Abstract:
:Skin is often affected in adverse drug reactions. Although the majority of cutaneous adverse drug reactions are benign and self-limiting, Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and drug rash with eosinophilia and systemic symptoms (DRESS), affecting multiple organs and systems, are potentially fatal. Many organs can be affected, including the mucosal membranes, gastrointestinal tract, liver, lungs, kidneys, and eyes. We discuss the causes, pathophysiologic aspects, and main clinical features of SJS, TEN, and DRESS as systemic diseases with skin involvement.
journal_name
Clin Dermatoljournal_title
Clinics in dermatologyauthors
Darlenski R,Kazandjieva J,Tsankov Ndoi
10.1016/j.clindermatol.2015.05.005subject
Has Abstractpub_date
2015-09-01 00:00:00pages
538-41issue
5eissn
0738-081Xissn
1879-1131pii
S0738-081X(15)00120-0journal_volume
33pub_type
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