The mTOR signaling pathway in pediatric neuroblastoma.

abstract：:To evaluate the quantitative aspects of the shift in production from fetal hemoglobin (HbF) to adult hemoglobin (HbA), the HbF and HbA mass were estimated in a preterm infant (gestational age 29 weeks) for 22 weeks after an exchange transfusion the second day of life, leading to an initial HbA% of 100. Up until the es...

journal_title：Pediatric hematology and oncology

authors： Refsum HE,Bechensteen AG,Lindemann R

更新日期：1998-09-01 00:00:00

abstract：:Thalassemic children are at a high risk of graft rejection in cord blood transplantation. To investigate this possible mechanism, the authors evaluated the effect of panel reactive antibody on the growth of CD34(+) cells in vitro. On semisolid medium, CD34(+) cells derived from cord blood were incubated with thalassem...

journal_title：Pediatric hematology and oncology

authors： Fang JP,Xu LH,Yang XG,Wu YF,Weng WJ,Xu HG

更新日期：2009-07-01 00:00:00

abstract：:In five patients under the age of 15 with hemophilia and inhibitors, due to frequent joint bleedings, 13 joints were treated with synoviorthesis (intra-articular injection of radioactive gold). The patients received high doses of factor VIII/IX for 2-4 days or were treated simultaneously with tolerance induction accor...

journal_title：Pediatric hematology and oncology

authors： Löfqvist T,Petersson C

更新日期：1992-04-01 00:00:00

abstract：:Growth hormone deficiency (GHD) is a recognized late effect of successful treatment of tumors requiring cranial irradiation. Growth after treatment was assessed in 16 patients with sarcomas of the orbital and parameningeal regions. Median age at diagnosis was 6.35 years and median follow-up was 7.2 years. Treatment co...

journal_title：Pediatric hematology and oncology

authors： Goddard AG,Harris SJ,Plowman PN,Savage MO,Kingston JE

更新日期：1999-01-01 00:00:00

abstract：:Neurological complications may occur following intensive chemotherapy and hematopoietic cell transplantation. Postirradiation somnolence syndrome has been observed in children with acute lymphoblastic leukemia who received central nervous system preventive therapy with 1800-2400 cGy cranial irradiation. The authors re...

journal_title：Pediatric hematology and oncology

authors： Miyahara M,Azuma E,Hirayama M,Kobayashi M,Hori H,Komada Y,Masuda H

更新日期：2000-09-01 00:00:00

abstract：:Objectives: Diffusion-weighted magnetic resonance imaging (DW-MRI) offers potential to monitor response and predict survival in high-grade gliomas (HGG) and diffuse intrinsic pontine gliomas (DIPG). We hypothesized that post-radiotherapy DW-MRI may provide prognostic imaging biomarkers in children and young adults wit...

journal_title：Pediatric hematology and oncology

authors： Carceller F,Jerome NP,Fowkes LA,Khabra K,Mackinnon A,Bautista F,Marshall LV,Vaidya S,Mandeville H,Morgan V,Leach MO,Koh DM

更新日期：2019-03-01 00:00:00

abstract：:Tolerance of full-dose methotrexate/6-mercaptopurine (MTX/6MP) maintenance therapy for childhood acute lymphoblastic leukemia (ALL) without side effects could reflect insufficient systemic drug exposure, and drug withdrawals due to toxicity might reduce the chance of cure. The present study included 122 children with ...

journal_title：Pediatric hematology and oncology

authors： Schmiegelow K

更新日期：1991-10-01 00:00:00

abstract：:Immune thrombocytopenia (ITP) is an acute self-limited disease of childhood, mostly resolving within 6 months irrespective of whether therapy is given or not. Treatment options when indicated include corticosteroids, intravenous immune globulin (IVIG), and anti-RhD immunoglobulin. We reviewed our 32 years' experience ...

journal_title：Pediatric hematology and oncology

authors： Yildiz I,Ozdemir N,Celkan T,Soylu S,Karaman S,Canbolat A,Dogru O,Erginoz E,Apak H

更新日期：2015-01-01 00:00:00

abstract：:This study investigated the influence of levamisole therapy on immunocompetent cells and lymphocyte reactivity to mitogens in 25 children with brain tumor. Eleven (11/25) patients were receiving chemotherapy and immunomodulating drug levamisole 3 months after neurosurgery, during maintenance chemotherapy, 2.5 mg/kg of...

journal_title：Pediatric hematology and oncology

authors： Hajnzić TF,Kastelan M,Lukac J,Hajnzić T

更新日期：1999-07-01 00:00:00

abstract：:This is a pilot study performed to determine the maximum tolerated number of courses of high-dose thiotepa and carboplatin with autologous peripheral blood progenitor cell (PBPC) transplantation in poor-risk pediatric central nervous system (CNS) tumor patients. Twelve patients were enrolled and a total of 24 PBPC tra...

