A variant of myelokathexis with hypogammaglobulinemia: lymphocytes as well as neutrophils may reverse in response to infections.

abstract：:Overall survival from cancer has greatly improved, although it still remains the second leading cause of mortality in the world. This result was achieved through the use of chemotherapy and radiotherapy, which are severely toxic to normal tissues. In the long-term follow-up of cancer patients, the development of secon...

journal_title：Pediatric hematology and oncology

authors： Varan A,Kebudi R

更新日期：2011-08-01 00:00:00

abstract：:The malignant cells of childhood acute lymphoblastic leukemia (ALL) do not form a homogenous entity but a collection of differently maturated blasts. The most immature leukemia cells may be more resistant to therapy than the bulk of more differentiated blasts. We studied 42 patients with childhood ALL treated accordin...

journal_title：Pediatric hematology and oncology

authors： Ahlers J,Witte KE,Schwarze CP,Lang P,Handgretinger R,Ebinger M

更新日期：2014-05-01 00:00:00

abstract：:The increased incidence of malignancies, especially acute leukemia, in Down syndrome has been clearly established. The association of Hodgkin's disease with Down syndrome has not been extensively documented, and only a few cases have been reported. We present here a case report of Hodgkin's disease in an 11-year-old f...

journal_title：Pediatric hematology and oncology

authors： Kusumakumary P,Jyothirmayi R,Chellam VG,Krishnan NM

更新日期：1996-09-01 00:00:00

abstract：:Since the mid-1960s intrathecal chemotherapy (methotrexate [MTX], cytarabine [Ara-C], or both, plus hydrocortisone) has constituted the standard approach to prophylaxis and treatment of central nervous system (CNS) leukemia and lymphoma. Intrathecal chemotherapy-related neurotoxicity has been described in a variable p...

journal_title：Pediatric hematology and oncology

authors： García-Tena J,López-Andreu JA,Ferrís J,Menor F,Mulas F,Millet E,Verdeguer A

更新日期：1995-07-01 00:00:00

abstract：BACKGROUND:The Wiskott-Aldrich syndrome (WAS) is X-linked recessive disorder associated with microplatelet thrombocytopenia, eczema, infections, and an increased risk of autoimmunity and lymphoid neoplasia. The originally described features of WAS include susceptibility to infections, microthrombocytopenia, and eczema....

journal_title：Pediatric hematology and oncology

authors： Kamuran K,Çetin M,Geylan H,Karaman S,Demir N,Yurekturk E,Yavuz İ,Yavuz G,Tuncer O

更新日期：2017-08-01 00:00:00

abstract：UNLABELLED:In settings of limited health resources, using leukocyte-filtered blood is limited to patients with leukocyte-mediated complications. The aim of this study was to determine the patterns of lung dysfunction among patients with β-thalassemia major (BTM) after the application of the leukostop filter during tran...

journal_title：Pediatric hematology and oncology

authors： Hamed Ael S,Ragab IA,Kamel TB,Abd-El-Gawad AO

更新日期：2013-11-01 00:00:00

abstract：AIM:To standardize diagnosis and treatment of childhood Wilms tumor (WT) in Turkey. METHODS AND PATIENTS:Between 1998 and 2006, WT patients were registered from 19 centers. Patients <16 years with unilateral WT whose treatment started in first postoperative 3 weeks were included. Treatments were stage I favorable (FH)...

journal_title：Pediatric hematology and oncology

authors： Akyüz C,Yalçin B,Yildiz I,Hazar V,Yörük A,Tokuç G,Akici F,Büyükpamukçu N,Kale G,Atahan L,Büyükünal C,Dervişoğlu S,Atkovar GA,Melikoğlu M,Karpuzoğlu G,Olgun N,Ayan I,Oğuz A,Yariş N,Dağdemir A,Darendeliler E,Sande

更新日期：2010-04-01 00:00:00

abstract：:Histone deacetylase inhibitors (HDACis) are epigenetic agents that display antitumor activities in experimental medulloblastoma (MB). Fingolimod (FTY720), an immunosuppressant agent currently used in the treatment of multiple sclerosis, also has anticancer actions and can act as an HDACi. Here we examined whether fing...

journal_title：Pediatric hematology and oncology

authors： Perla AS,Fratini L,Cardoso PS,de Farias CB,da Cunha Jaeger M,Roesler R

更新日期：2020-03-01 00:00:00

abstract：:Sixty-one long-term survivors, treated for brain tumors in childhood, were evaluated in term of neurological impairments, disability, and handicap. Thirty-eight patients (pts) (62%) had at least one impairment. Visual impairment was detected in 14 pts (24%), associated with recurrence (p = .012). Thirty-four patients ...

journal_title：Pediatric hematology and oncology

authors： Macedoni-Luksic M,Jereb B,Todorovski L

更新日期：2003-03-01 00:00:00

abstract：:This is a report of a case of acute respiratory failure following the administration of intrathecal methotrexate (MTX) for prophylaxis of central nervous system leukemia (CNS) in a 3-year-old girl with acute lymphoblastic leukemia. This could be attributed to acute metabolic or direct toxic effects of methotrexate to ...

