Cutaneous immune-related adverse events to checkpoint inhibitors.

Abstract:

:The development of immunotherapy has led to a paradigm shift in the treatment of both solid and hematologic malignancies. As immunomodulatory therapies are employed with increasing frequency, a greater number of immune-related adverse reactions are being reported, and the majority of these involve the skin. As a result, dermatologists are increasingly becoming involved in the management of these cutaneous adverse reactions-often providing critical recommendations regarding ongoing cancer treatment. Cutaneous immune-related adverse reactions can vary significantly from patient to patient, making early recognition and timely intervention imperative to mitigate associated morbidity and potential treatment interruption. Although there is considerable overlap in the cutaneous adverse events caused by these immune checkpoint inhibitors, specific eruptions are characteristically associated with particular checkpoint inhibitors. In addition, a patient's comorbidities or immune status can play a significant role in the presentation and management of such adverse reactions. This review characterizes and provides management guidelines for the various cutaneous toxicities associated with checkpoint inhibitor therapy, including CTLA-4 inhibitors, PD-1 inhibitors, and PD-L1 inhibitors. © 2020 Elsevier Inc. All rights reserved.

journal_name

Clin Dermatol

journal_title

Clinics in dermatology

authors

Malviya N,Tattersall IW,Leventhal J,Alloo A

doi

10.1016/j.clindermatol.2020.06.011

subject

Has Abstract

pub_date

2020-01-01 00:00:00

pages

660-678

issue

6

eissn

0738-081X

issn

1879-1131

pii

S0738-081X(20)30144-9

journal_volume

38

pub_type

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