Systemic drug reactions with skin involvement: Stevens-Johnson syndrome, toxic epidermal necrolysis, and DRESS.

Abstract:

:Skin is often affected in adverse drug reactions. Although the majority of cutaneous adverse drug reactions are benign and self-limiting, Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and drug rash with eosinophilia and systemic symptoms (DRESS), affecting multiple organs and systems, are potentially fatal. Many organs can be affected, including the mucosal membranes, gastrointestinal tract, liver, lungs, kidneys, and eyes. We discuss the causes, pathophysiologic aspects, and main clinical features of SJS, TEN, and DRESS as systemic diseases with skin involvement.

journal_name

Clin Dermatol

journal_title

Clinics in dermatology

authors

Darlenski R,Kazandjieva J,Tsankov N

doi

10.1016/j.clindermatol.2015.05.005

subject

Has Abstract

pub_date

2015-09-01 00:00:00

pages

538-41

issue

5

eissn

0738-081X

issn

1879-1131

pii

S0738-081X(15)00120-0

journal_volume

33

pub_type

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