Potential Nociceptive Regulatory Effect of Probiotic Lactobacillus rhamnosus PB01 (DSM 14870) on Mechanical Sensitivity in Diet-Induced Obesity Model.


:Treatments for obesity have been shown to reduce pain secondary to weight loss. Intestinal microbiota, as an endogenous factor, influences obesity and pain sensitivity but the effect of oral probiotic supplementation on musculoskeletal pain perception has not been studied systematically. The present study examined the effect of a single daily oral dose (1 × 10(9) CFU) of probiotics (Lactobacillus rhamnosus PB01, DSM14870) supplement on mechanical pain thresholds in behaving diet-induced obese (DIO) mice and their normal weight (NW) controls. The mice (N = 24, 6-week-old male) were randomly divided into four groups on either standard or high fat diet with and without probiotic supplementation. Both DIO and NW groups with probiotic supplementation maintained an insignificant weight gain while the control groups gained significant weight (P < 0.05). Similarly, both DIO and NW probiotics supplemented groups demonstrated a significantly (P < 0.05) lower sensitivity to mechanical stimulation compared to their corresponding control. The results of this study suggest a protective effect of probiotics on nociception circuits, which propose a direct result of the weight reduction or an indirect result of anti-inflammatory properties of the probiotics. Deciphering the exact underlying mechanism of the weight loss and lowering nociception effect of the probiotic applied in this study require further investigation.


Pain Res Manag


Dardmeh F,Nielsen HI,Alipour H,Kjærgaard B,Brandsborg E,Gazerani P




Has Abstract


2016-01-01 00:00:00










  • The influence of communicative relations on facial responses to pain: does it matter who is watching?

    abstract:BACKGROUND:Facial responses to pain are believed to be an act of communication and, as such, are likely to be affected by the relationship between sender and receiver. OBJECTIVES:To investigate this effect by examining the impact that variations in communicative relations (from being alone to being with an intimate ot...

    journal_title:Pain research & management

    pub_type: 杂志文章,随机对照试验


    authors: Karmann AJ,Lautenbacher S,Bauer F,Kunz M

    更新日期:2014-01-01 00:00:00

  • Assessing the Structure of the Ways of Coping Questionnaire in Fibromyalgia Patients Using Common Factor Analytic Approaches.

    abstract::The Ways of Coping Questionnaire (WCQ) is a widely used measure of coping processes. Despite its use in a variety of populations, there has been concern about the stability and structure of the WCQ across different populations. This study examines the factor structure of the WCQ in a large sample of individuals diagno...

    journal_title:Pain research & management

    pub_type: 杂志文章


    authors: Van Liew C,Santoro MS,Edwards L,Kang J,Cronan TA

    更新日期:2016-01-01 00:00:00

  • An analysis of articles on neonatal pain published from 1965 to 1999.

    abstract:OBJECTIVE:To analyze articles on neonatal pain indexed in MEDLINE from 1965 to 1999. METHODS:Papers published since 1965 and indexed in Medline (PubMed ) were considered. The search strategy was: 'pain' (MeSH terms) OR 'pain' (Title word) OR 'pain' (All Fields), AND 'infant, newborn' (MeSH terms). After the search was...

    journal_title:Pain research & management

    pub_type: 杂志文章,meta分析


    authors: Baños JE,Ruiz G,Guardiola E

    更新日期:2001-04-01 00:00:00

  • Periodontal Status and Quality of Life: Impact of Fear of Pain and Dental Fear.

    abstract::Background. Oral health-related quality of life (OHRQoL) is impacted by periodontal disease and orofacial pain. There is a limited research examining the impact of avoidance of care or physiological arousal related to the fear of pain response on periodontal-related OHRQoL. Methods. Data are from the Center for Oral H...

    journal_title:Pain research & management

    pub_type: 杂志文章


    authors: Wright CD,McNeil DW,Edwards CB,Crout RJ,Neiswanger K,Shaffer JR,Marazita ML

