Treatment of New World cutaneous and mucosal leishmaniases.


:The most extensive investigations of treatment of New World cutaneous leishmaniasis have been performed against L. panamensis disease in Colombia, and the relative value of regimens shown there may be instructive for disease from other areas. In Colombia, a 90-95% cure rate was achieved with three different drug regimens: The standard regimen of pentavalent antimony (20 mg/ kg/day for 20 days parenterally) A short course of pentamidine (3 mg/kg every other day for four injections intramuscularly The marketed combination of topical paromomycin (15%)-MBCl (12%) for 10 days, plus antimony (20 mg/kg/day parenterally) for 7 days. My view is that all these regimens could be chosen as first-line therapy for cutaneous disease in Colombia. The antimony regimen has the advantage of established use; the disadvantages are cost, requirement for injections each day for 20 days, and considerable morbidity in the last two weeks of therapy. The pentamidine regimen has the advantage of a short time course; the disadvantages are lack of experience with this new regimen and frequent, although moderate, morbidity. The combined topical-parenteral regimen has the advantage of requiring few and nontoxic injections; the primary disadvantage is that the regimen is novel and its efficacy has not been confirmed. It would be expected that cases of lesions in other areas caused by L. braziliensis complex would respond in a similar manner to these regimens. To date, however, only the efficacy of the standard antimonial regimen has been confirmed. In certain regions of Central America, other regimens may be effective. Thus, ketoconazole appears to be effective for the more rapidly self-curing forms of disease (cutaneous disease caused by L. mexicana and L. panamensis from Central America), and a short course of antimony may be effective against L. braziliensis in Guatemala.


Clin Dermatol


Clinics in dermatology


Berman JD




Has Abstract


1996-09-01 00:00:00














  • Cutaneous zygomycosis.

    abstract::Cutaneous zygomycosis is a fungal infection caused by zygomycetes that affects the skin. It occurs in uncontrolled diabetic patients and immunosuppressed individuals. It has 2 clinical forms: primary cutaneous zygomycosis and secondary cutaneous zygomycosis. The first is characterized by necrotic lesions and the fungu...

    journal_title:Clinics in dermatology

    pub_type: 杂志文章


    authors: Bonifaz A,Vázquez-González D,Tirado-Sánchez A,Ponce-Olivera RM

    更新日期:2012-07-01 00:00:00

  • Human papillomavirus status in extragenital nonmelanoma skin cancers.

    abstract::About 5% of all cancers worldwide can be attributed to human papillomaviruses (HPVs); namely, six sites are strongly associated with HPV infections: cervix, penis, vulva, vagina, anus, and oropharynx. Nonmelanoma skin cancers (NMSC), basal cell carcinoma (BCC), and squamous cell carcinoma (SCC) are the most common mal...

    journal_title:Clinics in dermatology

    pub_type: 杂志文章


    authors: Drvar DL,Lipozenčić J,Sabol I,Mokos ZB,Ilic I,Grce M

    更新日期:2014-03-01 00:00:00

  • Tropical rickettsioses.

    abstract::In recent years, a bewildering array of emerging rickettsial pathogens have been described throughout the world, including in the tropics. Here we present an updated overview of scrub typhus, murine typhus, and epidemic typhus. We also present an update on the emerging spotted fever group rickettsioses described in th...

    journal_title:Clinics in dermatology

    pub_type: 杂志文章,评审


    authors: Parola P,Raoult D

    更新日期:2006-05-01 00:00:00

  • Clinical aspects of full-thickness wound healing.

    abstract::Optimal management of full-thickness wounds requires a thorough knowledge of wound-healing principles and practices. In the absence of underlying disease, almost every full-thickness wound will heal with minimal intervention; however, the process can be enhanced by judicious wound management. The first clinical decisi...

    journal_title:Clinics in dermatology

    pub_type: 杂志文章,评审


    authors: Rivera AE,Spencer JM

    更新日期:2007-01-01 00:00:00

  • Miscellaneous skin disease and the metabolic syndrome.

    abstract::The link between the metabolic syndrome (MetS) and skin diseases is increasingly important, with new associations being discovered. The association between MetS and psoriasis or MetS and hidradenitis suppurativa is well known, although the relationship between MetS and various autoimmune or inflammatory diseases has o...

