Abstract:
:Safety issues are a major barrier to the use of cannabis and cannabinoid medications for clinical purposes. Information on the safety of herbal cannabis may be derived from studies of recreational cannabis use, but cannabis exposure and effects may differ widely between medical and recreational cannabis users. Standardized, quality-controlled cannabinoid products are available in Canada, and safety profiles of approved medications are available through the Canadian formulary. In the present article, the evidence behind major safety issues related to cannabis use is summarized, with the aim of promoting informed dialogue between physicians and patients in whom cannabinoid therapy is being considered. Caution is advised in interpreting these data, because clinical experience with cannabinoid use is in the early stages. There is a need for long-term safety monitoring of patients using cannabinoids for a wide variety of conditions, to further guide therapeutic decisions and public policy.
journal_name
Pain Res Managjournal_title
Pain research & managementauthors
Ware MA,Tawfik VLdoi
10.1155/2005/312357subject
Has Abstractpub_date
2005-10-01 00:00:00pages
31A-7Aeissn
1203-6765issn
1918-1523journal_volume
10 Suppl Apub_type
杂志文章,评审abstract:Background:Treatment of diabetic neuropathic pain (DNP) continues to be a major challenge, and underlying mechanisms of DNP remain elusive. We investigated treatment effects of B vitamins on DPN- and DNP-associated alterations of neurochemical signaling in the nociceptive dorsal root ganglion (DRG) neurons and the spin...
journal_title:Pain research & management
pub_type: 杂志文章
doi:10.1155/2020/3740162
更新日期:2020-02-10 00:00:00
abstract:Purpose:The purpose of this study was to investigate the prevalence of sleep disturbance and its clinical implication in patients with ASD. Methods:A total of 44 patients with ASD and 137 patients with lumbar spinal stenosis (LSS) were enrolled in the study. Forty four patients were selected from the LSS group after p...
journal_title:Pain research & management
pub_type: 杂志文章
doi:10.1155/2020/6294151
更新日期:2020-04-13 00:00:00
abstract:BACKGROUND:Reports indicate that characteristics of older adults with chronic pain may be different than those of younger persons. OBJECTIVE:To study the pain characteristics of older patients presenting to a tertiary pain clinic for the first time. METHODS:Age, sex and relative contributions of biomedical versus psy...
journal_title:Pain research & management
pub_type: 杂志文章
doi:10.1155/2008/541963
更新日期:2008-09-01 00:00:00
abstract::Staff shortages, deficient knowledge, inappropriate attitudes, demanding workloads, analgesic shortages, and low prioritization of pain management have been identified in earlier studies as the nursing-related barriers to optimal children's pain management. These studies have mainly been undertaken in developed countr...
journal_title:Pain research & management
pub_type: 杂志文章
doi:10.1155/2020/7125060
更新日期:2020-01-20 00:00:00
abstract:OBJECTIVES:To explore how adolescents' pain coping profiles relate to their expectations regarding psychological treatment recommendations, and to examine patients' functioning and engagement in psychological treatment three months following a multidisciplinary pain clinic evaluation. METHODS:Adolescents and their par...
journal_title:Pain research & management
pub_type: 杂志文章
doi:10.1155/2011/652853
更新日期:2011-05-01 00:00:00
abstract::Context. Postthoracotomy Ipsilateral Shoulder Pain (IPS) is a common and sometimes intractable pain syndrome. IPS is different from chest wall pain in type, origin, and treatments. Various treatments are suggested or applied for it but none of them is regarded as popular accepted effective one. Objectives. To review d...
journal_title:Pain research & management
pub_type: 杂志文章,评审
doi:10.1155/2016/3652726
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Chronic pain affects between 30% and 50% of the world population. Our objective was to estimate the prevalence of chronic pain in Brazil, describe and compare differences between pain types and characteristics, and identify the types of therapies adopted and the impact of pain on daily life. ...
journal_title:Pain research & management
pub_type: 杂志文章
doi:10.1155/2017/4643830
更新日期:2017-01-01 00:00:00
abstract::Background. Cardiovascular indices of pain are pervasive in the hospital setting. However, no prospective research has examined the development of cardiac responses to acutely painful procedures in the first year of life. Objectives. Our main goal was to synthesize existing evidence regarding the development of cardio...
