Perioperative Dexmedetomidine Fails to Improve Postoperative Analgesic Consumption and Postoperative Recovery in Patients Undergoing Lateral Thoracotomy for Thoracic Esophageal Cancer: A Randomized, Double-Blind, Placebo-Controlled Trial.

Abstract:

Objectives:Dexmedetomidine is widely used as an adjunct to general anesthesia. In this study, we evaluated the effects of perioperative dexmedetomidine infusion on postoperative analgesia in patients undergoing lateral thoracotomy for thoracic esophageal cancer. Methods:A total of 62 patients undergoing lateral thoracotomy for thoracic esophageal cancer were randomized to receive adjuvant therapy with either dexmedetomidine (0.5 μg/kg intravenous bolus injection for 10 min before induction of anesthesia, followed by continuous infusion of 0.2-0.4 μg/kg/h until the end of surgery, and 0.06 μg/kg/h for 5 days after surgery) or equal volumes of saline. Acute postoperative pain was treated with patient-controlled intravenous sufentanil and flurbiprofen axetil. The primary outcomes of this study were the numbers of analgesic requirements in the first postoperative 72 h. Results:Perioperative dexmedetomidine did not decrease the numbers of analgesic requirements in the first postoperative 72 h (dexmedetomidine group: 12.14 ± 4.76, saline group: 10.89 ± 5.66; p=0.367). Likewise, the groups did not differ with respect to total postoperative analgesic requirements, postoperative pain, perioperative inflammation, blood cell count, incidence of adverse events, surgical recovery (assessed at postoperative days 2 and 5 using the surgical recovery scale), length of hospital stay, hospital cost, incidence of chronic pain, or quality of life. Notably, dexmedetomidine had beneficial effects on decreasing intraoperative opioid consumption and improving postoperative sleep quality. Discussion. Perioperative dexmedetomidine has limited analgesic benefits in lateral thoracotomy for esophageal cancer when added to an opioid-based multimodal anesthetic regimen but can reduce opioid consumption.

journal_name

Pain Res Manag

authors

Mao Y,Sun X,Si L,Chen L,Liu X,Zhang Z,Gu E

doi

10.1155/2020/4145893

subject

Has Abstract

pub_date

2020-05-06 00:00:00

pages

4145893

eissn

1203-6765

issn

1918-1523

journal_volume

2020

pub_type

杂志文章,随机对照试验
  • The antiallodynic action of pregabalin may depend on the suppression of spinal neuronal hyperexcitability in rats with spared nerve injury.

    abstract:BACKGROUND:Pregabalin (PGB) is a novel antiepileptic drug and is also used as a first-line medication for the treatment of neuropathic pain. However, the mechanisms of its analgesic effects remain largely unknown. OBJECTIVES:To elucidate the mechanisms underlying the antiallodynic action of PGB in rats with neuropathi...

    journal_title:Pain research & management

    pub_type: 杂志文章

    doi:10.1155/2014/623830

    authors: Ding L,Cai J,Guo XY,Meng XL,Xing GG

    更新日期:2014-07-01 00:00:00

  • Systematic Administration of B Vitamins Alleviates Diabetic Pain and Inhibits Associated Expression of P2X3 and TRPV1 in Dorsal Root Ganglion Neurons and Proinflammatory Cytokines in Spinal Cord in Rats.

    abstract:Background:Treatment of diabetic neuropathic pain (DNP) continues to be a major challenge, and underlying mechanisms of DNP remain elusive. We investigated treatment effects of B vitamins on DPN- and DNP-associated alterations of neurochemical signaling in the nociceptive dorsal root ganglion (DRG) neurons and the spin...

    journal_title:Pain research & management

    pub_type: 杂志文章

    doi:10.1155/2020/3740162

    authors: He DD,Gao Y,Wang S,Xie Z,Song XJ

    更新日期:2020-02-10 00:00:00

  • Adolescents' pain coping profiles: expectations for treatment, functional outcomes and adherence to psychological treatment recommendations.

    abstract:OBJECTIVES:To explore how adolescents' pain coping profiles relate to their expectations regarding psychological treatment recommendations, and to examine patients' functioning and engagement in psychological treatment three months following a multidisciplinary pain clinic evaluation. METHODS:Adolescents and their par...

    journal_title:Pain research & management

    pub_type: 杂志文章

    doi:10.1155/2011/652853

    authors: Claar RL,Simons LE

    更新日期:2011-05-01 00:00:00

  • Assessment of pain response in capsaicin-induced dynamic mechanical allodynia using a novel and fully automated brushing device.

