The influence of risk factors in promoting thrombosis during childhood: the role of acquired factors.

abstract：:Treatment of Langerhans cell histiocytosis (LCH) is yet to be established. We treated seven patients with etoposide alone at a dose of 100 mg/m2/day for 3 days given every 3 to 4 weeks for six cycles. Three patients had received prior chemotherapy, two patients were less than 2 years of age, and two had liver dysfunct...

journal_title：Pediatric hematology and oncology

authors： Basade MM,Nair CN,Kurkure PA,Pai SK,Advani SH

更新日期：1996-03-01 00:00:00

abstract：:Beta-thalassemia major is a severe, transfusion-dependent anemia that also causes infertility due to iron deposition to endocrine organs after overtransfusion. Very few pregnancies have been reported among such patients after modern therapies. In this study, 32 women with thalassemia who were admitted to Ali Asghar Ch...

journal_title：Pediatric hematology and oncology

authors： Ansari S,Azarkeivan A,Tabaroki A

更新日期：2006-01-01 00:00:00

abstract：:The purpose of this study was to retrospectively analyze the clinical presentation, treatment, and outcomes of children with Wilms tumor (WT) and intravascular extension who were treated at a single institution. A retrospective review was conducted of medical records of all children with Wilms tumor and intravascular ...

journal_title：Pediatric hematology and oncology

authors： Aspiazu D,Fernandez-Pineda I,Cabello R,Ramirez G,Alvarez-Madrid A,De Agustin JC

更新日期：2012-02-01 00:00:00

abstract：:To investigate the possible clinical application of the hypothesis that insufficient induction of 3,4-dihydroxyphenylalanine decarboxylase (DDC) causes accumulation and secretion of 3,4-dihydroxyphenylalanine (DOPA) in unfavorable neuroblastomas, we measured plasma DOPA in 28 neuroblastoma patients. Abnormally high le...

journal_title：Pediatric hematology and oncology

authors： Ikeda H,Suzuki N,Takahashi A,Kuroiwa M,Matsuyama S

更新日期：1996-01-01 00:00:00

abstract：:A discussion of a 5-year-old child with congenital hemolytic anemia and severe hypotonia caused by triosephosphate (TPI) deficiency is presented. The complexities in the diagnosis and management of this condition is discussed and the relevant literature is reviewed. ...

journal_title：Pediatric hematology and oncology

authors： Linarello RE,Shetty AK,Thomas T,Warrier RP

更新日期：1998-11-01 00:00:00

abstract：:This study aimed to address the clinical impact of recombination-activating gene (RAG1) expression and tumor suppressor IKZF1 gene deletions in Philadelphia negative B-cell precursor acute lymphoblastic leukemia (B-ALL) patients. Fifty newly diagnosed pediatric Philadelphia negative B-ALL patients were included in thi...

journal_title：Pediatric hematology and oncology

authors： Aref S,Khaled N,Menshawy NE,Sabry M,Agder MA

更新日期：2020-08-01 00:00:00

abstract：:It has been suggested that breastfeeding may prevent inhibitor formation in patients with hemophilia. In a single-center retrospective cohort study, the authors studied the association between breastfeeding and inhibitor development in 90 severe hemophilia A patients born 1975-2003. Mean follow-up was 13.2 years (stan...

journal_title：Pediatric hematology and oncology

authors： Jansen IM,Fischer K,Van Der Bom JG,Van Den Berg HM

更新日期：2005-10-01 00:00:00

abstract：:Endothelial protein C receptor (EPCR) is primarily localized on the endothelial cells of large blood vessels and is very low or absent in the microvascular endothelium of most tissues. EPCR augments the thrombin/thrombomodulin-dependent activation of protein C by 5- to 20-fold. EPCR appears to be physiologically signi...

journal_title：Pediatric hematology and oncology

authors： Kendirli T,Ciftçi E,Ince E,Yurdakul E,Kansu A,Akar N

更新日期：2007-04-01 00:00:00

abstract：:Maternal education might be an important factor for the neuroblastoma risk in children, but it was conflicting. This meta-analysis was performed to evaluate the relationship between maternal education and neuroblastoma susceptibility and to explore whether maternal education was an important indicator to be associated...

journal_title：Pediatric hematology and oncology

authors： Wang P,Liao N,Liao XH,Liang B,Huang CX,Li W

更新日期：2013-02-01 00:00:00

abstract：:The treatment of a child with a relapsed state acute leukemia after allogeneic stem cell transplantation (allo-SCT) is a challenge. The authors report about a child with an acute myelogenous leukemia (AML), which relapsed after allo-SCT despite immunological intervention. It was further treated with a second line chem...

journal_title：Pediatric hematology and oncology

authors： Hartwig M,Weigel S,Bernig T,Bader P,Dölken R,Beck J

更新日期：2007-03-01 00:00:00

abstract：:Immune thrombocytopenia (ITP) is a frequently encountered disease in childhood. Recent reports pointed to the benefit of high-dose steroid in ITP treatment since it resulted in a better outcome in a shorter time than IV immunoglobulin therapy. In the authors' clinic, mainly after 1984, megadose methyl prednisolone (MD...