journal_title：Pediatric hematology and oncology

authors： Ozkaynak MF,Sandoval C,Levendoglu-Tugal O,Jayabose S

更新日期：2004-10-01 00:00:00

abstract：:A newborn infant presented with intraocular tumor that was clinically diagnosed as retinoblastoma and treated by exenteration of the globe. Within a few weeks however, a large abdominal mass was noted, which was found to involve the left kidney and right lobe of liver. Pathologic evaluation of the intraocular mass as ...

journal_title：Pediatric hematology and oncology

authors： Akhtar M,Ali MA,Sackey K,Bakry M,Johnson T

更新日期：1991-01-01 00:00:00

abstract：:A cooperative Italian study group on acute idiopathic thrombocytopenic purpura (AITP) has been designed to evaluate efficacy and safety of no treatment at the onset of the disease and sequential treatment with immunoglobulin and high dose steroid. One hundred thirty-eight patients with AITP entered in the trial. Eleve...

journal_title：Pediatric hematology and oncology

authors： Mori PG,Lanza T,Mancuso G,De Mattia D,Catera P,Miano C,Del Principe D,Cottafava F

更新日期：1988-01-01 00:00:00

abstract：:All pediatric osteosarcomas treated in our hospital between 1985 and 1995 were reviewed. There were 26 patients, 15 males and 11 females, aged 20 or less at diagnosis. All had limb primaries. Nineteen patients had localized disease and seven presented with metastases. Intensive multiagent chemotherapy was given both p...

journal_title：Pediatric hematology and oncology

authors： Kwong DL,Ha SY,Chau KY,Choi PH,Chan GC,Kwong PW,Lau YL

更新日期：1998-05-01 00:00:00

abstract：:To determine the effect of recombinant human granulocyte-colony stimulation factor (rhG-CSF) on the immune system, serum immunoglobulins, lymphocyte subsets, and serum cytokines were analyzed in eight pediatric patients with aplastic anemia (AA) during 8-week rhG-CSF therapy. The rhG-CSF was administered either subcut...

journal_title：Pediatric hematology and oncology

authors： Hibi S,Yoshihara T,Nakajima F,Misu H,Mabuchi O,Imashuku S

更新日期：1994-05-01 00:00:00

abstract：:In this paper we describe a 9-year-old girl with abdominal embryonal rhabdomyosarcoma. She had ascites and widespread metastatic disease at presentation and was oliguric but had a normal creatinine. Following the start of chemotherapy she developed acute renal failure secondary to the tumor lysis syndrome, requiring h...

journal_title：Pediatric hematology and oncology

authors： Khan J,Broadbent VA

更新日期：1993-04-01 00:00:00

abstract：:The Hungarian Pediatric Oncology Working Group intended to change the practice of prescribing diagnostic tests as well as to examine the possibility of introducing indicators about the time factors of medical care. A nationwide accepted protocol was established for these tests. The examined time factors were the lengt...

journal_title：Pediatric hematology and oncology

authors： Pásztélyi Z,Schuler D,Czvenits E

更新日期：2000-12-01 00:00:00

abstract：:The increased incidence of malignancies, especially acute leukemia, in Down syndrome has been clearly established. The association of Hodgkin's disease with Down syndrome has not been extensively documented, and only a few cases have been reported. We present here a case report of Hodgkin's disease in an 11-year-old f...

journal_title：Pediatric hematology and oncology

authors： Kusumakumary P,Jyothirmayi R,Chellam VG,Krishnan NM

更新日期：1996-09-01 00:00:00

abstract：:The difference between the effects of administration of recombinant human granulocyte colony-stimulating factor (rhG-CSF) and recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF) was studied in 39 children with neutropenia secondary to chemotherapy (absolute neutrophil count (ANC) less than 1,...

journal_title：Pediatric hematology and oncology

authors： Lydaki E,Bolonaki E,Stiakaki E,Dimitriou H,Kalmantis T,Kalmanti M

更新日期：1995-11-01 00:00:00

abstract：:High doses of intravenous deferoxamine via central venous line (CVL) has recently been shown to improve survival in patients with noncompliant thalassemia major (TM). The aim of this retrospective study was to evaluate the extent of CVL-related thrombosis and to determine the presence of prothrombotic factors in child...

journal_title：Pediatric hematology and oncology

authors： Finkelstein Y,Yaniv I,Berant M,Zilber R,Garty BZ,Epstein O,Lahav J,Tamary H

更新日期：2004-07-01 00:00:00

abstract：:Primary bone marrow lymphoma (PBML) is hard to diagnose in children, due to the difficult identification of malignant cells in bone marrow. The first case, a 5-year-old boy, showed knee swelling with an intermittent fever. The second case, a 12-year-old girl, showed fever of unknown origin without lymphadenopathy or h...

journal_title：Pediatric hematology and oncology

authors： Moritani K,Nakano N,Yonezawa S,Ochi F,Tauchi H,Eguchi-Ishimae M,Eguchi M,Ishii E,Nagai K

