Abstract：
:Topical corticosteroids are effective for the treatment of seborrheic dermatitis. The duration of treatment with mid- to high-potency formulations is limited by the well-known side effects associated with their long-term use; further, topical corticosteroids treat only the inflammation associated with the disease. This study assessed the antifungal activity of a new corticosteroid-free cream against Malassezia spp, which may be an important pathogenic factor in seborrheic dermatitis. This was a single-center, bilateral, open-label pilot study in 10 healthy volunteers. The nonsteroidal cream was applied twice daily to a designated target area on the chest for 7 days, and the number of colony-forming units of Malassezia spp taken by tape stripping after 7 days was compared with baseline. The percentage reduction from baseline to day 7 in the number of colony-forming units of Malassezia spp was 94% on the treated side versus 49% on the untreated side (P = .03). This pilot study shows the nonsteroidal topical cream has antifungal activities. Further exploration into its potential as a therapeutic alternative for seborrheic dermatitis is warranted.
journal_name
Clin Dermatoljournal_title
Clinics in dermatologyauthors
Kircik Ldoi
10.1016/j.clindermatol.2009.09.004subject
Has Abstractpub_date
2009-11-01 00:00:00pages
S44-7issue
6 Suppleissn
0738-081Xissn
1879-1131pii
S0738-081X(09)00194-1journal_volume
27pub_type
杂志文章abstract：:Dr. Ida Lystic is an assistant professor in the Division of Gastroenterology at the Byron Edwards & Samuel Thompson (BEST) Medical Center. Before becoming one of the BEST doctors, she completed her fellowship training at the Owen T. Henry and Eugene Rutherford (OTHER) Medical Center and her MD degree at the prestigiou...
journal_title：Clinics in dermatology
pub_type： 杂志文章
doi：10.1016/j.clindermatol.2018.02.001
更新日期：2018-01-01 00:00:00
abstract：:The large majority of cases reported worldwide as zygomycosis are infections caused by fungi belonging to the order Mucorales. These infections are invasive, often lethal, and they primarily affect immunocompromised patients. Cutaneous zygomycosis is the third most common clinical presentation, after sinusitis and pul...
journal_title：Clinics in dermatology
pub_type： 杂志文章,评审
doi：10.1016/j.clindermatol.2012.01.010
更新日期：2012-11-01 00:00:00
abstract：:Variations in pain perception have long been studied in the medical literature, especially for women in regards to their menstrual cycle. Anecdotally, women can be more sensitive to painful stimuli from cosmetic procedures during their menses; however, no studies have thoroughly examined variations in pain perception ...
journal_title：Clinics in dermatology
pub_type： 杂志文章,评审
doi：10.1016/j.clindermatol.2019.10.011
更新日期：2019-01-01 00:00:00
abstract：:Adjuvant immunosuppressive drugs are widely used to minimize corticosteroid-related adverse effects in the short-term and long-term management of cautoimmune bullous diseases. In bullous pemphigoid and pemphigus vulgaris, azathioprine and mycophenolate mofetil seem to be equally effective when used in combination with...
journal_title：Clinics in dermatology
pub_type： 杂志文章,评审
doi：10.1016/j.clindermatol.2011.03.013
更新日期：2012-01-01 00:00:00
abstract：:From ancient times, light has played a significant role in the treatment of diseases. The modern discoveries (eg, ultraviolet radiation) and modern inventions (eg, the electric generator or the electric lightbulb), as well as balneologic experiences of the treatment with sunlight, contributed to the transition from he...
journal_title：Clinics in dermatology
pub_type： 历史文章,杂志文章
doi：10.1016/j.clindermatol.2016.05.002
更新日期：2016-09-01 00:00:00
abstract：:Skin allografts were first used at the end of the last century by Girdner [Girdner JH. Skin grafting with graft taken from the dead subject. Med Rec (NY) 1881;20:119-20]; however, routine storage of human tissue developed only in the 1930s to 1940s [Webster JP. Refrigerated skin grafts. Ann Surg 1944;120:431-49] when ...
journal_title：Clinics in dermatology
pub_type： 杂志文章,评审
doi：10.1016/j.clindermatol.2004.07.016
更新日期：2005-07-01 00:00:00
abstract：:Corporate studies have consistently shown that millennials prefer more frequent and detailed feedback in the workplace. With most dermatology residents fitting the description of a millennial, we sought to study their preferences in feedback and then compare this to current feedback practices and cultures. Our study s...
journal_title：Clinics in dermatology
pub_type： 杂志文章
doi：10.1016/j.clindermatol.2018.10.001
更新日期：2019-01-01 00:00:00
abstract：:This contribution, which is somewhat of a departure from the usual format, will focus on dermatologic conditions that are consequences of the patients' choices of employment, hobby, or even other forms of recreation. Most of the cutaneous changes involve the hands and feet, and each is labeled according to the anatomi...
