Abstract:
:To evaluate the quantitative aspects of the shift in production from fetal hemoglobin (HbF) to adult hemoglobin (HbA), the HbF and HbA mass were estimated in a preterm infant (gestational age 29 weeks) for 22 weeks after an exchange transfusion the second day of life, leading to an initial HbA% of 100. Up until the estimated time of delivery, the HbA mass declined continuously, at a rate corresponding to a survival time of the transfused HbA erythrocytes of 100 days, and the rise in total hemoglobin mass could be ascribed solely to a rise in the HbF mass. HbF% maximum was reached 3 weeks before HbF mass maximum, and, thus, the HbF% and HbA% time courses gave no basis for evaluation of the production/destruction balance of HbF and HbA erythrocytes. The applied quantitative approach seems to be a useful additional procedure for evaluating the switch from HbF to HbA production and for estimating HbA erythrocyte survival time in preterm infants.
journal_name
Pediatr Hematol Oncoljournal_title
Pediatric hematology and oncologyauthors
Refsum HE,Bechensteen AG,Lindemann Rdoi
10.3109/08880019809016572subject
Has Abstractpub_date
1998-09-01 00:00:00pages
431-5issue
5eissn
0888-0018issn
1521-0669journal_volume
15pub_type
杂志文章abstract::A retrospective analysis was performed on febrile neutropenic episodes in patients with acute lymphoblastic leukemia (ALL) from 1992 to 2002. There were 222 febrile neutropenic episodes in 266 ALL patients with documented ANC < 500/mm(3). Of the 222 episodes, 98 (44%) had documented focus of infection; the rest were f...
journal_title:Pediatric hematology and oncology
pub_type: 杂志文章
doi:10.1080/08880010802106564
更新日期:2008-06-01 00:00:00
abstract::An episode of transient encephalopathy after the first course of intravenous high-dose methotrexate (HD-MTX; 1000 mg/m2) was observed in a 4-year-old girl with acute lymphoblastic leukemia. The neurological abnormalities took place 5 days after HD-MTX therapy. She experienced complex partial seizure and left hemipares...
journal_title:Pediatric hematology and oncology
pub_type: 杂志文章
doi:10.3109/08880019209018331
更新日期:1992-04-01 00:00:00
abstract::In this study, we aimed to determine serum adrenomedullin levels and compare them with levels of C-reactive protein (CRP) and procalcitonin (PCT). Cancer patients aged 0-18 years who experienced febrile neutropenia attacks were included in the study. Adrenomedullin, CRP, and PCT were analyzed at admission, day 3, and ...
journal_title:Pediatric hematology and oncology
pub_type: 临床试验,杂志文章
doi:10.3109/08880018.2015.1057310
更新日期:2015-01-01 00:00:00
abstract::It has been suggested that breastfeeding may prevent inhibitor formation in patients with hemophilia. In a single-center retrospective cohort study, the authors studied the association between breastfeeding and inhibitor development in 90 severe hemophilia A patients born 1975-2003. Mean follow-up was 13.2 years (stan...
journal_title:Pediatric hematology and oncology
pub_type: 杂志文章
doi:10.1080/08880010500198764
更新日期:2005-10-01 00:00:00
abstract::A prospective, population-based registration of children with immune thrombocytopenic purpura (ITP) was performed in Norway in 1996 and 1997. Ninety-two cases were identified, indicating an incidence of 5.3 per 100,000 children under 15 years. The sex ratio (female/male) was 1.2/1. Fifty-six percent presented with cut...
journal_title:Pediatric hematology and oncology
pub_type: 杂志文章
doi:10.1080/08880010050122816
更新日期:2000-10-01 00:00:00
abstract::Brucellosis produces a variety of nonspecific hematologic abnormalities. Hematologic complications of mild anemia and leukopenia have been frequently associated with acute brucellosis, but pancytopenia is less frequently seen. In this study, records of children with brucellosis aged under or equal to 16 years, admitte...
journal_title:Pediatric hematology and oncology
pub_type: 杂志文章
doi:10.3109/08880018.2010.536298
更新日期:2011-04-01 00:00:00
abstract::The purpose of this study was to evaluate the feasibility and tumor response of 3 cycles of sequential high-dose chemotherapy (HDCT) in advanced pediatric solid tumor patients. Medical records of 11 children who underwent 2 consequent courses of reduced conditioning HDCT followed by final HDCT with autologous HSC infu...
journal_title:Pediatric hematology and oncology
pub_type: 杂志文章
doi:10.3109/14992020903352226
更新日期:2010-02-01 00:00:00
abstract::Bloodstream infections (BSI) represent one of the most serious complications in patients in the hematology-oncology unit. In this study, the prevalence, distribution, drug sensitivity profiles, and clinical outcome of BSI were analyzed in pediatric patients with hematological malignancies. Patients admitted to the ped...