journal_title:Pain research & management
pub_type: 杂志文章,评审
doi:10.1155/2016/8458696
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Pain clinics tend to see more complex chronic pain patients than primary care settings, but the types of patients seen may differ among practices. OBJECTIVE:The aim of the present observational study was to describe the pain and demographic characteristics of patients attending a university-affiliated terti...
journal_title:Pain research & management
pub_type: 杂志文章
doi:10.1155/2007/658762
更新日期:2007-07-01 00:00:00
abstract:BACKGROUND:As the North American population ages, the prevalence of knee osteoarthritis and the surgical interventions (ie, total knee arthroplasty [TKA]) aimed at correcting pain and disability will also rise proportionally. Therefore, efforts to better understand the factors associated with surgical outcomes are warr...
journal_title:Pain research & management
pub_type: 杂志文章
doi:10.1155/2007/394960
更新日期:2007-10-01 00:00:00
abstract::Treatments for obesity have been shown to reduce pain secondary to weight loss. Intestinal microbiota, as an endogenous factor, influences obesity and pain sensitivity but the effect of oral probiotic supplementation on musculoskeletal pain perception has not been studied systematically. The present study examined the...
journal_title:Pain research & management
pub_type: 杂志文章
doi:10.1155/2016/5080438
更新日期:2016-01-01 00:00:00
abstract::Neuropathic pain (NeP), generated by disorders of the peripheral and central nervous system, can be particularly severe and disabling. Prevalence estimates indicate that 2% to 3% of the population in the developed world suffer from NeP, which suggests that up to one million Canadians have this disabling condition. Evi...
journal_title:Pain research & management
pub_type: 共识发展会议,杂志文章,实务指引
doi:10.1155/2007/730785
更新日期:2007-04-01 00:00:00
abstract:Background:Chronic low back pain (CLBP) arising from degenerative disc disease continues to be a challenging clinical and diagnostic problem whether treated with nonsurgical, pain intervention, or motion-preserving stabilization and arthrodesis. Methods:Fourteen patients with CLBP, greater than 6 months, unresponsive ...
journal_title:Pain research & management
pub_type: 杂志文章
doi:10.1155/2018/6857983
更新日期:2018-08-14 00:00:00
abstract:BACKGROUND:Pediatric chronic pain is a common problem with significant economic implications and devastating consequences on quality of life. The present report describes a case involving a 15-year-old girl with severe and debilitating chronic pain. RESULTS:Before her referral to a pain rehabilitation program, the pat...
journal_title:Pain research & management
pub_type: 杂志文章
doi:10.1155/2014/745458
更新日期:2014-07-01 00:00:00
abstract::The purpose of the present article was to assess the available literature concerning pain and autism. First, authors summarized the published articles on pain reactivity in people with autism. Second, the hypotheses envisaged to explain the presence of expressive particularities in people with autism spectrum disorder...
journal_title:Pain research & management
pub_type: 杂志文章,评审
doi:10.1155/2010/749275
更新日期:2010-07-01 00:00:00
abstract:BACKGROUND:Dynamic mechanical allodynia is traditionally induced by manual brushing of the skin. Brushing force and speed have been shown to influence the intensity of brush-evoked pain. There are still limited data available with respect to the optimal stroke number, length, force, angle and speed. Therefore, an autom...
journal_title:Pain research & management
pub_type: 杂志文章
doi:10.1155/2013/142582
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:Diminished executive function and attentional control has been reported in chronic pain patients. However, the precise pattern of impairment in these aspects of cognition in chronic pain remains unclear. Moreover, a decline in psychomotor speed could potentially influence executive and attentional control pe...
journal_title:Pain research & management
pub_type: 杂志文章
doi:10.1155/2012/962786
更新日期:2012-05-01 00:00:00
abstract::Radiotherapy is commonly used to treat cancer patients. Besides the curable effect, radiotherapy also could relieve the pain of cancer patients. However, cancer pain is gradually alleviated about two weeks after radiotherapy. In addition, cancer patients who receive radiotherapy may also suffer from pain flare or radi...
journal_title:Pain research & management
pub_type: 杂志文章,评审
doi:10.1155/2020/7565962
更新日期:2020-01-30 00:00:00
abstract:OBJECTIVE:To investigate the emotional and neurobehavioural status of patients suffering from chronic pain. METHODS:Fifteen male patients with chronic lower back pain and 15 healthy control subjects were studied for approximately six months. Pain was measured using a visual analogue scale. The WHO Neurobehavioral Core...