journal_title：Pediatric hematology and oncology

authors： Yetgin S,Yenicesu IC,Ersoy F

更新日期：2005-07-01 00:00:00

abstract：:The authors describe a 10-year-old boy with beta-thalassemia major who received double-unit unrelated cord blood transplantation and had a rocky post-transplantation course that included an episode of massive pericardial effusion. Pericardial tube drainage was performed for evacuating fluid. Results showed hemorrhagic...

journal_title：Pediatric hematology and oncology

authors： Chung HT,Hsieh TC,Yu MC,Chang YS,Lo WC,Jaing TH

更新日期：2007-06-01 00:00:00

abstract：:The authors report the results of 58 children with ALL in 2CR after related (n = 31) or unrelated (n = 27) AHSCT. Characteristics at diagnosis and initial and after relapse antileukemic treatment were similar in the related donor (RD) and the unrelated donor (UD) groups. Conditioning consisted of TBI/CY +/- VP-16 for ...

journal_title：Pediatric hematology and oncology

authors： Muñoz A,Diaz-Heredia C,Diaz MA,Badell I,Verdeguer A,Martinez A,Gomez P,Perez-Hurtado JM,Bureo E,Fernandez-Delgado R,Gonzalez-Valentin ME,Maldonado MS

更新日期：2008-06-01 00:00:00

abstract：:Hyperleukocytosis in patients with leukemia is associated with early mortality, especially due to the pulmonary and neurological complications of leukostasis. The prompt use of leukapheresis may improve patients' survival in the initial treatment period. The medical records of all previously untreated acute leukemia p...

journal_title：Pediatric hematology and oncology

authors： Yilmaz D,Karapinar B,Karadaş N,Duyu M,Yazici P,Ay Y,Balkan C,Aydinok Y,Kavakli K

更新日期：2014-05-01 00:00:00

abstract：:Unexplained menorrhagia and hematuria occurred in a 13-year-old female with a mild inherited platelet disorder who had never experienced prior bleeding as a result of this disorder. An intensive search revealed that this patient was receiving coumadin that was given by the mother. In addition, the mother drew large vo...

journal_title：Pediatric hematology and oncology

authors： Souid AK,Korins K,Keith D,Dubansky S,Sadowitz PD

更新日期：1993-07-01 00:00:00

abstract：:Two children are described who presented with fever and generalized seizures, days 50 and 200, respectively, after matched unrelated donor-bone marrow transplantation. Upon antiepileptic treatment the seizures vanished but somnolence and fever remained. Magnetic resonance imaging (MRI) of the brain was performed and r...

journal_title：Pediatric hematology and oncology

authors： Fischmeister G,Wiesbauer P,Holzmann HM,Peters C,Eibl M,Gadner H

更新日期：2000-07-01 00:00:00

abstract：:A case of a child with paroxysmal nocturnal hemoglobinuria (PNH) is characterized by an increased sensitivity of the erythrocyte to hemolytic action of complement. The widely used Ham test may not always be reliable. Recently, a panel of monoclonal antibodies has become available to detect various glycosylphosphatidyl...

journal_title：Pediatric hematology and oncology

authors： Kinugawa N,Shichishima T,Nishimura J,Kitani T

更新日期：1993-10-01 00:00:00

abstract：:The aim of this study was to investigate the impact of therapy on long-term gonadal function of young people cured of childhood lymphomas and to assess whether a prepubertal state during the treatment protects the gonads from chemotherapy and/or radiotherapy late effects. Clinical evaluation, semen analysis, and endoc...

journal_title：Pediatric hematology and oncology

authors： Ben Arush MW,Solt I,Lightman A,Linn S,Kuten A

更新日期：2000-04-01 00:00:00

abstract：:A major problem of hemophilia A (HA) treatment is the development of factor VIII (FVIII) inhibitor, which usually occurs shortly after initiating replacement therapy. Several studies showed the correlation between inhibitor development and polymorphisms in inflammatory and immune response genes of HA patients; however...

journal_title：Pediatric hematology and oncology

authors： Naderi N,Yousefi H,Mollazadeh S,Seyed Mikaeili A,Keshavarz Norouzpour M,Jazebi M,Moazezi Nekooi Asl SS,Namvar A,Azizi Saraji A,Agi E,Bolhassani A

更新日期：2019-02-01 00:00:00

abstract：:We report the outcome of 27 children with de novo acute megakaryoblastic leukemia (AMKL) (excluding Down syndrome) enrolled in the French multicenter prospective study ELAM02 (2005-2011). There was no difference in gender, initial leukocyte count, CNS involvement, and complete remission rate (88.9%), as compared to ot...

journal_title：Pediatric hematology and oncology

authors： Teyssier AC,Lapillonne H,Pasquet M,Ballerini P,Baruchel A,Ducassou S,Fenneteau O,Petit A,Cuccuini W,Ragu C,Preudhomme C,Mercher T,Sirvent N,Leverger G

