Abstract:
OBJECTIVE:A pilot study was conducted to assess whether both the rationale and feasibility exist for future randomized clinical trials to evaluate the combined use of naloxone infusion and tramadol/acetaminophen as opioid-sparing drugs in elderly patients undergoing lower extremity joint replacement surgery. DESIGN:Ten patients 70 years of age or older undergoing either total knee (n=7) or total hip (n=3) arthroplasty were treated prospectively. Each patient received two tablets of tramadol/acetaminophen (Tramacet; Janssen-Ortho Inc, Canada) preoperatively and every 6 h postoperatively, as well as a naloxone infusion started preoperatively at 0.25 microg/kg/h and continued up to 48 h postoperatively. In addition, standard intraoperative care was provided with 0.2 mg of intrathecal morphine, 1.4 mL of 0.75% bupivacaine, and an intra-articular infiltration of 100 mL of 0.3% ropivacaine and 30 mg of ketorolac, as well as standard postoperative morphine via patient-controlled analgesia orders and celecoxib 200 mg twice daily for five days. OUTCOME MEASURES:Compared with seven historical controls, also 70 years of age or older, who had undergone either a total knee (n=4) or total hip (n=3) arthroplasty, postoperative opioid use was reduced by 80%. Except for transient nausea and vomiting in 40% and 20% of patients, respectively, the 10 patients on tramadol/acetaminophen and naloxone tolerated the new regimen without difficulty. CONCLUSION:Consequently, a randomized, double-blinded clinical trial comparing standard therapy versus standard therapy plus these two drugs seems warranted. In such a trial, it would require approximately 20 subjects per treatment arm to detect a 80% decrease in morphine use.
journal_name
Pain Res Managjournal_title
Pain research & managementauthors
Imasogie NN,Singh S,Watson JT,Hurley D,Morley-Forster Pdoi
10.1155/2009/497217subject
Has Abstractpub_date
2009-03-01 00:00:00pages
103-8issue
2eissn
1203-6765issn
1918-1523journal_volume
14pub_type
临床试验,杂志文章abstract:BACKGROUND:Pain clinics tend to see more complex chronic pain patients than primary care settings, but the types of patients seen may differ among practices. OBJECTIVE:The aim of the present observational study was to describe the pain and demographic characteristics of patients attending a university-affiliated terti...
journal_title:Pain research & management
pub_type: 杂志文章
doi:10.1155/2007/658762
更新日期:2007-07-01 00:00:00
abstract:Background and Objective:A novel option for myofascial pain (MFP) management and muscle regeneration is intramuscular collagen injections. The aim of the study was to evaluate the efficiency of intramuscular injections of collagen and lidocaine in decreasing MFP within masseter muscles. Methods:Myofascial pain within ...
journal_title:Pain research & management
pub_type: 杂志文章,随机对照试验
doi:10.1155/2018/8261090
更新日期:2018-06-03 00:00:00
abstract:BACKGROUND:Tension-type headache is the most common form of headache and its chronic form, chronic tension-type headache (CTTH), is one of the most difficult to treat. The etiology of CTTH is not well understood, but is believed to be multifactorial and to vary among individuals. In the present study, the authors sough...
journal_title:Pain research & management
pub_type: 杂志文章
doi:10.1155/2013/796161
更新日期:2013-11-01 00:00:00
abstract::Several research studies have revealed that migraine has a solid link with gastrointestinal diseases especially irritable bowel syndrome (IBS). This study was carried out to investigate therapeutic potential of diet based on IgG elimination combined with probiotics on migraine plus irritable bowel syndrome. A total of...
journal_title:Pain research & management
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1155/2019/7890461
更新日期:2019-08-21 00:00:00
abstract:OBJECTIVE:The present randomized, double-blinded, crossover study compared the efficacy and safety of a seven-day buprenorphine transdermal system (BTDS) and placebo in patients with low back pain of moderate or greater severity for at least six weeks. METHODS:Prestudy analgesics were discontinued the evening before r...
journal_title:Pain research & management
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1155/2010/216725
更新日期:2010-05-01 00:00:00
abstract::Staff shortages, deficient knowledge, inappropriate attitudes, demanding workloads, analgesic shortages, and low prioritization of pain management have been identified in earlier studies as the nursing-related barriers to optimal children's pain management. These studies have mainly been undertaken in developed countr...
