Understanding the bone marrow microenvironment in hematologic malignancies: A focus on chemokine, integrin, and extracellular vesicle signaling.

abstract：:Adolescence is characterized by inter-related physiologic and emotional development. It is a particularly vulnerable period of life culminating into emergence as an adult. The majority of malignant bone tumors in pediatrics affect the adolescent patient. As a part of the treatment, amputation may be required for cure....

journal_title：Pediatric hematology and oncology

authors： Jaffe N,Zietz H

更新日期：2004-09-01 00:00:00

abstract：:Primary bone marrow lymphoma (PBML) is hard to diagnose in children, due to the difficult identification of malignant cells in bone marrow. The first case, a 5-year-old boy, showed knee swelling with an intermittent fever. The second case, a 12-year-old girl, showed fever of unknown origin without lymphadenopathy or h...

journal_title：Pediatric hematology and oncology

authors： Moritani K,Nakano N,Yonezawa S,Ochi F,Tauchi H,Eguchi-Ishimae M,Eguchi M,Ishii E,Nagai K

更新日期：2018-03-01 00:00:00

abstract：:The aim of this retrospective study was to analyze the outcome and identify risk factors associated with progression-free survival (PFS) in 36 children with high-risk neuroblastoma who underwent autologous peripheral blood progenitor cell (PBPC) transplantation between 1994 and 2010. The conditioning regimen used in a...

journal_title：Pediatric hematology and oncology

authors： Molina B,Alonso L,Gonzalez-Vicent M,Andion M,Hernandez C,Lassaletta A,Cormenzana M,Lopez-Ibor B,Villa M,Molina J,Diaz MA

更新日期：2011-03-01 00:00:00

abstract：:In this study, we aimed to determine serum adrenomedullin levels and compare them with levels of C-reactive protein (CRP) and procalcitonin (PCT). Cancer patients aged 0-18 years who experienced febrile neutropenia attacks were included in the study. Adrenomedullin, CRP, and PCT were analyzed at admission, day 3, and ...

journal_title：Pediatric hematology and oncology

authors： Demirkaya M,Tugcu D,Akcay A,Aydogan G,Akıcı F,Salcioglu Z,Ekmekci H,Sevinir B,Balci Ekmekci O

更新日期：2015-01-01 00:00:00

abstract：:Eighty-six patients with Ewing's sarcoma were analyzed as to the role of radiation therapy. Fifty-eight patients (P group) had removal of the involved part of the bone after preoperative chemotherapy, and 28 (NP group) had local treatment either at the same time or before chemotherapy. Thirty-six of 58 P-group patient...

journal_title：Pediatric hematology and oncology

authors： Jereb B,Ong RL,Mohan M,Caparros B,Exelby P

更新日期：1986-01-01 00:00:00

abstract：:The Department of Oncology at Hospital Infantil de México Federico Gómez (HIMFG) was the first unit in our country, and one of the first in Latin America, to specialize in the management of children with cancer. The HIMFG is part of the National Institutes of Health of Mexico, and is a reference hospital with research...

journal_title：Pediatric hematology and oncology

authors： Medina-Sanson A,Martínez-Avalos A,Gallegos-Castorena S,Juárez-Villegas LE,González-Montalvo P,Perales-Arroyo A,Gallegos-González E,Ayometzi-Ouchi MT

更新日期：2002-09-01 00:00:00

abstract：:We present the case of a female newborn with life-threatening bleeding of a ruptured infantile fibrosarcoma (IFS) and consecutive multiorgan dysfunction syndrome shortly after birth. After stabilization, the tumor could be treated without amputation due to surgery, laser therapy, and chemotherapy. The patient is free ...

journal_title：Pediatric hematology and oncology

authors： Kerl K,Nowacki M,Leuschner I,Masjosthusmann K,Frühwald MC

更新日期：2012-09-01 00:00:00

abstract：:During the last 5 years massive chemotherapy and autologous bone marrow transplantation have been increasingly explored in the treatment of pediatric solid tumors, mainly for neuroblastoma, Ewing's sarcoma, rhabdomyosarcoma, Wilms' tumor, germ cell tumors, osteosarcoma, and retinoblastoma. Although the disease course ...

journal_title：Pediatric hematology and oncology

authors： Yaniv I,Bouffet E,Irle C,Negrier S,Biron P,Favrot M,Philip I,Brunat-Mentigny M,Philip T

更新日期：1990-01-01 00:00:00

abstract：BACKGROUND:The Wiskott-Aldrich syndrome (WAS) is X-linked recessive disorder associated with microplatelet thrombocytopenia, eczema, infections, and an increased risk of autoimmunity and lymphoid neoplasia. The originally described features of WAS include susceptibility to infections, microthrombocytopenia, and eczema....

journal_title：Pediatric hematology and oncology

authors： Kamuran K,Çetin M,Geylan H,Karaman S,Demir N,Yurekturk E,Yavuz İ,Yavuz G,Tuncer O

