The influence of risk factors in promoting thrombosis during childhood: the role of acquired factors.

Abstract:

:Thrombo-embolism in childhood is a multifactorial disorder. The present study is a case-control study that investigated the role of genetic and acquired risk factors in 60 children with thrombosis and compared the results with the controls. Acquired and inherited risk factors precipitating thrombosis were present in 75 and 40% of the thrombotic children, respectively. The most frequent acquired risk factor was infection (58%). Of the genetic factors, factor V G20210A was the most common (38%). The comparison of the genetic and acquired risk factors in thrombotic versus nonthrombotic settings identified that acquired factors played a more significant role in causing thrombosis (OR:14.44; 95% CI: 7.05-29.94, p < .001). This study has clearly suggested that the prevention of acquired risk factors, particularly infection, could decrease the risk of thrombosis in pediatric cases.

journal_name

Pediatr Hematol Oncol

authors

Günes AM,Baytan B,Günay U

doi

10.1080/08880010600646324

subject

Has Abstract

pub_date

2006-07-01 00:00:00

pages

399-410

issue

5

eissn

0888-0018

issn

1521-0669

pii

P123MTN60155V55W

journal_volume

23

pub_type

杂志文章
  • Recombinant human erythropoietin beta therapy: an effective strategy to reduce transfusion requirement in children receiving anticancer treatment.

    abstract::In recent years erythropoietic agents have become important tools in the management of anemia in cancer patients, improving hemoglobin (Hb) concentrations, reducing the need for transfusion, and enhancing quality of life. In this prospective and historically controlled study, the effects of epoetin beta on Hb concentr...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章

    doi:10.1080/08880010802235132

    authors: Corapcioglu F,Aksu G,Basar EZ,Demirel A,Oncel S,Mutlu A

    更新日期:2008-09-01 00:00:00

  • Understanding the bone marrow microenvironment in hematologic malignancies: A focus on chemokine, integrin, and extracellular vesicle signaling.

    abstract::Signaling between leukemia cells and nonhematopoietic cells in the bone marrow microenvironment contributes to leukemia cell growth and survival. This complicated extrinsic mechanism of chemotherapy resistance relies on a number of pathways and factors, some of which have yet to be determined. Research on cell-cell cr...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章,评审

    doi:10.1080/08880018.2017.1395938

    authors: Sison EAR,Kurre P,Kim YM

    更新日期:2017-01-01 00:00:00

  • Does D-dimer predict cerebral sinovenous thrombosis in the newborn?

    abstract::Sinovenous thrombosis describes thrombosis in one or more of the cerebral venous sinuses. The incidence of SVT in childhood appears to be highest during the neonatal period. Although plasma level of D-dimer has been shown to be sensitive for the diagnosis of deep vein thrombosis and pulmonary embolism in adult patient...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章

    doi:10.1080/08880010701255769

    authors: Karagöl BS,Erdeve O,Fítöz S,Uysal Z,Atasay B,Arsan S

    更新日期:2007-07-01 00:00:00

  • MYCN amplification by differential PCR.

    abstract::A method is described to estimate MYCN (N-myc) oncogene amplification in neuroblastoma by the technique of differential polymerase chain reaction (PCR). The technique is quicker than conventional Southern blotting techniques and does not require radioactive materials. The ability to measure MYCN amplification from sma...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章

    doi:10.3109/08880019309016525

    authors: Huddart SN,Mann JR,McGukin AG,Corbett R

    更新日期:1993-01-01 00:00:00

  • Clinical value of RAG1 expression and IKZF1 deletions in Philadelphia negative pediatric B cell precursor acute lymphoblastic leukemia.

    abstract::This study aimed to address the clinical impact of recombination-activating gene (RAG1) expression and tumor suppressor IKZF1 gene deletions in Philadelphia negative B-cell precursor acute lymphoblastic leukemia (B-ALL) patients. Fifty newly diagnosed pediatric Philadelphia negative B-ALL patients were included in thi...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章

    doi:10.1080/08880018.2020.1767739

    authors: Aref S,Khaled N,Menshawy NE,Sabry M,Agder MA

    更新日期:2020-08-01 00:00:00

  • Efficacy of recombinant human granulocyte colony-stimulating factor and recombinant human granulocyte-macrophage colony-stimulating factor in neutropenic children with malignancies.