journal_title:Pediatric hematology and oncology
pub_type: 杂志文章
doi:10.1080/08880018.2019.1667462
更新日期:2019-11-01 00:00:00
abstract::Two children are described who presented with fever and generalized seizures, days 50 and 200, respectively, after matched unrelated donor-bone marrow transplantation. Upon antiepileptic treatment the seizures vanished but somnolence and fever remained. Magnetic resonance imaging (MRI) of the brain was performed and r...
journal_title:Pediatric hematology and oncology
pub_type: 杂志文章
doi:10.1080/08880010050034337
更新日期:2000-07-01 00:00:00
abstract::In 33 children, 23 with acute lymphoblastic leukemia (ALL) and 10 with solid tumors, the phenotype of the enzyme adenosine deaminase (ADA) was detected in the erythrocytes by electrophoresis in cellulose acetate. In all children the ADA enzyme activity was also determined in the plasma by spectrophotometry at the onse...
journal_title:Pediatric hematology and oncology
pub_type: 杂志文章
doi:10.3109/08880019609030840
更新日期:1996-07-01 00:00:00
abstract::A pheochromocytoma was diagnosed in a 14-year-old boy developing hypertension after treatment with imipramine for primary nocturnal enuresis. The mechanism of action is assumed to be an inhibition of the neuronal uptake of catecholamines being released in large quantities from the tumor. The diagnosis of pheochromocyt...
journal_title:Pediatric hematology and oncology
pub_type: 信件
doi:10.3109/08880018609031228
更新日期:1986-01-01 00:00:00
abstract::Adolescence is characterized by inter-related physiologic and emotional development. It is a particularly vulnerable period of life culminating into emergence as an adult. The majority of malignant bone tumors in pediatrics affect the adolescent patient. As a part of the treatment, amputation may be required for cure....
journal_title:Pediatric hematology and oncology
pub_type: 杂志文章
doi:10.1080/08880010490477374
更新日期:2004-09-01 00:00:00
abstract::This is a report of a case of acute respiratory failure following the administration of intrathecal methotrexate (MTX) for prophylaxis of central nervous system leukemia (CNS) in a 3-year-old girl with acute lymphoblastic leukemia. This could be attributed to acute metabolic or direct toxic effects of methotrexate to ...
journal_title:Pediatric hematology and oncology
pub_type: 杂志文章
doi:10.3109/08880019009033390
更新日期:1990-01-01 00:00:00
abstract::Maternal education might be an important factor for the neuroblastoma risk in children, but it was conflicting. This meta-analysis was performed to evaluate the relationship between maternal education and neuroblastoma susceptibility and to explore whether maternal education was an important indicator to be associated...
journal_title:Pediatric hematology and oncology
pub_type: 杂志文章,meta分析
doi:10.3109/08880018.2012.742605
更新日期:2013-02-01 00:00:00
abstract::Treatment of Langerhans cell histiocytosis (LCH) is yet to be established. We treated seven patients with etoposide alone at a dose of 100 mg/m2/day for 3 days given every 3 to 4 weeks for six cycles. Three patients had received prior chemotherapy, two patients were less than 2 years of age, and two had liver dysfunct...
journal_title:Pediatric hematology and oncology
pub_type: 杂志文章
doi:10.3109/08880019609030806
更新日期:1996-03-01 00:00:00
abstract::This study evaluated the efficacy of hydroxyurea treatment in the prevention of vaso-occlusive crises among children and teenagers with severe sickle cell anemia and sickle cell beta-thalassemia. Nineteen children and young adults with severe sickle cell disease were enrolled to the hydroxyurea treatment trial. The in...
journal_title:Pediatric hematology and oncology
pub_type: 临床试验,杂志文章
doi:10.1080/088800199277272
更新日期:1999-05-01 00:00:00
abstract::Background: Preclinical studies show that TLR9 agonists can eradicate leukemia by induction of immune responses in vivo against AML and ALL. These studies demonstrated that TLR9 agonists induce an immediate NK response followed by adaptive T and B cells responses resulting in long term anti-leukemia immunity. Methods:...
journal_title:Pediatric hematology and oncology
pub_type: 杂志文章
doi:10.1080/08880018.2019.1667461
更新日期:2019-11-01 00:00:00
abstract::Thalassemic children are at a high risk of graft rejection in cord blood transplantation. To investigate this possible mechanism, the authors evaluated the effect of panel reactive antibody on the growth of CD34(+) cells in vitro. On semisolid medium, CD34(+) cells derived from cord blood were incubated with thalassem...
journal_title:Pediatric hematology and oncology
pub_type: 杂志文章
doi:10.1080/08880010902976098
更新日期:2009-07-01 00:00:00
abstract::Six transfusion-dependent beta-thalassemia major patients were treated with allogeneic peripheral blood stem cell (PBSC) transplant. The donors were HLA identical siblings except one donor who was a father with one-antigen mismatch of HLA-B loci. The donors were mobilized with G-CSF and PBSC was infused without manipu...
