Abstract:
:Treatments for obesity have been shown to reduce pain secondary to weight loss. Intestinal microbiota, as an endogenous factor, influences obesity and pain sensitivity but the effect of oral probiotic supplementation on musculoskeletal pain perception has not been studied systematically. The present study examined the effect of a single daily oral dose (1 × 10(9) CFU) of probiotics (Lactobacillus rhamnosus PB01, DSM14870) supplement on mechanical pain thresholds in behaving diet-induced obese (DIO) mice and their normal weight (NW) controls. The mice (N = 24, 6-week-old male) were randomly divided into four groups on either standard or high fat diet with and without probiotic supplementation. Both DIO and NW groups with probiotic supplementation maintained an insignificant weight gain while the control groups gained significant weight (P < 0.05). Similarly, both DIO and NW probiotics supplemented groups demonstrated a significantly (P < 0.05) lower sensitivity to mechanical stimulation compared to their corresponding control. The results of this study suggest a protective effect of probiotics on nociception circuits, which propose a direct result of the weight reduction or an indirect result of anti-inflammatory properties of the probiotics. Deciphering the exact underlying mechanism of the weight loss and lowering nociception effect of the probiotic applied in this study require further investigation.
journal_name
Pain Res Managjournal_title
Pain research & managementauthors
Dardmeh F,Nielsen HI,Alipour H,Kjærgaard B,Brandsborg E,Gazerani Pdoi
10.1155/2016/5080438subject
Has Abstractpub_date
2016-01-01 00:00:00pages
5080438eissn
1203-6765issn
1918-1523journal_volume
2016pub_type
杂志文章abstract:Objective:To assess the validity of an exposure score obtained from the Xm2 tool for all pharmacological and nonpharmacological strategies used by individuals to manage chronic pain. Methods:Using data from individuals with chronic pain, eXposure multimodal (Xm2) scores were calculated by assigning one point for every...
journal_title:Pain research & management
pub_type: 杂志文章
doi:10.1155/2018/2530286
更新日期:2018-12-12 00:00:00
abstract:BACKGROUND:A relationship between smoking and development of pain syndromes has been suggested in the literature. The present study examined associations between smoke exposure and other related variables, and pain response to suprathreshold electrical stimulation. METHODS:Subjects were prospectively recruited from a ...
journal_title:Pain research & management
pub_type: 杂志文章
doi:10.1155/2008/240573
更新日期:2008-05-01 00:00:00
abstract::Chronic pain is frequently associated with significant psychological issues, such as depression or anxiety. Psychological treatments, such as psychotherapy, can often alleviate both psychological and pain symptoms. However, there is limited research about the association between psychological symptoms and perceived pa...
journal_title:Pain research & management
pub_type: 杂志文章
doi:10.1155/2018/8713084
更新日期:2018-04-19 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Chronic pain affects between 30% and 50% of the world population. Our objective was to estimate the prevalence of chronic pain in Brazil, describe and compare differences between pain types and characteristics, and identify the types of therapies adopted and the impact of pain on daily life. ...
journal_title:Pain research & management
pub_type: 杂志文章
doi:10.1155/2017/4643830
更新日期:2017-01-01 00:00:00
abstract:Background:Occlusal appliances are still widely used instruments in the management of orofacial pain in dentistry, yet alone or as a part of multimodal therapy. However, some of those modalities have been lacking thorough randomized assessment, and there is a conflicting evidence available. It is hypothesized that pain...
journal_title:Pain research & management
pub_type: 杂志文章,随机对照试验
doi:10.1155/2019/7954291
更新日期:2019-03-11 00:00:00
abstract:Purpose:A possible relationship between sleep bruxism (SB) and several sleep disorders has been suggested in children, which could influence sleep quality and quality of life. This study aims to assess such correlations in a large sample of school children. Methods:Parents of 741 consecutive children aged between 8 an...
journal_title:Pain research & management
pub_type: 杂志文章
doi:10.1155/2020/3408928
更新日期:2020-07-30 00:00:00
abstract:BACKGROUND:Pregabalin (PGB) is a novel antiepileptic drug and is also used as a first-line medication for the treatment of neuropathic pain. However, the mechanisms of its analgesic effects remain largely unknown. OBJECTIVES:To elucidate the mechanisms underlying the antiallodynic action of PGB in rats with neuropathi...
journal_title:Pain research & management
pub_type: 杂志文章
doi:10.1155/2014/623830
更新日期:2014-07-01 00:00:00
abstract::Context. Postthoracotomy Ipsilateral Shoulder Pain (IPS) is a common and sometimes intractable pain syndrome. IPS is different from chest wall pain in type, origin, and treatments. Various treatments are suggested or applied for it but none of them is regarded as popular accepted effective one. Objectives. To review d...
