Abstract:
:This study evaluated the efficacy of hydroxyurea treatment in the prevention of vaso-occlusive crises among children and teenagers with severe sickle cell anemia and sickle cell beta-thalassemia. Nineteen children and young adults with severe sickle cell disease were enrolled to the hydroxyurea treatment trial. The incidence of vaso-occlusive crises, acute chest syndrome, hemolytic crises, splenic sequestration episodes, blood transfusions, and hospital days in the 2 years before hydroxyurea (HU) treatment were compared with the same parameters in the first 2 years of treatment. The patients received a mean dose of 21.3 mg/kg/day daily and were treated during a mean period of 40.3 +/- 14 months (range 20 to 68 months). Significant increases were observed after 1 month in the Hgb, MCV, MCH, and MCHC levels and were more notable after 3 months. The increase in the Hgb F level became important after 3 months of HU therapy and was highly significant (p < .001) beyond 6 months. No differences were observed in the RDW, reticulocyte count, Hgb S, and Hgb A2. Severe neutropenia was observed in one case. A decrease in the frequency of vaso-occlusive crises, acute chest syndrome, hemolytic crises, blood transfusions, and days spent in the hospital was demonstrated during the HU treatment period compared to the same period before. The clinical and laboratory response to HU was dramatic in severely affected sickle cell anemia (SCA) patients. The response to HU in children and teenagers with severe sickle cell anemia is similar to the response in adults, and no severe adverse effects were observed.
journal_name
Pediatr Hematol Oncoljournal_title
Pediatric hematology and oncologyauthors
Koren A,Segal-Kupershmit D,Zalman L,Levin C,Abu Hana M,Palmor H,Luder A,Attias Ddoi
10.1080/088800199277272subject
Has Abstractpub_date
1999-05-01 00:00:00pages
221-32issue
3eissn
0888-0018issn
1521-0669journal_volume
16pub_type
临床试验,杂志文章abstract::Spontaneous remission/regression of cancer is defined as partial or complete disappearance of malignant disease temporarily or permanently in the absence of medical treatment. This event is named as spontaneous regression for solid tumors and spontaneous remission for leukemia. The authors report the case of a girl ag...
journal_title:Pediatric hematology and oncology
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journal_title:Pediatric hematology and oncology
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journal_title:Pediatric hematology and oncology
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journal_title:Pediatric hematology and oncology
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journal_title:Pediatric hematology and oncology
pub_type: 临床试验,杂志文章
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journal_title:Pediatric hematology and oncology
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journal_title:Pediatric hematology and oncology
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journal_title:Pediatric hematology and oncology
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journal_title:Pediatric hematology and oncology
pub_type: 杂志文章
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journal_title:Pediatric hematology and oncology
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journal_title:Pediatric hematology and oncology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1999-03-01 00:00:00
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journal_title:Pediatric hematology and oncology
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journal_title:Pediatric hematology and oncology
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journal_title:Pediatric hematology and oncology
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journal_title:Pediatric hematology and oncology
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journal_title:Pediatric hematology and oncology
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