journal_title：Pediatric hematology and oncology

authors： Martins da Cunha AC,Bartsch CH,Gadner H

更新日期：1990-01-01 00:00:00

abstract：:This is a pilot study performed to determine the maximum tolerated number of courses of high-dose thiotepa and carboplatin with autologous peripheral blood progenitor cell (PBPC) transplantation in poor-risk pediatric central nervous system (CNS) tumor patients. Twelve patients were enrolled and a total of 24 PBPC tra...

journal_title：Pediatric hematology and oncology

authors： Ozkaynak MF,Sandoval C,Levendoglu-Tugal O,Jayabose S

更新日期：2004-10-01 00:00:00

abstract：:A method is described to estimate MYCN (N-myc) oncogene amplification in neuroblastoma by the technique of differential polymerase chain reaction (PCR). The technique is quicker than conventional Southern blotting techniques and does not require radioactive materials. The ability to measure MYCN amplification from sma...

journal_title：Pediatric hematology and oncology

authors： Huddart SN,Mann JR,McGukin AG,Corbett R

更新日期：1993-01-01 00:00:00

abstract：:Tolerance of full-dose methotrexate/6-mercaptopurine (MTX/6MP) maintenance therapy for childhood acute lymphoblastic leukemia (ALL) without side effects could reflect insufficient systemic drug exposure, and drug withdrawals due to toxicity might reduce the chance of cure. The present study included 122 children with ...

journal_title：Pediatric hematology and oncology

authors： Schmiegelow K

更新日期：1991-10-01 00:00:00

abstract：:During the last 5 years massive chemotherapy and autologous bone marrow transplantation have been increasingly explored in the treatment of pediatric solid tumors, mainly for neuroblastoma, Ewing's sarcoma, rhabdomyosarcoma, Wilms' tumor, germ cell tumors, osteosarcoma, and retinoblastoma. Although the disease course ...

journal_title：Pediatric hematology and oncology

authors： Yaniv I,Bouffet E,Irle C,Negrier S,Biron P,Favrot M,Philip I,Brunat-Mentigny M,Philip T

更新日期：1990-01-01 00:00:00

abstract：:A single institution's experience of three patients with nephroblastoma extending via the inferior vena cava to the right heart is described. The case reports and the pertinent literature illustrate that preoperative failure to detect the intracardial extension increases the risk of right outflow obstruction and pulmo...

journal_title：Pediatric hematology and oncology

authors： Kremens B,Sadony V,Goepel M,Hellinger A,Havers W

更新日期：1991-10-01 00:00:00

abstract：:The aim of this study was to identify genes distinctively expressed or suppressed in childhood leukemia with different prognoses, using cDNA microarray and quantitative reverse transcription-polymerase chain reaction (RT-PCR). The expression levels of the selected genes by cDNA microarray were quantified in primary le...

journal_title：Pediatric hematology and oncology

authors： Hattori H,Matsuzaki A,Suminoe A,Koga Y,Tashiro K,Hara T

更新日期：2006-03-01 00:00:00

abstract：:The development of myeloid leukemias and myelodysplastic syndrome (MDS) is common in children with trisomy 8 mosaicism. However, the mechanisms by which the presence of an additional chromosome 8 translates to an increased risk of leukemias and MDS is currently unknown. The authors describe the analysis of stromal cel...

journal_title：Pediatric hematology and oncology

authors： Narendran A,Hawkins LM,Ganjavi H,Vanek W,Gee MF,Barlow JW,Johnson G,Malkin D,Freedman MH

更新日期：2004-04-01 00:00:00

abstract：:Signaling between leukemia cells and nonhematopoietic cells in the bone marrow microenvironment contributes to leukemia cell growth and survival. This complicated extrinsic mechanism of chemotherapy resistance relies on a number of pathways and factors, some of which have yet to be determined. Research on cell-cell cr...

journal_title：Pediatric hematology and oncology

authors： Sison EAR,Kurre P,Kim YM

更新日期：2017-01-01 00:00:00

abstract：:A 12-year-old female is reported who presented with right hip pain for 6 months. With massive splenohepatomegaly and leukocytosis, CML was suspected and confirmed on bone-marrow examination and cytogenetics. Further investigations confirmed avascular necrosis (AVN) of the right femoral head. CML was treated by hydroxy...

journal_title：Pediatric hematology and oncology

authors： Kumar S,Bansal D,Prakash M,Sharma P

更新日期：2014-09-01 00:00:00

abstract：BACKGROUND:Clinical data and data on outcome of extra-osseous Ewing tumors are scarce. PROCEDURE:After a search for Ewing tumors in the database of a single institution over a period of 20 years, 16 out of 192 cases were found to have extra-osseous primary tumors. RESULTS:Ages at initial diagnosis ranged from 2.5 to ...