journal_title:Pain research & management
pub_type: 杂志文章,评审
doi:10.1155/2016/3652726
更新日期:2016-01-01 00:00:00
abstract:Background:Treatment of diabetic neuropathic pain (DNP) continues to be a major challenge, and underlying mechanisms of DNP remain elusive. We investigated treatment effects of B vitamins on DPN- and DNP-associated alterations of neurochemical signaling in the nociceptive dorsal root ganglion (DRG) neurons and the spin...
journal_title:Pain research & management
pub_type: 杂志文章
doi:10.1155/2020/3740162
更新日期:2020-02-10 00:00:00
abstract:Objectives:The easily performed "cough-trick" (CT) reduces pain during venipuncture (VP), although the underlying mechanism remains unclear. The aim was to investigate the pain-reducing effect of CT during VP in comparison with two distraction methods, as well as under the influence of naloxone. Methods:54 healthy mal...
journal_title:Pain research & management
pub_type: 临床试验,杂志文章
doi:10.1155/2019/9459103
更新日期:2019-12-12 00:00:00
abstract::There is limited evidence to underpin the assessment and management of pain in children with profound cognitive impairment and these children are vulnerable to poor pain assessment and management. Health professionals working with children with profound cognitive impairment from a single paediatric tertiary referral c...
journal_title:Pain research & management
pub_type: 杂志文章
doi:10.1155/2016/8617182
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVE:The present randomized, double-blinded, crossover study compared the efficacy and safety of a seven-day buprenorphine transdermal system (BTDS) and placebo in patients with low back pain of moderate or greater severity for at least six weeks. METHODS:Prestudy analgesics were discontinued the evening before r...
journal_title:Pain research & management
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1155/2010/216725
更新日期:2010-05-01 00:00:00
abstract:Objectives:To examine the interrater and intrarater reliability and construct validity of the Pain Behaviour Scale during standard physical performance tests in people with chronic low back pain and to confirm the test-retest reliability of the physical performance tests in this population. The Pain Behaviour Scale (Pa...
journal_title:Pain research & management
pub_type: 杂志文章
doi:10.1155/2019/2508019
更新日期:2019-02-03 00:00:00
abstract:BACKGROUND:Methadone is one of the most important medications used for the treatment of refractory pain in the palliative care setting, and is usually initially prescribed by one of a limited number of physicians who have acquired authorization for its use. A lack of authorized physicians able to take over prescribing ...
journal_title:Pain research & management
pub_type: 杂志文章
doi:10.1155/2013/740379
更新日期:2013-03-01 00:00:00
abstract:BACKGROUND AND AIMS:The inhibitory pathways that play a role in spinal modulation include local interneurons and descending control. Clinical data regarding the role of these pathways in acute pain is lacking. Accordingly, the aim of this study was to evaluate cerebrospinal fluid (CSF) levels of noradrenaline, serotoni...
journal_title:Pain research & management
pub_type: 杂志文章
doi:10.1155/2017/2752658
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:We recently introduced the efficacy safety score (ESS) as a new "call-out algorithm" for management of postoperative pain and side effects. In this study, we report the influence of ESS recorded hourly during the first 8 hours after surgery on the mobility degree, postoperative nonsurgical complications, and...
journal_title:Pain research & management
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1155/2017/9431984
更新日期:2017-01-01 00:00:00
abstract::Chronic back pain is often a result of coexisting pathologies; secondary causes of pain can become more apparent sources of pain once the primary pathology has been addressed. The objective of our study was to determine if there is an increase in diagnosis of Sacroiliac joint pain following a Lumbar Rhizotomy. A list ...
journal_title:Pain research & management
pub_type: 杂志文章
doi:10.1155/2017/4830142
更新日期:2017-01-01 00:00:00
abstract::Safety issues are a major barrier to the use of cannabis and cannabinoid medications for clinical purposes. Information on the safety of herbal cannabis may be derived from studies of recreational cannabis use, but cannabis exposure and effects may differ widely between medical and recreational cannabis users. Standar...
journal_title:Pain research & management
pub_type: 杂志文章,评审
doi:10.1155/2005/312357
更新日期:2005-10-01 00:00:00
abstract:Objective:This study aimed at assessing the clinical effectiveness of acupuncture for lateral epicondylitis (LE). Methods:The following databases were systematically searched: China National Knowledge Infrastructure, Chinese Science and Technology Periodical Database, Wan Fang database, Chinese Biomedicine Literature,...
