Osteosarcoma as a second malignancy after treatment for neuroblastoma.

Abstract:

:A 4-month old girl was diagnosed as having stage IV neuroblastoma of the right adrenal gland. Preoperative chemotherapy was given, followed by local surgical excision. Postoperatively, irradiation of the tumor bed and adjuvant chemotherapy was given for 11 months. Nine years after cessation of chemotherapy, the patient developed left hip-joint pain. Biopsy of the ischium showed chondroblastic osteosarcoma. Limb salvage surgery was performed after preoperative chemotherapy. Postoperatively, adjuvant chemotherapy was given for 14 months. Twenty-two months after treatment for the secondary osteosarcoma, the patient has been remained in disease-free condition without any evidence of relapse. A second osteosarcoma occurring outside the radiation field after treatment for neuroblastoma is quite rare. This unusual case emphasized the need for close monitoring for development of second malignant neoplasms in survivors of neuroblastoma even in the absence of a known predisposing factor, such as radiation therapy.

journal_name

Pediatr Hematol Oncol

authors

Iwata A,Hirota T,Konno K,Fujimoto T,Sumida S,Sato K,Hara K

doi

10.1080/088800101750476050

subject

Has Abstract

pub_date

2001-10-01 00:00:00

pages

465-9

issue

7

eissn

0888-0018

issn

1521-0669

pii

L31R9QHT9R8PE0QX

journal_volume

18

pub_type

杂志文章
  • Therapy response correlates with ALDH activity in ALDH low-positive childhood acute lymphoblastic leukemias.

    abstract::The malignant cells of childhood acute lymphoblastic leukemia (ALL) do not form a homogenous entity but a collection of differently maturated blasts. The most immature leukemia cells may be more resistant to therapy than the bulk of more differentiated blasts. We studied 42 patients with childhood ALL treated accordin...

    journal_title:Pediatric hematology and oncology

    pub_type: 临床试验,杂志文章

    doi:10.3109/08880018.2013.859189

    authors: Ahlers J,Witte KE,Schwarze CP,Lang P,Handgretinger R,Ebinger M

    更新日期:2014-05-01 00:00:00

  • Primary diffuse leptomeningeal glioneuronal tumors of the central nervous system: Report of three cases and review of literature.

    abstract::Primary diffuse leptomeningeal glioneuronal tumors (DLGNT) are rare tumors, recently recognized as a unique entity based on their unique pathologic and clinical characteristics. We report three cases of DLGNT and compare their clinical characteristics and presentation with other reported cases, and with primary leptom...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章,评审

    doi:10.1080/08880018.2019.1711270

    authors: Abongwa C,Cotter J,Tamrazi B,Dhall G,Davidson T,Margol A

    更新日期:2020-04-01 00:00:00

  • Angioimmunoblastic lymphadenopathy with dysproteinemia: report of a case in infancy with review of literature.

    abstract::A case of angioimmunoblastic lymphadenopathy with dysproteinemia (AILD) in infancy is reported. The disease had a mild onset with generalized lymphadenopathy, hepatosplenomegaly, thrombocytopenia, polyclonal hypergammaglobulinemia, and T-cell deficiency. The AILD course lasted more than 100 months, alternating clinica...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章,评审

    doi:10.3109/08880018909014579

    authors: de Terlizzi M,Toma MG,Santostasi T,Colella R,Ceci A,De Benedictis G

    更新日期:1989-01-01 00:00:00

  • Experience with cefepime versus meropenem as empiric monotherapy for neutropenia and fever in pediatric patients with solid tumors.

    abstract::A prospective, open-label, randomized, comparative study in pediatric cancer patients was conducted to evaluate the efficacy and safety of cefepime and meropenem in the empiric therapy of febrile neutropenic patients. Febrile episodes were classified as microbiologically documented infection, clinical documented infec...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章,随机对照试验

    doi:10.1080/08880010500506867

    authors: Oguz A,Karadeniz C,Citak EC,Cil V,Eldes N

    更新日期:2006-04-01 00:00:00

  • Inflammatory pseudotumor of the lung in children.

