The influence of risk factors in promoting thrombosis during childhood: the role of acquired factors.


:Thrombo-embolism in childhood is a multifactorial disorder. The present study is a case-control study that investigated the role of genetic and acquired risk factors in 60 children with thrombosis and compared the results with the controls. Acquired and inherited risk factors precipitating thrombosis were present in 75 and 40% of the thrombotic children, respectively. The most frequent acquired risk factor was infection (58%). Of the genetic factors, factor V G20210A was the most common (38%). The comparison of the genetic and acquired risk factors in thrombotic versus nonthrombotic settings identified that acquired factors played a more significant role in causing thrombosis (OR:14.44; 95% CI: 7.05-29.94, p < .001). This study has clearly suggested that the prevention of acquired risk factors, particularly infection, could decrease the risk of thrombosis in pediatric cases.


Pediatr Hematol Oncol


Günes AM,Baytan B,Günay U




Has Abstract


2006-07-01 00:00:00














  • Red blood cell distribution width is not a reliable biomarker for low iron stores in children with cystic fibrosis.

    abstract::Low iron stores in children, absolute iron deficiency (AID), can lead to impaired neurodevelopment and requires iron therapy. In the presence of infection/inflammation, like in cystic fibrosis (CF), serum ferritin (SF) is not a reliable biomarker for AID. Red blood cell distribution width (RDW) is a promising alternat...

    journal_title:Pediatric hematology and oncology

    pub_type: 临床试验,杂志文章


    authors: Akkermans MD,Uijterschout L,Nuijsink M,Hendriks DM,van Goudoever JB,Brus F

    更新日期:2017-02-01 00:00:00

  • Usefulness of positron emission tomography-CT for diagnosis of primary bone marrow lymphoma in children.

    abstract::Primary bone marrow lymphoma (PBML) is hard to diagnose in children, due to the difficult identification of malignant cells in bone marrow. The first case, a 5-year-old boy, showed knee swelling with an intermittent fever. The second case, a 12-year-old girl, showed fever of unknown origin without lymphadenopathy or h...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章


    authors: Moritani K,Nakano N,Yonezawa S,Ochi F,Tauchi H,Eguchi-Ishimae M,Eguchi M,Ishii E,Nagai K

    更新日期:2018-03-01 00:00:00

  • Multidisciplinary management of osteosarcoma: experience in Hong Kong.

    abstract::All pediatric osteosarcomas treated in our hospital between 1985 and 1995 were reviewed. There were 26 patients, 15 males and 11 females, aged 20 or less at diagnosis. All had limb primaries. Nineteen patients had localized disease and seven presented with metastases. Intensive multiagent chemotherapy was given both p...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章


    authors: Kwong DL,Ha SY,Chau KY,Choi PH,Chan GC,Kwong PW,Lau YL

    更新日期:1998-05-01 00:00:00

  • Relationship between modified CT severity index and clinical features of L-asparaginase-associated pancreatitis in pediatric acute lymphoblastic leukemia.

    abstract:PURPOSE:To describe clinical and CT features of L-asparaginase-associated pancreatitis (L-AP) and to correlate CT grades with clinical parameters. METHODS:A total of 16 children (M:F = 9:7; mean age, 8.1 years) who developed L-AP after L-asparaginase (L-asp) treatment and underwent abdominal CT scan were included. We ...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章


    authors: Oh HJ,Im SA,Lee JW,Chung NG,Cho B

    更新日期:2014-10-01 00:00:00

  • Molecular characterization of homozygous (high HbA2) beta-thalassemia intermedia in Greece.

    abstract::Homozygous beta-thalassemia is usually characterized by severe anemia requiring regular blood transfusion for survival. For homozygous patients with milder clinical manifestations and no dependence on transfusion therapy, the term thalassemia intermedia is usually applied. Genetic mechanisms that may ameliorate the cl...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章


    authors: Kanavakis E,Traeger-Synodinos J,Tzetis M,Metaxotou-Mavromati A,Ladis V,Kattamis C

    更新日期:1995-01-01 00:00:00

  • Association of maternal education with the neuroblastoma susceptibility in children: a meta-analysis.

    abstract::Maternal education might be an important factor for the neuroblastoma risk in children, but it was conflicting. This meta-analysis was performed to evaluate the relationship between maternal education and neuroblastoma susceptibility and to explore whether maternal education was an important indicator to be associated...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章,meta分析


    authors: Wang P,Liao N,Liao XH,Liang B,Huang CX,Li W

    更新日期:2013-02-01 00:00:00

  • Usefulness of power Doppler ultrasonography and superparamagnetic iron oxide enhanced magnetic resonance imaging for diagnosis of focal nodular hyperplasia of the liver after treatment of neuroblastoma.