    abstract::The difference between the effects of administration of recombinant human granulocyte colony-stimulating factor (rhG-CSF) and recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF) was studied in 39 children with neutropenia secondary to chemotherapy (absolute neutrophil count (ANC) less than 1,...

    journal_title:Pediatric hematology and oncology

    pub_type: 临床试验,杂志文章

    doi:10.3109/08880019509030769

    authors: Lydaki E,Bolonaki E,Stiakaki E,Dimitriou H,Kalmantis T,Kalmanti M

    更新日期:1995-11-01 00:00:00

  • Inflammatory and immune response genes: A genetic analysis of inhibitor development in Iranian hemophilia A patients.

    abstract::A major problem of hemophilia A (HA) treatment is the development of factor VIII (FVIII) inhibitor, which usually occurs shortly after initiating replacement therapy. Several studies showed the correlation between inhibitor development and polymorphisms in inflammatory and immune response genes of HA patients; however...

    journal_title:Pediatric hematology and oncology

    pub_type: 临床试验,杂志文章

    doi:10.1080/08880018.2019.1585503

    authors: Naderi N,Yousefi H,Mollazadeh S,Seyed Mikaeili A,Keshavarz Norouzpour M,Jazebi M,Moazezi Nekooi Asl SS,Namvar A,Azizi Saraji A,Agi E,Bolhassani A

    更新日期:2019-02-01 00:00:00

  • Unexpected result in the etiological approaching to an anemic case: a leech infestation.

    abstract::One of the causes of the childhood anemia is gastrointestinal system bleeding, which rarely results from parasites. The authors report on a 3-year-old boy with severe anemia and a history of hematemesis. While they were investigating the cause of the anemia and the hematemesis, a leech showing itself in the nasal pass...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章

    doi:10.1080/08880010390232763

    authors: Demirören K,Calişkan U

    更新日期:2003-10-01 00:00:00

  • Effect of hydroxyurea in sickle cell anemia: a clinical trial in children and teenagers with severe sickle cell anemia and sickle cell beta-thalassemia.

    abstract::This study evaluated the efficacy of hydroxyurea treatment in the prevention of vaso-occlusive crises among children and teenagers with severe sickle cell anemia and sickle cell beta-thalassemia. Nineteen children and young adults with severe sickle cell disease were enrolled to the hydroxyurea treatment trial. The in...

    journal_title:Pediatric hematology and oncology

    pub_type: 临床试验,杂志文章

    doi:10.1080/088800199277272

    authors: Koren A,Segal-Kupershmit D,Zalman L,Levin C,Abu Hana M,Palmor H,Luder A,Attias D

    更新日期:1999-05-01 00:00:00

  • Maintenance immunotherapy by repetitive low-dose donor lymphocytes infusions in a child with relapse state aml after allogeneic stem cell transplantation.

    abstract::The treatment of a child with a relapsed state acute leukemia after allogeneic stem cell transplantation (allo-SCT) is a challenge. The authors report about a child with an acute myelogenous leukemia (AML), which relapsed after allo-SCT despite immunological intervention. It was further treated with a second line chem...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章

    doi:10.1080/08880010601125443

    authors: Hartwig M,Weigel S,Bernig T,Bader P,Dölken R,Beck J

    更新日期:2007-03-01 00:00:00

  • Treatment of alpha-fetoprotein secreting hepatoblastoma by response of serum alpha-fetoprotein levels: a new concept.

    abstract::Hepatoblastoma, the commonest primary malignant liver tumor in infants and children, is usually associated with elevated serum alpha-fetoprotein (AFP) levels. The authors sought to determine if AFP levels can be used to modify treatment, thereby avoiding the wait for formal imaging studies and prolonged suboptimal tre...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章

    doi:10.1080/088800101753328475

    authors: Sayar D,Yaniv I,Goshen Y,Cohen IJ

    更新日期:2001-12-01 00:00:00

  • Rare factor VII variant inherited through genetic variant in proband's mother and another genetic variant in proband's father.