    abstract::Two children with inflammatory pseudotumor (IPT) of the lung are reported. Symptomless "cystic" lesions were present on routine chest x ray. Morphological study of these peculiar lesions included light microscopic, immunohistochemical, and ultrastructural analysis. Histologic appearance of the lesion varied from the f...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章

    doi:10.3109/08880019109033439

    authors: Vujanić GM,Dojĉinov D

    更新日期:1991-04-01 00:00:00

  • Clinical versus laboratory tumor lysis syndrome in children with acute leukemia.

    abstract::Renal and metabolic complications of tumor lysis syndrome (TLS) were recognized frequently in the 1960s and 1970s. Strategies were designed to prevent TLS. We conducted a retrospective chart review study to identify the current TLS risk in children with acute leukemia. Children were considered to have "laboratory tumo...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章

    doi:10.3109/08880019509029545

    authors: Kedar A,Grow W,Neiberger RE

    更新日期:1995-03-01 00:00:00

  • Two CD34+ stem cells from umbilical cord blood enrichment methods.

    abstract::The authors describe the relation between clamping time and blood volume collected, and two enrichment systems of CD34+ stem cells from umbilical cord blood, to determine an excellent recovery with high proliferate ability and bone marrow reconstitution. After an obstetrician-based cord blood collection, the purificat...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章

    doi:10.1080/08880010252899406

    authors: Pafumi C,Bosco P,Cavallaro A,Farina M,Leonardi I,Pernicone G,Bandiera S,Russo A,Giardina P,Chiarenza M,Calogero AE

    更新日期:2002-06-01 00:00:00

  • Shift from fetal to adult hemoglobin production in a preterm infant after exchange transfusion: a quantitative approach.

    abstract::To evaluate the quantitative aspects of the shift in production from fetal hemoglobin (HbF) to adult hemoglobin (HbA), the HbF and HbA mass were estimated in a preterm infant (gestational age 29 weeks) for 22 weeks after an exchange transfusion the second day of life, leading to an initial HbA% of 100. Up until the es...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章

    doi:10.3109/08880019809016572

    authors: Refsum HE,Bechensteen AG,Lindemann R

    更新日期:1998-09-01 00:00:00

  • Bone marrow recovery of hematopoietic stem cells and microenvironment after chemotherapy in childhood acute lymphoblastic leukemia: consecutive observations according to chemotherapy schedule.

    abstract::We investigated bone marrow (BM) recovery of hematopoietic stem cells (HSC) and hematopoietic microenvironment after chemotherapy in childhood acute lymphoblastic leukemia (ALL). Twenty-nine de novo childhood ALL patients were enrolled and BM biopsy sections at diagnosis (BM0), after induction (BM1), consolidation (BM...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章

    doi:10.1080/08880018.2019.1623354

    authors: Park SH,Lee MJ,Park CJ,Jang S,Seo EJ,Im HJ,Seo JJ

    更新日期:2019-05-01 00:00:00

  • Prevalence of hypertension determined by ambulatory blood pressure monitoring (ABPM) and body composition in long-term survivors of childhood cancer.

    abstract:AIM:In recent years, survival rates of childhood cancers have significantly increased, and occurrence of long-term adverse late effects (eg, insulin resistance, diabetes mellitus, metabolic syndrome, hypertension) has become increasingly important. Early diagnosis of obesity/hypertension in childhood is essential to av...

    journal_title:Pediatric hematology and oncology

    pub_type: 临床试验,杂志文章

    doi:10.1080/08880018.2018.1425784

    authors: Guler E,Col N,Buyukcelik M,Balat A

    更新日期:2018-02-01 00:00:00

  • Male gonadal function in survivors of childhood Hodgkin and non-Hodgkin lymphoma.