    abstract::Focal nodular hyperplasia (FNH) of the liver is rare in children, and it is usually diagnosed through a biopsy of the liver or hepatectomy. The authors report a case of a 10-year-old girl with multiple focal nodular hyperplasia lesions of the liver after the completion of tumor therapy for advanced neuroblastoma, and ...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章


    authors: Sugito K,Kusafuka T,Kawashima H,Uekusa S,Furuya T,Ohashi K,Inoue M,Ikeda T,Koshinaga T,Maebayashi T

    更新日期:2010-04-01 00:00:00

  • Avascular necrosis of femoral head as the initial manifestation of CML.

    abstract::A 12-year-old female is reported who presented with right hip pain for 6 months. With massive splenohepatomegaly and leukocytosis, CML was suspected and confirmed on bone-marrow examination and cytogenetics. Further investigations confirmed avascular necrosis (AVN) of the right femoral head. CML was treated by hydroxy...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章


    authors: Kumar S,Bansal D,Prakash M,Sharma P

    更新日期:2014-09-01 00:00:00

  • Clinical and genetic studies of familial hemophagocytic lymphohistiocytosis in Oman: need for early treatment.

    abstract::Hemophagocytic lymphohistiocytosis (HLH) embraces the frequently indistinguishable conditions of familial hemophagocytic lymphohistiocytosis (FHL) and virus-associated hemophagocytic syndrome (VAHS). Without therapy FHL is invariably fatal, but successful therapy, including chemotherapy and immunotherapy followed by b...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章


    authors: Al-Lamki Z,Wali YA,Pathare A,Ericson KG,Henter JI

    更新日期:2003-12-01 00:00:00

  • Efficacy and safety of human umbilical cord derived mesenchymal stem cell therapy in children with severe aplastic anemia following allogeneic hematopoietic stem cell transplantation: a retrospective case series of 37 patients.

    abstract::The treatment of pediatric severe aplastic anemia (SAA) with allogeneic hematopoietic stem cell transplantation (allo-HSCT), presents major challenges including the risks of graft failure, septic complications, and graft-versus-host disease (GVHD). Additive infusions of human umbilical cord derived mesenchymal stem ce...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章


    authors: Si Y,Yang K,Qin M,Zhang C,Du Z,Zhang X,Liu Y,Yue Y,Feng Z

    更新日期:2014-02-01 00:00:00

  • The efficacy of heparinization in prolonging patency of arterial and central venous catheters in children: a randomized double-blind trial.

    abstract::This study evaluates the efficacy of heparinization in prolonging patency of arterial and central venous catheters in children. A randomized double-blind trial in a tertiary 10-bed pediatric intensive care unit was used to evaluate 300 children (age older than 4 weeks, younger than 18 years). Trial medication consiste...

    journal_title:Pediatric hematology and oncology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: de Neef M,Heijboer H,van Woensel JB,de Haan RJ

    更新日期:2002-12-01 00:00:00

  • Soft tissue density variations in thalassemia major: a possible pitfall in lumbar bone mineral density measurements by dual-energy X-ray absorptiometry.

    abstract::Osteoporosis is common in patients with thalassemia major. A 16-year-old patient with thalassemia major was referred for evaluation of osteoporosis. The results of dual-energy X-ray absorptiometry in a patient with thalassemia major are presented. The patient underwent measurements of the spine in both AP and lateral ...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章


    authors: Yildiz M,Canatan D

    更新日期:2005-12-01 00:00:00

  • Splenic angiomatoid nodular transformation in a child with increased erythrocyte sedimentation rate.

    abstract::An 11-year-old girl was referred to the authors' hospital with a complaint of growth retardation. Physical examination revealed splenomegaly. Laboratory examination revealed increased sedimentation rate. Her imaging studies showed a splenic mass. Splenectomy was performed and histopathological examination revealed scl...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章


    authors: Kuybulu A,Sipahi T,Topal I,Uner A

    更新日期:2009-10-01 00:00:00

  • Fever and neutropenia hospital discharges in children with cancer: A 2012 update.