    abstract::An 11-year-old girl with hereditary factor-VII deficiency and her family have been studied for factor VII coagulation activity (VII:C) and factor VII antigen level (VII:Ag). The proband had 11% VII:C, whereas her VII:Ag was at a level that corresponds to about 50% coagulation activity. Forty-two members of the proband...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章

    doi:10.3109/08880018709141261

    authors: Svendsen J,Osterud B

    更新日期:1987-01-01 00:00:00

  • Vincristine and irinotecan in children with relapsed hepatoblastoma: a single-institution experience.

    abstract:PURPOSE:This study was to determine the efficacy of vincristine and irinotecan in children with relapsed hepatoblastoma (HB). METHODS:A total of 10 patients with relapsed HB were enrolled. Three patients were excluded. Patients received irinotecan 50 mg/m(2)/day, day 1-5 and vincristine 1.5 mg/m(2)/day, day 1, repeate...

    journal_title:Pediatric hematology and oncology

    pub_type: 临床试验,杂志文章

    doi:10.3109/08880018.2014.909913

    authors: Zhang YT,Feng LH,Zhong XD,Wang LZ,Chang J

    更新日期:2015-02-01 00:00:00

  • Euthyroid sick syndrome in children with Hodgkin disease.

    abstract::Euthyroid sick syndrome is related to profound changes in thyroid metabolism induced by nonthyroidal diseases. To determine whether children with newly diagnosed Hodgkin disease might present thyroid abnormalities and to establish their predictive value, the authors performed regular thyroid function testing. Seven ch...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章

    doi:10.1080/08880010151114886

    authors: Mohn A,Di Marzio A,Cerruto M,Angrilli F,Fioritoni C,Chiarelli F

    更新日期:2001-04-01 00:00:00

  • Inflammatory pseudotumor of the lung in children.

    abstract::Two children with inflammatory pseudotumor (IPT) of the lung are reported. Symptomless "cystic" lesions were present on routine chest x ray. Morphological study of these peculiar lesions included light microscopic, immunohistochemical, and ultrastructural analysis. Histologic appearance of the lesion varied from the f...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章

    doi:10.3109/08880019109033439

    authors: Vujanić GM,Dojĉinov D

    更新日期:1991-04-01 00:00:00

  • Alectinib is effective, safe and tolerable in an adolescent with stage IVB ALK-rearranged adenocarcinoma of the lung.

    abstract::Anaplastic lymphoma kinase (ALK) inhibitors such as crizotinib and alectinib have been shown to have significant activity in ALK-rearranged non-small cell lung cancers (NSCLC). There are no data for alectinib's safety or efficacy in younger patients, though it is superior to crizotinib in adult trials. We present a 14...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章

    doi:10.1080/08880018.2018.1541492

    authors: Balzer BWR,Loo C,Wegner EA,Nath CE,Lee S,Smith C,Lewis CR,Trahair TN,Anazodo AC

    更新日期:2018-01-01 00:00:00

  • Highlights of the third International Conference on Immunotherapy in Pediatric Oncology.

    abstract::The third International Conference on Immunotherapy in Pediatric Oncology was held in Frankfurt/Main, Germany, October 1-2, 2012. Major topics of the conference included (i) cellular therapies using antigen-specific and gene-modified T cells for targeting leukemia and pediatric solid tumors; (ii) overcoming hurdles an...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章

    doi:10.3109/08880018.2013.802106

    authors: Brehm C,Huenecke S,Pfirrmann V,Rossig C,Mackall CL,Bollard CM,Gottschalk S,Schlegel PG,Klingebiel T,Bader P

    更新日期:2013-08-01 00:00:00

  • Overview of clinical studies of childhood acute lymphoblastic leukemia for more than ten years by the Japanese Children's Cancer and Leukemia Study Group.

