00
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journal_title:Pain research & management
pub_type: 杂志文章,评审
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更新日期:2011-11-01 00:00:00
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journal_title:Pain research & management
pub_type: 杂志文章,评审
doi:10.1155/2005/312357
更新日期:2005-10-01 00:00:00
abstract:Background:Type D personality (TDP) is a sign of tapered stress and compromises treatment outcomes including those of hip arthroplasty. The common dissatisfaction with total knee arthroplasty (TKA) is predicted by fear avoidance, pain catastrophizing and emotional lability, with poor quality of life (QoL) reflecting th...
journal_title:Pain research & management
pub_type: 杂志文章
doi:10.1155/2019/6393101
更新日期:2019-01-03 00:00:00
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journal_title:Pain research & management
pub_type: 杂志文章,meta分析
doi:10.1155/2020/8506591
更新日期:2020-03-20 00:00:00
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journal_title:Pain research & management
pub_type: 杂志文章
doi:10.1155/2018/4193275
更新日期:2018-07-08 00:00:00
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journal_title:Pain research & management
pub_type: 杂志文章
doi:10.1155/2020/3740162
更新日期:2020-02-10 00:00:00
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journal_title:Pain research & management
pub_type: 临床试验,杂志文章
doi:10.1155/2002/502984
更新日期:2002-10-01 00:00:00
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journal_title:Pain research & management
pub_type: 杂志文章
doi:10.1155/2017/4830142
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Chronic pain affects between 30% and 50% of the world population. Our objective was to estimate the prevalence of chronic pain in Brazil, describe and compare differences between pain types and characteristics, and identify the types of therapies adopted and the impact of pain on daily life. ...
journal_title:Pain research & management
pub_type: 杂志文章
doi:10.1155/2017/4643830
更新日期:2017-01-01 00:00:00
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journal_title:Pain research & management
pub_type: 杂志文章
doi:10.1155/2008/240573
更新日期:2008-05-01 00:00:00
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journal_title:Pain research & management
pub_type: 杂志文章
doi:10.1155/2016/5940206
更新日期:2016-01-01 00:00:00
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journal_title:Pain research & management
pub_type: 杂志文章,随机对照试验
doi:10.1155/2014/195286
更新日期:2014-01-01 00:00:00
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journal_title:Pain research & management
pub_type: 杂志文章
doi:10.1155/2011/652853
更新日期:2011-05-01 00:00:00
abstract::Chronic pain syndromes are associated with alterations in sleep continuity and sleep architecture. One perspective of this relationship, which has not received much attention to date, is that disturbances of sleep affect pain. To fathom this direction of cause, experimental human and animal studies on the effects of s...
journal_title:Pain research & management
pub_type: 杂志文章,评审
doi:10.1155/2004/949187
更新日期:2004-04-01 00:00:00
abstract::Context. Postthoracotomy Ipsilateral Shoulder Pain (IPS) is a common and sometimes intractable pain syndrome. IPS is different from chest wall pain in type, origin, and treatments. Various treatments are suggested or applied for it but none of them is regarded as popular accepted effective one. Objectives. To review d...
journal_title:Pain research & management
pub_type: 杂志文章,评审
doi:10.1155/2016/3652726
更新日期:2016-01-01 00:00:00
abstract::The provision of care for patients with type II diabetes in primary care must involve assessing patients for peripheral neuropathy of the feet. Objectives. This paper will demonstrate that painful diabetic neuropathy (PDN) is poorly assessed for and treated in primary care. Methods. A critical analysis of research wil...
journal_title:Pain research & management
pub_type: 杂志文章
doi:10.1155/2016/1974863
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Exercising for ≥ 150 min/week is a recommended strategy for self-managing arthritis. However, exercise nonadherence is a problem. Arthritis pain anxiety may interfere with regular exercise. According to the fear-avoidance model, individuals may confront their pain anxiety by using adaptive self-regulatory re...
journal_title:Pain research & management
pub_type: 杂志文章
doi:10.1155/2015/853961
更新日期:2015-03-01 00:00:00
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journal_title:Pain research & management
pub_type: 临床试验,杂志文章
doi:10.1155/2019/9459103
更新日期:2019-12-12 00:00:00
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journal_title:Pain research & management
pub_type: 杂志文章
doi:10.1155/2016/5080438
更新日期:2016-01-01 00:00:00
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journal_title:Pain research & management
pub_type: 杂志文章
doi:10.1155/2016/7297826
更新日期:2016-01-01 00:00:00