Abstract:
Objectives:A recent work has reported that the elevated osteopontin (OPN) levels in the articular cartilage and synovial fluid are correlated with the progressive osteoarthritis (OA) joint damage, and OPN has a protective effect against OA by suppressing the expressions of OA-associated genes. The present study examined whether the OPN deficiency was susceptible to OA through the regulation of chondrocyte senescence and apoptosis and the expressions of OA-associated genes. Methods:The mRNA levels of COL2A1 and OPN were compared between human OA chondrocytes and normal chondrocytes. The effects of OPN siRNA on the SA-β-Gal expressions and the percentage of apoptotic chondrocytes were examined by using SA-β-Gal staining and apoptosis assay, and the effects on the expressions of COL2A1 and OA-associated genes (COL10A1, IL-1β, TNF-ɑ, MMP-13, and ADAMTS5) were examined by western blot analysis and quantitative real-time RT-PCR. Furthermore, an in vivo OA model was established to examine the effects of OPN siRNA on the senescence and apoptosis of OA chondrocytes and the expressions of OA-associated genes. Results:The mRNA levels of COL2A1 and OPN were decreased in knee OA chondrocytes in comparison with those in normal chondrocytes. The OPN deficiency enhanced the senescence and apoptosis of OA chondrocytes and increased the expressions of COL10A1, IL-1β, TNF-ɑ, MMP-13, and ADAMTS5 but decreased the expression of COL2A1. Meanwhile, OPN deficiency could result in severe, accelerated OA in vivo, which was also associated with enhanced senescence and apoptosis of chondrocytes and elevated expressions of OA-associated genes. Conclusions:The findings of this study suggest that the OPN deficiency can result in accelerated OA, which is associated with enhanced senescence and apoptosis of OA chondrocytes and the upregulated expressions of OA-associated genes.
journal_name
Pain Res Managjournal_title
Pain research & managementauthors
Tian J,Cheng C,Kuang SD,Su C,Zhao X,Xiong YL,Li YS,Gao SGdoi
10.1155/2020/3428587subject
Has Abstractpub_date
2020-10-22 00:00:00pages
3428587eissn
1203-6765issn
1918-1523journal_volume
2020pub_type
杂志文章abstract::Background. Oral health-related quality of life (OHRQoL) is impacted by periodontal disease and orofacial pain. There is a limited research examining the impact of avoidance of care or physiological arousal related to the fear of pain response on periodontal-related OHRQoL. Methods. Data are from the Center for Oral H...
journal_title:Pain research & management
pub_type: 杂志文章
doi:10.1155/2017/5491923
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:As the North American population ages, the prevalence of knee osteoarthritis and the surgical interventions (ie, total knee arthroplasty [TKA]) aimed at correcting pain and disability will also rise proportionally. Therefore, efforts to better understand the factors associated with surgical outcomes are warr...
journal_title:Pain research & management
pub_type: 杂志文章
doi:10.1155/2007/394960
更新日期:2007-10-01 00:00:00
abstract:Background:Chronic low back pain (CLBP) arising from degenerative disc disease continues to be a challenging clinical and diagnostic problem whether treated with nonsurgical, pain intervention, or motion-preserving stabilization and arthrodesis. Methods:Fourteen patients with CLBP, greater than 6 months, unresponsive ...
journal_title:Pain research & management
pub_type: 杂志文章
doi:10.1155/2018/6857983
更新日期:2018-08-14 00:00:00
abstract:OBJECTIVES:To explore how adolescents' pain coping profiles relate to their expectations regarding psychological treatment recommendations, and to examine patients' functioning and engagement in psychological treatment three months following a multidisciplinary pain clinic evaluation. METHODS:Adolescents and their par...
journal_title:Pain research & management
pub_type: 杂志文章
doi:10.1155/2011/652853
更新日期:2011-05-01 00:00:00
abstract:OBJECTIVE:The present randomized, double-blinded, crossover study compared the efficacy and safety of a seven-day buprenorphine transdermal system (BTDS) and placebo in patients with low back pain of moderate or greater severity for at least six weeks. METHODS:Prestudy analgesics were discontinued the evening before r...
journal_title:Pain research & management
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1155/2010/216725
更新日期:2010-05-01 00:00:00
abstract:Purpose:A possible relationship between sleep bruxism (SB) and several sleep disorders has been suggested in children, which could influence sleep quality and quality of life. This study aims to assess such correlations in a large sample of school children. Methods:Parents of 741 consecutive children aged between 8 an...
journal_title:Pain research & management
pub_type: 杂志文章
doi:10.1155/2020/3408928
更新日期:2020-07-30 00:00:00
abstract:Background:Despite the large body of research on sex differences in pain, there is a lack of knowledge about the influence of gender in the patient-provider encounter. The purpose of this study was to review literature on gendered norms about men and women with pain and gender bias in the treatment of pain. The second ...
