Peripheral interleukin-1ß levels are elevated in chronic tension-type headache patients.

Abstract:

BACKGROUND:Tension-type headache is the most common form of headache and its chronic form, chronic tension-type headache (CTTH), is one of the most difficult to treat. The etiology of CTTH is not well understood, but is believed to be multifactorial and to vary among individuals. In the present study, the authors sought to identify common mechanisms of CTTH pathology. Empirical studies have implicated various immunomodulatory cytokines as mediators of chronic pain disorders, including CTTH. OBJECTIVES:To determine the role of peripheral cytokines and genetic factors in the development of CTTH. METHODS:A panel of cytokines hypothesized to play a role in the pathogenesis of CTTH was measured using cytometric bead arrays and ELISAs in 56 individuals with CTTH and 42 healthy control participants between 18 and 65 years of age. RESULTS:Levels of interleukin (IL)-1β were significantly elevated in participants diagnosed with CTTH relative to healthy controls, while IL-18 levels were found to be significantly elevated in men with CTTH. Because the levels of these immune mediators were increased in the apparent absence of injury or infection, the authors sought to determine whether genetic changes were responsible for fluctuations in cytokine levels. Polymerase chain reaction and restriction fragment length polymorphism analyses were used to determine individual genotypes at key single nucleotide polymorphism positions in the IL-1B gene. No association was observed between CTTH and single nucleotide polymorphisms in the IL-1β gene. CONCLUSIONS:These findings suggest that increases in key proinflammatory cytokine levels are associated with CTTH and the pathology of the disorder involves sterile neurovascular inflammation.

journal_name

Pain Res Manag

authors

Della Vedova C,Cathcart S,Dohnalek A,Lee V,Hutchinson MR,Immink MA,Hayball J

doi

10.1155/2013/796161

subject

Has Abstract

pub_date

2013-11-01 00:00:00

pages

301-6

issue

6

eissn

1203-6765

issn

1918-1523

pii

15249

journal_volume

18

pub_type

杂志文章
  • The antiallodynic action of pregabalin may depend on the suppression of spinal neuronal hyperexcitability in rats with spared nerve injury.

    abstract:BACKGROUND:Pregabalin (PGB) is a novel antiepileptic drug and is also used as a first-line medication for the treatment of neuropathic pain. However, the mechanisms of its analgesic effects remain largely unknown. OBJECTIVES:To elucidate the mechanisms underlying the antiallodynic action of PGB in rats with neuropathi...

    journal_title:Pain research & management

    pub_type: 杂志文章

    doi:10.1155/2014/623830

    authors: Ding L,Cai J,Guo XY,Meng XL,Xing GG

    更新日期:2014-07-01 00:00:00

  • Continuing methadone for pain in palliative care.

    abstract:BACKGROUND:Methadone is one of the most important medications used for the treatment of refractory pain in the palliative care setting, and is usually initially prescribed by one of a limited number of physicians who have acquired authorization for its use. A lack of authorized physicians able to take over prescribing ...

    journal_title:Pain research & management

    pub_type: 杂志文章

    doi:10.1155/2013/740379

    authors: Hawley P,Liebscher R,Wilford J

    更新日期:2013-03-01 00:00:00

  • Navigating Uncertainty: Health Professionals' Knowledge, Skill, and Confidence in Assessing and Managing Pain in Children with Profound Cognitive Impairment.

    abstract::There is limited evidence to underpin the assessment and management of pain in children with profound cognitive impairment and these children are vulnerable to poor pain assessment and management. Health professionals working with children with profound cognitive impairment from a single paediatric tertiary referral c...

    journal_title:Pain research & management

    pub_type: 杂志文章

    doi:10.1155/2016/8617182

    authors: Carter B,Simons J,Bray L,Arnott J

    更新日期:2016-01-01 00:00:00

  • Nursing-Related Barriers to Children's Pain Management at Selected Hospitals in Ghana: A Descriptive Qualitative Study.

    abstract::Staff shortages, deficient knowledge, inappropriate attitudes, demanding workloads, analgesic shortages, and low prioritization of pain management have been identified in earlier studies as the nursing-related barriers to optimal children's pain management. These studies have mainly been undertaken in developed countr...

