Abstract：
:The most extensive investigations of treatment of New World cutaneous leishmaniasis have been performed against L. panamensis disease in Colombia, and the relative value of regimens shown there may be instructive for disease from other areas. In Colombia, a 90-95% cure rate was achieved with three different drug regimens: The standard regimen of pentavalent antimony (20 mg/ kg/day for 20 days parenterally) A short course of pentamidine (3 mg/kg every other day for four injections intramuscularly The marketed combination of topical paromomycin (15%)-MBCl (12%) for 10 days, plus antimony (20 mg/kg/day parenterally) for 7 days. My view is that all these regimens could be chosen as first-line therapy for cutaneous disease in Colombia. The antimony regimen has the advantage of established use; the disadvantages are cost, requirement for injections each day for 20 days, and considerable morbidity in the last two weeks of therapy. The pentamidine regimen has the advantage of a short time course; the disadvantages are lack of experience with this new regimen and frequent, although moderate, morbidity. The combined topical-parenteral regimen has the advantage of requiring few and nontoxic injections; the primary disadvantage is that the regimen is novel and its efficacy has not been confirmed. It would be expected that cases of lesions in other areas caused by L. braziliensis complex would respond in a similar manner to these regimens. To date, however, only the efficacy of the standard antimonial regimen has been confirmed. In certain regions of Central America, other regimens may be effective. Thus, ketoconazole appears to be effective for the more rapidly self-curing forms of disease (cutaneous disease caused by L. mexicana and L. panamensis from Central America), and a short course of antimony may be effective against L. braziliensis in Guatemala.
journal_name
Clin Dermatoljournal_title
Clinics in dermatologyauthors
Berman JDdoi
10.1016/0738-081x(96)00048-xsubject
Has Abstractpub_date
1996-09-01 00:00:00pages
519-22issue
5eissn
0738-081Xissn
1879-1131pii
0738-081X(96)00048-Xjournal_volume
14pub_type
杂志文章abstract：:Cutaneous leishmaniasis is a widespread tropical infection caused by numerous different species of Leishmania protozoa that are transmitted by sandflies. Its clinical presentations are extremely diverse and dependent on a variety of parasite and host factors that are poorly understood. Diagnosis should aim to identify...
journal_title：Clinics in dermatology
pub_type： 杂志文章,评审
doi：10.1016/j.clindermatol.2006.05.008
更新日期：2007-03-01 00:00:00
abstract：:The incidence of cutaneous melanoma has increased substantially in most white populations during the past several decades. Despite improvements in the early recognition of melanoma and the use of novel diagnostic techniques that enhance our diagnostic capabilities, disease-related mortality remains a significant publi...
journal_title：Clinics in dermatology
pub_type： 杂志文章
doi：10.1016/j.clindermatol.2008.09.002
更新日期：2009-01-01 00:00:00
abstract：:Skin health depends on an intact barrier composed of protein-rich corneocytes surrounded by the lamellar intercellular lipids. This barrier provides waterproof protection for the body, preventing infection, regulating electrolyte balance, maintaining body temperature, and providing a mechanism for sensation. Damage to...
journal_title：Clinics in dermatology
pub_type： 杂志文章
doi：10.1016/j.clindermatol.2011.08.018
更新日期：2012-05-01 00:00:00
abstract：:Acne is the most common of skin diseases, being characterized as a chronic inflammatory disease of the pilosebaceous unit. Although acne is usually straightforward to diagnose and treat, some patients have difficult or rare forms of acne. What seems to be "nonresponding acne" in a patient may be caused by another acne...
journal_title：Clinics in dermatology
pub_type： 杂志文章
doi：10.1016/j.clindermatol.2016.10.005
更新日期：2017-01-01 00:00:00
abstract：:The world population of adults aged 60 years or more is increasing globally, and this development can impact skin disease morbidity and mortality, as well as being reflected in the health care system organization. There is substantial evidence that the burden from a remarkable number of skin nonmalignant and malignant...
journal_title：Clinics in dermatology
pub_type： 杂志文章
doi：10.1016/j.clindermatol.2019.04.005
更新日期：2019-01-01 00:00:00
abstract：:Facial erythema (the "red face") is a straightforward clinical finding, and it is evident even to the untrained eye; however, a red face does not represent a single cutaneous entity. It may be due to a plethora of distinct underlying conditions of varying severity, including rosacea, demodicosis, dermatomyositis, lupu...
journal_title：Clinics in dermatology
pub_type： 杂志文章,评审
doi：10.1016/j.clindermatol.2016.10.015
更新日期：2017-01-01 00:00:00
abstract：:Less than 20 of the hundreds of carotenoids found in nature are found in the human body. These carotenoids are present in the body from the foods or dietary supplements that humans consume. The body does not synthesize them. Among the carotenoids present in the body, only lutein and its coexistent isomer, zeaxanthin, ...
journal_title：Clinics in dermatology
pub_type： 杂志文章,评审
doi：10.1016/j.clindermatol.2008.01.011
更新日期：2009-03-01 00:00:00
abstract：:As new laser devices continue to emerge, it becomes increasingly important for the clinical dermatologist to understand the basic principles behind their operation. A fundamental understanding of how lasers interact with tissue will enable the physician to choose the most appropriate laser for a given clinical situati...