    abstract::The aim of this study was to investigate the impact of therapy on long-term gonadal function of young people cured of childhood lymphomas and to assess whether a prepubertal state during the treatment protects the gonads from chemotherapy and/or radiotherapy late effects. Clinical evaluation, semen analysis, and endoc...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章

    doi:10.1080/088800100276415

    authors: Ben Arush MW,Solt I,Lightman A,Linn S,Kuten A

    更新日期:2000-04-01 00:00:00

  • Case of a child with paroxysmal nocturnal hemoglobinuria diagnosed by flow cytometry.

    abstract::A case of a child with paroxysmal nocturnal hemoglobinuria (PNH) is characterized by an increased sensitivity of the erythrocyte to hemolytic action of complement. The widely used Ham test may not always be reliable. Recently, a panel of monoclonal antibodies has become available to detect various glycosylphosphatidyl...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章

    doi:10.3109/08880019309029514

    authors: Kinugawa N,Shichishima T,Nishimura J,Kitani T

    更新日期:1993-10-01 00:00:00

  • Responsiveness to parenteral iron therapy in children with oral iron-refractory iron-deficiency anemia.

    abstract:UNLABELLED:Intravenous (IV) ferric iron (Fe)-carbohydrate complexes are used for treating Fe deficiency in children with iron-refractory iron-deficiency anemia (IRIDA). An optimal treatment has yet to be determined. There are relatively little publications on the responsiveness to IV iron therapy in children with IRIDA...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章

    doi:10.3109/08880018.2013.829540

    authors: Akin M,Atay E,Oztekin O,Karadeniz C,Karakus YT,Yilmaz B,Erdogan F

    更新日期:2014-02-01 00:00:00

  • Pneumatosis cystoides intestinalis with abdominal free air in a 2-year-old girl after allogeneic bone marrow transplantation.

    abstract::A 2-year-old girl with acute lymphoblastic leukemia (ALL) showing a t(4;11)(q21;q23) karyotype underwent allogeneic bone marrow transplantation (BMT) with the conditioning regimen of L-PAM (70 mg/m2/d for 3 days), busulfan (140 mg/m2/d for 2 days), and total body irradiation (12 Gy). On day 57, the patient developed p...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章

    doi:10.3109/08880019809009512

    authors: Takanashi M,Hibi S,Todo S,Sawada T,Tsunamoto K,Imashuku S

    更新日期:1998-01-01 00:00:00

  • Delayed spontaneous remission in a child with primary acquired chronic pure red cell aplasia.

    abstract::The acquired form of pure red cell aplasia (PRCA) presents either as an acute self-limited disease, predominantly seen in children, or as a chronic illness more frequently seen in adults with rare spontaneous remissions. A 14-year-old boy presented with pallor, without hepatosplenomegaly, jaundice, lymphadenopathy, pe...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章

    doi:10.3109/08880018.2010.493577

    authors: Khalil A,Elhasid R,Ben Barak A,Ben Arush MW

    更新日期:2010-10-01 00:00:00

  • Effect of using bedside leukocyte filter on pulmonary functions in patients with thalassemia major.

    abstract:UNLABELLED:In settings of limited health resources, using leukocyte-filtered blood is limited to patients with leukocyte-mediated complications. The aim of this study was to determine the patterns of lung dysfunction among patients with β-thalassemia major (BTM) after the application of the leukostop filter during tran...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章

    doi:10.3109/08880018.2013.838724

    authors: Hamed Ael S,Ragab IA,Kamel TB,Abd-El-Gawad AO

    更新日期:2013-11-01 00:00:00

  • Pleuropulmonary blastoma: an aggressive intrathoracic neoplasm of childhood.

    abstract::A case of a 4-year-old girl with pleuropulmonary blastoma is reported. Surgical resection of the tumor was performed and histologic examination revealed pleuropulmonary blastoma with rhabdomyosarcomatous differentiation. Postoperative chemotherapy was administered and 3 weeks after initiation of treatment protocol a s...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章

    doi:10.1080/088800101750238568

    authors: Perdikogianni C,Stiakaki E,Danilatou V,Delides G,Kalmanti M

    更新日期:2001-06-01 00:00:00

  • The influence of risk factors in promoting thrombosis during childhood: the role of acquired factors.