journal_title:Pain research & management
pub_type: 杂志文章
doi:10.1155/2020/7125060
更新日期:2020-01-20 00:00:00
abstract:Objective:This study aimed at assessing the clinical effectiveness of acupuncture for lateral epicondylitis (LE). Methods:The following databases were systematically searched: China National Knowledge Infrastructure, Chinese Science and Technology Periodical Database, Wan Fang database, Chinese Biomedicine Literature,...
journal_title:Pain research & management
pub_type: 杂志文章,meta分析
doi:10.1155/2020/8506591
更新日期:2020-03-20 00:00:00
abstract::The Ways of Coping Questionnaire (WCQ) is a widely used measure of coping processes. Despite its use in a variety of populations, there has been concern about the stability and structure of the WCQ across different populations. This study examines the factor structure of the WCQ in a large sample of individuals diagno...
journal_title:Pain research & management
pub_type: 杂志文章
doi:10.1155/2016/7297826
更新日期:2016-01-01 00:00:00
abstract:Objective:The aim of this study was to estimate the incidence of delirium and its risk factors among critically ill cancer patients in an intensive care unit (ICU). Materials and Methods:This is a prospective cohort study. The Confusion Assessment Method for the Intensive Care Unit (CAM-ICU) was measured daily at morn...
journal_title:Pain research & management
pub_type: 杂志文章
doi:10.1155/2018/4193275
更新日期:2018-07-08 00:00:00
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journal_title:Pain research & management
pub_type: 杂志文章,评审
doi:10.1155/2014/938352
更新日期:2014-07-01 00:00:00
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journal_title:Pain research & management
pub_type: 杂志文章,meta分析
doi:10.1155/2001/213030
更新日期:2001-04-01 00:00:00
abstract:Purpose:The purpose of this study was to investigate the prevalence of sleep disturbance and its clinical implication in patients with ASD. Methods:A total of 44 patients with ASD and 137 patients with lumbar spinal stenosis (LSS) were enrolled in the study. Forty four patients were selected from the LSS group after p...
journal_title:Pain research & management
pub_type: 杂志文章
doi:10.1155/2020/6294151
更新日期:2020-04-13 00:00:00
abstract:BACKGROUND:Alexithymia is a disturbance in awareness and cognitive processing of affect that is associated with over-reporting of physical symptoms, including pain. The relationship between alexithymia and other psychological constructs that are often associated with pain has yet to be evaluated. OBJECTIVES:The presen...
journal_title:Pain research & management
pub_type: 杂志文章
doi:10.1155/2009/468321
更新日期:2009-07-01 00:00:00
abstract::Background. Observers' responses to pain are recently investigated to more comprehensively explain chronic pain (CP) and disability. However, the role of family context, defined as interference in roles, communication, and problem-solving, and how (i.e., through which mechanisms) these variables contribute to CP relat...
journal_title:Pain research & management
pub_type: 杂志文章
doi:10.1155/2016/6838596
更新日期:2016-01-01 00:00:00
abstract::Chronic pain is frequently associated with significant psychological issues, such as depression or anxiety. Psychological treatments, such as psychotherapy, can often alleviate both psychological and pain symptoms. However, there is limited research about the association between psychological symptoms and perceived pa...
journal_title:Pain research & management
pub_type: 杂志文章
doi:10.1155/2018/8713084
更新日期:2018-04-19 00:00:00
abstract::Whiplash-associated disorder (WAD) represents a significant public health problem, resulting in substantial social and economic costs throughout the industrialized world. While many treatments have been advocated for patients with WAD, scientific evidence supporting their effectiveness is often lacking. A systematic r...
journal_title:Pain research & management
pub_type: 杂志文章,评审
doi:10.1155/2010/487279
更新日期:2010-09-01 00:00:00
abstract:BACKGROUND:Diminished executive function and attentional control has been reported in chronic pain patients. However, the precise pattern of impairment in these aspects of cognition in chronic pain remains unclear. Moreover, a decline in psychomotor speed could potentially influence executive and attentional control pe...
journal_title:Pain research & management
pub_type: 杂志文章
doi:10.1155/2012/962786
更新日期:2012-05-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Few studies have examined the relationship between disability and borderline personality symptomatology, and, among those that have, findings have been inconsistent. In the present study, the relationship between medical disability and borderline personality symptomatology was examined in a sam...
