The influence of risk factors in promoting thrombosis during childhood: the role of acquired factors.

Abstract:

:Thrombo-embolism in childhood is a multifactorial disorder. The present study is a case-control study that investigated the role of genetic and acquired risk factors in 60 children with thrombosis and compared the results with the controls. Acquired and inherited risk factors precipitating thrombosis were present in 75 and 40% of the thrombotic children, respectively. The most frequent acquired risk factor was infection (58%). Of the genetic factors, factor V G20210A was the most common (38%). The comparison of the genetic and acquired risk factors in thrombotic versus nonthrombotic settings identified that acquired factors played a more significant role in causing thrombosis (OR:14.44; 95% CI: 7.05-29.94, p < .001). This study has clearly suggested that the prevention of acquired risk factors, particularly infection, could decrease the risk of thrombosis in pediatric cases.

journal_name

Pediatr Hematol Oncol

authors

Günes AM,Baytan B,Günay U

doi

10.1080/08880010600646324

subject

Has Abstract

pub_date

2006-07-01 00:00:00

pages

399-410

issue

5

eissn

0888-0018

issn

1521-0669

pii

P123MTN60155V55W

journal_volume

23

pub_type

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