    abstract:BACKGROUND:Dynamic mechanical allodynia is traditionally induced by manual brushing of the skin. Brushing force and speed have been shown to influence the intensity of brush-evoked pain. There are still limited data available with respect to the optimal stroke number, length, force, angle and speed. Therefore, an autom...

    journal_title:Pain research & management

    pub_type: 杂志文章

    doi:10.1155/2013/142582

    authors: du Jardin KG,Gregersen LS,Røsland T,Uggerhøj KH,Petersen LJ,Arendt-Nielsen L,Gazerani P

    更新日期:2013-01-01 00:00:00

  • The influence of communicative relations on facial responses to pain: does it matter who is watching?

    abstract:BACKGROUND:Facial responses to pain are believed to be an act of communication and, as such, are likely to be affected by the relationship between sender and receiver. OBJECTIVES:To investigate this effect by examining the impact that variations in communicative relations (from being alone to being with an intimate ot...

    journal_title:Pain research & management

    pub_type: 杂志文章,随机对照试验

    doi:10.1155/2014/195286

    authors: Karmann AJ,Lautenbacher S,Bauer F,Kunz M

    更新日期:2014-01-01 00:00:00

  • The Effect of Mulligan Mobilization Technique in Older Adults with Neck Pain: A Randomized Controlled, Double-Blind Study.

    abstract:Background:The purpose of this study was to examine the effect of Mulligan mobilization technique (MMT) on pain, range of motion (ROM), functional level, kinesiophobia, depression, and quality of life (QoL) in older adults with neck pain (NP). Methods:Forty-two older adults with NP were included in the study, and they...

    journal_title:Pain research & management

    pub_type: 杂志文章,随机对照试验

    doi:10.1155/2018/2856375

    authors: Buyukturan O,Buyukturan B,Sas S,Karartı C,Ceylan İ

    更新日期:2018-05-15 00:00:00

  • Comparison of Transcutaneous Electrical Nerve Stimulation and Parasternal Block for Postoperative Pain Management after Cardiac Surgery.

    abstract::Background. Parasternal block and transcutaneous electrical nerve stimulation (TENS) have been demonstrated to produce effective analgesia and reduce postoperative opioid requirements in patients undergoing cardiac surgery. Objectives. To compare the effectiveness of TENS and parasternal block on early postoperative p...

    journal_title:Pain research & management

    pub_type: 杂志文章,随机对照试验

    doi:10.1155/2016/4261949

    authors: Ozturk NK,Baki ED,Kavakli AS,Sahin AS,Ayoglu RU,Karaveli A,Emmiler M,Inanoglu K,Karsli B

    更新日期:2016-01-01 00:00:00

  • Mechanisms of "Cough-Trick" for Pain Relief during Venipuncture: An Experimental Crossover Investigation in Healthy Volunteers.

    abstract:Objectives:The easily performed "cough-trick" (CT) reduces pain during venipuncture (VP), although the underlying mechanism remains unclear. The aim was to investigate the pain-reducing effect of CT during VP in comparison with two distraction methods, as well as under the influence of naloxone. Methods:54 healthy mal...

    journal_title:Pain research & management

    pub_type: 临床试验,杂志文章

    doi:10.1155/2019/9459103

    authors: Usichenko TI,Janner H,Gagarine M,Pavlovic D,Lang E,Hahnenkamp K

    更新日期:2019-12-12 00:00:00

  • Demographic and psychosocial predictors of acute perioperative pain for total knee arthroplasty.

    abstract:BACKGROUND:As the North American population ages, the prevalence of knee osteoarthritis and the surgical interventions (ie, total knee arthroplasty [TKA]) aimed at correcting pain and disability will also rise proportionally. Therefore, efforts to better understand the factors associated with surgical outcomes are warr...

    journal_title:Pain research & management

    pub_type: 杂志文章

    doi:10.1155/2007/394960

    authors: Roth ML,Tripp DA,Harrison MH,Sullivan M,Carson P

    更新日期:2007-10-01 00:00:00

  • Pain relief as a primary treatment goal: at what point does functioning and well-being become more important? A case study of an adolescent with debilitating chronic pain.

    abstract:BACKGROUND:Pediatric chronic pain is a common problem with significant economic implications and devastating consequences on quality of life. The present report describes a case involving a 15-year-old girl with severe and debilitating chronic pain. RESULTS:Before her referral to a pain rehabilitation program, the pat...