journal_title:Pain research & management
pub_type: 杂志文章,评审
doi:10.1155/2018/6358624
更新日期:2018-02-25 00:00:00
abstract:Objectives:Dexmedetomidine is widely used as an adjunct to general anesthesia. In this study, we evaluated the effects of perioperative dexmedetomidine infusion on postoperative analgesia in patients undergoing lateral thoracotomy for thoracic esophageal cancer. Methods:A total of 62 patients undergoing lateral thorac...
journal_title:Pain research & management
pub_type: 杂志文章,随机对照试验
doi:10.1155/2020/4145893
更新日期:2020-05-06 00:00:00
abstract:BACKGROUND:Although a variety of national organizations such as the Canadian Pain Society, the American Pain Society and the Joint Commission on Accreditation of Health Care Organizations have advanced the idea that pain should be assessed on a routine basis, there is little evidence that systematic pain assessment inf...
journal_title:Pain research & management
pub_type: 杂志文章
doi:10.1155/2009/638585
更新日期:2009-05-01 00:00:00
abstract::Context. Postthoracotomy Ipsilateral Shoulder Pain (IPS) is a common and sometimes intractable pain syndrome. IPS is different from chest wall pain in type, origin, and treatments. Various treatments are suggested or applied for it but none of them is regarded as popular accepted effective one. Objectives. To review d...
journal_title:Pain research & management
pub_type: 杂志文章,评审
doi:10.1155/2016/3652726
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:A relationship between smoking and development of pain syndromes has been suggested in the literature. The present study examined associations between smoke exposure and other related variables, and pain response to suprathreshold electrical stimulation. METHODS:Subjects were prospectively recruited from a ...
journal_title:Pain research & management
pub_type: 杂志文章
doi:10.1155/2008/240573
更新日期:2008-05-01 00:00:00
abstract::Neuropathic pain (NeP), generated by disorders of the peripheral and central nervous system, can be particularly severe and disabling. Prevalence estimates indicate that 2% to 3% of the population in the developed world suffer from NeP, which suggests that up to one million Canadians have this disabling condition. Evi...
journal_title:Pain research & management
pub_type: 共识发展会议,杂志文章,实务指引
doi:10.1155/2007/730785
更新日期:2007-04-01 00:00:00
abstract:BACKGROUND:Exercising for ≥ 150 min/week is a recommended strategy for self-managing arthritis. However, exercise nonadherence is a problem. Arthritis pain anxiety may interfere with regular exercise. According to the fear-avoidance model, individuals may confront their pain anxiety by using adaptive self-regulatory re...
journal_title:Pain research & management
pub_type: 杂志文章
doi:10.1155/2015/853961
更新日期:2015-03-01 00:00:00
abstract:Objective:In this study, we compared the effects of intermittent pneumatic compression along with conventional treatment with cold-pack treatment along with conventional treatment on clinical outcomes in patients with knee osteoarthritis. Methods:Eighty-nine patients with knee osteoarthritis participated in this study...
journal_title:Pain research & management
pub_type: 杂志文章,随机对照试验
doi:10.1155/2019/8514808
更新日期:2019-05-02 00:00:00
abstract::Objectives. The aim of this study was to determine the effectiveness of preoperative administration of single-dose of paracetamol-codeine, in the relieving of acute postoperative pain after the surgical removal of an impacted mandibular third molar. Materials and Methods. The study cohort consisted of 32 Caucasian out...
journal_title:Pain research & management
pub_type: 杂志文章,随机对照试验
doi:10.1155/2017/9246352
更新日期:2017-01-01 00:00:00
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journal_title:Pain research & management
pub_type: 杂志文章
doi:10.1155/2010/952816
更新日期:2010-11-01 00:00:00
abstract:BACKGROUND:We recently introduced the efficacy safety score (ESS) as a new "call-out algorithm" for management of postoperative pain and side effects. In this study, we report the influence of ESS recorded hourly during the first 8 hours after surgery on the mobility degree, postoperative nonsurgical complications, and...
journal_title:Pain research & management
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1155/2017/9431984
更新日期:2017-01-01 00:00:00
abstract:Objectives:To examine the interrater and intrarater reliability and construct validity of the Pain Behaviour Scale during standard physical performance tests in people with chronic low back pain and to confirm the test-retest reliability of the physical performance tests in this population. The Pain Behaviour Scale (Pa...