    abstract::Since 1981, the Children's Cancer and Leukemia Study Group (CCLSG) has developed a series of protocols for treatment of acute lymphoblastic leukemia (ALL) in childhood. In the first randomized controlled study of the 811 protocol (1981-1983) a comparison of conventional daily 6-mercaptopurine and methotrexate with a p...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章,评审

    doi:10.3109/08880019709030881

    authors: Koizumi S,Fujimoto T,Oka T,Watanabe S,Kikuta A,Tsuchiya T,Matsushita T,Asami K,Yanase T,Mimaya J,Ohta S,Miyake M,Nishikawa K,Furuyama T,Yamamura Y,Takaue Y,Ninomiya T,Shimokawa T,Iwai A,Ishida Y,Ariyoshi N,Kimur

    更新日期:1997-01-01 00:00:00

  • Specific deficit analyses in motor performance and quality of life of pediatric cancer patients--a cross-sectional pilot study.

    abstract::Although survival rates in childhood cancer have distinctly improved, pediatric cancer patients often experience various disease- and treatment-related side effects with long-term consequences. Despite current studies investigating inactivity and limitations in physical functioning and quality of life in pediatric can...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章

    doi:10.3109/08880018.2013.776155

    authors: Beulertz J,Bloch W,Prokop A,Baumann FT

    更新日期:2013-05-01 00:00:00

  • Fingolimod (FTY720) reduces viability and survival and increases histone H3 acetylation in medulloblastoma cells.

    abstract::Histone deacetylase inhibitors (HDACis) are epigenetic agents that display antitumor activities in experimental medulloblastoma (MB). Fingolimod (FTY720), an immunosuppressant agent currently used in the treatment of multiple sclerosis, also has anticancer actions and can act as an HDACi. Here we examined whether fing...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章

    doi:10.1080/08880018.2019.1699213

    authors: Perla AS,Fratini L,Cardoso PS,de Farias CB,da Cunha Jaeger M,Roesler R

    更新日期:2020-03-01 00:00:00

  • Causes for hospitalization and death in Iranian patients with β-thalassemia major.

    abstract::There are limited studies that have focused on the causes for hospitalization as an indicator of morbidity in patients with β-thalassemia major (BTM). A cross-sectional study was conducted to determine the main causes for hospitalization and death in hospitalized BTM patients in a referral hospital in Shiraz, southern...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章

    doi:10.3109/08880018.2010.503336

    authors: Bazrgar M,Peiravian F,Abedpour F,Karimi M

    更新日期:2011-03-01 00:00:00

  • Panel reactive antibody in thalassemic serum inhibits proliferation and differentiation of cord blood CD34+ cells in vitro.

    abstract::Thalassemic children are at a high risk of graft rejection in cord blood transplantation. To investigate this possible mechanism, the authors evaluated the effect of panel reactive antibody on the growth of CD34(+) cells in vitro. On semisolid medium, CD34(+) cells derived from cord blood were incubated with thalassem...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章

    doi:10.1080/08880010902976098

    authors: Fang JP,Xu LH,Yang XG,Wu YF,Weng WJ,Xu HG

    更新日期:2009-07-01 00:00:00

  • Efficacy and safety of human umbilical cord derived mesenchymal stem cell therapy in children with severe aplastic anemia following allogeneic hematopoietic stem cell transplantation: a retrospective case series of 37 patients.

    abstract::The treatment of pediatric severe aplastic anemia (SAA) with allogeneic hematopoietic stem cell transplantation (allo-HSCT), presents major challenges including the risks of graft failure, septic complications, and graft-versus-host disease (GVHD). Additive infusions of human umbilical cord derived mesenchymal stem ce...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章

    doi:10.3109/08880018.2013.867556

    authors: Si Y,Yang K,Qin M,Zhang C,Du Z,Zhang X,Liu Y,Yue Y,Feng Z

    更新日期:2014-02-01 00:00:00

  • A novel karyotype in acute myeloid leukemia with basophilia.