journal_title:Pain research & management
pub_type: 杂志文章
doi:10.1155/2010/952816
更新日期:2010-11-01 00:00:00
abstract:Objectives:Dexmedetomidine is widely used as an adjunct to general anesthesia. In this study, we evaluated the effects of perioperative dexmedetomidine infusion on postoperative analgesia in patients undergoing lateral thoracotomy for thoracic esophageal cancer. Methods:A total of 62 patients undergoing lateral thorac...
journal_title:Pain research & management
pub_type: 杂志文章,随机对照试验
doi:10.1155/2020/4145893
更新日期:2020-05-06 00:00:00
abstract::Pain is one of the commonest reasons why children visit the hospital. Inadequately treated pain in children can negatively affect their physical, psychological, and social well-being; it also places financial burden on families of affected children and healthcare systems in general. Considering the eventual suffering ...
journal_title:Pain research & management
pub_type: 杂志文章
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更新日期:2020-02-13 00:00:00
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journal_title:Pain research & management
pub_type: 杂志文章
doi:10.1155/2015/853961
更新日期:2015-03-01 00:00:00
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journal_title:Pain research & management
pub_type: 杂志文章
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更新日期:2017-01-01 00:00:00
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journal_title:Pain research & management
pub_type: 杂志文章,随机对照试验
doi:10.1155/2016/4261949
更新日期:2016-01-01 00:00:00
abstract:Purpose:A possible relationship between sleep bruxism (SB) and several sleep disorders has been suggested in children, which could influence sleep quality and quality of life. This study aims to assess such correlations in a large sample of school children. Methods:Parents of 741 consecutive children aged between 8 an...
journal_title:Pain research & management
pub_type: 杂志文章
doi:10.1155/2020/3408928
更新日期:2020-07-30 00:00:00
abstract:Objectives:To examine the interrater and intrarater reliability and construct validity of the Pain Behaviour Scale during standard physical performance tests in people with chronic low back pain and to confirm the test-retest reliability of the physical performance tests in this population. The Pain Behaviour Scale (Pa...
journal_title:Pain research & management
pub_type: 杂志文章
doi:10.1155/2019/2508019
更新日期:2019-02-03 00:00:00
abstract:Background:Despite the large body of research on sex differences in pain, there is a lack of knowledge about the influence of gender in the patient-provider encounter. The purpose of this study was to review literature on gendered norms about men and women with pain and gender bias in the treatment of pain. The second ...
journal_title:Pain research & management
pub_type: 杂志文章,评审
doi:10.1155/2018/6358624
更新日期:2018-02-25 00:00:00
abstract:Objectives:A recent work has reported that the elevated osteopontin (OPN) levels in the articular cartilage and synovial fluid are correlated with the progressive osteoarthritis (OA) joint damage, and OPN has a protective effect against OA by suppressing the expressions of OA-associated genes. The present study examine...
journal_title:Pain research & management
pub_type: 杂志文章
doi:10.1155/2020/3428587
更新日期:2020-10-22 00:00:00
abstract:BACKGROUND:Facial responses to pain are believed to be an act of communication and, as such, are likely to be affected by the relationship between sender and receiver. OBJECTIVES:To investigate this effect by examining the impact that variations in communicative relations (from being alone to being with an intimate ot...
journal_title:Pain research & management
pub_type: 杂志文章,随机对照试验
doi:10.1155/2014/195286
更新日期:2014-01-01 00:00:00
abstract:Objective:To assess the validity of an exposure score obtained from the Xm2 tool for all pharmacological and nonpharmacological strategies used by individuals to manage chronic pain. Methods:Using data from individuals with chronic pain, eXposure multimodal (Xm2) scores were calculated by assigning one point for every...
journal_title:Pain research & management
pub_type: 杂志文章
doi:10.1155/2018/2530286
更新日期:2018-12-12 00:00:00
abstract:BACKGROUND:A relationship between smoking and development of pain syndromes has been suggested in the literature. The present study examined associations between smoke exposure and other related variables, and pain response to suprathreshold electrical stimulation. METHODS:Subjects were prospectively recruited from a ...
journal_title:Pain research & management
pub_type: 杂志文章
doi:10.1155/2008/240573
更新日期:2008-05-01 00:00:00