    更新日期:2017-01-01 00:00:00

  • Prediction of adaptive self-regulatory responses to arthritis pain anxiety in exercising adults: does pain acceptance matter?

    abstract:BACKGROUND:Exercising for ≥ 150 min/week is a recommended strategy for self-managing arthritis. However, exercise nonadherence is a problem. Arthritis pain anxiety may interfere with regular exercise. According to the fear-avoidance model, individuals may confront their pain anxiety by using adaptive self-regulatory re...

    journal_title:Pain research & management

    pub_type: 杂志文章


    authors: Cary MA,Gyurcsik NC,Brawley LR

    更新日期:2015-03-01 00:00:00

  • Negative Affect, Type D Personality, Quality of Life, and Dysfunctional Outcomes of Total Knee Arthroplasty.

    abstract:Background:Type D personality (TDP) is a sign of tapered stress and compromises treatment outcomes including those of hip arthroplasty. The common dissatisfaction with total knee arthroplasty (TKA) is predicted by fear avoidance, pain catastrophizing and emotional lability, with poor quality of life (QoL) reflecting th...

    journal_title:Pain research & management

    pub_type: 杂志文章


    authors: Vogel M,Riediger C,Krippl M,Frommer J,Lohmann C,Illiger S

    更新日期:2019-01-03 00:00:00

  • A Better Way to Decrease Knee Swelling in Patients with Knee Osteoarthritis: A Single-Blind Randomised Controlled Trial.

    abstract:Objective:In this study, we compared the effects of intermittent pneumatic compression along with conventional treatment with cold-pack treatment along with conventional treatment on clinical outcomes in patients with knee osteoarthritis. Methods:Eighty-nine patients with knee osteoarthritis participated in this study...

    journal_title:Pain research & management

    pub_type: 杂志文章,随机对照试验


    authors: Sari Z,Aydoğdu O,Demirbüken İ,Yurdalan SU,Polat MG

    更新日期:2019-05-02 00:00:00

  • Persistent pain in a community-based sample of children and adolescents.

    abstract:BACKGROUND:Very few studies have investigated the psychological factors associated with the pain experiences of children and adolescents in community samples. OBJECTIVES:To examine the lifetime prevalence of, and psychological variables associated with, persistent pain in a community sample of children and adolescents...

    journal_title:Pain research & management

    pub_type: 杂志文章


    authors: Fuss S,Pagé G,Katz J

    更新日期:2011-09-01 00:00:00

  • Knowledge and Attitude towards Pain Management among Nurses Working at University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia.

    abstract::Introduction. Pain is unpleasant sensory and emotional experience associated with actual and potential tissue damage. Inadequate pain management has been shown to affect patient outcomes by potentially increasing hospital stay and delaying recovery; thus, the management of pain has major implications for nursing. The ...

    journal_title:Pain research & management

    pub_type: 杂志文章


    authors: Liyew B,Dejen Tilahun A,Habtie Bayu N,Kassew T

    更新日期:2020-03-18 00:00:00

  • Differential predictors of pain and disability in patients with whiplash injuries.

    abstract::The psychological predictors of pain and disability were examined in a sample of people who sustained whiplash injuries during rear-end motor vehicle accidents. Sixty-five patients referred to a specialty pain clinic with a diagnosis of whiplash injury completed measures of depression, anxiety, catastrophizing, pain a...

    journal_title:Pain research & management

    pub_type: 杂志文章


    authors: Sullivan MJ,Stanish W,Sullivan ME,Tripp D

    更新日期:2002-07-01 00:00:00

  • Efficacy of Preoperative Administration of Paracetamol-Codeine on Pain following Impacted Mandibular Third Molar Surgery: A Randomized, Split-Mouth, Placebo-Controlled, Double-Blind Clinical Trial.

    abstract::Objectives. The aim of this study was to determine the effectiveness of preoperative administration of single-dose of paracetamol-codeine, in the relieving of acute postoperative pain after the surgical removal of an impacted mandibular third molar. Materials and Methods. The study cohort consisted of 32 Caucasian out...