    journal_title:Pain research & management

    pub_type: 杂志文章

    doi:10.1155/2020/7125060

    authors: Kusi Amponsah A,Kyei EF,Agyemang JB,Boakye H,Kyei-Dompim J,Ahoto CK,Oduro E

    更新日期:2020-01-20 00:00:00

  • Sleep Disturbance and Its Clinical Implication in Patients with Adult Spinal Deformity: Comparison with Lumbar Spinal Stenosis.

    abstract:Purpose:The purpose of this study was to investigate the prevalence of sleep disturbance and its clinical implication in patients with ASD. Methods:A total of 44 patients with ASD and 137 patients with lumbar spinal stenosis (LSS) were enrolled in the study. Forty four patients were selected from the LSS group after p...

    journal_title:Pain research & management

    pub_type: 杂志文章

    doi:10.1155/2020/6294151

    authors: Kim HJ,Hong SJ,Park JH,Ki H

    更新日期:2020-04-13 00:00:00

  • OPN Deficiency Increases the Severity of Osteoarthritis Associated with Aberrant Chondrocyte Senescence and Apoptosis and Upregulates the Expression of Osteoarthritis-Associated Genes.

    abstract:Objectives:A recent work has reported that the elevated osteopontin (OPN) levels in the articular cartilage and synovial fluid are correlated with the progressive osteoarthritis (OA) joint damage, and OPN has a protective effect against OA by suppressing the expressions of OA-associated genes. The present study examine...

    journal_title:Pain research & management

    pub_type: 杂志文章

    doi:10.1155/2020/3428587

    authors: Tian J,Cheng C,Kuang SD,Su C,Zhao X,Xiong YL,Li YS,Gao SG

    更新日期:2020-10-22 00:00:00

  • Effects of Mobilization Time on Occurrence of New Fractures after Vertebroplasty.

    abstract:Introduction:Osteoporotic vertebral fracture treatment options include vertebroplasty, in which development of new fractures is among the possible complications which may develop during the postoperative period. We aim to evaluate whether or not postoperative mobilization time has effect on occurrence of new fractures....

    journal_title:Pain research & management

    pub_type: 杂志文章

    doi:10.1155/2019/9292617

    authors: Akpolat AO,Karaca S

    更新日期:2019-06-03 00:00:00

  • Comparison of Transcutaneous Electrical Nerve Stimulation and Parasternal Block for Postoperative Pain Management after Cardiac Surgery.

    abstract::Background. Parasternal block and transcutaneous electrical nerve stimulation (TENS) have been demonstrated to produce effective analgesia and reduce postoperative opioid requirements in patients undergoing cardiac surgery. Objectives. To compare the effectiveness of TENS and parasternal block on early postoperative p...

    journal_title:Pain research & management

    pub_type: 杂志文章,随机对照试验

    doi:10.1155/2016/4261949

    authors: Ozturk NK,Baki ED,Kavakli AS,Sahin AS,Ayoglu RU,Karaveli A,Emmiler M,Inanoglu K,Karsli B

    更新日期:2016-01-01 00:00:00

  • Effects of Diet Based on IgG Elimination Combined with Probiotics on Migraine Plus Irritable Bowel Syndrome.

    abstract::Several research studies have revealed that migraine has a solid link with gastrointestinal diseases especially irritable bowel syndrome (IBS). This study was carried out to investigate therapeutic potential of diet based on IgG elimination combined with probiotics on migraine plus irritable bowel syndrome. A total of...

    journal_title:Pain research & management

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1155/2019/7890461

    authors: Xie Y,Zhou G,Xu Y,He B,Wang Y,Ma R,Chang Y,He D,Xu C,Xiao Z

    更新日期:2019-08-21 00:00:00

  • Ultra low-dose naloxone and tramadol/acetaminophen in elderly patients undergoing joint replacement surgery: a pilot study.

    abstract:OBJECTIVE:A pilot study was conducted to assess whether both the rationale and feasibility exist for future randomized clinical trials to evaluate the combined use of naloxone infusion and tramadol/acetaminophen as opioid-sparing drugs in elderly patients undergoing lower extremity joint replacement surgery. DESIGN:Te...

    journal_title:Pain research & management

    pub_type: 临床试验,杂志文章

    doi:10.1155/2009/497217

    authors: Imasogie NN,Singh S,Watson JT,Hurley D,Morley-Forster P

    更新日期:2009-03-01 00:00:00

  • Unrelieved pain: a crisis.