    abstract::Fever and neutropenia (FN) is a common precipitant for hospitalization among children with cancer, but hospital utilization trends are not well described. This study describes national trends for hospital discharges for FN among children with cancer for the year 2012, compared with the authors' previous analysis from ...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章,多中心研究


    authors: Mueller EL,Croop J,Carroll AE

    更新日期:2016-02-01 00:00:00

  • Increased urinary HVA levels in neuroblastoma screens related to diet, not tumor.

    abstract::At present, urinary vanillylmandelic acid (VMA) and/or homovanillic acid (HVA), metabolites of catecholamines, are the most sensitive diagnostic markers of neuroblastoma. They can be measured by the high-performance liquid chromatographic method, which has been used to screen for neuroblastoma in infants in Japan. Fro...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章


    authors: Numata K,Kusui H,Kawakatsu H,Kizaki Z,Sawada T

    更新日期:1997-11-01 00:00:00

  • Late effects of treatment for wilms tumor.

    abstract::Advancements in surgery, radiotherapy, and chemotherapy have greatly improved the cures rates for children with Wilms tumor. However, a number of therapy-related late effects have been observed in long-term survivors. Generally, late complications are a consequence of treatment type and intensity; the use of radiother...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章,评审


    authors: Wright KD,Green DM,Daw NC

    更新日期:2009-09-01 00:00:00

  • Low vitamin D levels are associated with both iron deficiency and anemia in children and adolescents.

    abstract:BACKGROUND:We aimed to examine the association between vitamin D deficiency and anemia in a nationally representative sample of Korean children and adolescents. METHODS:Cross-sectional data on 2526 children and adolescents aged 10-20 years from the Korea National Health and Nutrition Examination Survey-V (2010-2012) w...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章,多中心研究


    authors: Lee JA,Hwang JS,Hwang IT,Kim DH,Seo JH,Lim JS

    更新日期:2015-03-01 00:00:00

  • Practice guidelines in pediatric hematooncology: implementation and survey. A possible way for medical quality assurance.

    abstract::The Hungarian Pediatric Oncology Working Group intended to change the practice of prescribing diagnostic tests as well as to examine the possibility of introducing indicators about the time factors of medical care. A nationwide accepted protocol was established for these tests. The examined time factors were the lengt...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章


    authors: Pásztélyi Z,Schuler D,Czvenits E

    更新日期:2000-12-01 00:00:00

  • 3,4-dihydroxyphenylalanine (DOPA) metabolism in screening-detected and non-screening-detected neuroblastoma.

    abstract::To investigate the possible clinical application of the hypothesis that insufficient induction of 3,4-dihydroxyphenylalanine decarboxylase (DDC) causes accumulation and secretion of 3,4-dihydroxyphenylalanine (DOPA) in unfavorable neuroblastomas, we measured plasma DOPA in 28 neuroblastoma patients. Abnormally high le...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章


    authors: Ikeda H,Suzuki N,Takahashi A,Kuroiwa M,Matsuyama S

    更新日期:1996-01-01 00:00:00

  • An analysis of children with brucellosis associated with pancytopenia.

    abstract::Brucellosis produces a variety of nonspecific hematologic abnormalities. Hematologic complications of mild anemia and leukopenia have been frequently associated with acute brucellosis, but pancytopenia is less frequently seen. In this study, records of children with brucellosis aged under or equal to 16 years, admitte...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章


    authors: Akbayram S,Dogan M,Akgun C,Peker E,Parlak M,Caksen H,Oner AF

    更新日期:2011-04-01 00:00:00

  • Management of plexiform neurofibroma with interferon alpha.

    abstract::Plexiform neurofibroma is a relatively common but potentially devastating manifestation of neurofibromatosis type 1 (NF 1). A substantial number of plexiform neurofibroma causes morbidity. Various treatment modalities are considered to decrease pain. In this paper a case with plexiform neurofibroma causing severe pain...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章


    authors: Citak EC,Oguz A,Karadeniz C,Okur A,Memis L,Boyunaga O

    更新日期:2008-09-01 00:00:00

  • Relapse of primitive mediastinal lymphoma as a myeloid mass following beam autologous transplant and subsequent refractoriness to matched unrelated umbilical cord blood allograft.

    abstract::Outlining the treatment for an unclassifiable lymphoid malignancy is often difficult. A highly undifferentiated lymphomatous mass that relapsed in spite of intense chemotherapy and autologous transplant is reported. At relapse, there was differentiation into myeloid lineage. Though remission was achieved with AML-type...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章


    authors: Anoop P,Lancaster DL,Ethell ME,Potter MN,Wotherspoon A

    更新日期:2009-03-01 00:00:00

  • Clear cell sarcoma: a dilemma on pathological staging and clinical management.