journal_title：Pediatric hematology and oncology

authors： van den Berg H,Heinen RC,van der Pal HJ,Merks JH

更新日期：2009-06-01 00:00:00

abstract：:Immune thrombocytopenia (ITP) is an acute self-limited disease of childhood, mostly resolving within 6 months irrespective of whether therapy is given or not. Treatment options when indicated include corticosteroids, intravenous immune globulin (IVIG), and anti-RhD immunoglobulin. We reviewed our 32 years' experience ...

journal_title：Pediatric hematology and oncology

authors： Yildiz I,Ozdemir N,Celkan T,Soylu S,Karaman S,Canbolat A,Dogru O,Erginoz E,Apak H

更新日期：2015-01-01 00:00:00

abstract：:Infections remain a serious complication in pediatric oncology patients. To determine if daily bathing with Chlorhexidine gluconate can decrease the rate of nosocomial infection in pediatric oncology patients, we reviewed rates of infections in pediatric oncology patients over a 14-month span. Intervention group recei...

journal_title：Pediatric hematology and oncology

authors： Raulji CM,Clay K,Velasco C,Yu LC

更新日期：2015-01-01 00:00:00

abstract：:In the French nonHodgkin's lymphoma protocols, central nervous system prophylaxis is provided by high-dose methotrexate (HD-MTX), given as a 3-hour IV infusion of 3 g/m2 MTX along with intrathecal MTX injection. The incidence of CNS relapse is less than 3%. We designed a study to evaluate the MTX transfer across the b...

journal_title：Pediatric hematology and oncology

authors： Vassal G,Valteau D,Bonnay M,Patte C,Aubier F,Lemerle J

更新日期：1990-01-01 00:00:00

abstract：INTRODUCTION:Children with low von Willebrand factor (VWF) activity or type 1 von Willebrand disease (VWD) have increased risk of bleeding after adenotonsillar procedures and the optimal perioperative management to minimize bleeding is unknown. AIM:To report the effectiveness and safety of an institutional protocol in...

journal_title：Pediatric hematology and oncology

authors： Diaz R,Musso M,Mahoney D

更新日期：2020-08-17 00:00:00

abstract：:Olfactory neuroblastoma, a rare malignancy of the olfactory epithelium, is an uncommon tumor in children. It occurs mostly in older individuals and the treatment strategies are based on the experience with adults. In this report, clinical characteristics and treatment results of 2 patients with olfactory neuroblastoma...

journal_title：Pediatric hematology and oncology

authors： Küpeli S,Yalçin B,Büyükpamukçu M

更新日期：2011-02-01 00:00:00

abstract：:Autologous blood-derived stem cells were used for stem-cell rescue in a 5-year-old boy with chemotherapy-resistant B-Non-Hodgkin's lymphoma (B-NHL) involving bone marrow. The high dose chemoradiotherapy was carried out 5 months after initial diagnosis during partial remission. The preparative regimen consisted of 12 G...

journal_title：Pediatric hematology and oncology

authors： Emminger W,Emminger-Schmidmeier W,Ambros P,Gadner H,Höcker P,Radaszkiewicz T,Hinterberger W

更新日期：1990-01-01 00:00:00

abstract：:Thrombo-embolism in childhood is a multifactorial disorder. The present study is a case-control study that investigated the role of genetic and acquired risk factors in 60 children with thrombosis and compared the results with the controls. Acquired and inherited risk factors precipitating thrombosis were present in 7...

journal_title：Pediatric hematology and oncology

authors： Günes AM,Baytan B,Günay U

更新日期：2006-07-01 00:00:00

abstract：:The objective of this study was to ascertain the reactions and experiences of parents whose children were defined as false-positive cases in a research program of screening 6-month-old babies for neuroblastoma. Parents of seven of the eight infants falling into this category participated in the study. Parents of five ...

journal_title：Pediatric hematology and oncology

authors： Bell S,Parker L,Cole M,Craft AW

更新日期：1994-03-01 00:00:00

abstract：:The clinical usefulness of the measurement of red cell zinc protoporphyrin (ZPP), an indicator of iron-deficient erythropoiesis, was assessed in a group of UK children undergoing investigation for red cell microcytosis. Of 213 children studied, 136 had increased ZPP values. Of these, 86 also had reduced iron stores as...

journal_title：Pediatric hematology and oncology

authors： Hinchliffe RF,Lilleyman JS,Steel GJ,Bellamy GJ

更新日期：1995-09-01 00:00:00

abstract：:This study evaluated the effects of urokinase in the prevention of central venous catheter (CVC)-related complications in children with malignancy. Fifteen patients with 16 CVCs (study group A) received an intraluminal application of urokinase (10,000 IU in each catheter lumen for 4 h) once a week. They were monitored...

journal_title：Pediatric hematology and oncology

authors： Kalmanti M,Germanakis J,Stiakaki E,Syfridaki C,Christidou A,Tsetis D,Vardas P,Charisis G

更新日期：2002-04-01 00:00:00