journal_title：Clinics in dermatology
pub_type： 杂志文章
doi：10.1016/j.clindermatol.2016.09.002
更新日期：2017-01-01 00:00:00
abstract：:The introduction of sentinel lymph node biopsy (SLNB) has been an important development in the management of malignant melanoma. Lymph nodes have long been known to play a key role in melanoma metastasis. The importance of nodal staging accounted for the previous surgical practice of elective lymph node dissection (EL...
journal_title：Clinics in dermatology
pub_type： 杂志文章,评审
doi：10.1016/j.clindermatol.2003.12.011
更新日期：2004-05-01 00:00:00
abstract：:Cosmeceuticals are used for nourishing and improving the appearance of the skin and are also documented as effective agents for treating various dermatologic conditions. Cosmeceutical preparations from herbal origin are most popular among consumers because these agents are mostly nontoxic and possess strong antioxidan...
journal_title：Clinics in dermatology
pub_type： 杂志文章,评审
doi：10.1016/j.clindermatol.2009.05.012
更新日期：2009-09-01 00:00:00
abstract：:Acne is the most common of skin diseases, being characterized as a chronic inflammatory disease of the pilosebaceous unit. Although acne is usually straightforward to diagnose and treat, some patients have difficult or rare forms of acne. What seems to be "nonresponding acne" in a patient may be caused by another acne...
journal_title：Clinics in dermatology
pub_type： 杂志文章
doi：10.1016/j.clindermatol.2016.10.005
更新日期：2017-01-01 00:00:00
abstract：:Dermatologic manifestations of parathyroid-related disorders, although rare in sporadic cases, are not uncommon in familial syndromes. Patients with familial hyperparathyroidism have several types of skin lesions. In multiple endocrine neoplasia 1, patients commonly have angiofibromas (85%) and collagenomas (70%), les...
journal_title：Clinics in dermatology
pub_type： 杂志文章,评审
doi：10.1016/j.clindermatol.2006.04.003
更新日期：2006-07-01 00:00:00
abstract：:Most defects in dermatologic surgery can be repaired by primary closure. If this is not feasible, then local flaps should be employed. Where flaps are unfeasible or would result in an additional cosmetic deformity, then a full-thickness skin graft should be employed. If the defect is too large for a full-thickness ski...
journal_title：Clinics in dermatology
pub_type： 杂志文章
doi：10.1016/0738-081x(87)90031-9
更新日期：1987-10-01 00:00:00
abstract：:Diabetes mellitus is a metabolic disorder characterized by elevated fasting and postprandial blood glucose levels. It is also accompanied with a variety of multisystem complications that include the blood vessels, nervous system, eyes, kidneys, and skin. The main cutaneous complications are discussed. ...
journal_title：Clinics in dermatology
pub_type： 杂志文章,评审
doi：10.1016/j.clindermatol.2007.10.015
更新日期：2008-05-01 00:00:00
abstract：:Oral manifestations of nutritional deficiencies can affect the mucous membranes, teeth, periodontal tissue, salivary glands, and perioral skin. This contribution reviews how the water-soluble vitamins (B(2), B(3), B(6), B(12), C, and folic acid), fat-soluble vitamins (A, D, and E), and minerals (calcium, fluoride, iro...
journal_title：Clinics in dermatology
pub_type： 杂志文章
doi：10.1016/j.clindermatol.2010.03.025
更新日期：2010-07-01 00:00:00
abstract：:In 2002, new guidelines for interactions with the pharmaceutical industry and physicians were published as an official code of conduct. Adherence to the guidelines was voluntary, and there were no provisions for discipline to companies who did not subscribe to the code or who subscribed but did not comply. Many of the...
journal_title：Clinics in dermatology
pub_type： 杂志文章
doi：10.1016/j.clindermatol.2009.02.005
更新日期：2009-07-01 00:00:00
abstract：:The use of many drugs in dermatologic diseases may cause ocular side effects. Some may regress after discontinuation of the therapy, but others persist or progress even after the cessation of treatment. This review presents four groups of commonly prescribed drugs-antimalarial medicines, glucocorticoids, retinoids, an...
journal_title：Clinics in dermatology
pub_type： 杂志文章,评审
doi：10.1016/j.clindermatol.2015.11.012
更新日期：2016-03-01 00:00:00
abstract：:Human epidermis consists of a stratified epithelium mainly composed of keratinocytes and relies on a stem cell compartment to undergo constant regeneration. Genetic mutations affecting the capacity of basal keratinocytes to adhere firmly to the epidermal basement membrane lead to severe, and very often lethal, blister...
journal_title：Clinics in dermatology
pub_type： 杂志文章,评审
doi：10.1016/j.clindermatol.2004.07.017
更新日期：2005-07-01 00:00:00
abstract：:The quest for clarifying the pathophysiology of atopic dermatitis (eczema) has lasted for 25 centuries. Yearning to discern the primum movens of atopic dermatitis, physicians aimed to identify the curative therapy. Recent scientific efforts has brought to the light an ever-growing amount of interplaying pathophysiolog...