journal_title:Pain research & management
pub_type: 杂志文章
doi:10.1155/2019/2508019
更新日期:2019-02-03 00:00:00
abstract:BACKGROUND:The impact of telephone consultations between pain specialists and primary care physicians regarding the care of patients with chronic pain is unknown. OBJECTIVES:To evaluate the impact of telephone consultations between pain specialists and primary care physicians regarding the care of patients with chroni...
journal_title:Pain research & management
pub_type: 杂志文章
doi:10.1155/2015/345432
更新日期:2015-11-01 00:00:00
abstract:Objective:To assess the validity of an exposure score obtained from the Xm2 tool for all pharmacological and nonpharmacological strategies used by individuals to manage chronic pain. Methods:Using data from individuals with chronic pain, eXposure multimodal (Xm2) scores were calculated by assigning one point for every...
journal_title:Pain research & management
pub_type: 杂志文章
doi:10.1155/2018/2530286
更新日期:2018-12-12 00:00:00
abstract::Background. Cardiovascular indices of pain are pervasive in the hospital setting. However, no prospective research has examined the development of cardiac responses to acutely painful procedures in the first year of life. Objectives. Our main goal was to synthesize existing evidence regarding the development of cardio...
journal_title:Pain research & management
pub_type: 杂志文章,评审
doi:10.1155/2016/8458696
更新日期:2016-01-01 00:00:00
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journal_title:Pain research & management
pub_type: 杂志文章,随机对照试验
doi:10.1155/2016/4216469
更新日期:2016-01-01 00:00:00
abstract::Chronic back pain is often a result of coexisting pathologies; secondary causes of pain can become more apparent sources of pain once the primary pathology has been addressed. The objective of our study was to determine if there is an increase in diagnosis of Sacroiliac joint pain following a Lumbar Rhizotomy. A list ...
journal_title:Pain research & management
pub_type: 杂志文章
doi:10.1155/2017/4830142
更新日期:2017-01-01 00:00:00
abstract:OBJECTIVE:To analyze articles on neonatal pain indexed in MEDLINE from 1965 to 1999. METHODS:Papers published since 1965 and indexed in Medline (PubMed ) were considered. The search strategy was: 'pain' (MeSH terms) OR 'pain' (Title word) OR 'pain' (All Fields), AND 'infant, newborn' (MeSH terms). After the search was...
journal_title:Pain research & management
pub_type: 杂志文章,meta分析
doi:10.1155/2001/213030
更新日期:2001-04-01 00:00:00
abstract:BACKGROUND:Tension-type headache is the most common form of headache and its chronic form, chronic tension-type headache (CTTH), is one of the most difficult to treat. The etiology of CTTH is not well understood, but is believed to be multifactorial and to vary among individuals. In the present study, the authors sough...
journal_title:Pain research & management
pub_type: 杂志文章
doi:10.1155/2013/796161
更新日期:2013-11-01 00:00:00
abstract:BACKGROUND:Methadone is one of the most important medications used for the treatment of refractory pain in the palliative care setting, and is usually initially prescribed by one of a limited number of physicians who have acquired authorization for its use. A lack of authorized physicians able to take over prescribing ...
journal_title:Pain research & management
pub_type: 杂志文章
doi:10.1155/2013/740379
更新日期:2013-03-01 00:00:00
abstract::Introduction. Pain is unpleasant sensory and emotional experience associated with actual and potential tissue damage. Inadequate pain management has been shown to affect patient outcomes by potentially increasing hospital stay and delaying recovery; thus, the management of pain has major implications for nursing. The ...
journal_title:Pain research & management
pub_type: 杂志文章
doi:10.1155/2020/6036575
更新日期:2020-03-18 00:00:00
abstract::Safety issues are a major barrier to the use of cannabis and cannabinoid medications for clinical purposes. Information on the safety of herbal cannabis may be derived from studies of recreational cannabis use, but cannabis exposure and effects may differ widely between medical and recreational cannabis users. Standar...
journal_title:Pain research & management
pub_type: 杂志文章,评审
doi:10.1155/2005/312357
更新日期:2005-10-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Chronic pain affects between 30% and 50% of the world population. Our objective was to estimate the prevalence of chronic pain in Brazil, describe and compare differences between pain types and characteristics, and identify the types of therapies adopted and the impact of pain on daily life. ...
journal_title:Pain research & management
pub_type: 杂志文章
doi:10.1155/2017/4643830
更新日期:2017-01-01 00:00:00
abstract:Objective:The aim of this study was to estimate the incidence of delirium and its risk factors among critically ill cancer patients in an intensive care unit (ICU). Materials and Methods:This is a prospective cohort study. The Confusion Assessment Method for the Intensive Care Unit (CAM-ICU) was measured daily at morn...
journal_title:Pain research & management
pub_type: 杂志文章
doi:10.1155/2018/4193275
更新日期:2018-07-08 00:00:00