The analgesic efficacy of intra-articular acetaminophen in an experimental model of carrageenan-induced arthritis.

Abstract:

BACKGROUND:Acetaminophen is one of the most common drugs used for the treatment of pain and fever. OBJECTIVES:To examine the effects of intra-articular (IA) acetaminophen on carrageenan-induced arthritic pain-related behaviour and spinal c-Fos expression in rats. METHODS:The present study was performed using 20 Sprague Dawley rats. Forty microlitres of IA 0.9% NaCl was injected in the control group, and 40 µL of IA carrageenan was injected in the carrageenan group. One hour after carrageenan injection, 400 µg of IA acetaminophen was injected in the IA acetaminophen group, and 400 µg of intraperitoneal (IP) acetaminophen was injected in the IP acetaminophen group. One day before injection, and 4 h and 8 h after injection, diameters of both knee joints, motility of the rat, paw loading and joint mobility were assessed. After the rats were euthanized, L3 and L4 spinal segments were excised for c-Fos assessment. RESULTS:IA acetaminophen decreased both the severity and distribution of c-Fos expression. IP acetaminophen decreased only the distribution of c-Fos expression. IA acetaminophen decreased knee diameter at 8 h. IA and IP acetaminophen increased rat motility and paw loading scores. Joint mobility scores of IP acetaminophen were similar to saline at 8 h. CONCLUSIONS:Results of the present study indicate an analgesic and⁄or possible anti-inflammatory effect of IA acetaminophen and provide further evidence on the efficacy of systemic acetaminophen injection in reducing arthritic pain.

journal_name

Pain Res Manag

authors

Arun O,Canbay O,Celebi N,Sahin A,Konan A,Atilla P,Aypar U

doi

10.1155/2013/148392

subject

Has Abstract

pub_date

2013-09-01 00:00:00

pages

e63-7

issue

5

eissn

1203-6765

issn

1918-1523

journal_volume

18

pub_type

杂志文章
  • Efficacy of Preoperative Administration of Paracetamol-Codeine on Pain following Impacted Mandibular Third Molar Surgery: A Randomized, Split-Mouth, Placebo-Controlled, Double-Blind Clinical Trial.

    abstract::Objectives. The aim of this study was to determine the effectiveness of preoperative administration of single-dose of paracetamol-codeine, in the relieving of acute postoperative pain after the surgical removal of an impacted mandibular third molar. Materials and Methods. The study cohort consisted of 32 Caucasian out...

    journal_title:Pain research & management

    pub_type: 杂志文章,随机对照试验

    doi:10.1155/2017/9246352

    authors: Cristalli MP,La Monaca G,De Angelis C,Pranno N,Annibali S

    更新日期:2017-01-01 00:00:00

  • Pharmacological management of chronic neuropathic pain - consensus statement and guidelines from the Canadian Pain Society.

    abstract::Neuropathic pain (NeP), generated by disorders of the peripheral and central nervous system, can be particularly severe and disabling. Prevalence estimates indicate that 2% to 3% of the population in the developed world suffer from NeP, which suggests that up to one million Canadians have this disabling condition. Evi...

    journal_title:Pain research & management

    pub_type: 共识发展会议,杂志文章,实务指引

    doi:10.1155/2007/730785

    authors: Moulin DE,Clark AJ,Gilron I,Ware MA,Watson CP,Sessle BJ,Coderre T,Morley-Forster PK,Stinson J,Boulanger A,Peng P,Finley GA,Taenzer P,Squire P,Dion D,Cholkan A,Gilani A,Gordon A,Henry J,Jovey R,Lynch M,Mailis-Gag

    更新日期:2007-04-01 00:00:00

  • The 27-item coping strategies questionnaire-revised: confirmatory factor analysis, reliability and validity in Italian-speaking subjects with chronic pain.

    abstract:BACKGROUND:Increasing attention is being devoted to cognitive-behavioural measures to improve interventions for chronic pain. OBJECTIVE:To develop an Italian version of the Coping Strategies Questionnaire - Revised (CSQ-R), and to validate it in a study involving 345 Italian subjects with chronic pain. METHODS:The qu...

    journal_title:Pain research & management

    pub_type: 杂志文章

    doi:10.1155/2014/956828

    authors: Monticone M,Ferrante S,Giorgi I,Galandra C,Rocca B,Foti C

    更新日期:2014-05-01 00:00:00

  • The antiallodynic action of pregabalin may depend on the suppression of spinal neuronal hyperexcitability in rats with spared nerve injury.