    journal_title:Pain research & management

    pub_type: 杂志文章

    doi:10.1155/2014/745458

    authors: Tseng AS,Weiss K,Harrison T,Hansen D,Bruce B

    更新日期:2014-07-01 00:00:00

  • Negative Affect, Type D Personality, Quality of Life, and Dysfunctional Outcomes of Total Knee Arthroplasty.

    abstract:Background:Type D personality (TDP) is a sign of tapered stress and compromises treatment outcomes including those of hip arthroplasty. The common dissatisfaction with total knee arthroplasty (TKA) is predicted by fear avoidance, pain catastrophizing and emotional lability, with poor quality of life (QoL) reflecting th...

    journal_title:Pain research & management

    pub_type: 杂志文章

    doi:10.1155/2019/6393101

    authors: Vogel M,Riediger C,Krippl M,Frommer J,Lohmann C,Illiger S

    更新日期:2019-01-03 00:00:00

  • Correlation between Parental-Reported Tooth Grinding and Sleep Disorders: Investigation in a Cohort of 741 Consecutive Children.

    abstract:Purpose:A possible relationship between sleep bruxism (SB) and several sleep disorders has been suggested in children, which could influence sleep quality and quality of life. This study aims to assess such correlations in a large sample of school children. Methods:Parents of 741 consecutive children aged between 8 an...

    journal_title:Pain research & management

    pub_type: 杂志文章

    doi:10.1155/2020/3408928

    authors: Segù M,Pollis M,Santagostini A,Meola F,Manfredini D

    更新日期:2020-07-30 00:00:00

  • Sleep Disturbance and Its Clinical Implication in Patients with Adult Spinal Deformity: Comparison with Lumbar Spinal Stenosis.

    abstract:Purpose:The purpose of this study was to investigate the prevalence of sleep disturbance and its clinical implication in patients with ASD. Methods:A total of 44 patients with ASD and 137 patients with lumbar spinal stenosis (LSS) were enrolled in the study. Forty four patients were selected from the LSS group after p...

    journal_title:Pain research & management

    pub_type: 杂志文章

    doi:10.1155/2020/6294151

    authors: Kim HJ,Hong SJ,Park JH,Ki H

    更新日期:2020-04-13 00:00:00

  • "Brave Men" and "Emotional Women": A Theory-Guided Literature Review on Gender Bias in Health Care and Gendered Norms towards Patients with Chronic Pain.

    abstract:Background:Despite the large body of research on sex differences in pain, there is a lack of knowledge about the influence of gender in the patient-provider encounter. The purpose of this study was to review literature on gendered norms about men and women with pain and gender bias in the treatment of pain. The second ...

    journal_title:Pain research & management

    pub_type: 杂志文章,评审

    doi:10.1155/2018/6358624

    authors: Samulowitz A,Gremyr I,Eriksson E,Hensing G

    更新日期:2018-02-25 00:00:00

  • Persistent pain in a community-based sample of children and adolescents.

    abstract:BACKGROUND:Very few studies have investigated the psychological factors associated with the pain experiences of children and adolescents in community samples. OBJECTIVES:To examine the lifetime prevalence of, and psychological variables associated with, persistent pain in a community sample of children and adolescents...

    journal_title:Pain research & management

    pub_type: 杂志文章

    doi:10.1155/2011/534652

    authors: Fuss S,Pagé G,Katz J

    更新日期:2011-09-01 00:00:00

  • Pain characteristics of adults 65 years of age and older referred to a tertiary care pain clinic.

    abstract:BACKGROUND:Reports indicate that characteristics of older adults with chronic pain may be different than those of younger persons. OBJECTIVE:To study the pain characteristics of older patients presenting to a tertiary pain clinic for the first time. METHODS:Age, sex and relative contributions of biomedical versus psy...

    journal_title:Pain research & management

    pub_type: 杂志文章

    doi:10.1155/2008/541963

    authors: Mailis-Gagnon A,Nicholson K,Yegneswaran B,Zurowski M

    更新日期:2008-09-01 00:00:00

  • Comparison of Different Histone Deacetylase Inhibitors in Attenuating Inflammatory Pain in Rats.

    abstract::Histone deacetylase inhibitors (HDACIs), which interfere with the epigenetic process of histone acetylation, have shown analgesic effects in animal models of persistent pain. The HDAC family comprises 18 genes; however, the different effects of distinct classes of HDACIs on pain relief remain unclear. The aim of this ...