    abstract::Thrombo-embolism in childhood is a multifactorial disorder. The present study is a case-control study that investigated the role of genetic and acquired risk factors in 60 children with thrombosis and compared the results with the controls. Acquired and inherited risk factors precipitating thrombosis were present in 7...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章

    doi:10.1080/08880010600646324

    authors: Günes AM,Baytan B,Günay U

    更新日期:2006-07-01 00:00:00

  • Nutritional vitamin B12 deficiency in infancy: three case reports and a review of the literature.

    abstract::Three cases of vitamin B12 deficiency that occurred during infancy are presented. These cases appeared to be the result of pre-existing maternal deficiency. All three infants demonstrated evidence of neurodevelopmental delay at presentation, and one had sustained loss of milestones and developed involuntary motor move...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章,评审

    doi:10.3109/08880018909034282

    authors: Doyle JJ,Langevin AM,Zipursky A

    更新日期:1989-01-01 00:00:00

  • Treatment of acute idiopathic thrombocytopenic purpura (AITP): cooperative Italian study group results.

    abstract::A cooperative Italian study group on acute idiopathic thrombocytopenic purpura (AITP) has been designed to evaluate efficacy and safety of no treatment at the onset of the disease and sequential treatment with immunoglobulin and high dose steroid. One hundred thirty-eight patients with AITP entered in the trial. Eleve...

    journal_title:Pediatric hematology and oncology

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.3109/08880018809031267

    authors: Mori PG,Lanza T,Mancuso G,De Mattia D,Catera P,Miano C,Del Principe D,Cottafava F

    更新日期:1988-01-01 00:00:00

  • Transfusion and chelation practices in sickle cell disease: a regional perspective.

    abstract::Although most common in tropical regions, population migration has meant that sickle cell disease is now one of the most prevalent genetic diseases worldwide. The issues and challenges faced by physicians and patients have been discussed by an international group of experts representing 4 key regions: the USA, Europe,...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章

    doi:10.3109/08880018.2010.505506

    authors: Vichinsky EP,Ohene-Frempong K,Thein SL,Lobo CL,Inati A,Thompson AA,Smith-Whitley K,Kwiatkowski JL,Swerdlow PS,Porter JB,Marks PW

    更新日期:2011-03-01 00:00:00

  • Association of maternal education with the neuroblastoma susceptibility in children: a meta-analysis.

    abstract::Maternal education might be an important factor for the neuroblastoma risk in children, but it was conflicting. This meta-analysis was performed to evaluate the relationship between maternal education and neuroblastoma susceptibility and to explore whether maternal education was an important indicator to be associated...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章,meta分析

    doi:10.3109/08880018.2012.742605

    authors: Wang P,Liao N,Liao XH,Liang B,Huang CX,Li W

    更新日期:2013-02-01 00:00:00

  • Delayed Granulocyte Colony-Stimulating Factor (G-CSF) Administration after Chemotherapy Reduces Total G-CSF Doses without Affecting Neutrophil Recovery in a Randomized Clinical Study in Children with Solid Tumors.

    abstract::The use of G-CSF after myelotoxic chemotherapy accelerates neutrophil recovery reducing the risk of febrile neutropenia. Current guidelines recommend initiating G-CSF 24 hours after myelotoxic chemotherapy. However, the optimal timing of post-chemotherapy G-CSF administration has not been elucidated. Our previous work...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章

    doi:10.1080/08880018.2020.1779885

    authors: Yankelevich M,Hoogstra DJ,Abrams J,Chu R,Bhambhani K,Taub JW

    更新日期:2020-11-01 00:00:00

  • Pregnancy in patients treated for beta thalassemia major in two centers (Ali Asghar Children's Hospital and Thalassemia Clinic): outcome for mothers and newborn infants.