    journal_title:Clinics in dermatology

    pub_type: 杂志文章,评审


    authors: Seremet S,Gurel MS

    更新日期:2018-01-01 00:00:00

  • Thermage: the nonablative radiofrequency for rejuvenation.

    abstract::Thermage is a noninvasive nonablative device that uses monopolar radiofrequency energy to bulk heat underlying skin while protecting the epidermis to produce skin tightening. It is used for the treatment of rhytids on the face including the periorbital region and lower face, and more recently, for off-face application...

    journal_title:Clinics in dermatology

    pub_type: 杂志文章


    authors: Sukal SA,Geronemus RG

    更新日期:2008-11-01 00:00:00

  • Surgery at the BEST Medical Center-Clyde's Adventures in BEST Land: Down the Rabbit Hole.

    abstract::Dr. Ida Lystic is an assistant professor in the Division of Gastroenterology at the Byron Edwards & Samuel Thompson (BEST) Medical Center. Before becoming one of the BEST doctors, she completed her fellowship training at the Owen T. Henry and Eugene Rutherford (OTHER) Medical Center and her MD degree at the prestigiou...

    journal_title:Clinics in dermatology

    pub_type: 杂志文章


    authors: Cohen PR

    更新日期:2018-01-01 00:00:00

  • Pityriasis rosea and other infectious eruptions during pregnancy: Possible life-threatening health conditions for the fetus.

    abstract::Any infectious illness presenting with an eruption in a pregnant patient may be associated with an increased risk of fetal loss. The viruses that can infect the placenta during maternal infection and can be transmitted to the fetus and cause congenital disease include the rubella virus, the measles virus, the varicell...

    journal_title:Clinics in dermatology

    pub_type: 杂志文章


    authors: Rebora A,Ciccarese G,Herzum A,Parodi A,Drago F

    更新日期:2020-01-01 00:00:00

  • The "red face": Not always rosacea.

    abstract::Facial erythema (the "red face") is a straightforward clinical finding, and it is evident even to the untrained eye; however, a red face does not represent a single cutaneous entity. It may be due to a plethora of distinct underlying conditions of varying severity, including rosacea, demodicosis, dermatomyositis, lupu...

    journal_title:Clinics in dermatology

    pub_type: 杂志文章,评审


    authors: Dessinioti C,Antoniou C

    更新日期:2017-01-01 00:00:00

  • Treatment of alopecia areata with squaric acid dibutylester.

    abstract::Squaric acid dibutylester is a topical sensitizing agent utilized for the treatment of alopecia areata. The mechanism of action is not fully understood, but is believed to redirect the inflammatory response by invoking allergic contact dermatitis. Several studies have compared the efficacy of squaric acid dibutylester...

    journal_title:Clinics in dermatology

    pub_type: 杂志文章,评审


    authors: Hill ND,Bunata K,Hebert AA

    更新日期:2015-05-01 00:00:00

  • Infective dermatitis.

    abstract::Infective dermatitis represents a severe form of recurrent eczematous skin change that presents in childhood. It was first described in 1966. Later, the association of infective dermatitis with an underlying human T-cell lymphotropic virus infection was recognized. Chronic infective dermatitis is associated with an in...

    journal_title:Clinics in dermatology

    pub_type: 杂志文章


    authors: Trope BM,Lenzi ME

    更新日期:2009-05-01 00:00:00

  • Severe cutaneous adverse drug reactions: who should treat, where and how?: Facts and controversies.

    abstract::Toxic epidermal necrolysis (TEN) and Stevens-Johnson syndrome (SJS) are uncommon but extremely serious and often life-threatening mucocutaneous reactions characterized by extensive epithelial sloughing and systemic symptoms. There is no effective evidence-based treatment for severe cutaneous adverse reactions (SCAR) t...

    journal_title:Clinics in dermatology

    pub_type: 杂志文章


    authors: Wolf R,Davidovici B

    更新日期:2010-05-01 00:00:00

  • Sarcoidosis and malignancy.

    abstract::Malignancy in patients with sarcoidosis occurs in 3 settings. The first setting relates to patients with hematologic malignancies. It includes the sarcoidosis-lymphoma syndrome, which refers to the development of lymphoma at least 1 to 2 years after the diagnosis of sarcoidosis. It also includes patients with sarcoido...

    journal_title:Clinics in dermatology

    pub_type: 杂志文章,评审


    authors: Cohen PR,Kurzrock R

    更新日期:2007-05-01 00:00:00

  • Performing research in pregnancy: Challenges and perspectives.