更新日期：2017-08-01 00:00:00

abstract：:We present the management challenge provided by a patient with kaposiform hemangioendothelioma associated with Kasabach-Merritt phenomenon. A female child presented at 14 months of age with an ecchymotic swelling of her right upper arm and axilla. Subsequently, she developed profound thrombocytopenia and hypofibrinoge...

journal_title：Pediatric hematology and oncology

authors： Blei F,Karp N,Rofsky N,Rosen R,Greco MA

更新日期：1998-07-01 00:00:00

abstract：:Breastfeeding is well-known to have a protective effect against infection in infants. It has been suggested that breast milk may play a role in the prevention of certain childhood cancer. We investigated this issue in a case-control study comprising 300 patients with childhood cancer. There was 73 patients (24.3%) wit...

journal_title：Pediatric hematology and oncology

authors： Küçükçongar A,Oğuz A,Pınarlı FG,Karadeniz C,Okur A,Kaya Z,Çelik B

更新日期：2015-01-01 00:00:00

abstract：:The purpose of this study was to retrospectively analyze the clinical presentation, treatment, and outcomes of children with Wilms tumor (WT) and intravascular extension who were treated at a single institution. A retrospective review was conducted of medical records of all children with Wilms tumor and intravascular ...

journal_title：Pediatric hematology and oncology

authors： Aspiazu D,Fernandez-Pineda I,Cabello R,Ramirez G,Alvarez-Madrid A,De Agustin JC

更新日期：2012-02-01 00:00:00

abstract：:This study evaluated the efficacy of hydroxyurea treatment in the prevention of vaso-occlusive crises among children and teenagers with severe sickle cell anemia and sickle cell beta-thalassemia. Nineteen children and young adults with severe sickle cell disease were enrolled to the hydroxyurea treatment trial. The in...

journal_title：Pediatric hematology and oncology

authors： Koren A,Segal-Kupershmit D,Zalman L,Levin C,Abu Hana M,Palmor H,Luder A,Attias D

更新日期：1999-05-01 00:00:00

abstract：:The authors describe a 10-year-old boy with beta-thalassemia major who received double-unit unrelated cord blood transplantation and had a rocky post-transplantation course that included an episode of massive pericardial effusion. Pericardial tube drainage was performed for evacuating fluid. Results showed hemorrhagic...

journal_title：Pediatric hematology and oncology

authors： Chung HT,Hsieh TC,Yu MC,Chang YS,Lo WC,Jaing TH

更新日期：2007-06-01 00:00:00

abstract：:In five patients under the age of 15 with hemophilia and inhibitors, due to frequent joint bleedings, 13 joints were treated with synoviorthesis (intra-articular injection of radioactive gold). The patients received high doses of factor VIII/IX for 2-4 days or were treated simultaneously with tolerance induction accor...

journal_title：Pediatric hematology and oncology

authors： Löfqvist T,Petersson C

更新日期：1992-04-01 00:00:00

abstract：:Sixty-one long-term survivors, treated for brain tumors in childhood, were evaluated in term of neurological impairments, disability, and handicap. Thirty-eight patients (pts) (62%) had at least one impairment. Visual impairment was detected in 14 pts (24%), associated with recurrence (p = .012). Thirty-four patients ...

journal_title：Pediatric hematology and oncology

authors： Macedoni-Luksic M,Jereb B,Todorovski L

更新日期：2003-03-01 00:00:00

abstract：:Immune thrombocytopenia (ITP) is an acute self-limited disease of childhood, mostly resolving within 6 months irrespective of whether therapy is given or not. Treatment options when indicated include corticosteroids, intravenous immune globulin (IVIG), and anti-RhD immunoglobulin. We reviewed our 32 years' experience ...

journal_title：Pediatric hematology and oncology

authors： Yildiz I,Ozdemir N,Celkan T,Soylu S,Karaman S,Canbolat A,Dogru O,Erginoz E,Apak H

更新日期：2015-01-01 00:00:00

abstract：:The effectiveness of the different pharmacological agents and different doses of systemic corticosteroids was analyzed. A total of 1109 patients (median age 8 months; F/M: 2.3) with hemangioma, followed up in our unit for 23 years, were evaluated retrospectively. Forty-five of them received systemic corticosteroids. T...

journal_title：Pediatric hematology and oncology

authors： Akyüz C,Yariş N,Kutluk MT,Büyükpamukçu M

更新日期：2001-01-01 00:00:00

abstract：:Neuroblastoma is the most common solid tumor in childhood and is the most frequent neural crest tumor (NCT). More than 90% of the patients excrete high levels of vanilmandelic acid (VMA) and homovanillic acid (HVA) in the urine. Original biochemical methods for measuring these two metabolites of catecholamines employe...

journal_title：Pediatric hematology and oncology

authors： Gregianin LJ,McGill AC,Pinheiro CM,Brunetto AL

更新日期：1997-05-01 00:00:00

abstract：:In 33 children, 23 with acute lymphoblastic leukemia (ALL) and 10 with solid tumors, the phenotype of the enzyme adenosine deaminase (ADA) was detected in the erythrocytes by electrophoresis in cellulose acetate. In all children the ADA enzyme activity was also determined in the plasma by spectrophotometry at the onse...