    journal_title:Pain research & management

    pub_type: 杂志文章,随机对照试验


    authors: Cristalli MP,La Monaca G,De Angelis C,Pranno N,Annibali S

    更新日期:2017-01-01 00:00:00

  • Effects of Mobilization Time on Occurrence of New Fractures after Vertebroplasty.

    abstract:Introduction:Osteoporotic vertebral fracture treatment options include vertebroplasty, in which development of new fractures is among the possible complications which may develop during the postoperative period. We aim to evaluate whether or not postoperative mobilization time has effect on occurrence of new fractures....

    journal_title:Pain research & management

    pub_type: 杂志文章


    authors: Akpolat AO,Karaca S

    更新日期:2019-06-03 00:00:00

  • Physician-to-physician telephone consultations for chronic pain patients: A pragmatic randomized trial.

    abstract:BACKGROUND:The impact of telephone consultations between pain specialists and primary care physicians regarding the care of patients with chronic pain is unknown. OBJECTIVES:To evaluate the impact of telephone consultations between pain specialists and primary care physicians regarding the care of patients with chroni...

    journal_title:Pain research & management

    pub_type: 杂志文章


    authors: Clark AJ,Taenzer P,Drummond N,Spanswick CC,Montgomery LS,Findlay T,Pereira JX,Williamson T,Palacios-Derflingher L,Braun T

    更新日期:2015-11-01 00:00:00

  • Does participation in a pain course based on the International Association for the Study of Pain's curricula guidelines change student knowledge about pain?

    abstract:BACKGROUND:The People in Pain course was set up as a joint initiative of the Departments of Occupational Therapy and Physiotherapy within the School of Health and Rehabilitation Sciences at The University of Queensland. It was instigated in response to the publication of Pain Curricula for Occupational Therapy and Phys...

    journal_title:Pain research & management

    pub_type: 杂志文章


    authors: Strong J,Meredith P,Darnell R,Chong M,Roche P

    更新日期:2003-10-01 00:00:00

  • A Clinical Randomized Controlled Trial of Acupuncture Treatment of Gastroparesis Using Different Acupoints.

    abstract:Objective:To explore the effect of "selecting acupoints by site" on the synergy effect of "acupoint compatibility" according to the clinical efficacy of acupuncture treatment of patients with gastroparesis. Methods:A total of 99 patients who met the diagnostic criteria for gastroparesis were enrolled in 3 clinical cen...

    journal_title:Pain research & management

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Xuefen W,Ping L,Li L,Xiaoli C,Yue Z

    更新日期:2020-04-25 00:00:00

  • Adolescents' pain coping profiles: expectations for treatment, functional outcomes and adherence to psychological treatment recommendations.

    abstract:OBJECTIVES:To explore how adolescents' pain coping profiles relate to their expectations regarding psychological treatment recommendations, and to examine patients' functioning and engagement in psychological treatment three months following a multidisciplinary pain clinic evaluation. METHODS:Adolescents and their par...

    journal_title:Pain research & management

    pub_type: 杂志文章


    authors: Claar RL,Simons LE

    更新日期:2011-05-01 00:00:00

  • Spirometry-related pain and distress in adolescents and young adults with cystic fibrosis: the role of acceptance.

    abstract:OBJECTIVE:To investigate the occurrence of spirometry-related pain and distress in adolescents and young adults with cystic fibrosis (CF), and to investigate the role of acceptance of illness in spirometry-related pain and distress. METHODS:A total of 36 adolescents and young adults with CF (12 to 22 years of age) com...

    journal_title:Pain research & management

    pub_type: 杂志文章


    authors: Casier A,Goubert L,Vervoort T,Theunis M,Huse D,De Baets F,Matthys D,Crombez G

    更新日期:2013-11-01 00:00:00

  • Transforaminal Epiduroscopic Basivertebral Nerve Laser Ablation for Chronic Low Back Pain Associated with Modic Changes: A Preliminary Open-Label Study.

