Advanced nasopharyngeal carcinoma in the young: The Northern Israel Oncology Center experience, 1973-1991.

Abstract:

:Between 1973 and 1991, 10 patients with locally advanced [stages III and IV] nasopharyngeal carcinoma were treated at the Northern Israel Oncology Center. All patients were treated with wide-field irradiation to the primary tumor, including the base of skull, neck, and supraclavicular region. After 1984, 6 patients also received cisplatin/5FU-based chemotherapy prior to radiotherapy and 1 patient received it after radiotherapy. All the patients who received chemotherapy are alive with no evidence of disease, for a mean disease-free survival of 96 months (range, 77 to 108 months), and no serious therapy-related late side-effects have been noted, except in one patient. We conclude that adjuvant chemotherapy may be effective in improving outcome, but only randomized prospective studies can evaluate its exact role.

journal_name

Pediatr Hematol Oncol

authors

Arush MW,Stein ME,Rosenblatt E,Lavie R,Kuten A

doi

10.3109/08880019509029568

subject

Has Abstract

pub_date

1995-05-01 00:00:00

pages

271-6

issue

3

eissn

0888-0018

issn

1521-0669

journal_volume

12

pub_type

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