journal_title:Pain research & management
pub_type: 杂志文章,meta分析
doi:10.1155/2020/8506591
更新日期:2020-03-20 00:00:00
abstract:OBJECTIVE:To investigate the occurrence of spirometry-related pain and distress in adolescents and young adults with cystic fibrosis (CF), and to investigate the role of acceptance of illness in spirometry-related pain and distress. METHODS:A total of 36 adolescents and young adults with CF (12 to 22 years of age) com...
journal_title:Pain research & management
pub_type: 杂志文章
doi:10.1155/2013/276923
更新日期:2013-11-01 00:00:00
abstract::Radiotherapy is commonly used to treat cancer patients. Besides the curable effect, radiotherapy also could relieve the pain of cancer patients. However, cancer pain is gradually alleviated about two weeks after radiotherapy. In addition, cancer patients who receive radiotherapy may also suffer from pain flare or radi...
journal_title:Pain research & management
pub_type: 杂志文章,评审
doi:10.1155/2020/7565962
更新日期:2020-01-30 00:00:00
abstract:BACKGROUND:Very few studies have investigated the psychological factors associated with the pain experiences of children and adolescents in community samples. OBJECTIVES:To examine the lifetime prevalence of, and psychological variables associated with, persistent pain in a community sample of children and adolescents...
journal_title:Pain research & management
pub_type: 杂志文章
doi:10.1155/2011/534652
更新日期:2011-09-01 00:00:00
abstract:BACKGROUND:Diminished executive function and attentional control has been reported in chronic pain patients. However, the precise pattern of impairment in these aspects of cognition in chronic pain remains unclear. Moreover, a decline in psychomotor speed could potentially influence executive and attentional control pe...
journal_title:Pain research & management
pub_type: 杂志文章
doi:10.1155/2012/962786
更新日期:2012-05-01 00:00:00
abstract::Several research studies have revealed that migraine has a solid link with gastrointestinal diseases especially irritable bowel syndrome (IBS). This study was carried out to investigate therapeutic potential of diet based on IgG elimination combined with probiotics on migraine plus irritable bowel syndrome. A total of...
journal_title:Pain research & management
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1155/2019/7890461
更新日期:2019-08-21 00:00:00
abstract::Background. Observers' responses to pain are recently investigated to more comprehensively explain chronic pain (CP) and disability. However, the role of family context, defined as interference in roles, communication, and problem-solving, and how (i.e., through which mechanisms) these variables contribute to CP relat...
journal_title:Pain research & management
pub_type: 杂志文章
doi:10.1155/2016/6838596
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:The impact of telephone consultations between pain specialists and primary care physicians regarding the care of patients with chronic pain is unknown. OBJECTIVES:To evaluate the impact of telephone consultations between pain specialists and primary care physicians regarding the care of patients with chroni...
journal_title:Pain research & management
pub_type: 杂志文章
doi:10.1155/2015/345432
更新日期:2015-11-01 00:00:00
abstract::Background. Cardiovascular indices of pain are pervasive in the hospital setting. However, no prospective research has examined the development of cardiac responses to acutely painful procedures in the first year of life. Objectives. Our main goal was to synthesize existing evidence regarding the development of cardio...
journal_title:Pain research & management
pub_type: 杂志文章,评审
doi:10.1155/2016/8458696
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVE:A pilot study was conducted to assess whether both the rationale and feasibility exist for future randomized clinical trials to evaluate the combined use of naloxone infusion and tramadol/acetaminophen as opioid-sparing drugs in elderly patients undergoing lower extremity joint replacement surgery. DESIGN:Te...
journal_title:Pain research & management
pub_type: 临床试验,杂志文章
doi:10.1155/2009/497217
更新日期:2009-03-01 00:00:00
abstract::Neuropathic pain (NeP), generated by disorders of the peripheral and central nervous system, can be particularly severe and disabling. Prevalence estimates indicate that 2% to 3% of the population in the developed world suffer from NeP, which suggests that up to one million Canadians have this disabling condition. Evi...
journal_title:Pain research & management
pub_type: 共识发展会议,杂志文章,实务指引
doi:10.1155/2007/730785
更新日期:2007-04-01 00:00:00
abstract:Background:Type D personality (TDP) is a sign of tapered stress and compromises treatment outcomes including those of hip arthroplasty. The common dissatisfaction with total knee arthroplasty (TKA) is predicted by fear avoidance, pain catastrophizing and emotional lability, with poor quality of life (QoL) reflecting th...
journal_title:Pain research & management
pub_type: 杂志文章
doi:10.1155/2019/6393101
更新日期:2019-01-03 00:00:00