    abstract::Despite many recent advances in the past 40 years in the understanding of pain mechanisms, and in pain diagnosis and management, considerable gaps in knowledge remain, with chronic pain present in epidemic proportions in most countries. It is often unrelieved and is associated with significant socioeconomic burdens. S...

    journal_title:Pain research & management

    pub_type: 杂志文章,评审

    doi:10.1155/2011/513423

    authors: Sessle B

    更新日期:2011-11-01 00:00:00

  • Safety issues concerning the medical use of cannabis and cannabinoids.

    abstract::Safety issues are a major barrier to the use of cannabis and cannabinoid medications for clinical purposes. Information on the safety of herbal cannabis may be derived from studies of recreational cannabis use, but cannabis exposure and effects may differ widely between medical and recreational cannabis users. Standar...

    journal_title:Pain research & management

    pub_type: 杂志文章,评审

    doi:10.1155/2005/312357

    authors: Ware MA,Tawfik VL

    更新日期:2005-10-01 00:00:00

  • Negative Affect, Type D Personality, Quality of Life, and Dysfunctional Outcomes of Total Knee Arthroplasty.

    abstract:Background:Type D personality (TDP) is a sign of tapered stress and compromises treatment outcomes including those of hip arthroplasty. The common dissatisfaction with total knee arthroplasty (TKA) is predicted by fear avoidance, pain catastrophizing and emotional lability, with poor quality of life (QoL) reflecting th...

    journal_title:Pain research & management

    pub_type: 杂志文章

    doi:10.1155/2019/6393101

    authors: Vogel M,Riediger C,Krippl M,Frommer J,Lohmann C,Illiger S

    更新日期:2019-01-03 00:00:00

  • Effectiveness of Acupuncture for Lateral Epicondylitis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

    abstract:Objective:This study aimed at assessing the clinical effectiveness of acupuncture for lateral epicondylitis (LE). Methods:The following databases were systematically searched: China National Knowledge Infrastructure, Chinese Science and Technology Periodical Database, Wan Fang database, Chinese Biomedicine Literature,...

    journal_title:Pain research & management

    pub_type: 杂志文章,meta分析

    doi:10.1155/2020/8506591

    authors: Zhou Y,Guo Y,Zhou R,Wu P,Liang F,Yang Z

    更新日期:2020-03-20 00:00:00

  • Incidence of Delirium in Critically Ill Cancer Patients.

    abstract:Objective:The aim of this study was to estimate the incidence of delirium and its risk factors among critically ill cancer patients in an intensive care unit (ICU). Materials and Methods:This is a prospective cohort study. The Confusion Assessment Method for the Intensive Care Unit (CAM-ICU) was measured daily at morn...

    journal_title:Pain research & management

    pub_type: 杂志文章

    doi:10.1155/2018/4193275

    authors: Sánchez-Hurtado LA,Hernández-Sánchez N,Del Moral-Armengol M,Guevara-García H,García-Guillén FJ,Herrera-Gómez Á,Ñamendys-Silva SA

    更新日期:2018-07-08 00:00:00

  • Systematic Administration of B Vitamins Alleviates Diabetic Pain and Inhibits Associated Expression of P2X3 and TRPV1 in Dorsal Root Ganglion Neurons and Proinflammatory Cytokines in Spinal Cord in Rats.

    abstract:Background:Treatment of diabetic neuropathic pain (DNP) continues to be a major challenge, and underlying mechanisms of DNP remain elusive. We investigated treatment effects of B vitamins on DPN- and DNP-associated alterations of neurochemical signaling in the nociceptive dorsal root ganglion (DRG) neurons and the spin...

    journal_title:Pain research & management

    pub_type: 杂志文章

    doi:10.1155/2020/3740162

    authors: He DD,Gao Y,Wang S,Xie Z,Song XJ

    更新日期:2020-02-10 00:00:00

  • Perceived cognitive deficits, emotional distress and disability following whiplash injury.

    abstract:OBJECTIVES:To describe the pattern of perceived cognitive deficits in patients with whiplash injury, to examine the relation between perceived cognitive deficits and disability, and to examine the determinants of perceived cognitive deficits in patients with whiplash injury. PARTICIPANTS:A total of 81 individuals part...