    abstract::Acute basophilic leukemia is a distinct entity of Acute Myeloid Leukemia (AML) with primary differentiation to basophils. Increased basophil count has been described in AML cases with translocation t(6;9)(p23;q34) or other chromosomal abnormalities. We describe a 15-year old female teenager with AML and excess periphe...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章

    doi:10.3109/08880018.2014.883655

    authors: Servitzoglou M,Grenzelia M,Baka M,Harisi M,Pourtsidis A,Bouhoutsou D,Varvoutsi M,Doganis D,Dana H,Divane A,Kosmidis H

    更新日期:2014-03-01 00:00:00

  • Neutrophil apoptosis in patients with beta-thalassemia major.

    abstract::Increased susceptibility to infection is reported in patients with beta-thalassemia major due to toxic effect of iron on neutrophil functions and reticuloendothelial system dysfunction. This study investigated the association between the neutrophil apoptosis and frequency of infection episodes, desferrioxamine treatme...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章

    doi:10.1080/713842280

    authors: Oren H,Sahin B,Irken G,Ateş H,Duman M,Yilmaz S,Türker M,Atabay B,Yaprak I

    更新日期:2003-04-01 00:00:00

  • Subnormal growth during puberty in children treated for acute lymphoblastic leukemia.

    abstract::Growth was studied longitudinally in 19 children who were long-term survivors after acute lymphoblastic leukemia (ALL). Of the children, 13 were girls; 6 were boys. They had all undergone a 3-year cytostatic treatment period which included vincristine, adriamycin, asparaginase, methotrexate, purinethol, and prednisone...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章

    doi:10.3109/08880019209016589

    authors: Sempoux P,Moëll C,Cornu G,Malvaux P,Maes M

    更新日期:1992-07-01 00:00:00

  • Pleuropulmonary blastoma: an aggressive intrathoracic neoplasm of childhood.

    abstract::A case of a 4-year-old girl with pleuropulmonary blastoma is reported. Surgical resection of the tumor was performed and histologic examination revealed pleuropulmonary blastoma with rhabdomyosarcomatous differentiation. Postoperative chemotherapy was administered and 3 weeks after initiation of treatment protocol a s...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章

    doi:10.1080/088800101750238568

    authors: Perdikogianni C,Stiakaki E,Danilatou V,Delides G,Kalmanti M

    更新日期:2001-06-01 00:00:00

  • Infections in childhood acute lymphoblastic leukemia: an analysis of 222 febrile neutropenic episodes.

    abstract::A retrospective analysis was performed on febrile neutropenic episodes in patients with acute lymphoblastic leukemia (ALL) from 1992 to 2002. There were 222 febrile neutropenic episodes in 266 ALL patients with documented ANC < 500/mm(3). Of the 222 episodes, 98 (44%) had documented focus of infection; the rest were f...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章

    doi:10.1080/08880010802106564

    authors: Bakhshi S,Padmanjali KS,Arya LS

    更新日期:2008-06-01 00:00:00

  • A case of acute lymphoblastic leukemia presenting as severe hypercalcemia.

    abstract::A 9-year-old girl presented at the Pediatric Emergency Department with an acute onset of gastrointestinal symptoms due to hypercalcemia. Despite the absence of circulating blast, bone marrow biopsy was diagnostic of acute lymphoblastic leukemia. The hypercalcemia was initially treated with intravenous hydration and fu...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章

    doi:10.1080/08880010490477248

    authors: Buonuomo PS,Ruggiero A,Piastra M,Riccardi R,Polidori G,Chiaretti A

    更新日期:2004-09-01 00:00:00

  • MRI changes in the "normal" pineal gland following chemotherapy for suprasellar germ cell tumors.

    abstract::Primary CNS germ cell tumors (GCT) arise in the suprasellar and pineal regions. Suprasellar GCT may remain radiographically occult during the early symptomatic period. Although theoretically possible, it is more difficult to identify presymptomatic disease in the pineal region. Given the sensitivity of GCT to cytotoxi...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章

    doi:10.1080/08880010701665777

    authors: MacDonald SM,Desai N,Heller G,Rolnitzky L,Allen JC

    更新日期:2008-01-01 00:00:00