    abstract::There are numerous barriers to conducting clinical research in pregnancy, including ethical considerations, logistical difficulties, and federal regulations. Due to these challenges, there is a paucity of data on the safe and appropriate use of dermatologic therapies in pregnancy, even for easily accessed over-the-cou...

    journal_title:Clinics in dermatology

    pub_type: 杂志文章


    authors: Hartman RI,Kimball AB

    更新日期:2016-05-01 00:00:00

  • The modern paradigm of phototherapy.

    abstract::The recognition of medical benefits obtained with suberythemogenic doses of natural sunlight extends back centuries. Modern medical application of phototherapy has been in place for over 100 years. It is the nature of scientific discovery to depend upon the use of new investigational methods or new devices to gain a b...

    journal_title:Clinics in dermatology

    pub_type: 杂志文章,评审


    authors: Zanolli M

    更新日期:2003-09-01 00:00:00

  • Monitoring biologics for the treatment of psoriasis.

    abstract::Monitoring patients on therapy consists of 2 parts: evaluation of response and mitigation of risk. Biologics for the treatment of psoriasis are no different. Although laboratory assessments are sometimes necessary, the key elements to appropriate monitoring are clinical assessments and vigilant reinforcement of signs ...

    journal_title:Clinics in dermatology

    pub_type: 杂志文章,评审


    authors: Papp KA

    更新日期:2008-09-01 00:00:00

  • Inflammatory ulcers.

    abstract::Skin ulcerations may develop as a manifestation of a variety of different diseases or may result from some nondisease phenomena. Inflammatory ulcers refer specifically to those ulcerations in which inflammation is the primary pathologic process resulting in lesion formation; that is, inflammation is the cause rather t...

    journal_title:Clinics in dermatology

    pub_type: 杂志文章,评审


    authors: Hoffman MD

    更新日期:2007-01-01 00:00:00

  • Robert Koch (1843-1910) and dermatology on his 171st birthday.

    abstract::Robert Koch (1843-1910) received the Nobel Prize in Medicine in 1905 for his studies of tuberculosis. He contributed significantly to microbiology, isolating also cholera and anthrax pathogens, and introducing several postulates in this field. In addition, he developed staining methods, as well as culturing and micros...

    journal_title:Clinics in dermatology

    pub_type: 传,历史文章,杂志文章


    authors: Grzybowski A,Pietrzak K

    更新日期:2014-05-01 00:00:00

  • Antimicrobials in dermatologic surgery: facts and controversies.

    abstract::The two main uses of antimicrobials in dermatologic surgery include prophylaxis for bacteremia and prevention of localized surgical skin infection (LSSI). Bacteremia can result in hematogenous surgical infections such as infective endocarditis and prosthetic joint infection. Comprehensive guidelines from the American ...

    journal_title:Clinics in dermatology

    pub_type: 杂志文章


    authors: Shurman DL,Benedetto AV

    更新日期:2010-09-01 00:00:00

  • Phototherapy for atopic dermatitis.

    abstract::Phototherapy is a second-line treatment for moderate to severe atopic dermatitis (AD) that effectively decreases cutaneous inflammation with minimal or no systemic side effects. Children in grade school, adolescents, and adults may benefit from phototherapy, when they have chronic AD refractory to first-line topical t...

    journal_title:Clinics in dermatology

    pub_type: 杂志文章,评审


    authors: Rodenbeck DL,Silverberg JI,Silverberg NB

    更新日期:2016-09-01 00:00:00

  • A brief report on the history of phototherapy.

    abstract::From ancient times, light has played a significant role in the treatment of diseases. The modern discoveries (eg, ultraviolet radiation) and modern inventions (eg, the electric generator or the electric lightbulb), as well as balneologic experiences of the treatment with sunlight, contributed to the transition from he...

    journal_title:Clinics in dermatology

    pub_type: 历史文章,杂志文章


    authors: Grzybowski A,Sak J,Pawlikowski J

    更新日期:2016-09-01 00:00:00

  • Pyoderma gangrenosum: uncommon presentations.

    abstract::Pyoderma gangrenosum (PG) is a rare, inflammatory, noninfective, nonneoplastic skin disorder, which is often associated with systemic diseases. These include inflammatory bowel disease, rheumatoid arthritis, paraproteinaemia, or hematologic malignancy, which can be found in up to 50% of patients with some variants of ...

