Pilot study of propranolol premedication to reduce FDG uptake in brown adipose tissue on PET scans of adolescent and young adult oncology patients.

Abstract:

OBJECTIVE:Physiologic uptake of 18F-fluorodeoxyglucose (FDG) in brown adipose tissue (adipose tissue) of cancer patients may confound interpretation of positron emission tomography (PET) scans. Uptake in adipose tissue occurs in up to half of pediatric oncology patients undergoing PET scans, and is especially common in adolescents. adipose tissue is innervated by the sympathetic nervous system, and beta blockers such as propranolol have shown efficacy in reducing adipose tissue uptake on PET scans done in older adult oncology patients. PARTICIPANTS:Because propranolol may cause hypoglycemia or other side effects in fasting patients, we prospectively assessed the safety of a single dose of 20 mg propranolol in adolescent and young adult oncology patients undergoing FDG-PET imaging. METHODS:Ten patients (median age 18 years, range 14-24) received propranolol premedication prior to FDG-PET. RESULTS:No adverse effects or clinically significant changes in serum glucose, heart rate, or blood pressure were observed. Five of the 10 patients had adipose tissue identified on previous PET scans. However, following propranolol administration only, one patient had persistent uptake in adipose tissue. CONCLUSIONS:Propranolol was convenient and safe in fasting adolescent and young adult oncology patients undergoing PET scans. Larger studies are warranted to better define the effectiveness of this approach.

journal_name

Pediatr Hematol Oncol

authors

George A,Sinha P,Conrad G,Memon AA,Dressler EV,Wagner LM

doi

10.1080/08880018.2017.1338806

subject

Has Abstract

pub_date

2017-04-01 00:00:00

pages

149-156

issue

3

eissn

0888-0018

issn

1521-0669

journal_volume

34

pub_type

临床试验,杂志文章
  • Primary spinal epidural extraosseous Ewing's sarcoma mimicking a spinal abscess.

    abstract::Ewing's sarcoma is one of the most common malignant tumors of the skeletal system in children and young adults. It most frequently stems from the long bones of the extremities. However, though uncommon, extraosseous localization can be seen. Epidural extraosseous presentations are extremely rare. In this case, the aut...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章

    doi:10.1080/08880010701534163

    authors: Erkutlu I,Buyukhatipoglu H,Alptekin M,Ozsarac C,Buyukbese I,Gok A

    更新日期:2007-10-01 00:00:00

  • Nonossifying fibromyxoid tumor of soft tissue.

    abstract::A firm, painless tumor of the temporal region was excised in a 3-year-old girl. The diagnosis of nonossifying fibromyxoid tumor was established on pathologic examination, which showed that most of the cells formed cords and tubulelike structures in a myxoid background. Bone and osteoid were lacking. The child is free ...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章

    doi:10.3109/08880019409140547

    authors: Leray V,Gosseye S,Sempoux C,Ninane J,Vanwijck R

    更新日期:1994-07-01 00:00:00

  • Redefined role of radiation in combined treatment of Ewing's sarcoma.

    abstract::Eighty-six patients with Ewing's sarcoma were analyzed as to the role of radiation therapy. Fifty-eight patients (P group) had removal of the involved part of the bone after preoperative chemotherapy, and 28 (NP group) had local treatment either at the same time or before chemotherapy. Thirty-six of 58 P-group patient...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章

    doi:10.3109/08880018609031206

    authors: Jereb B,Ong RL,Mohan M,Caparros B,Exelby P

    更新日期:1986-01-01 00:00:00

  • Metastatic osteosarcoma to the liver after treatment for synovial sarcoma: a case report.

    abstract::Metastatic osteosarcoma most commonly affects the lungs and other bones. Hepatic metastasis at the time of diagnosis is extremely rare. A 14-year-old boy with synovial sarcoma of the left popliteal fossa was treated with surgical resection, radiotherapy for microscopic residual disease, and 1 year of chemotherapy (vin...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章

    doi:10.1080/088800101300002955

    authors: Daw NC,Kaste SC,Hill DA,Kun LE,Pratt CB

    更新日期:2001-03-01 00:00:00

  • Prenatal diagnosis of hemoglobinopathies in Hacettepe University, Turkey.