    journal_title:Pain research & management

    pub_type: 临床试验,杂志文章

    doi:10.1155/2002/502984

    authors: Sullivan MJ,Hall E,Bartolacci R,Sullivan ME,Adams H

    更新日期:2002-10-01 00:00:00

  • Lumbar Radiofrequency Rhizotomy in Patients with Chronic Low Back Pain Increases the Diagnosis of Sacroiliac Joint Dysfunction in Subsequent Follow-Up Visits.

    abstract::Chronic back pain is often a result of coexisting pathologies; secondary causes of pain can become more apparent sources of pain once the primary pathology has been addressed. The objective of our study was to determine if there is an increase in diagnosis of Sacroiliac joint pain following a Lumbar Rhizotomy. A list ...

    journal_title:Pain research & management

    pub_type: 杂志文章

    doi:10.1155/2017/4830142

    authors: Rimmalapudi VK,Kumar S

    更新日期:2017-01-01 00:00:00

  • Prevalence of Chronic Pain, Treatments, Perception, and Interference on Life Activities: Brazilian Population-Based Survey.

    abstract:BACKGROUND AND OBJECTIVES:Chronic pain affects between 30% and 50% of the world population. Our objective was to estimate the prevalence of chronic pain in Brazil, describe and compare differences between pain types and characteristics, and identify the types of therapies adopted and the impact of pain on daily life. ...

    journal_title:Pain research & management

    pub_type: 杂志文章

    doi:10.1155/2017/4643830

    authors: de Souza JB,Grossmann E,Perissinotti DMN,de Oliveira Junior JO,da Fonseca PRB,Posso IP

    更新日期:2017-01-01 00:00:00

  • Effects of smoke exposure and other lifestyle factors on pain response to electrical stimulation in women.

    abstract:BACKGROUND:A relationship between smoking and development of pain syndromes has been suggested in the literature. The present study examined associations between smoke exposure and other related variables, and pain response to suprathreshold electrical stimulation. METHODS:Subjects were prospectively recruited from a ...

    journal_title:Pain research & management

    pub_type: 杂志文章

    doi:10.1155/2008/240573

    authors: Wee JY,Hopman WM

    更新日期:2008-05-01 00:00:00

  • The Chronic Pain Myth Scale: Development and Validation of a French-Canadian Instrument Measuring Knowledge, Beliefs, and Attitudes of People in the Community towards Chronic Pain.

    abstract::Background. In order to better design awareness programs on chronic pain (CP), measurement of knowledge, beliefs, and attitudes of people in the community towards this condition is most useful. Objectives. To develop and validate a French-Canadian scale that could be used for this purpose. Methods. Items of the Chroni...

    journal_title:Pain research & management

    pub_type: 杂志文章

    doi:10.1155/2016/5940206

    authors: Lacasse A,Connelly JA,Choinière M

    更新日期:2016-01-01 00:00:00

  • The influence of communicative relations on facial responses to pain: does it matter who is watching?

    abstract:BACKGROUND:Facial responses to pain are believed to be an act of communication and, as such, are likely to be affected by the relationship between sender and receiver. OBJECTIVES:To investigate this effect by examining the impact that variations in communicative relations (from being alone to being with an intimate ot...

    journal_title:Pain research & management

    pub_type: 杂志文章,随机对照试验

    doi:10.1155/2014/195286

    authors: Karmann AJ,Lautenbacher S,Bauer F,Kunz M

    更新日期:2014-01-01 00:00:00

  • Adolescents' pain coping profiles: expectations for treatment, functional outcomes and adherence to psychological treatment recommendations.

    abstract:OBJECTIVES:To explore how adolescents' pain coping profiles relate to their expectations regarding psychological treatment recommendations, and to examine patients' functioning and engagement in psychological treatment three months following a multidisciplinary pain clinic evaluation. METHODS:Adolescents and their par...

    journal_title:Pain research & management

    pub_type: 杂志文章

    doi:10.1155/2011/652853

    authors: Claar RL,Simons LE

    更新日期:2011-05-01 00:00:00

  • The effect of sleep deprivation on pain.

    abstract::Chronic pain syndromes are associated with alterations in sleep continuity and sleep architecture. One perspective of this relationship, which has not received much attention to date, is that disturbances of sleep affect pain. To fathom this direction of cause, experimental human and animal studies on the effects of s...

