Subnormal growth during puberty in children treated for acute lymphoblastic leukemia.

Abstract:

:Growth was studied longitudinally in 19 children who were long-term survivors after acute lymphoblastic leukemia (ALL). Of the children, 13 were girls; 6 were boys. They had all undergone a 3-year cytostatic treatment period which included vincristine, adriamycin, asparaginase, methotrexate, purinethol, and prednisone. Prophylactic cerebral irradiation (20-24 Gy) had been given to all children; 4 of them had also been given irradiation to the spine (10 Gy). The pattern of growth was nearly identical in girls and boys. Growth in relation to the therapy was almost normal, whereas growth during puberty was subnormal and final height was 1.3 SD less than expected at onset of disease. The growth pattern was the same for children with cerebrospinal irradiation as for those with cerebral irradiation. In view of the present results and previous studies on growth hormone (GH) secretion after cerebral irradiation, we suggest that treatment with luteinizing hormone releasing hormone (LHRH) or GH could be considered at puberty for children who have been treated for ALL, including cerebral irradiation, and who have a poor prognosis for final height.

journal_name

Pediatr Hematol Oncol

authors

Sempoux P,Moëll C,Cornu G,Malvaux P,Maes M

doi

10.3109/08880019209016589

subject

Has Abstract

pub_date

1992-07-01 00:00:00

pages

217-22

issue

3

eissn

0888-0018

issn

1521-0669

journal_volume

9

pub_type

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