    abstract:Background:Chronic low back pain (CLBP) arising from degenerative disc disease continues to be a challenging clinical and diagnostic problem whether treated with nonsurgical, pain intervention, or motion-preserving stabilization and arthrodesis. Methods:Fourteen patients with CLBP, greater than 6 months, unresponsive ...

    journal_title:Pain research & management

    pub_type: 杂志文章


    authors: Kim HS,Adsul N,Yudoyono F,Paudel B,Kim KJ,Choi SH,Kim JH,Chung SK,Choi JH,Jang JS,Jang IT,Oh SH

    更新日期:2018-08-14 00:00:00

  • OPN Deficiency Increases the Severity of Osteoarthritis Associated with Aberrant Chondrocyte Senescence and Apoptosis and Upregulates the Expression of Osteoarthritis-Associated Genes.

    abstract:Objectives:A recent work has reported that the elevated osteopontin (OPN) levels in the articular cartilage and synovial fluid are correlated with the progressive osteoarthritis (OA) joint damage, and OPN has a protective effect against OA by suppressing the expressions of OA-associated genes. The present study examine...

    journal_title:Pain research & management

    pub_type: 杂志文章


    authors: Tian J,Cheng C,Kuang SD,Su C,Zhao X,Xiong YL,Li YS,Gao SG

    更新日期:2020-10-22 00:00:00

  • Incorporating Family Function into Chronic Pain Disability: The Role of Catastrophizing.

    abstract::Background. Observers' responses to pain are recently investigated to more comprehensively explain chronic pain (CP) and disability. However, the role of family context, defined as interference in roles, communication, and problem-solving, and how (i.e., through which mechanisms) these variables contribute to CP relat...

    journal_title:Pain research & management

    pub_type: 杂志文章


    authors: Akbari F,Dehghani M,Khatibi A,Vervoort T

    更新日期:2016-01-01 00:00:00

  • Incidence of Delirium in Critically Ill Cancer Patients.

    abstract:Objective:The aim of this study was to estimate the incidence of delirium and its risk factors among critically ill cancer patients in an intensive care unit (ICU). Materials and Methods:This is a prospective cohort study. The Confusion Assessment Method for the Intensive Care Unit (CAM-ICU) was measured daily at morn...

    journal_title:Pain research & management

    pub_type: 杂志文章


    authors: Sánchez-Hurtado LA,Hernández-Sánchez N,Del Moral-Armengol M,Guevara-García H,García-Guillén FJ,Herrera-Gómez Á,Ñamendys-Silva SA

    更新日期:2018-07-08 00:00:00

  • Continuing methadone for pain in palliative care.

    abstract:BACKGROUND:Methadone is one of the most important medications used for the treatment of refractory pain in the palliative care setting, and is usually initially prescribed by one of a limited number of physicians who have acquired authorization for its use. A lack of authorized physicians able to take over prescribing ...

    journal_title:Pain research & management

    pub_type: 杂志文章


    authors: Hawley P,Liebscher R,Wilford J

    更新日期:2013-03-01 00:00:00

  • "Brave Men" and "Emotional Women": A Theory-Guided Literature Review on Gender Bias in Health Care and Gendered Norms towards Patients with Chronic Pain.

    abstract:Background:Despite the large body of research on sex differences in pain, there is a lack of knowledge about the influence of gender in the patient-provider encounter. The purpose of this study was to review literature on gendered norms about men and women with pain and gender bias in the treatment of pain. The second ...

    journal_title:Pain research & management

    pub_type: 杂志文章,评审


    authors: Samulowitz A,Gremyr I,Eriksson E,Hensing G

    更新日期:2018-02-25 00:00:00

  • Navigating Uncertainty: Health Professionals' Knowledge, Skill, and Confidence in Assessing and Managing Pain in Children with Profound Cognitive Impairment.