    abstract::Between 1983 and 2008, prenatal diagnostic procedures for identifying hemoglobinopathies were performed in 947 at-risk fetuses. Seventy-six percent of the fetuses were at risk for β-thalassemia major and 16% for sickle cell anemia; only a small percentage (7%) were at risk for compound heterozygosity of β-thalassemia ...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章

    doi:10.3109/08880018.2010.507690

    authors: Beksac MS,Gumruk F,Gurgey A,Cakar N,Mumusoglu S,Ozyuncu O,Altay C

    更新日期:2011-02-01 00:00:00

  • Does D-dimer predict cerebral sinovenous thrombosis in the newborn?

    abstract::Sinovenous thrombosis describes thrombosis in one or more of the cerebral venous sinuses. The incidence of SVT in childhood appears to be highest during the neonatal period. Although plasma level of D-dimer has been shown to be sensitive for the diagnosis of deep vein thrombosis and pulmonary embolism in adult patient...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章

    doi:10.1080/08880010701255769

    authors: Karagöl BS,Erdeve O,Fítöz S,Uysal Z,Atasay B,Arsan S

    更新日期:2007-07-01 00:00:00

  • Isolated relapse of acute lymphoblastic leukemia in the breast of a young female.

    abstract::A 20-year-old female developed a relapse of B-precursor acute lymphoblastic leukemia (ALL) as a mass in her left breast after 6 years of maintained continuous complete remission. No leukemic lesions were identified in other sites such as the bone marrow or cerebrospinal fluid. The relapsed leukemic cells in the breast...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章

    doi:10.1080/08880010802258399

    authors: Todo K,Morimoto A,Osone S,Nukina S,Ohtsuka T,Ishida H,Yoshihara T,Todo S

    更新日期:2008-09-01 00:00:00

  • Pleuropulmonary blastoma: an aggressive intrathoracic neoplasm of childhood.

    abstract::A case of a 4-year-old girl with pleuropulmonary blastoma is reported. Surgical resection of the tumor was performed and histologic examination revealed pleuropulmonary blastoma with rhabdomyosarcomatous differentiation. Postoperative chemotherapy was administered and 3 weeks after initiation of treatment protocol a s...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章

    doi:10.1080/088800101750238568

    authors: Perdikogianni C,Stiakaki E,Danilatou V,Delides G,Kalmanti M

    更新日期:2001-06-01 00:00:00

  • School functioning for the child with leukemia in continuous first remission: screening high-risk children.

    abstract::It is well known in the literature that cancer creates educationally related barriers for all children, which may or may not contribute to clinically relevant school problems. The goal of this study was to obtain a base rate for the characteristic pattern of school functioning for children with leukemia, so that the c...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章

    doi:10.3109/08880019709030898

    authors: Adamoli L,Deasy-Spinetta P,Corbetta A,Jankovic M,Lia R,Locati A,Fraschini D,Masera G,Spinetta JJ

    更新日期:1997-03-01 00:00:00

  • Profiling Loss of Heterozygosity Patterns in a Cohort of Favorable Histology Nephroblastoma Egyptian Patients: What is Consistent With the Rest of the World.

    abstract::According to the Fifth National Wilms Tumor Study (NWTS-5), tumor-specific loss of heterozygosity (LOH) for chromosomes 1p and 16q identifies a subset of patients with Wilms tumor (WT) who despite having favorable histology (FH) have a significantly increased risk of relapse and death. We aimed to find out 1p and 16q ...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章

    doi:10.3109/08880018.2015.1071902

    authors: Fawzy M,Bahanassy A,Samir A,Hafez H

    更新日期:2015-01-01 00:00:00

  • Nesiritide in a pediatric oncology patient with renal insufficiency and myocardial dysfunction following septic shock.