journal_title：Clinics in dermatology
pub_type： 杂志文章,评审
doi：10.1016/j.clindermatol.2009.03.009
更新日期：2010-01-01 00:00:00
abstract：:Toxic epidermal necrolysis (TEN) and Stevens-Johnson syndrome (SJS) are uncommon but extremely serious and often life-threatening mucocutaneous reactions characterized by extensive epithelial sloughing and systemic symptoms. There is no effective evidence-based treatment for severe cutaneous adverse reactions (SCAR) t...
journal_title：Clinics in dermatology
pub_type： 杂志文章
doi：10.1016/j.clindermatol.2009.06.020
更新日期：2010-05-01 00:00:00
abstract：:Squaric acid dibutylester is a topical sensitizing agent utilized for the treatment of alopecia areata. The mechanism of action is not fully understood, but is believed to redirect the inflammatory response by invoking allergic contact dermatitis. Several studies have compared the efficacy of squaric acid dibutylester...
journal_title：Clinics in dermatology
pub_type： 杂志文章,评审
doi：10.1016/j.clindermatol.2014.12.001
更新日期：2015-05-01 00:00:00
abstract：:Actinic keratoses (AKs) represent the earliest stage in the development of squamous cell carcinoma (SCC) and represent important biomarkers for individuals at risk for development of invasive SCC. Based on clinical morphology, AK can be subdivided into three different grades, which correspond to specific dermatoscopic...
journal_title：Clinics in dermatology
pub_type： 杂志文章
doi：10.1016/j.clindermatol.2013.05.028
更新日期：2014-01-01 00:00:00
abstract：:Somatic symptom disorder (SSD) is defined by the prominence of somatic symptoms associated with abnormal thoughts, feelings, and behaviors related to the symptoms, resulting in significant distress and impairment. Individuals with these disorders are more commonly encountered in primary care and other medical settings...
journal_title：Clinics in dermatology
pub_type： 杂志文章
doi：10.1016/j.clindermatol.2017.01.010
更新日期：2017-01-01 00:00:00
abstract：:A new or changing melanocytic nevus in a child or adolescent often leads to concern in parents and physicians. To avoid undue alarm and unnecessary procedures, dermatologists should be aware of the natural history and clinical spectrum of nevi in pediatric patients, as well as findings that are potentially worrisome i...
journal_title：Clinics in dermatology
pub_type： 杂志文章,评审
doi：10.1016/j.clindermatol.2014.12.015
更新日期：2015-05-01 00:00:00
abstract：:Most neoplasms of the nail apparatus have different clinical appearances, courses, and biological behaviors as compared with similar tumors located elsewhere on the skin. Some of these tumors are unique to the nail, such as onychomatricoma. As a general rule, benign lesions respect the general architecture of the nail...
journal_title：Clinics in dermatology
pub_type： 杂志文章,评审
doi：10.1016/j.clindermatol.2013.06.014
更新日期：2013-09-01 00:00:00
abstract：:The cause and effect between ultraviolet light and cutaneous lupus erythematosus (CLE) is clear. In LE patients indeed, photosensitivity is one of the major diagnostic criteria of the systemic form of lupus erythematosus. This strong clinical association has led to the postulate that abnormal photosensitivity particip...
journal_title：Clinics in dermatology
pub_type： 杂志文章,评审
doi：10.1016/j.clindermatol.2003.12.017
更新日期：2004-03-01 00:00:00
abstract：:Facial erythema (the "red face") is a straightforward clinical finding, and it is evident even to the untrained eye; however, a red face does not represent a single cutaneous entity. It may be due to a plethora of distinct underlying conditions of varying severity, including rosacea, demodicosis, dermatomyositis, lupu...
journal_title：Clinics in dermatology
pub_type： 杂志文章,评审
doi：10.1016/j.clindermatol.2016.10.015
更新日期：2017-01-01 00:00:00
abstract：:Community-acquired methicillin-resistant Staphylococcus aureus (CAMRSA) infection is currently a problem of epidemic proportion. Athletes represent a specific group of individuals who are at increased risk to develop CAMRSA skin infections. In this article, the previously published reports of cutaneous CAMRSA infectio...
journal_title：Clinics in dermatology
pub_type： 杂志文章,评审
doi：10.1016/j.clindermatol.2007.10.006
更新日期：2008-01-01 00:00:00
abstract：:Teledermatology has emerged as a promising solution for pediatric and adult patients accessing dermatologic care in a health care environment fraught with barriers to access. Teledermatology has been extensively evaluated in terms of diagnostic accuracy, clinical outcomes, patient and provider satisfaction, and costs,...
journal_title：Clinics in dermatology
pub_type： 杂志文章,评审
doi：10.1016/j.clindermatol.2017.08.009
更新日期：2017-01-01 00:00:00
abstract：:From the Eskimo in Greenland to the tribes in Polynesia-the whole world knows the art of tattoo. Despite their wide popularity the relation between the skin diseases and the tattooed pictures aren't studied in depth. With the appearance of professional tattoo studios, the risk of infectious complications was reduced. ...
journal_title：Clinics in dermatology
pub_type： 杂志文章,评审
doi：10.1016/j.clindermatol.2007.05.012
更新日期：2007-07-01 00:00:00