journal_title：Clinics in dermatology
pub_type： 杂志文章,评审
doi：10.1016/j.clindermatol.2005.10.019
更新日期：2006-01-01 00:00:00
abstract：:Sjogren's Syndrome (SS) is a systemic autoimmune disease characterized by dry eyes (keratoconjunctivis sicca) and dry mouth (xerostomia). To fulfill diagnostic criteria, patients must have objective signs of dryness on examination and laboratory confirmation of an autoimmune process as evidenced by a positive autoanti...
journal_title：Clinics in dermatology
pub_type： 杂志文章,评审
doi：10.1016/j.clindermatol.2006.07.005
更新日期：2006-09-01 00:00:00
abstract：:Many authors recognize the beneficial effects of using protein-rich substances in formulations of various topical applications. Proteins quickly were considered useful ingredients for creating a suitable environment for healthy skin and hair because of their ability to bind water with the horny layer of skin and its a...
journal_title：Clinics in dermatology
pub_type： 杂志文章,评审
doi：10.1016/j.clindermatol.2008.04.004
更新日期：2008-07-01 00:00:00
abstract：:Alopecia is a skin condition of great social and psychologic impact. Primary alopecia originates from the hair follicles and usually does not have systemic manifestations; however, secondary alopecia can affect the hair follicles in the setting of systemic diseases, medications, and external trauma. Connective tissue ...
journal_title：Clinics in dermatology
pub_type： 杂志文章,评审
doi：10.1016/j.clindermatol.2019.07.026
更新日期：2019-01-01 00:00:00
abstract：:Skin is often affected in adverse drug reactions. Although the majority of cutaneous adverse drug reactions are benign and self-limiting, Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and drug rash with eosinophilia and systemic symptoms (DRESS), affecting multiple organs and systems, are potential...
journal_title：Clinics in dermatology
pub_type： 杂志文章,评审
doi：10.1016/j.clindermatol.2015.05.005
更新日期：2015-09-01 00:00:00
abstract：:Skin cancer is both common and responsible for significant morbidity and mortality. Opportunities for both primary and secondary prevention are available to both dermatologists and non-dermatologists. Counseling selected patients about ultraviolet avoidance and proper use of sunscreens is recommended. Due to technical...
journal_title：Clinics in dermatology
pub_type： 杂志文章
doi：10.1016/j.clindermatol.2013.05.002
更新日期：2013-11-01 00:00:00
abstract：:Personality disorders (PDs) are stable and enduring patterns of thought, feeling, and behavior that deviate from one's cultural norms and cause impairment in functionality. Patients with PDs are commonly encountered in the dermatologic setting and can be perceived by providers as "difficult." Given that PDs are chroni...
journal_title：Clinics in dermatology
pub_type： 杂志文章
doi：10.1016/j.clindermatol.2017.01.009
更新日期：2017-01-01 00:00:00
abstract：:Variations in pain perception have long been studied in the medical literature, especially for women in regards to their menstrual cycle. Anecdotally, women can be more sensitive to painful stimuli from cosmetic procedures during their menses; however, no studies have thoroughly examined variations in pain perception ...
journal_title：Clinics in dermatology
pub_type： 杂志文章,评审
doi：10.1016/j.clindermatol.2019.10.011
更新日期：2019-01-01 00:00:00
abstract：:Skin, together with its appendages, forms an organ with several defensive roles; among them it acts as a barrier, which is one of its very important protective functions. There has been increased interest in studying the effects of age on these functions. There are different intensities and timing involved in this pro...
journal_title：Clinics in dermatology
pub_type： 杂志文章,评审
doi：10.1016/j.clindermatol.2011.08.024
更新日期：2012-05-01 00:00:00
abstract：:Malignancy in patients with sarcoidosis occurs in 3 settings. The first setting relates to patients with hematologic malignancies. It includes the sarcoidosis-lymphoma syndrome, which refers to the development of lymphoma at least 1 to 2 years after the diagnosis of sarcoidosis. It also includes patients with sarcoido...
journal_title：Clinics in dermatology
pub_type： 杂志文章,评审
doi：10.1016/j.clindermatol.2007.03.010
更新日期：2007-05-01 00:00:00
abstract：:Teledermatology has emerged as a promising solution for pediatric and adult patients accessing dermatologic care in a health care environment fraught with barriers to access. Teledermatology has been extensively evaluated in terms of diagnostic accuracy, clinical outcomes, patient and provider satisfaction, and costs,...
journal_title：Clinics in dermatology
pub_type： 杂志文章,评审
doi：10.1016/j.clindermatol.2017.08.009
更新日期：2017-01-01 00:00:00
abstract：:In life there are some people who are confident enought that they do not require reassurance and then there are others that need it constantly just to be able to function in their daily living. I am fortunate enough to experience the gift of reassurance and being able to give it back. As a first time mother, many of t...