更新日期：2017-11-01 00:00:00

abstract：:Nesiritide is a recombinant formulation of B-type natriuretic peptide used most commonly in the treatment of adults with decompensated congestive heart failure. The physiologic effects of BNP include natriuresis, diuresis, and smooth muscle relaxation. These physiologic effects result in its beneficial therapeutic eff...

journal_title：Pediatric hematology and oncology

authors： Wheeler AD,Tobias JD

更新日期：2005-06-01 00:00:00

abstract：:A 3-year-old boy presented with recurrent strokes and pallor. Hematological investigations revealed severe iron deficiency anemia without thrombocytosis. The magnetic resonance angiogragraphy findings were suggestive of moyamoya syndrome. The association of moyamoya syndrome with severe iron deficiency anemia has not ...

journal_title：Pediatric hematology and oncology

authors： Meena SS,Ramkumar TV,Sharma S,Aneja S,Kumar A

更新日期：2012-05-01 00:00:00

abstract：:The objective of this study was to ascertain the reactions and experiences of parents whose children were defined as false-positive cases in a research program of screening 6-month-old babies for neuroblastoma. Parents of seven of the eight infants falling into this category participated in the study. Parents of five ...

journal_title：Pediatric hematology and oncology

authors： Bell S,Parker L,Cole M,Craft AW

更新日期：1994-03-01 00:00:00

abstract：:A case of a 4-year-old girl with pleuropulmonary blastoma is reported. Surgical resection of the tumor was performed and histologic examination revealed pleuropulmonary blastoma with rhabdomyosarcomatous differentiation. Postoperative chemotherapy was administered and 3 weeks after initiation of treatment protocol a s...

journal_title：Pediatric hematology and oncology

authors： Perdikogianni C,Stiakaki E,Danilatou V,Delides G,Kalmanti M

更新日期：2001-06-01 00:00:00

abstract：:Down syndrome (DS) is an important risk factor associated with acute leukemia (AL). The presence of polymorphisms that reduce 5,10-methylenetetrahydrofolate reductase (MTHFR) activity has been linked to the multifactorial leukemogenic process. The authors have conducted a study to test whether 677C-->T and/or 1298A-->...

journal_title：Pediatric hematology and oncology

authors： Amorim MR,Zanrosso CW,Magalhães IQ,Pereira SC,Figueiredo A,Emerenciano M,Pinheiro VR,d'Andréa ML,Orioli IM,Koifman S,Pombo-de-Oliveira MS

更新日期：2008-12-01 00:00:00

abstract：:A firm, painless tumor of the temporal region was excised in a 3-year-old girl. The diagnosis of nonossifying fibromyxoid tumor was established on pathologic examination, which showed that most of the cells formed cords and tubulelike structures in a myxoid background. Bone and osteoid were lacking. The child is free ...

journal_title：Pediatric hematology and oncology

authors： Leray V,Gosseye S,Sempoux C,Ninane J,Vanwijck R

更新日期：1994-07-01 00:00:00

abstract：:We report a patient who developed chronic myelogenous leukemia (CML) at 12 months of age. She was treated aggressively with stem cell transplant (SCT), interferon, donor lymphocytes and imatinib, with subsequent molecular progression. She received dasatinib, achieving a complete molecular response. Dasatinib was disco...

journal_title：Pediatric hematology and oncology

authors： Triche L,Yarbrough A,Roth M,Ying A,Wells R

更新日期：2020-08-01 00:00:00

abstract：:Some clinical manifestations of acute leukemia in children can mimic orthopedic conditions, and t is variable presentation often makes diagnosis difficult. Bone changes in leukemia are well documented, but there are only a few accounts of children with acute leukemia who present with bone fractures. This report descri...

journal_title：Pediatric hematology and oncology

authors： Alioglu B,Tuncay IC,Ozyurek E,Avci Z,Ozbek N

更新日期：2009-01-01 00:00:00

abstract：:The development of myeloid leukemias and myelodysplastic syndrome (MDS) is common in children with trisomy 8 mosaicism. However, the mechanisms by which the presence of an additional chromosome 8 translates to an increased risk of leukemias and MDS is currently unknown. The authors describe the analysis of stromal cel...

journal_title：Pediatric hematology and oncology

authors： Narendran A,Hawkins LM,Ganjavi H,Vanek W,Gee MF,Barlow JW,Johnson G,Malkin D,Freedman MH

更新日期：2004-04-01 00:00:00

abstract：:Clear cell sarcoma of the kidney (CCSK) has been classified as high risk tumour in the previous UK and international Wilms tumor studies. The current Society of Paediatric Oncology (SIOP) trial, UK version, advocates chemotherapy including doxorubicin prior to nephrectomy. Pathological staging and histology of the res...

journal_title：Pediatric hematology and oncology

authors： Ng A,Jenkinson H,Morland B,Grundy R

更新日期：2005-04-01 00:00:00