    abstract:BACKGROUND:Pregabalin (PGB) is a novel antiepileptic drug and is also used as a first-line medication for the treatment of neuropathic pain. However, the mechanisms of its analgesic effects remain largely unknown. OBJECTIVES:To elucidate the mechanisms underlying the antiallodynic action of PGB in rats with neuropathi...

    journal_title:Pain research & management

    pub_type: 杂志文章

    doi:10.1155/2014/623830

    authors: Ding L,Cai J,Guo XY,Meng XL,Xing GG

    更新日期:2014-07-01 00:00:00

  • Ultra low-dose naloxone and tramadol/acetaminophen in elderly patients undergoing joint replacement surgery: a pilot study.

    abstract:OBJECTIVE:A pilot study was conducted to assess whether both the rationale and feasibility exist for future randomized clinical trials to evaluate the combined use of naloxone infusion and tramadol/acetaminophen as opioid-sparing drugs in elderly patients undergoing lower extremity joint replacement surgery. DESIGN:Te...

    journal_title:Pain research & management

    pub_type: 临床试验,杂志文章

    doi:10.1155/2009/497217

    authors: Imasogie NN,Singh S,Watson JT,Hurley D,Morley-Forster P

    更新日期:2009-03-01 00:00:00

  • The effect of sleep deprivation on pain.

    abstract::Chronic pain syndromes are associated with alterations in sleep continuity and sleep architecture. One perspective of this relationship, which has not received much attention to date, is that disturbances of sleep affect pain. To fathom this direction of cause, experimental human and animal studies on the effects of s...

    journal_title:Pain research & management

    pub_type: 杂志文章,评审

    doi:10.1155/2004/949187

    authors: Kundermann B,Krieg JC,Schreiber W,Lautenbacher S

    更新日期:2004-04-01 00:00:00

  • Disability and borderline personality disorder in chronic pain patients.

    abstract:BACKGROUND AND OBJECTIVE:Few studies have examined the relationship between disability and borderline personality symptomatology, and, among those that have, findings have been inconsistent. In the present study, the relationship between medical disability and borderline personality symptomatology was examined in a sam...

    journal_title:Pain research & management

    pub_type: 杂志文章

    doi:10.1155/2010/952816

    authors: Sansone RA,Sinclair JD,Wiederman MW

    更新日期:2010-11-01 00:00:00

  • Can we improve parents' management of their children's postoperative pain at home?

    abstract:BACKGROUND:Thousands of children undergo surgery each year, and a shift toward same-day surgeries and decreased lengths of hospital stay results in parents being increasingly responsible for their child's postoperative care. Recent studies have tested interventions designed to improve parent management of their childre...

    journal_title:Pain research & management

    pub_type: 杂志文章,评审

    doi:10.1155/2014/938352

    authors: MacLaren Chorney J,Twycross A,Mifflin K,Archibald K

    更新日期:2014-07-01 00:00:00

  • Systematic Administration of B Vitamins Alleviates Diabetic Pain and Inhibits Associated Expression of P2X3 and TRPV1 in Dorsal Root Ganglion Neurons and Proinflammatory Cytokines in Spinal Cord in Rats.

    abstract:Background:Treatment of diabetic neuropathic pain (DNP) continues to be a major challenge, and underlying mechanisms of DNP remain elusive. We investigated treatment effects of B vitamins on DPN- and DNP-associated alterations of neurochemical signaling in the nociceptive dorsal root ganglion (DRG) neurons and the spin...

    journal_title:Pain research & management

    pub_type: 杂志文章

    doi:10.1155/2020/3740162

    authors: He DD,Gao Y,Wang S,Xie Z,Song XJ

    更新日期:2020-02-10 00:00:00

  • Nursing-Related Barriers to Children's Pain Management at Selected Hospitals in Ghana: A Descriptive Qualitative Study.

    abstract::Staff shortages, deficient knowledge, inappropriate attitudes, demanding workloads, analgesic shortages, and low prioritization of pain management have been identified in earlier studies as the nursing-related barriers to optimal children's pain management. These studies have mainly been undertaken in developed countr...

    journal_title:Pain research & management

    pub_type: 杂志文章

    doi:10.1155/2020/7125060

    authors: Kusi Amponsah A,Kyei EF,Agyemang JB,Boakye H,Kyei-Dompim J,Ahoto CK,Oduro E