    abstract::Nesiritide is a recombinant formulation of B-type natriuretic peptide used most commonly in the treatment of adults with decompensated congestive heart failure. The physiologic effects of BNP include natriuresis, diuresis, and smooth muscle relaxation. These physiologic effects result in its beneficial therapeutic eff...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章

    doi:10.1080/08880010590935248

    authors: Wheeler AD,Tobias JD

    更新日期:2005-06-01 00:00:00

  • Evaluation of patients with intracranial tumors and central diabetes insipidus.

    abstract::The aim of the study is to evaluate the etiologic and clinical characteristics, treatment regimens, and outcome of the patients with intracranial tumors presenting with central diabetes insipidus (DI). Sixty-nine patients with intracranial tumors presenting with central DI between 1972 and 2012 were retrospectively ev...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章

    doi:10.3109/08880018.2013.816984

    authors: Varan A,Atas E,Aydın B,Yalçın B,Akyüz C,Kutluk T,Büyükpamukçu M

    更新日期:2013-10-01 00:00:00

  • Spontaneous acute cerebral hematoma in a child with factor XIII deficiency.

    abstract::Factor XIII deficiency is a very rare bleeding disorder. We report here on the clinical outcome of a young child with intracranial bleeding due to factor XIII deficiency. Clinicians should bear in mind that severe factor XIII deficiency is associated with a significant risk of unexpected intracranial hemorrhage (ICH)....

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章

    doi:10.3109/08880018.2013.798059

    authors: Bay A,Sirikci A,Dogan A,Leblebisatan G,Yilmaz F

    更新日期:2013-11-01 00:00:00

  • Autologous bone marrow transplantation in pediatric solid tumors.

    abstract::During the last 5 years massive chemotherapy and autologous bone marrow transplantation have been increasingly explored in the treatment of pediatric solid tumors, mainly for neuroblastoma, Ewing's sarcoma, rhabdomyosarcoma, Wilms' tumor, germ cell tumors, osteosarcoma, and retinoblastoma. Although the disease course ...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章,评审

    doi:10.3109/08880019009034318

    authors: Yaniv I,Bouffet E,Irle C,Negrier S,Biron P,Favrot M,Philip I,Brunat-Mentigny M,Philip T

    更新日期:1990-01-01 00:00:00

  • Vincristine and irinotecan in children with relapsed hepatoblastoma: a single-institution experience.

    abstract:PURPOSE:This study was to determine the efficacy of vincristine and irinotecan in children with relapsed hepatoblastoma (HB). METHODS:A total of 10 patients with relapsed HB were enrolled. Three patients were excluded. Patients received irinotecan 50 mg/m(2)/day, day 1-5 and vincristine 1.5 mg/m(2)/day, day 1, repeate...

    journal_title:Pediatric hematology and oncology

    pub_type: 临床试验,杂志文章

    doi:10.3109/08880018.2014.909913

    authors: Zhang YT,Feng LH,Zhong XD,Wang LZ,Chang J

    更新日期:2015-02-01 00:00:00

  • Delayed Granulocyte Colony-Stimulating Factor (G-CSF) Administration after Chemotherapy Reduces Total G-CSF Doses without Affecting Neutrophil Recovery in a Randomized Clinical Study in Children with Solid Tumors.

    abstract::The use of G-CSF after myelotoxic chemotherapy accelerates neutrophil recovery reducing the risk of febrile neutropenia. Current guidelines recommend initiating G-CSF 24 hours after myelotoxic chemotherapy. However, the optimal timing of post-chemotherapy G-CSF administration has not been elucidated. Our previous work...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章

    doi:10.1080/08880018.2020.1779885

    authors: Yankelevich M,Hoogstra DJ,Abrams J,Chu R,Bhambhani K,Taub JW

    更新日期:2020-11-01 00:00:00

  • Primary immunodeficiency disorders in the developing world: data from a hospital-based registry in India.

    abstract::Primary immunodeficiency disorders (PID) are under-reported from the developing world. We present data regarding diagnosis and outcome from a hospital-based registry in India. Forty-seven patients fulfilled diagnostic criteria. Majority were males. Subgroups were disorders of immune dysregulation-29%, B&T-cell abnorma...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章

    doi:10.3109/08880018.2013.805346

    authors: Chinnabhandar V,Yadav SP,Kaul D,Verma IC,Sachdeva A

    更新日期:2014-04-01 00:00:00

  • Infections in childhood acute lymphoblastic leukemia: an analysis of 222 febrile neutropenic episodes.