    journal_title:Pain research & management

    pub_type: 杂志文章,评审

    doi:10.1155/2004/949187

    authors: Kundermann B,Krieg JC,Schreiber W,Lautenbacher S

    更新日期:2004-04-01 00:00:00

  • Postthoracotomy Ipsilateral Shoulder Pain: A Literature Review on Characteristics and Treatment.

    abstract::Context. Postthoracotomy Ipsilateral Shoulder Pain (IPS) is a common and sometimes intractable pain syndrome. IPS is different from chest wall pain in type, origin, and treatments. Various treatments are suggested or applied for it but none of them is regarded as popular accepted effective one. Objectives. To review d...

    journal_title:Pain research & management

    pub_type: 杂志文章,评审

    doi:10.1155/2016/3652726

    authors: Yousefshahi F,Predescu O,Colizza M,Asenjo JF

    更新日期:2016-01-01 00:00:00

  • The Need for Improved Management of Painful Diabetic Neuropathy in Primary Care.

    abstract::The provision of care for patients with type II diabetes in primary care must involve assessing patients for peripheral neuropathy of the feet. Objectives. This paper will demonstrate that painful diabetic neuropathy (PDN) is poorly assessed for and treated in primary care. Methods. A critical analysis of research wil...

    journal_title:Pain research & management

    pub_type: 杂志文章

    doi:10.1155/2016/1974863

    authors: Sobhy T

    更新日期:2016-01-01 00:00:00

  • Prediction of adaptive self-regulatory responses to arthritis pain anxiety in exercising adults: does pain acceptance matter?

    abstract:BACKGROUND:Exercising for ≥ 150 min/week is a recommended strategy for self-managing arthritis. However, exercise nonadherence is a problem. Arthritis pain anxiety may interfere with regular exercise. According to the fear-avoidance model, individuals may confront their pain anxiety by using adaptive self-regulatory re...

    journal_title:Pain research & management

    pub_type: 杂志文章

    doi:10.1155/2015/853961

    authors: Cary MA,Gyurcsik NC,Brawley LR

    更新日期:2015-03-01 00:00:00

  • Mechanisms of "Cough-Trick" for Pain Relief during Venipuncture: An Experimental Crossover Investigation in Healthy Volunteers.

    abstract:Objectives:The easily performed "cough-trick" (CT) reduces pain during venipuncture (VP), although the underlying mechanism remains unclear. The aim was to investigate the pain-reducing effect of CT during VP in comparison with two distraction methods, as well as under the influence of naloxone. Methods:54 healthy mal...

    journal_title:Pain research & management

    pub_type: 临床试验,杂志文章

    doi:10.1155/2019/9459103

    authors: Usichenko TI,Janner H,Gagarine M,Pavlovic D,Lang E,Hahnenkamp K

    更新日期:2019-12-12 00:00:00

  • Potential Nociceptive Regulatory Effect of Probiotic Lactobacillus rhamnosus PB01 (DSM 14870) on Mechanical Sensitivity in Diet-Induced Obesity Model.

    abstract::Treatments for obesity have been shown to reduce pain secondary to weight loss. Intestinal microbiota, as an endogenous factor, influences obesity and pain sensitivity but the effect of oral probiotic supplementation on musculoskeletal pain perception has not been studied systematically. The present study examined the...

    journal_title:Pain research & management

    pub_type: 杂志文章

    doi:10.1155/2016/5080438

    authors: Dardmeh F,Nielsen HI,Alipour H,Kjærgaard B,Brandsborg E,Gazerani P

    更新日期:2016-01-01 00:00:00

  • Assessing the Structure of the Ways of Coping Questionnaire in Fibromyalgia Patients Using Common Factor Analytic Approaches.

    abstract::The Ways of Coping Questionnaire (WCQ) is a widely used measure of coping processes. Despite its use in a variety of populations, there has been concern about the stability and structure of the WCQ across different populations. This study examines the factor structure of the WCQ in a large sample of individuals diagno...

    journal_title:Pain research & management

    pub_type: 杂志文章

    doi:10.1155/2016/7297826

    authors: Van Liew C,Santoro MS,Edwards L,Kang J,Cronan TA

    更新日期:2016-01-01 00:00:00