    abstract::There is limited evidence to underpin the assessment and management of pain in children with profound cognitive impairment and these children are vulnerable to poor pain assessment and management. Health professionals working with children with profound cognitive impairment from a single paediatric tertiary referral c...

    journal_title:Pain research & management

    pub_type: 杂志文章


    authors: Carter B,Simons J,Bray L,Arnott J

    更新日期:2016-01-01 00:00:00

  • The analgesic efficacy of intra-articular acetaminophen in an experimental model of carrageenan-induced arthritis.

    abstract:BACKGROUND:Acetaminophen is one of the most common drugs used for the treatment of pain and fever. OBJECTIVES:To examine the effects of intra-articular (IA) acetaminophen on carrageenan-induced arthritic pain-related behaviour and spinal c-Fos expression in rats. METHODS:The present study was performed using 20 Sprag...

    journal_title:Pain research & management

    pub_type: 杂志文章


    authors: Arun O,Canbay O,Celebi N,Sahin A,Konan A,Atilla P,Aypar U

    更新日期:2013-09-01 00:00:00

  • Emotional and neurobehavioural status in chronic pain patients.

    abstract:OBJECTIVE:To investigate the emotional and neurobehavioural status of patients suffering from chronic pain. METHODS:Fifteen male patients with chronic lower back pain and 15 healthy control subjects were studied for approximately six months. Pain was measured using a visual analogue scale. The WHO Neurobehavioral Core...

    journal_title:Pain research & management

    pub_type: 杂志文章


    authors: Shuchang H,Mingwei H,Hongxiao J,Si W,Xing Y,Antonius D,Opler M

    更新日期:2011-01-01 00:00:00

  • Can we improve parents' management of their children's postoperative pain at home?

    abstract:BACKGROUND:Thousands of children undergo surgery each year, and a shift toward same-day surgeries and decreased lengths of hospital stay results in parents being increasingly responsible for their child's postoperative care. Recent studies have tested interventions designed to improve parent management of their childre...

    journal_title:Pain research & management

    pub_type: 杂志文章,评审


    authors: MacLaren Chorney J,Twycross A,Mifflin K,Archibald K

    更新日期:2014-07-01 00:00:00

  • Xm2 Scores for Estimating Total Exposure to Multimodal Strategies Identified by Pharmacists for Managing Pain: Validity Testing and Clinical Relevance.

    abstract:Objective:To assess the validity of an exposure score obtained from the Xm2 tool for all pharmacological and nonpharmacological strategies used by individuals to manage chronic pain. Methods:Using data from individuals with chronic pain, eXposure multimodal (Xm2) scores were calculated by assigning one point for every...

    journal_title:Pain research & management

    pub_type: 杂志文章


    authors: Axon DR,Bhattacharjee S,Warholak TL,Slack MK

    更新日期:2018-12-12 00:00:00

  • Comparison of Different Histone Deacetylase Inhibitors in Attenuating Inflammatory Pain in Rats.

    abstract::Histone deacetylase inhibitors (HDACIs), which interfere with the epigenetic process of histone acetylation, have shown analgesic effects in animal models of persistent pain. The HDAC family comprises 18 genes; however, the different effects of distinct classes of HDACIs on pain relief remain unclear. The aim of this ...

    journal_title:Pain research & management

    pub_type: 杂志文章


    authors: Mao Y,Zhou J,Liu X,Gu E,Zhang Z,Tao W

    更新日期:2019-01-27 00:00:00

  • Effects of smoke exposure and other lifestyle factors on pain response to electrical stimulation in women.

    abstract:BACKGROUND:A relationship between smoking and development of pain syndromes has been suggested in the literature. The present study examined associations between smoke exposure and other related variables, and pain response to suprathreshold electrical stimulation. METHODS:Subjects were prospectively recruited from a ...

    journal_title:Pain research & management

    pub_type: 杂志文章


    authors: Wee JY,Hopman WM

    更新日期:2008-05-01 00:00:00