    abstract::A retrospective analysis was performed on febrile neutropenic episodes in patients with acute lymphoblastic leukemia (ALL) from 1992 to 2002. There were 222 febrile neutropenic episodes in 266 ALL patients with documented ANC < 500/mm(3). Of the 222 episodes, 98 (44%) had documented focus of infection; the rest were f...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章

    doi:10.1080/08880010802106564

    authors: Bakhshi S,Padmanjali KS,Arya LS

    更新日期:2008-06-01 00:00:00

  • Triosephosphate isomerase deficiency in a child with congenital hemolytic anemia and severe hypotonia.

    abstract::A discussion of a 5-year-old child with congenital hemolytic anemia and severe hypotonia caused by triosephosphate (TPI) deficiency is presented. The complexities in the diagnosis and management of this condition is discussed and the relevant literature is reviewed. ...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章

    doi:10.3109/08880019809018318

    authors: Linarello RE,Shetty AK,Thomas T,Warrier RP

    更新日期:1998-11-01 00:00:00

  • Maintenance immunotherapy by repetitive low-dose donor lymphocytes infusions in a child with relapse state aml after allogeneic stem cell transplantation.

    abstract::The treatment of a child with a relapsed state acute leukemia after allogeneic stem cell transplantation (allo-SCT) is a challenge. The authors report about a child with an acute myelogenous leukemia (AML), which relapsed after allo-SCT despite immunological intervention. It was further treated with a second line chem...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章

    doi:10.1080/08880010601125443

    authors: Hartwig M,Weigel S,Bernig T,Bader P,Dölken R,Beck J

    更新日期:2007-03-01 00:00:00

  • Pregnancy in patients treated for beta thalassemia major in two centers (Ali Asghar Children's Hospital and Thalassemia Clinic): outcome for mothers and newborn infants.

    abstract::Beta-thalassemia major is a severe, transfusion-dependent anemia that also causes infertility due to iron deposition to endocrine organs after overtransfusion. Very few pregnancies have been reported among such patients after modern therapies. In this study, 32 women with thalassemia who were admitted to Ali Asghar Ch...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章,多中心研究

    doi:10.1080/08880010500313306

    authors: Ansari S,Azarkeivan A,Tabaroki A

    更新日期:2006-01-01 00:00:00

  • Prognostic significance of adenosine deaminase in children with malignancies.

    abstract::In 33 children, 23 with acute lymphoblastic leukemia (ALL) and 10 with solid tumors, the phenotype of the enzyme adenosine deaminase (ADA) was detected in the erythrocytes by electrophoresis in cellulose acetate. In all children the ADA enzyme activity was also determined in the plasma by spectrophotometry at the onse...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章

    doi:10.3109/08880019609030840

    authors: Hatzistilianou M,Athanassiadou F,Catriu D,Makedou A,Hitoglou S,Papaeconomou A

    更新日期:1996-07-01 00:00:00

  • Neutropenic enterocolitis in children with acute lymphoblastic leukemia.

    abstract::Neutropenic enterocolitis is an acute, life-threatening inflammation of the small and large bowel, often seen in children with malignancies during periods of prolonged or severe neutropenia. During the period 1990-1995, 180 children were treated at the authors' center for acute lymphoblastic leukemia using a standard ...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章

    doi:10.1080/088800100276712

    authors: Jain Y,Arya LS,Kataria R

    更新日期:2000-01-01 00:00:00

  • A variant of myelokathexis with hypogammaglobulinemia: lymphocytes as well as neutrophils may reverse in response to infections.