journal_title：Pediatric hematology and oncology

authors： Hatzistilianou M,Athanassiadou F,Catriu D,Makedou A,Hitoglou S,Papaeconomou A

更新日期：1996-07-01 00:00:00

abstract：:Infantile hemangioendothelioma is the most common hepatic vascular tumor in infants less than 6 months of age, with a prevalence of 1%. Serum alpha-fetoprotein levels have been used as an important tumor marker for hepatoblastoma, hepatocellular carcinoma, and germ cell tumors. It is rarely elevated in hepatic hemangi...

journal_title：Pediatric hematology and oncology

authors： Sari N,Yalçin B,Akyüz C,Haliloglu M,Büyükpamukçu M

更新日期：2006-12-01 00:00:00

abstract：OBJECTIVE:Venous thrombotic events (VTE) are a well-recognized complication in pediatric cancer patients. Population-based data on the incidence and characteristics of VTE in all pediatric cancer patients are limited. This information is crucial to identify patients at high risk and design targeted interventions accord...

journal_title：Pediatric hematology and oncology

authors： Asyyed Z,MacDonald T,Digout C,Kulkarni K

更新日期：2017-03-01 00:00:00

abstract：:Primary immunodeficiency disorders (PID) are under-reported from the developing world. We present data regarding diagnosis and outcome from a hospital-based registry in India. Forty-seven patients fulfilled diagnostic criteria. Majority were males. Subgroups were disorders of immune dysregulation-29%, B&T-cell abnorma...

journal_title：Pediatric hematology and oncology

authors： Chinnabhandar V,Yadav SP,Kaul D,Verma IC,Sachdeva A

更新日期：2014-04-01 00:00:00

abstract：:The objective of this study was to ascertain the reactions and experiences of parents whose children were defined as false-positive cases in a research program of screening 6-month-old babies for neuroblastoma. Parents of seven of the eight infants falling into this category participated in the study. Parents of five ...

journal_title：Pediatric hematology and oncology

authors： Bell S,Parker L,Cole M,Craft AW

更新日期：1994-03-01 00:00:00

abstract：INTRODUCTION:Chronic liver disease causes a disruption of procoagulant and anticoagulant factors, resulting in a fragile state, prone to increased rates of both bleeding and thrombosis. Currently, there is limited literature describing the changes observed in pediatric liver disease and extrahepatic portal vein obstruc...

journal_title：Pediatric hematology and oncology

authors： Beattie W,Magnusson M,Hardikar W,Monagle P,Ignjatovic V

更新日期：2017-03-01 00:00:00

abstract：:Six transfusion-dependent beta-thalassemia major patients were treated with allogeneic peripheral blood stem cell (PBSC) transplant. The donors were HLA identical siblings except one donor who was a father with one-antigen mismatch of HLA-B loci. The donors were mobilized with G-CSF and PBSC was infused without manipu...

journal_title：Pediatric hematology and oncology

authors： Fang J,Huang S,Chen C,Zhou D,Wu Y,Bao R

更新日期：2002-10-01 00:00:00

abstract：:The acquired form of pure red cell aplasia (PRCA) presents either as an acute self-limited disease, predominantly seen in children, or as a chronic illness more frequently seen in adults with rare spontaneous remissions. A 14-year-old boy presented with pallor, without hepatosplenomegaly, jaundice, lymphadenopathy, pe...

journal_title：Pediatric hematology and oncology

authors： Khalil A,Elhasid R,Ben Barak A,Ben Arush MW

更新日期：2010-10-01 00:00:00

abstract：INTRODUCTION:Children with low von Willebrand factor (VWF) activity or type 1 von Willebrand disease (VWD) have increased risk of bleeding after adenotonsillar procedures and the optimal perioperative management to minimize bleeding is unknown. AIM:To report the effectiveness and safety of an institutional protocol in...

journal_title：Pediatric hematology and oncology

authors： Diaz R,Musso M,Mahoney D

更新日期：2020-08-17 00:00:00

abstract：:A cooperative Italian study group on acute idiopathic thrombocytopenic purpura (AITP) has been designed to evaluate efficacy and safety of no treatment at the onset of the disease and sequential treatment with immunoglobulin and high dose steroid. One hundred thirty-eight patients with AITP entered in the trial. Eleve...

journal_title：Pediatric hematology and oncology

authors： Mori PG,Lanza T,Mancuso G,De Mattia D,Catera P,Miano C,Del Principe D,Cottafava F

更新日期：1988-01-01 00:00:00

abstract：:Bloodstream infections (BSI) represent one of the most serious complications in patients in the hematology-oncology unit. In this study, the prevalence, distribution, drug sensitivity profiles, and clinical outcome of BSI were analyzed in pediatric patients with hematological malignancies. Patients admitted to the ped...

journal_title：Pediatric hematology and oncology

authors： Chen S,Liu S,Yuan X,Mai H,Lin J,Wen F

更新日期：2019-11-01 00:00:00