    abstract::Beta-thalassemia major is a severe, transfusion-dependent anemia that also causes infertility due to iron deposition to endocrine organs after overtransfusion. Very few pregnancies have been reported among such patients after modern therapies. In this study, 32 women with thalassemia who were admitted to Ali Asghar Ch...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章,多中心研究

    doi:10.1080/08880010500313306

    authors: Ansari S,Azarkeivan A,Tabaroki A

    更新日期:2006-01-01 00:00:00

  • Etoposide in Langerhans cell histiocytosis in children: a preliminary experience.

    abstract::Treatment of Langerhans cell histiocytosis (LCH) is yet to be established. We treated seven patients with etoposide alone at a dose of 100 mg/m2/day for 3 days given every 3 to 4 weeks for six cycles. Three patients had received prior chemotherapy, two patients were less than 2 years of age, and two had liver dysfunct...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章

    doi:10.3109/08880019609030806

    authors: Basade MM,Nair CN,Kurkure PA,Pai SK,Advani SH

    更新日期:1996-03-01 00:00:00

  • Enteroviral meningoencephalitis in immunocompromised children after matched unrelated donor-bone marrow transplantation.

    abstract::Two children are described who presented with fever and generalized seizures, days 50 and 200, respectively, after matched unrelated donor-bone marrow transplantation. Upon antiepileptic treatment the seizures vanished but somnolence and fever remained. Magnetic resonance imaging (MRI) of the brain was performed and r...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章

    doi:10.1080/08880010050034337

    authors: Fischmeister G,Wiesbauer P,Holzmann HM,Peters C,Eibl M,Gadner H

    更新日期:2000-07-01 00:00:00

  • Efficacy of recombinant human granulocyte colony-stimulating factor and recombinant human granulocyte-macrophage colony-stimulating factor in neutropenic children with malignancies.

    abstract::The difference between the effects of administration of recombinant human granulocyte colony-stimulating factor (rhG-CSF) and recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF) was studied in 39 children with neutropenia secondary to chemotherapy (absolute neutrophil count (ANC) less than 1,...

    journal_title:Pediatric hematology and oncology

    pub_type: 临床试验,杂志文章

    doi:10.3109/08880019509030769

    authors: Lydaki E,Bolonaki E,Stiakaki E,Dimitriou H,Kalmantis T,Kalmanti M

    更新日期:1995-11-01 00:00:00

  • Neutrophil apoptosis in patients with beta-thalassemia major.

    abstract::Increased susceptibility to infection is reported in patients with beta-thalassemia major due to toxic effect of iron on neutrophil functions and reticuloendothelial system dysfunction. This study investigated the association between the neutrophil apoptosis and frequency of infection episodes, desferrioxamine treatme...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章

    doi:10.1080/713842280

    authors: Oren H,Sahin B,Irken G,Ateş H,Duman M,Yilmaz S,Türker M,Atabay B,Yaprak I

    更新日期:2003-04-01 00:00:00

  • Medulloblastoma-biology and microenvironment: a review.

    abstract::Medulloblastoma (MB) is a cancer of the cerebellum and the most common primary pediatric malignancy of the central nervous system. Classified as a primitive neural ectoderm tumor; it is thought to arise from granule cell precursors in the cerebellum. The standard of care consists of surgery, chemotherapy and age-depen...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章,评审

    doi:10.3109/08880018.2012.698372

    authors: Byrd T,Grossman RG,Ahmed N

    更新日期:2012-09-01 00:00:00

  • Hodgkin's disease in association with Down syndrome: a case report.

    abstract::The increased incidence of malignancies, especially acute leukemia, in Down syndrome has been clearly established. The association of Hodgkin's disease with Down syndrome has not been extensively documented, and only a few cases have been reported. We present here a case report of Hodgkin's disease in an 11-year-old f...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章

    doi:10.3109/08880019609030860

    authors: Kusumakumary P,Jyothirmayi R,Chellam VG,Krishnan NM

    更新日期:1996-09-01 00:00:00