    abstract::A 7-year-old boy with prolonged and marked leukopenia diagnosed at 6 months of age is described. The polymorphonuclear cells presented no hypersegmented nuclei or concentrated nuclear chromatin, although vacuolated myeloid cells appeared in bone marrow smears. Neutrophils reversed in response to administration of G-CS...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章

    doi:10.1080/088800100276532

    authors: Arai J,Wakiguchi H,Hisakawa H,Kubota H,Kurashige T

    更新日期:2000-03-01 00:00:00

  • A single institutional experience: is epoetin alpha effective in anemic children with cancer?

    abstract::The authors aimed to investigate the efficacy of epoetin-alpha on hemoglobin levels and red cell transfusion requirement in children with both hematologic malignancy (HM, n = 27) and solid tumors (ST, n = 14). Epoetin-alpha was given (150 U/kg or 250 U/kg, thrice weekly) for 12 weeks. Epoetin alpha significantly incre...

    journal_title:Pediatric hematology and oncology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Yilmaz D,Cetingül N,Kantar M,Oniz H,Kansoy S,Kavakli K

    更新日期:2004-01-01 00:00:00

  • Serum galactomannan screening for diagnosis of invasive pulmonary aspergillosis in children after stem cell transplantation or with high-risk leukemia.

    abstract::Both transplanted and leukemia patients are at high risk (HR) for invasive pulmonary aspergillosis (IPA). Methods for rapid diagnosis are crucial. Our objective was to investigate the impact of serial serum galactomannan assay (GMA) screening on IPA diagnosis in children. Between January 2010 and December 2011, all ch...

    journal_title:Pediatric hematology and oncology

    pub_type: 临床试验,杂志文章

    doi:10.3109/08880018.2014.981900

    authors: Gefen A,Zaidman I,Shachor-Meyouhas Y,Avidor I,Hakim F,Weyl Ben-Arush M,Kassis I

    更新日期:2015-03-01 00:00:00

  • Amputee skiers: lofty ambassadors in the rehabilitation of cancer.

    abstract::Adolescence is characterized by inter-related physiologic and emotional development. It is a particularly vulnerable period of life culminating into emergence as an adult. The majority of malignant bone tumors in pediatrics affect the adolescent patient. As a part of the treatment, amputation may be required for cure....

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章

    doi:10.1080/08880010490477374

    authors: Jaffe N,Zietz H

    更新日期:2004-09-01 00:00:00

  • Clinical value of RAG1 expression and IKZF1 deletions in Philadelphia negative pediatric B cell precursor acute lymphoblastic leukemia.

    abstract::This study aimed to address the clinical impact of recombination-activating gene (RAG1) expression and tumor suppressor IKZF1 gene deletions in Philadelphia negative B-cell precursor acute lymphoblastic leukemia (B-ALL) patients. Fifty newly diagnosed pediatric Philadelphia negative B-ALL patients were included in thi...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章

    doi:10.1080/08880018.2020.1767739

    authors: Aref S,Khaled N,Menshawy NE,Sabry M,Agder MA

    更新日期:2020-08-01 00:00:00

  • Increased expression of multidrug resistance gene (MDR1) at relapse in a child with acute lymphoblastic leukemia.

    abstract::Modern treatment protocols lead to complete remission in a high proportion of patients with childhood acute lymphoblastic leukemia (ALL). However, a large number of them show a relapse of the disease. Treatment failure in these patients is mainly attributable to de novo or acquired resistance to a wide variety of cyto...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章

    doi:10.1080/08880010600719303

    authors: Kourti M,Vavatsi N,Gombakis N,Tzimagiorgis G,Sidi V,Koliouskas D,Athanassiadou F

    更新日期:2006-09-01 00:00:00

  • Homozygous 23-bp insertion of endothelial protein c receptor gene in a child with fatal sepsis.

    abstract::Endothelial protein C receptor (EPCR) is primarily localized on the endothelial cells of large blood vessels and is very low or absent in the microvascular endothelium of most tissues. EPCR augments the thrombin/thrombomodulin-dependent activation of protein C by 5- to 20-fold. EPCR appears to be physiologically signi...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章

    doi:10.1080/08880010701198811

    authors: Kendirli T,Ciftçi E,Ince E,Yurdakul E,Kansu A,Akar N

    更新日期:2007-04-01 00:00:00