    journal_title:Pain research & management

    pub_type: 杂志文章

    doi:10.1155/2019/1648919

    authors: Mao Y,Zhou J,Liu X,Gu E,Zhang Z,Tao W

    更新日期:2019-01-27 00:00:00

  • Prevalence of Chronic Pain, Treatments, Perception, and Interference on Life Activities: Brazilian Population-Based Survey.

    abstract:BACKGROUND AND OBJECTIVES:Chronic pain affects between 30% and 50% of the world population. Our objective was to estimate the prevalence of chronic pain in Brazil, describe and compare differences between pain types and characteristics, and identify the types of therapies adopted and the impact of pain on daily life. ...

    journal_title:Pain research & management

    pub_type: 杂志文章

    doi:10.1155/2017/4643830

    authors: de Souza JB,Grossmann E,Perissinotti DMN,de Oliveira Junior JO,da Fonseca PRB,Posso IP

    更新日期:2017-01-01 00:00:00

  • Effects of Exercise Training Combined with Increased Physical Activity to Prevent Chronic Pain in Community-Dwelling Older Adults: A Preliminary Randomized Controlled Trial.

    abstract:Objective:With the aim of developing a chronic pain prevention program, this randomized controlled trial examined whether exercise training combined with increased physical activity more effectively improves pain and physical activity than exercise training alone in community-dwelling older adults without chronic pain....

    journal_title:Pain research & management

    pub_type: 杂志文章,随机对照试验

    doi:10.1155/2018/2132039

    authors: Hirase T,Kataoka H,Inokuchi S,Nakano J,Sakamoto J,Okita M

    更新日期:2018-04-05 00:00:00

  • Pharmacological management of chronic neuropathic pain - consensus statement and guidelines from the Canadian Pain Society.

    abstract::Neuropathic pain (NeP), generated by disorders of the peripheral and central nervous system, can be particularly severe and disabling. Prevalence estimates indicate that 2% to 3% of the population in the developed world suffer from NeP, which suggests that up to one million Canadians have this disabling condition. Evi...

    journal_title:Pain research & management

    pub_type: 共识发展会议,杂志文章,实务指引

    doi:10.1155/2007/730785

    authors: Moulin DE,Clark AJ,Gilron I,Ware MA,Watson CP,Sessle BJ,Coderre T,Morley-Forster PK,Stinson J,Boulanger A,Peng P,Finley GA,Taenzer P,Squire P,Dion D,Cholkan A,Gilani A,Gordon A,Henry J,Jovey R,Lynch M,Mailis-Gag

    更新日期:2007-04-01 00:00:00

  • Effectiveness of Acupuncture for Lateral Epicondylitis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

    abstract:Objective:This study aimed at assessing the clinical effectiveness of acupuncture for lateral epicondylitis (LE). Methods:The following databases were systematically searched: China National Knowledge Infrastructure, Chinese Science and Technology Periodical Database, Wan Fang database, Chinese Biomedicine Literature,...

    journal_title:Pain research & management

    pub_type: 杂志文章,meta分析

    doi:10.1155/2020/8506591

    authors: Zhou Y,Guo Y,Zhou R,Wu P,Liang F,Yang Z

    更新日期:2020-03-20 00:00:00

  • Does participation in a pain course based on the International Association for the Study of Pain's curricula guidelines change student knowledge about pain?

    abstract:BACKGROUND:The People in Pain course was set up as a joint initiative of the Departments of Occupational Therapy and Physiotherapy within the School of Health and Rehabilitation Sciences at The University of Queensland. It was instigated in response to the publication of Pain Curricula for Occupational Therapy and Phys...

    journal_title:Pain research & management

    pub_type: 杂志文章

    doi:10.1155/2003/263802

    authors: Strong J,Meredith P,Darnell R,Chong M,Roche P

    更新日期:2003-10-01 00:00:00

  • The 27-item coping strategies questionnaire-revised: confirmatory factor analysis, reliability and validity in Italian-speaking subjects with chronic pain.

    abstract:BACKGROUND:Increasing attention is being devoted to cognitive-behavioural measures to improve interventions for chronic pain. OBJECTIVE:To develop an Italian version of the Coping Strategies Questionnaire - Revised (CSQ-R), and to validate it in a study involving 345 Italian subjects with chronic pain. METHODS:The qu...