    更新日期:2020-01-20 00:00:00

  • Application of Anchoring Technique in Unilateral Percutaneous Vertebroplasty for Neurologically Intact Kümmell's Disease.

    abstract:Purpose:We aimed to present our experience in anchoring technique and evaluate the efficacy and safety of unilateral percutaneous vertebroplasty in patients with neurologically intact Kümmell's disease. Methods:From January 2014 to December 2017, 29 patients (17 males and 12 females) with neurologically intact Kümmell...

    journal_title:Pain research & management

    pub_type: 杂志文章

    doi:10.1155/2020/4145096

    authors: Qin R,Zhang X,Liu H,Zhou B,Zhou P,Hu C

    更新日期:2020-05-24 00:00:00

  • Incorporating Family Function into Chronic Pain Disability: The Role of Catastrophizing.

    abstract::Background. Observers' responses to pain are recently investigated to more comprehensively explain chronic pain (CP) and disability. However, the role of family context, defined as interference in roles, communication, and problem-solving, and how (i.e., through which mechanisms) these variables contribute to CP relat...

    journal_title:Pain research & management

    pub_type: 杂志文章

    doi:10.1155/2016/6838596

    authors: Akbari F,Dehghani M,Khatibi A,Vervoort T

    更新日期:2016-01-01 00:00:00

  • Effects of Exercise Training Combined with Increased Physical Activity to Prevent Chronic Pain in Community-Dwelling Older Adults: A Preliminary Randomized Controlled Trial.

    abstract:Objective:With the aim of developing a chronic pain prevention program, this randomized controlled trial examined whether exercise training combined with increased physical activity more effectively improves pain and physical activity than exercise training alone in community-dwelling older adults without chronic pain....

    journal_title:Pain research & management

    pub_type: 杂志文章,随机对照试验

    doi:10.1155/2018/2132039

    authors: Hirase T,Kataoka H,Inokuchi S,Nakano J,Sakamoto J,Okita M

    更新日期:2018-04-05 00:00:00

  • Does participation in a pain course based on the International Association for the Study of Pain's curricula guidelines change student knowledge about pain?

    abstract:BACKGROUND:The People in Pain course was set up as a joint initiative of the Departments of Occupational Therapy and Physiotherapy within the School of Health and Rehabilitation Sciences at The University of Queensland. It was instigated in response to the publication of Pain Curricula for Occupational Therapy and Phys...

    journal_title:Pain research & management

    pub_type: 杂志文章

    doi:10.1155/2003/263802

    authors: Strong J,Meredith P,Darnell R,Chong M,Roche P

    更新日期:2003-10-01 00:00:00

  • Knowledge and Attitude towards Pain Management among Nurses Working at University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia.

    abstract::Introduction. Pain is unpleasant sensory and emotional experience associated with actual and potential tissue damage. Inadequate pain management has been shown to affect patient outcomes by potentially increasing hospital stay and delaying recovery; thus, the management of pain has major implications for nursing. The ...

    journal_title:Pain research & management

    pub_type: 杂志文章

    doi:10.1155/2020/6036575

    authors: Liyew B,Dejen Tilahun A,Habtie Bayu N,Kassew T

    更新日期:2020-03-18 00:00:00

  • Comparison of Early Effectiveness of Three Different Intervention Methods in Patients with Chronic Orofacial Pain: A Randomized, Controlled Clinical Trial.

    abstract:Background:Occlusal appliances are still widely used instruments in the management of orofacial pain in dentistry, yet alone or as a part of multimodal therapy. However, some of those modalities have been lacking thorough randomized assessment, and there is a conflicting evidence available. It is hypothesized that pain...

    journal_title:Pain research & management

    pub_type: 杂志文章,随机对照试验

    doi:10.1155/2019/7954291

    authors: Dalewski B,Kamińska A,Szydłowski M,Kozak M,Sobolewska E

    更新日期:2019-03-11 00:00:00

  • Effects of smoke exposure and other lifestyle factors on pain response to electrical stimulation in women.

    abstract:BACKGROUND:A relationship between smoking and development of pain syndromes has been suggested in the literature. The present study examined associations between smoke exposure and other related variables, and pain response to suprathreshold electrical stimulation. METHODS:Subjects were prospectively recruited from a ...