journal_title：Clinics in dermatology
pub_type： 杂志文章
doi：10.1016/j.clindermatol.2015.10.002
更新日期：2015-11-01 00:00:00
abstract：:Shortly after syphilis appeared in Europe at the time of Columbus' voyage to the New World, the big pox, as it was often known, became a serious issue in Russia for diagnosis, treatment, and prevention. Members of the Russian royal family were made aware of the disease from adolescence onward. Czar Peter the Great had...
journal_title：Clinics in dermatology
pub_type： 历史文章,杂志文章
doi：10.1016/j.clindermatol.2019.09.002
更新日期：2020-01-01 00:00:00
abstract：:Most defects in dermatologic surgery can be repaired by primary closure. If this is not feasible, then local flaps should be employed. Where flaps are unfeasible or would result in an additional cosmetic deformity, then a full-thickness skin graft should be employed. If the defect is too large for a full-thickness ski...
journal_title：Clinics in dermatology
pub_type： 杂志文章
doi：10.1016/0738-081x(87)90031-9
更新日期：1987-10-01 00:00:00
abstract：:The ability of botulinum toxin A (BTX-A) to improve the appearance of facial lines was first reported among patients who had been receiving injections for facial dystonias or surgical procedures. Since that time, there has been very extensive use of this treatment for relaxation of a wide variety of facial muscles and...
journal_title：Clinics in dermatology
pub_type： 杂志文章
doi：10.1016/j.clindermatol.2003.12.025
更新日期：2004-01-01 00:00:00
abstract：:While autoimmunity as cause of disease is well-established, other categories of immune-mediated diseases that are not produced by targeting of self-antigens by antibodies is in the process of being described. These so-called autoinflammatory diseases arise when an inappropriate activation of antigen-independent mechan...
journal_title：Clinics in dermatology
pub_type： 杂志文章,评审
doi：10.1016/j.clindermatol.2014.02.004
更新日期：2014-07-01 00:00:00
abstract：:Intrahepatic cholestasis of pregnancy, also known as obstetric cholestasis, is a pruritic condition of pregnancy characterized by an underlying elevation in circulating bile acids and liver derangement, and associated with adverse fetal outcomes, such as preterm labor and stillbirth. Limited understanding of the under...
journal_title：Clinics in dermatology
pub_type： 杂志文章,评审
doi：10.1016/j.clindermatol.2016.02.004
更新日期：2016-05-01 00:00:00
abstract：:Many physicians tend to regard their upcoming retirement with great trepidation. They are worried that after years of productive activity they will become useless and lose all their connections with medicine. This essay will try to impress on readers that this way of thinking is absolutely incorrect, and it will provi...
journal_title：Clinics in dermatology
pub_type： 杂志文章
doi：10.1016/j.clindermatol.2020.05.010
更新日期：2020-01-01 00:00:00
abstract：:The link between the metabolic syndrome (MetS) and skin diseases is increasingly important, with new associations being discovered. The association between MetS and psoriasis or MetS and hidradenitis suppurativa is well known, although the relationship between MetS and various autoimmune or inflammatory diseases has o...
journal_title：Clinics in dermatology
pub_type： 杂志文章,评审
doi：10.1016/j.clindermatol.2017.09.016
更新日期：2018-01-01 00:00:00
abstract：:Systemic sclerosis is an uncommon autoimmune connective tissue disease with multiorgan system involvement and significant associated morbidity and mortality. Cutaneous signs and clinical manifestations are of particular importance, as they may be recognized before systemic manifestations, allowing earlier risk stratif...
journal_title：Clinics in dermatology
pub_type： 杂志文章,评审
doi：10.1016/j.clindermatol.2018.04.004
更新日期：2018-01-01 00:00:00
abstract：:Oral manifestations of nutritional deficiencies can affect the mucous membranes, teeth, periodontal tissue, salivary glands, and perioral skin. This contribution reviews how the water-soluble vitamins (B(2), B(3), B(6), B(12), C, and folic acid), fat-soluble vitamins (A, D, and E), and minerals (calcium, fluoride, iro...
journal_title：Clinics in dermatology
pub_type： 杂志文章
doi：10.1016/j.clindermatol.2010.03.025
更新日期：2010-07-01 00:00:00
abstract：:Major gaps still exist in the knowledge about leprosy, particularly with regard to how it spreads. Leprosy epidemiology remains complicated due to the specific characteristics of Mycobacterium leprae. To describe epidemiologic trends for the 21st century, the first part of this paper gives an overview of the epidemiol...
journal_title：Clinics in dermatology
pub_type： 杂志文章
doi：10.1016/j.clindermatol.2015.11.001
更新日期：2016-01-01 00:00:00
abstract：:Stress is thought to suppress immune function and increase susceptibility to infections and cancer. Paradoxically, stress is also known to exacerbate autoimmune/proinflammatory disorders (eg, psoriasis, atopic dermatitis) that should be ameliorated by immunosuppression. Here we review studies showing that although chr...
journal_title：Clinics in dermatology
pub_type： 杂志文章,评审
doi：10.1016/j.clindermatol.2011.11.003
更新日期：2013-01-01 00:00:00