更新日期：2018-03-01 00:00:00

abstract：:Low iron stores in children, absolute iron deficiency (AID), can lead to impaired neurodevelopment and requires iron therapy. In the presence of infection/inflammation, like in cystic fibrosis (CF), serum ferritin (SF) is not a reliable biomarker for AID. Red blood cell distribution width (RDW) is a promising alternat...

journal_title：Pediatric hematology and oncology

authors： Akkermans MD,Uijterschout L,Nuijsink M,Hendriks DM,van Goudoever JB,Brus F

更新日期：2017-02-01 00:00:00

abstract：:Adolescence is characterized by inter-related physiologic and emotional development. It is a particularly vulnerable period of life culminating into emergence as an adult. The majority of malignant bone tumors in pediatrics affect the adolescent patient. As a part of the treatment, amputation may be required for cure....

journal_title：Pediatric hematology and oncology

authors： Jaffe N,Zietz H

更新日期：2004-09-01 00:00:00

abstract：:Growth was studied longitudinally in 19 children who were long-term survivors after acute lymphoblastic leukemia (ALL). Of the children, 13 were girls; 6 were boys. They had all undergone a 3-year cytostatic treatment period which included vincristine, adriamycin, asparaginase, methotrexate, purinethol, and prednisone...

journal_title：Pediatric hematology and oncology

authors： Sempoux P,Moëll C,Cornu G,Malvaux P,Maes M

更新日期：1992-07-01 00:00:00

abstract：:Between 1973 and 1991, 10 patients with locally advanced [stages III and IV] nasopharyngeal carcinoma were treated at the Northern Israel Oncology Center. All patients were treated with wide-field irradiation to the primary tumor, including the base of skull, neck, and supraclavicular region. After 1984, 6 patients al...

journal_title：Pediatric hematology and oncology

authors： Arush MW,Stein ME,Rosenblatt E,Lavie R,Kuten A

更新日期：1995-05-01 00:00:00

abstract：:Modern treatment protocols lead to complete remission in a high proportion of patients with childhood acute lymphoblastic leukemia (ALL). However, a large number of them show a relapse of the disease. Treatment failure in these patients is mainly attributable to de novo or acquired resistance to a wide variety of cyto...

journal_title：Pediatric hematology and oncology

authors： Kourti M,Vavatsi N,Gombakis N,Tzimagiorgis G,Sidi V,Koliouskas D,Athanassiadou F

更新日期：2006-09-01 00:00:00

abstract：OBJECTIVE:Physiologic uptake of 18F-fluorodeoxyglucose (FDG) in brown adipose tissue (adipose tissue) of cancer patients may confound interpretation of positron emission tomography (PET) scans. Uptake in adipose tissue occurs in up to half of pediatric oncology patients undergoing PET scans, and is especially common in...

journal_title：Pediatric hematology and oncology

authors： George A,Sinha P,Conrad G,Memon AA,Dressler EV,Wagner LM

更新日期：2017-04-01 00:00:00

abstract：:Invasive aspergillosis is a fungal infection that is being observed increasingly in immunocompromised patients due to the use of more aggressive chemotherapeutic regimens. To our knowledge, no case of pneumothorax and pneumopericardium associated with invasive pulmonary aspergillosis has been reported to date. High-do...

journal_title：Pediatric hematology and oncology

authors： Merino JM,Díaz MA,Ramírez M,Ruano D,Madero L

更新日期：1995-03-01 00:00:00

abstract：:Metastatic osteosarcoma most commonly affects the lungs and other bones. Hepatic metastasis at the time of diagnosis is extremely rare. A 14-year-old boy with synovial sarcoma of the left popliteal fossa was treated with surgical resection, radiotherapy for microscopic residual disease, and 1 year of chemotherapy (vin...

journal_title：Pediatric hematology and oncology

authors： Daw NC,Kaste SC,Hill DA,Kun LE,Pratt CB

更新日期：2001-03-01 00:00:00

abstract：:Very little has been published on the use of romiplostim to treat primary immune thrombocytopenia (ITP), refractory to previous treatments, in children. The objective of this study was to determine its efficacy and safety in pediatric patients in a university general hospital. Retrospective, longitudinal observational...

journal_title：Pediatric hematology and oncology

authors： Escudero Vilaplana V,Aragonés JH,Fernández-Llamazares CM,Bieler CB,Rodríguez SM,Sáez MS

更新日期：2012-03-01 00:00:00

abstract：:Thrombo-embolism in childhood is a multifactorial disorder. The present study is a case-control study that investigated the role of genetic and acquired risk factors in 60 children with thrombosis and compared the results with the controls. Acquired and inherited risk factors precipitating thrombosis were present in 7...

journal_title：Pediatric hematology and oncology

authors： Günes AM,Baytan B,Günay U

更新日期：2006-07-01 00:00:00