    journal_title:Pain research & management

    pub_type: 杂志文章

    doi:10.1155/2008/240573

    authors: Wee JY,Hopman WM

    更新日期:2008-05-01 00:00:00

  • Buprenorphine transdermal system for opioid therapy in patients with chronic low back pain.

    abstract:OBJECTIVE:The present randomized, double-blinded, crossover study compared the efficacy and safety of a seven-day buprenorphine transdermal system (BTDS) and placebo in patients with low back pain of moderate or greater severity for at least six weeks. METHODS:Prestudy analgesics were discontinued the evening before r...

    journal_title:Pain research & management

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1155/2010/216725

    authors: Gordon A,Rashiq S,Moulin DE,Clark AJ,Beaulieu AD,Eisenhoffer J,Piraino PS,Quigley P,Harsanyi Z,Darke AC

    更新日期:2010-05-01 00:00:00

  • Potential Nociceptive Regulatory Effect of Probiotic Lactobacillus rhamnosus PB01 (DSM 14870) on Mechanical Sensitivity in Diet-Induced Obesity Model.

    abstract::Treatments for obesity have been shown to reduce pain secondary to weight loss. Intestinal microbiota, as an endogenous factor, influences obesity and pain sensitivity but the effect of oral probiotic supplementation on musculoskeletal pain perception has not been studied systematically. The present study examined the...

    journal_title:Pain research & management

    pub_type: 杂志文章

    doi:10.1155/2016/5080438

    authors: Dardmeh F,Nielsen HI,Alipour H,Kjærgaard B,Brandsborg E,Gazerani P

    更新日期:2016-01-01 00:00:00

  • Comparison between Collagen and Lidocaine Intramuscular Injections in Terms of Their Efficiency in Decreasing Myofascial Pain within Masseter Muscles: A Randomized, Single-Blind Controlled Trial.

    abstract:Background and Objective:A novel option for myofascial pain (MFP) management and muscle regeneration is intramuscular collagen injections. The aim of the study was to evaluate the efficiency of intramuscular injections of collagen and lidocaine in decreasing MFP within masseter muscles. Methods:Myofascial pain within ...

    journal_title:Pain research & management

    pub_type: 杂志文章,随机对照试验

    doi:10.1155/2018/8261090

    authors: Nitecka-Buchta A,Walczynska-Dragon K,Batko-Kapustecka J,Wieckiewicz M

    更新日期:2018-06-03 00:00:00

  • Physician-to-physician telephone consultations for chronic pain patients: A pragmatic randomized trial.

    abstract:BACKGROUND:The impact of telephone consultations between pain specialists and primary care physicians regarding the care of patients with chronic pain is unknown. OBJECTIVES:To evaluate the impact of telephone consultations between pain specialists and primary care physicians regarding the care of patients with chroni...

    journal_title:Pain research & management

    pub_type: 杂志文章

    doi:10.1155/2015/345432

    authors: Clark AJ,Taenzer P,Drummond N,Spanswick CC,Montgomery LS,Findlay T,Pereira JX,Williamson T,Palacios-Derflingher L,Braun T

    更新日期:2015-11-01 00:00:00

  • OPN Deficiency Increases the Severity of Osteoarthritis Associated with Aberrant Chondrocyte Senescence and Apoptosis and Upregulates the Expression of Osteoarthritis-Associated Genes.

    abstract:Objectives:A recent work has reported that the elevated osteopontin (OPN) levels in the articular cartilage and synovial fluid are correlated with the progressive osteoarthritis (OA) joint damage, and OPN has a protective effect against OA by suppressing the expressions of OA-associated genes. The present study examine...

    journal_title:Pain research & management

    pub_type: 杂志文章

    doi:10.1155/2020/3428587

    authors: Tian J,Cheng C,Kuang SD,Su C,Zhao X,Xiong YL,Li YS,Gao SG

    更新日期:2020-10-22 00:00:00

  • Executive and attentional functions in chronic pain: does performance decrease with increasing task load?

    abstract:BACKGROUND:Diminished executive function and attentional control has been reported in chronic pain patients. However, the precise pattern of impairment in these aspects of cognition in chronic pain remains unclear. Moreover, a decline in psychomotor speed could potentially influence executive and attentional control pe...

    journal_title:Pain research & management

    pub_type: 杂志文章

    doi:10.1155/2012/962786

    authors: Oosterman J,Derksen LC,van Wijck AJ,Kessels RP,Veldhuijzen DS

    更新日期:2012-05-01 00:00:00

  • The influence of communicative relations on facial responses to pain: does it matter who is watching?