    abstract::Clear cell sarcoma of the kidney (CCSK) has been classified as high risk tumour in the previous UK and international Wilms tumor studies. The current Society of Paediatric Oncology (SIOP) trial, UK version, advocates chemotherapy including doxorubicin prior to nephrectomy. Pathological staging and histology of the res...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章


    authors: Ng A,Jenkinson H,Morland B,Grundy R

    更新日期:2005-04-01 00:00:00

  • Usefulness of red cell zinc protoporphyrin concentration in the investigation of microcytosis in children.

    abstract::The clinical usefulness of the measurement of red cell zinc protoporphyrin (ZPP), an indicator of iron-deficient erythropoiesis, was assessed in a group of UK children undergoing investigation for red cell microcytosis. Of 213 children studied, 136 had increased ZPP values. Of these, 86 also had reduced iron stores as...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章


    authors: Hinchliffe RF,Lilleyman JS,Steel GJ,Bellamy GJ

    更新日期:1995-09-01 00:00:00

  • Etiology, drug sensitivity profiles and clinical outcome of bloodstream infections: A retrospective study of 784 pediatric patients with hematological and neoplastic diseases.

    abstract::Bloodstream infections (BSI) represent one of the most serious complications in patients in the hematology-oncology unit. In this study, the prevalence, distribution, drug sensitivity profiles, and clinical outcome of BSI were analyzed in pediatric patients with hematological malignancies. Patients admitted to the ped...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章


    authors: Chen S,Liu S,Yuan X,Mai H,Lin J,Wen F

    更新日期:2019-11-01 00:00:00

  • Panel reactive antibody in thalassemic serum inhibits proliferation and differentiation of cord blood CD34+ cells in vitro.

    abstract::Thalassemic children are at a high risk of graft rejection in cord blood transplantation. To investigate this possible mechanism, the authors evaluated the effect of panel reactive antibody on the growth of CD34(+) cells in vitro. On semisolid medium, CD34(+) cells derived from cord blood were incubated with thalassem...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章


    authors: Fang JP,Xu LH,Yang XG,Wu YF,Weng WJ,Xu HG

    更新日期:2009-07-01 00:00:00

  • Euthyroid sick syndrome in children with Hodgkin disease.

    abstract::Euthyroid sick syndrome is related to profound changes in thyroid metabolism induced by nonthyroidal diseases. To determine whether children with newly diagnosed Hodgkin disease might present thyroid abnormalities and to establish their predictive value, the authors performed regular thyroid function testing. Seven ch...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章


    authors: Mohn A,Di Marzio A,Cerruto M,Angrilli F,Fioritoni C,Chiarelli F

    更新日期:2001-04-01 00:00:00

  • Intrathecal chemotherapy-related myeloencephalopathy in a young child with acute lymphoblastic leukemia.

    abstract::Since the mid-1960s intrathecal chemotherapy (methotrexate [MTX], cytarabine [Ara-C], or both, plus hydrocortisone) has constituted the standard approach to prophylaxis and treatment of central nervous system (CNS) leukemia and lymphoma. Intrathecal chemotherapy-related neurotoxicity has been described in a variable p...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章


    authors: García-Tena J,López-Andreu JA,Ferrís J,Menor F,Mulas F,Millet E,Verdeguer A

    更新日期:1995-07-01 00:00:00

  • Prognostic significance of adenosine deaminase in children with malignancies.

    abstract::In 33 children, 23 with acute lymphoblastic leukemia (ALL) and 10 with solid tumors, the phenotype of the enzyme adenosine deaminase (ADA) was detected in the erythrocytes by electrophoresis in cellulose acetate. In all children the ADA enzyme activity was also determined in the plasma by spectrophotometry at the onse...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章


    authors: Hatzistilianou M,Athanassiadou F,Catriu D,Makedou A,Hitoglou S,Papaeconomou A

    更新日期:1996-07-01 00:00:00

  • The clinical findings and prophylactic treatment in children with factor X deficiency.

    abstract::Factor X (FX) is the component of both extrinsic and intrinsic coagulation cascade and is the first enzyme of the common pathway which results in thrombus. Congenital FX deficiency (FXD) is an extremely rare coagulation defect. In this study, we aimed to investigate the clinical and laboratory data of the patients dia...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章


    authors: Karabel M,Söker M,Yıldırım AT,Oymak Y,Kelekçi S,Karabel D

    更新日期:2013-11-01 00:00:00