Maintenance immunotherapy by repetitive low-dose donor lymphocytes infusions in a child with relapse state aml after allogeneic stem cell transplantation.

Abstract:

:The treatment of a child with a relapsed state acute leukemia after allogeneic stem cell transplantation (allo-SCT) is a challenge. The authors report about a child with an acute myelogenous leukemia (AML), which relapsed after allo-SCT despite immunological intervention. It was further treated with a second line chemotherapy followed by an infusion of stem cells and donor lymphocytes. Because of an immense risk for a further relapse, an immunological maintenance therapy was also performed, consisting of repetitive infusions of low doses of donor lymphocytes combined with low-dose chemotherapy. Presently, the child is in continuous complete remission and has a good quality of life.

journal_name

Pediatr Hematol Oncol

authors

Hartwig M,Weigel S,Bernig T,Bader P,Dölken R,Beck J

doi

10.1080/08880010601125443

subject

Has Abstract

pub_date

2007-03-01 00:00:00

pages

137-40

issue

2

eissn

0888-0018

issn

1521-0669

pii

777192103

journal_volume

24

pub_type

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