    abstract:BACKGROUND:Facial responses to pain are believed to be an act of communication and, as such, are likely to be affected by the relationship between sender and receiver. OBJECTIVES:To investigate this effect by examining the impact that variations in communicative relations (from being alone to being with an intimate ot...

    journal_title:Pain research & management

    pub_type: 杂志文章,随机对照试验

    doi:10.1155/2014/195286

    authors: Karmann AJ,Lautenbacher S,Bauer F,Kunz M

    更新日期:2014-01-01 00:00:00

  • A research synthesis of therapeutic interventions for whiplash-associated disorder (WAD): part 4 - noninvasive interventions for chronic WAD.

    abstract::Whiplash-associated disorder (WAD) represents a significant public health problem, resulting in substantial social and economic costs throughout the industrialized world. While many treatments have been advocated for patients with WAD, scientific evidence supporting their effectiveness is often lacking. A systematic r...

    journal_title:Pain research & management

    pub_type: 杂志文章,评审

    doi:10.1155/2010/487279

    authors: Teasell RW,McClure JA,Walton D,Pretty J,Salter K,Meyer M,Sequeira K,Death B

    更新日期:2010-09-01 00:00:00

  • Unrelieved pain: a crisis.

    abstract::Despite many recent advances in the past 40 years in the understanding of pain mechanisms, and in pain diagnosis and management, considerable gaps in knowledge remain, with chronic pain present in epidemic proportions in most countries. It is often unrelieved and is associated with significant socioeconomic burdens. S...

    journal_title:Pain research & management

    pub_type: 杂志文章,评审

    doi:10.1155/2011/513423

    authors: Sessle B

    更新日期:2011-11-01 00:00:00

  • Effectiveness of Acupuncture for Lateral Epicondylitis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

    abstract:Objective:This study aimed at assessing the clinical effectiveness of acupuncture for lateral epicondylitis (LE). Methods:The following databases were systematically searched: China National Knowledge Infrastructure, Chinese Science and Technology Periodical Database, Wan Fang database, Chinese Biomedicine Literature,...

    journal_title:Pain research & management

    pub_type: 杂志文章,meta分析

    doi:10.1155/2020/8506591

    authors: Zhou Y,Guo Y,Zhou R,Wu P,Liang F,Yang Z

    更新日期:2020-03-20 00:00:00

  • Does routine pain assessment result in better care?

    abstract:BACKGROUND:Although a variety of national organizations such as the Canadian Pain Society, the American Pain Society and the Joint Commission on Accreditation of Health Care Organizations have advanced the idea that pain should be assessed on a routine basis, there is little evidence that systematic pain assessment inf...

    journal_title:Pain research & management

    pub_type: 杂志文章

    doi:10.1155/2009/638585

    authors: Hadjistavropoulos T,MacNab Y,Lints-Martindale A,Martin R,Hadjistavropoulos H

    更新日期:2009-05-01 00:00:00

  • Pain characteristics of adults 65 years of age and older referred to a tertiary care pain clinic.

    abstract:BACKGROUND:Reports indicate that characteristics of older adults with chronic pain may be different than those of younger persons. OBJECTIVE:To study the pain characteristics of older patients presenting to a tertiary pain clinic for the first time. METHODS:Age, sex and relative contributions of biomedical versus psy...

    journal_title:Pain research & management

    pub_type: 杂志文章

    doi:10.1155/2008/541963

    authors: Mailis-Gagnon A,Nicholson K,Yegneswaran B,Zurowski M

    更新日期:2008-09-01 00:00:00

  • Xm2 Scores for Estimating Total Exposure to Multimodal Strategies Identified by Pharmacists for Managing Pain: Validity Testing and Clinical Relevance.

    abstract:Objective:To assess the validity of an exposure score obtained from the Xm2 tool for all pharmacological and nonpharmacological strategies used by individuals to manage chronic pain. Methods:Using data from individuals with chronic pain, eXposure multimodal (Xm2) scores were calculated by assigning one point for every...

    journal_title:Pain research & management

    pub_type: 杂志文章

    doi:10.1155/2018/2530286

    authors: Axon DR,Bhattacharjee S,Warholak TL,Slack MK

    更新日期:2018-12-12 00:00:00