Abstract:
BACKGROUND:Pregabalin (PGB) is a novel antiepileptic drug and is also used as a first-line medication for the treatment of neuropathic pain. However, the mechanisms of its analgesic effects remain largely unknown. OBJECTIVES:To elucidate the mechanisms underlying the antiallodynic action of PGB in rats with neuropathic pain. METHODS:In a rat model of neuropathic pain induced by spared nerve injury, mechanical allodynia, as a behavioural sign of neuropathic pain, was assessed by measuring 50% paw withdrawal threshold with von Frey filaments. Activities of dorsal horn wide dynamic range (WDR) neurons were examined by extracellular electrophysiological recording in vivo. RESULTS:Spinal administration of PGB exerted a significant antiallodynic effect and a prominent inhibitory effect on the hypersensitivity of dorsal horn WDR neurons in rats with spared nerve injury. CONCLUSION:The antiallodynic action of PGB is likely dependent on the suppression of WDR neuron hyperexcitability in rats with neuropathic pain.
journal_name
Pain Res Managjournal_title
Pain research & managementauthors
Ding L,Cai J,Guo XY,Meng XL,Xing GGdoi
10.1155/2014/623830subject
Has Abstractpub_date
2014-07-01 00:00:00pages
205-11issue
4eissn
1203-6765issn
1918-1523pii
16248journal_volume
19pub_type
杂志文章abstract:Background:The purpose of this study was to examine the effect of Mulligan mobilization technique (MMT) on pain, range of motion (ROM), functional level, kinesiophobia, depression, and quality of life (QoL) in older adults with neck pain (NP). Methods:Forty-two older adults with NP were included in the study, and they...
journal_title:Pain research & management
pub_type: 杂志文章,随机对照试验
doi:10.1155/2018/2856375
更新日期:2018-05-15 00:00:00
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journal_title:Pain research & management
pub_type: 杂志文章,随机对照试验
doi:10.1155/2018/2132039
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journal_title:Pain research & management
pub_type: 杂志文章,评审
doi:10.1155/2016/3652726
更新日期:2016-01-01 00:00:00
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journal_title:Pain research & management
pub_type: 杂志文章
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更新日期:2011-05-01 00:00:00
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journal_title:Pain research & management
pub_type: 杂志文章
doi:10.1155/2016/6838596
更新日期:2016-01-01 00:00:00
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journal_title:Pain research & management
pub_type: 杂志文章
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更新日期:2020-02-13 00:00:00
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journal_title:Pain research & management
pub_type: 杂志文章,随机对照试验
doi:10.1155/2019/8514808
更新日期:2019-05-02 00:00:00
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journal_title:Pain research & management
pub_type: 杂志文章
doi:10.1155/2017/5757108
更新日期:2017-01-01 00:00:00
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journal_title:Pain research & management
pub_type: 杂志文章
doi:10.1155/2014/745458
更新日期:2014-07-01 00:00:00
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journal_title:Pain research & management
pub_type: 杂志文章
doi:10.1155/2008/240573
更新日期:2008-05-01 00:00:00
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journal_title:Pain research & management
pub_type: 杂志文章
doi:10.1155/2017/5491923
更新日期:2017-01-01 00:00:00
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journal_title:Pain research & management
pub_type: 杂志文章
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更新日期:2020-07-30 00:00:00
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journal_title:Pain research & management
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2010-05-01 00:00:00
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journal_title:Pain research & management
pub_type: 杂志文章
doi:10.1155/2003/263802
更新日期:2003-10-01 00:00:00
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journal_title:Pain research & management
pub_type: 杂志文章
doi:10.1155/2002/176378
更新日期:2002-07-01 00:00:00
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journal_title:Pain research & management
pub_type: 杂志文章
doi:10.1155/2016/5940206
更新日期:2016-01-01 00:00:00
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journal_title:Pain research & management
pub_type: 杂志文章,随机对照试验
doi:10.1155/2018/8261090
更新日期:2018-06-03 00:00:00
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journal_title:Pain research & management
pub_type: 杂志文章,meta分析
doi:10.1155/2001/213030
更新日期:2001-04-01 00:00:00
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journal_title:Pain research & management
pub_type: 杂志文章
doi:10.1155/2013/276923
更新日期:2013-11-01 00:00:00
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journal_title:Pain research & management
pub_type: 杂志文章,评审
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更新日期:2018-02-25 00:00:00
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journal_title:Pain research & management
pub_type: 杂志文章
doi:10.1155/2015/345432
更新日期:2015-11-01 00:00:00
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pub_type: 杂志文章
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更新日期:2020-02-10 00:00:00
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journal_title:Pain research & management
pub_type: 杂志文章
doi:10.1155/2015/853961
更新日期:2015-03-01 00:00:00
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journal_title:Pain research & management
pub_type: 杂志文章
doi:10.1155/2012/962786
更新日期:2012-05-01 00:00:00
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journal_title:Pain research & management
pub_type: 杂志文章
doi:10.1155/2014/956828
更新日期:2014-05-01 00:00:00
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journal_title:Pain research & management
pub_type: 杂志文章,随机对照试验
doi:10.1155/2020/4145893
更新日期:2020-05-06 00:00:00
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journal_title:Pain research & management
pub_type: 杂志文章
doi:10.1155/2016/1974863
更新日期:2016-01-01 00:00:00
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journal_title:Pain research & management
pub_type: 杂志文章
doi:10.1155/2011/825636
更新日期:2011-01-01 00:00:00
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journal_title:Pain research & management
pub_type: 杂志文章
doi:10.1155/2013/142582
更新日期:2013-01-01 00:00:00
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journal_title:Pain research & management
pub_type: 临床试验,杂志文章
doi:10.1155/2019/9459103
更新日期:2019-12-12 00:00:00