    journal_title:Pain research & management

    pub_type: 杂志文章

    doi:10.1155/2014/956828

    authors: Monticone M,Ferrante S,Giorgi I,Galandra C,Rocca B,Foti C

    更新日期:2014-05-01 00:00:00

  • Effects of Mobilization Time on Occurrence of New Fractures after Vertebroplasty.

    abstract:Introduction:Osteoporotic vertebral fracture treatment options include vertebroplasty, in which development of new fractures is among the possible complications which may develop during the postoperative period. We aim to evaluate whether or not postoperative mobilization time has effect on occurrence of new fractures....

    journal_title:Pain research & management

    pub_type: 杂志文章

    doi:10.1155/2019/9292617

    authors: Akpolat AO,Karaca S

    更新日期:2019-06-03 00:00:00

  • Neural mechanisms of temporomandibular joint and masticatory muscle pain: a possible role for peripheral glutamate receptor mechanisms.

    abstract::The purpose of the present review is to correlate recent knowledge of the role of peripheral ionotropic glutamate receptors in the temporomandibular joint and muscle pain from animal and human experimental pain models with findings in patients. Chronic pain is common, and many people suffer from chronic pain condition...

    journal_title:Pain research & management

    pub_type: 杂志文章,评审

    doi:10.1155/2005/860354

    authors: Lam DK,Sessle BJ,Cairns BE,Hu JW

    更新日期:2005-10-01 00:00:00

  • The Need for Improved Management of Painful Diabetic Neuropathy in Primary Care.

    abstract::The provision of care for patients with type II diabetes in primary care must involve assessing patients for peripheral neuropathy of the feet. Objectives. This paper will demonstrate that painful diabetic neuropathy (PDN) is poorly assessed for and treated in primary care. Methods. A critical analysis of research wil...

    journal_title:Pain research & management

    pub_type: 杂志文章

    doi:10.1155/2016/1974863

    authors: Sobhy T

    更新日期:2016-01-01 00:00:00

  • Comparison of Early Effectiveness of Three Different Intervention Methods in Patients with Chronic Orofacial Pain: A Randomized, Controlled Clinical Trial.

    abstract:Background:Occlusal appliances are still widely used instruments in the management of orofacial pain in dentistry, yet alone or as a part of multimodal therapy. However, some of those modalities have been lacking thorough randomized assessment, and there is a conflicting evidence available. It is hypothesized that pain...

    journal_title:Pain research & management

    pub_type: 杂志文章,随机对照试验

    doi:10.1155/2019/7954291

    authors: Dalewski B,Kamińska A,Szydłowski M,Kozak M,Sobolewska E

    更新日期:2019-03-11 00:00:00

  • Emotional and neurobehavioural status in chronic pain patients.

    abstract:OBJECTIVE:To investigate the emotional and neurobehavioural status of patients suffering from chronic pain. METHODS:Fifteen male patients with chronic lower back pain and 15 healthy control subjects were studied for approximately six months. Pain was measured using a visual analogue scale. The WHO Neurobehavioral Core...

    journal_title:Pain research & management

    pub_type: 杂志文章

    doi:10.1155/2011/825636

    authors: Shuchang H,Mingwei H,Hongxiao J,Si W,Xing Y,Antonius D,Opler M

    更新日期:2011-01-01 00:00:00

  • Incorporating Family Function into Chronic Pain Disability: The Role of Catastrophizing.

    abstract::Background. Observers' responses to pain are recently investigated to more comprehensively explain chronic pain (CP) and disability. However, the role of family context, defined as interference in roles, communication, and problem-solving, and how (i.e., through which mechanisms) these variables contribute to CP relat...

    journal_title:Pain research & management

    pub_type: 杂志文章

    doi:10.1155/2016/6838596

    authors: Akbari F,Dehghani M,Khatibi A,Vervoort T

    更新日期:2016-01-01 00:00:00

  • Can we improve parents' management of their children's postoperative pain at home?

    abstract:BACKGROUND:Thousands of children undergo surgery each year, and a shift toward same-day surgeries and decreased lengths of hospital stay results in parents being increasingly responsible for their child's postoperative care. Recent studies have tested interventions designed to improve parent management of their childre...

    journal_title:Pain research & management

    pub_type: 杂志文章,评审

    doi:10.1155/2014/938352

    authors: MacLaren Chorney J,Twycross A,Mifflin K,Archibald K

    更新日期:2014-07-01 00:00:00