journal_title:Pain research & management
pub_type: 杂志文章
doi:10.1155/2011/825636
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:A relationship between smoking and development of pain syndromes has been suggested in the literature. The present study examined associations between smoke exposure and other related variables, and pain response to suprathreshold electrical stimulation. METHODS:Subjects were prospectively recruited from a ...
journal_title:Pain research & management
pub_type: 杂志文章
doi:10.1155/2008/240573
更新日期:2008-05-01 00:00:00
abstract::There is limited evidence to underpin the assessment and management of pain in children with profound cognitive impairment and these children are vulnerable to poor pain assessment and management. Health professionals working with children with profound cognitive impairment from a single paediatric tertiary referral c...
journal_title:Pain research & management
pub_type: 杂志文章
doi:10.1155/2016/8617182
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Acetaminophen is one of the most common drugs used for the treatment of pain and fever. OBJECTIVES:To examine the effects of intra-articular (IA) acetaminophen on carrageenan-induced arthritic pain-related behaviour and spinal c-Fos expression in rats. METHODS:The present study was performed using 20 Sprag...
journal_title:Pain research & management
pub_type: 杂志文章
doi:10.1155/2013/148392
更新日期:2013-09-01 00:00:00
abstract::Several research studies have revealed that migraine has a solid link with gastrointestinal diseases especially irritable bowel syndrome (IBS). This study was carried out to investigate therapeutic potential of diet based on IgG elimination combined with probiotics on migraine plus irritable bowel syndrome. A total of...
journal_title:Pain research & management
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1155/2019/7890461
更新日期:2019-08-21 00:00:00
abstract::Chronic back pain is often a result of coexisting pathologies; secondary causes of pain can become more apparent sources of pain once the primary pathology has been addressed. The objective of our study was to determine if there is an increase in diagnosis of Sacroiliac joint pain following a Lumbar Rhizotomy. A list ...
journal_title:Pain research & management
pub_type: 杂志文章
doi:10.1155/2017/4830142
更新日期:2017-01-01 00:00:00
abstract:OBJECTIVE:A pilot study was conducted to assess whether both the rationale and feasibility exist for future randomized clinical trials to evaluate the combined use of naloxone infusion and tramadol/acetaminophen as opioid-sparing drugs in elderly patients undergoing lower extremity joint replacement surgery. DESIGN:Te...
journal_title:Pain research & management
pub_type: 临床试验,杂志文章
doi:10.1155/2009/497217
更新日期:2009-03-01 00:00:00
abstract:Objectives:Dexmedetomidine is widely used as an adjunct to general anesthesia. In this study, we evaluated the effects of perioperative dexmedetomidine infusion on postoperative analgesia in patients undergoing lateral thoracotomy for thoracic esophageal cancer. Methods:A total of 62 patients undergoing lateral thorac...
journal_title:Pain research & management
pub_type: 杂志文章,随机对照试验
doi:10.1155/2020/4145893
更新日期:2020-05-06 00:00:00
abstract:Background:Despite the large body of research on sex differences in pain, there is a lack of knowledge about the influence of gender in the patient-provider encounter. The purpose of this study was to review literature on gendered norms about men and women with pain and gender bias in the treatment of pain. The second ...
journal_title:Pain research & management
pub_type: 杂志文章,评审
doi:10.1155/2018/6358624
更新日期:2018-02-25 00:00:00
abstract::Pain is one of the commonest reasons why children visit the hospital. Inadequately treated pain in children can negatively affect their physical, psychological, and social well-being; it also places financial burden on families of affected children and healthcare systems in general. Considering the eventual suffering ...
journal_title:Pain research & management
pub_type: 杂志文章
doi:10.1155/2020/7283473
更新日期:2020-02-13 00:00:00
abstract:BACKGROUND:We recently introduced the efficacy safety score (ESS) as a new "call-out algorithm" for management of postoperative pain and side effects. In this study, we report the influence of ESS recorded hourly during the first 8 hours after surgery on the mobility degree, postoperative nonsurgical complications, and...
journal_title:Pain research & management
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1155/2017/9431984
更新日期:2017-01-01 00:00:00
abstract::The provision of care for patients with type II diabetes in primary care must involve assessing patients for peripheral neuropathy of the feet. Objectives. This paper will demonstrate that painful diabetic neuropathy (PDN) is poorly assessed for and treated in primary care. Methods. A critical analysis of research wil...
journal_title:Pain research & management
pub_type: 杂志文章
doi:10.1155/2016/1974863
更新日期:2016-01-01 00:00:00