journal_title:Pediatric hematology and oncology
pub_type: 杂志文章
doi:10.1080/08880010290097260
更新日期:2002-10-01 00:00:00
abstract::Primary erythrocytosis diagnosed in a 10-month-old female and followed for 12 years is described. The erythrocytosis was associated with an abnormally elevated set point of erythropoietin production in which the sensitivity fluctuated independently, but corresponded to the alterations in the oxygen-carrying capacity o...
journal_title:Pediatric hematology and oncology
pub_type: 杂志文章
doi:10.3109/08880019109033455
更新日期:1991-07-01 00:00:00
abstract::Ondansetron, a highly selective 5-HT3 receptor antagonist, is available in an intravenous (IV) formulation and tables, but syrup would be particularly useful in children. As chemotherapy can affect taste perceptions, this study was undertaken to determine the preference between two flavors of ondansetron syrup in chil...
journal_title:Pediatric hematology and oncology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.3109/08880019609030816
更新日期:1996-03-01 00:00:00
abstract::Chronic granulomatous disease (CGD) is a rare genetically determined immunodeficiency. Neutrophils from CGD patients show a defective killing of phagocytosed fungi and bacteria, due not only to an impairment in oxidative burst, but also to absence of normal pH value within phagocytic vacuole following phagocytosis. Be...
journal_title:Pediatric hematology and oncology
pub_type: 杂志文章
doi:10.1080/08880010590907267
更新日期:2005-03-01 00:00:00
abstract::Neuroblastoma presenting with obstructive jaundice is a rare event. Management of this condition includes surgery, chemotherapy, radiotherapy, temporary cholecystostomy tube, endoscopic retrograde cholangiopancreatography (ERCP), and internal biliary drainage (IBD). We herein describe our experience with one infant af...
journal_title:Pediatric hematology and oncology
pub_type: 杂志文章
doi:10.3109/08880018.2014.981901
更新日期:2015-04-01 00:00:00
abstract:BACKGROUND:The authors report the experience at the Children's Hospital Los Angeles with brain tumors diagnosed before 6 months of age, describing the characteristics of the patients, their tumors, treatment strategies, and prognostic factors. METHODS:Thirty-three children who were identified between 1979 and 2005 wer...
journal_title:Pediatric hematology and oncology
pub_type: 杂志文章
doi:10.3109/08880010903447342
更新日期:2010-03-01 00:00:00
abstract::Renal and metabolic complications of tumor lysis syndrome (TLS) were recognized frequently in the 1960s and 1970s. Strategies were designed to prevent TLS. We conducted a retrospective chart review study to identify the current TLS risk in children with acute leukemia. Children were considered to have "laboratory tumo...
journal_title:Pediatric hematology and oncology
pub_type: 杂志文章
doi:10.3109/08880019509029545
更新日期:1995-03-01 00:00:00
abstract::We report the outcome of 27 children with de novo acute megakaryoblastic leukemia (AMKL) (excluding Down syndrome) enrolled in the French multicenter prospective study ELAM02 (2005-2011). There was no difference in gender, initial leukocyte count, CNS involvement, and complete remission rate (88.9%), as compared to ot...
journal_title:Pediatric hematology and oncology
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1080/08880018.2017.1414905
更新日期:2017-11-01 00:00:00
abstract::A 4-month old girl was diagnosed as having stage IV neuroblastoma of the right adrenal gland. Preoperative chemotherapy was given, followed by local surgical excision. Postoperatively, irradiation of the tumor bed and adjuvant chemotherapy was given for 11 months. Nine years after cessation of chemotherapy, the patien...
journal_title:Pediatric hematology and oncology
pub_type: 杂志文章
doi:10.1080/088800101750476050
更新日期:2001-10-01 00:00:00
abstract::We investigated bone marrow (BM) recovery of hematopoietic stem cells (HSC) and hematopoietic microenvironment after chemotherapy in childhood acute lymphoblastic leukemia (ALL). Twenty-nine de novo childhood ALL patients were enrolled and BM biopsy sections at diagnosis (BM0), after induction (BM1), consolidation (BM...
journal_title:Pediatric hematology and oncology
pub_type: 杂志文章
doi:10.1080/08880018.2019.1623354
更新日期:2019-05-01 00:00:00
abstract::Although survival rates in childhood cancer have distinctly improved, pediatric cancer patients often experience various disease- and treatment-related side effects with long-term consequences. Despite current studies investigating inactivity and limitations in physical functioning and quality of life in pediatric can...
journal_title:Pediatric hematology and oncology
pub_type: 杂志文章
doi:10.3109/08880018.2013.776155
更新日期:2013-05-01 00:00:00
abstract::The majority of the anemias during childhood are hypochromic and microcytic. The aim of the present study was to determine the status of α-thalassemia mutations and its association with other etiologies, such as iron deficiency anemia (IDA) and β-thalassemia trait, that are frequently seen hypochromic microcytic anemi...
journal_title:Pediatric hematology and oncology
pub_type: 杂志文章
doi:10.3109/08880018.2012.661831
更新日期:2012-04-01 00:00:00