Abstract:
:Genodermatoses are inherited disorders presenting with cutaneous manifestations with or without the involvement of other systems. The majority of these disorders, particularly in cases that present with a cutaneous patterning, may be explained in the context of genetic mosaicism. Despite the barriers to the genetic analysis of mosaic disorders, next-generation sequencing has led to a substantial progress in understanding their pathogenesis, which has significant implications for the clinical management and genetic counseling. Advances in paired and deep sequencing technologies in particular have made the study of mosaic disorders more feasible. In this review, we provide an overview of genetic mosaicism as well as mosaic cutaneous disorders and the techniques required to study them.
journal_name
Clin Dermatoljournal_title
Clinics in dermatologyauthors
Cheraghlou S,Lim Y,Choate KAdoi
10.1016/j.clindermatol.2020.03.008subject
Has Abstractpub_date
2020-01-01 00:00:00pages
408-420issue
4eissn
0738-081Xissn
1879-1131pii
S0738-081X(20)30045-6journal_volume
38pub_type
杂志文章,评审abstract::In summary, there is much overlap among the three types of localized cutaneous pemphigoid discussed. They all tend to affect the same age group, in general. They all may remain regional or be associated with a generalized eruption consistent with bullous pemphigoid. These three variants of subepidermal blistering dise...
journal_title:Clinics in dermatology
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journal_title:Clinics in dermatology
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journal_title:Clinics in dermatology
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journal_title:Clinics in dermatology
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journal_title:Clinics in dermatology
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abstract::Cutaneous zygomycosis is a fungal infection caused by zygomycetes that affects the skin. It occurs in uncontrolled diabetic patients and immunosuppressed individuals. It has 2 clinical forms: primary cutaneous zygomycosis and secondary cutaneous zygomycosis. The first is characterized by necrotic lesions and the fungu...
journal_title:Clinics in dermatology
pub_type: 杂志文章
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journal_title:Clinics in dermatology
pub_type: 杂志文章,评审
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journal_title:Clinics in dermatology
pub_type: 历史文章,杂志文章
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journal_title:Clinics in dermatology
pub_type: 杂志文章
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journal_title:Clinics in dermatology
pub_type: 杂志文章,评审
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journal_title:Clinics in dermatology
pub_type: 杂志文章,评审
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journal_title:Clinics in dermatology
pub_type: 杂志文章,评审
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journal_title:Clinics in dermatology
pub_type: 杂志文章
doi:10.1016/j.clindermatol.2017.03.002
更新日期:2017-01-01 00:00:00
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journal_title:Clinics in dermatology
pub_type: 杂志文章
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journal_title:Clinics in dermatology
pub_type: 杂志文章,评审
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journal_title:Clinics in dermatology
pub_type: 杂志文章,评审
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journal_title:Clinics in dermatology
pub_type: 杂志文章,评审
doi:10.1016/j.clindermatol.2013.11.009
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journal_title:Clinics in dermatology
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journal_title:Clinics in dermatology
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journal_title:Clinics in dermatology
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journal_title:Clinics in dermatology
pub_type: 杂志文章,评审
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journal_title:Clinics in dermatology
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journal_title:Clinics in dermatology
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journal_title:Clinics in dermatology
pub_type: 杂志文章
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journal_title:Clinics in dermatology
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journal_title:Clinics in dermatology
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journal_title:Clinics in dermatology
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journal_title:Clinics in dermatology
pub_type: 杂志文章
doi:10.1016/j.clindermatol.2016.09.002
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abstract::Psoriasis is a chronic inflammatory disorder characterized by substantial psychiatric comorbidity. Historically, anecdotal observations have suggested that psychosocial distress can trigger flares of psoriasis, but over the past several decades, high-quality data from experimental studies support the assertion that st...
journal_title:Clinics in dermatology
pub_type: 杂志文章
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