Acute megakaryoblastic leukemia (excluding Down syndrome) remains an acute myeloid subgroup with inferior outcome in the French ELAM02 trial.

Abstract:

:We report the outcome of 27 children with de novo acute megakaryoblastic leukemia (AMKL) (excluding Down syndrome) enrolled in the French multicenter prospective study ELAM02 (2005-2011). There was no difference in gender, initial leukocyte count, CNS involvement, and complete remission rate (88.9%), as compared to other acute myeloid leukemia (AML) subtypes. AMKL patients had a significantly poorer outcome (5-year overall survival 54% [CI 95% 33%-71%] than children with other AML subtypes (5-year overall survival 73% [CI 95% 68%-77%] p = 0.02). Gender, age, CNS leukemia, hyperleukocytosis, complete remission or cytogenetic subgroups were not significant prognostic factors of disease-free survival. AMKL (excluding Down syndrom) remains an AML subgroup with inferior outcome.

journal_name

Pediatr Hematol Oncol

authors

Teyssier AC,Lapillonne H,Pasquet M,Ballerini P,Baruchel A,Ducassou S,Fenneteau O,Petit A,Cuccuini W,Ragu C,Preudhomme C,Mercher T,Sirvent N,Leverger G

doi

10.1080/08880018.2017.1414905

subject

Has Abstract

pub_date

2017-11-01 00:00:00

pages

425-427

issue

8

eissn

0888-0018

issn

1521-0669

journal_volume

34

pub_type

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