    journal_title:Clinics in dermatology

    pub_type: 杂志文章,评审


    authors: Ahmadi S,Powell FC

    更新日期:2005-11-01 00:00:00

  • Paraviral eruptions in the era of COVID-19: Do some skin manifestations point to a natural resistance to SARS-CoV-2?

    abstract::Paraviral eruptions, such as the papular-purpuric gloves and socks syndrome or eruptive pseudoangiomatosis, share the following features that distinguish them from a classic viral eruption: they are highly recognizable; the eruption usually lasts a few weeks; many different viruses and sometimes other agents can trigg...

    journal_title:Clinics in dermatology

    pub_type: 杂志文章,评审


    authors: Lipsker D

    更新日期:2020-01-01 00:00:00

  • Complicated surgical techniques. I. Flaps and grafts.

    abstract::Most defects in dermatologic surgery can be repaired by primary closure. If this is not feasible, then local flaps should be employed. Where flaps are unfeasible or would result in an additional cosmetic deformity, then a full-thickness skin graft should be employed. If the defect is too large for a full-thickness ski...

    journal_title:Clinics in dermatology

    pub_type: 杂志文章


    authors: Coleman W 3rd

    更新日期:1987-10-01 00:00:00

  • Acne: Kids are not just little people.

    abstract::Acne vulgaris is a common inflammatory disease of the pilosebaceous follicles that affects patients of all ages, from neonates to adults. We have compared and contrasted the clinical presentation of acne in neonates, infants, children, teenagers, and young adults and review the scenarios in which further systemic endo...

    journal_title:Clinics in dermatology

    pub_type: 杂志文章,评审


    authors: Que SKT,Whitaker-Worth DL,Chang MW

    更新日期:2016-01-01 00:00:00

  • Hand dermatitis: uncommon presentations.

    abstract::Hand dermatitis is a common diagnosis seen in dermatologic and general practice. It can present with typical morphology, but uncommon manifestations are possible. This review reports on common and uncommon presentations of irritant and allergic hand dermatitis focusing on uncommon localizations, time course, and morph...

    journal_title:Clinics in dermatology

    pub_type: 杂志文章,评审


    authors: Bauer A

    更新日期:2005-09-01 00:00:00

  • Peter the Great and sexually transmitted diseases.

    abstract::Shortly after syphilis appeared in Europe at the time of Columbus' voyage to the New World, the big pox, as it was often known, became a serious issue in Russia for diagnosis, treatment, and prevention. Members of the Russian royal family were made aware of the disease from adolescence onward. Czar Peter the Great had...

    journal_title:Clinics in dermatology

    pub_type: 历史文章,杂志文章


    authors: Zimin I,Grzybowski A

    更新日期:2020-01-01 00:00:00

  • Nail tumors.

    abstract::Most neoplasms of the nail apparatus have different clinical appearances, courses, and biological behaviors as compared with similar tumors located elsewhere on the skin. Some of these tumors are unique to the nail, such as onychomatricoma. As a general rule, benign lesions respect the general architecture of the nail...

    journal_title:Clinics in dermatology

    pub_type: 杂志文章,评审


    authors: Richert B,Lecerf P,Caucanas M,André J

    更新日期:2013-09-01 00:00:00

  • Sentinel lymph node biopsy.

    abstract::The introduction of sentinel lymph node biopsy (SLNB) has been an important development in the management of malignant melanoma. Lymph nodes have long been known to play a key role in melanoma metastasis. The importance of nodal staging accounted for the previous surgical practice of elective lymph node dissection (EL...

    journal_title:Clinics in dermatology

    pub_type: 杂志文章,评审


    authors: Lee KK,Vetto JT,Mehrany K,Swanson NA

    更新日期:2004-05-01 00:00:00

  • The Ubangi misnomer.

    abstract::Lip plates are a form of body modification practiced today by several tribes in Africa and Amazonia. In 1930, the American people were introduced to lip plates in a most spectacular fashion, when the Ringling Bros. and Barnum & Bailey Circus brought in 13 Congolese natives to star as the newest attraction in their sid...

    journal_title:Clinics in dermatology

    pub_type: 杂志文章


    authors: Hoenig LJ

    更新日期:2020-01-01 00:00:00