Inflammatory and immune response genes: A genetic analysis of inhibitor development in Iranian hemophilia A patients.

abstract：:Adrenocortical carcinoma (ACC) is a rare, aggressive endocrine neoplasm. Complete surgical resection is the single most important treatment. Most available information has been learned from experience with its more frequent adult counterpart. In this study, we assessed the features and survival outcome of patients wit...

journal_title：Pediatric hematology and oncology

authors： Zekri W,Hammad M,Rashed WM,Ahmed G,Elshafie M,Adly MH,Elborai Y,Abdalla B,Taha H,Elkinaae N,Refaat A,Younis A,Alfaar AS

更新日期：2020-04-01 00:00:00

abstract：:We report the outcome of 27 children with de novo acute megakaryoblastic leukemia (AMKL) (excluding Down syndrome) enrolled in the French multicenter prospective study ELAM02 (2005-2011). There was no difference in gender, initial leukocyte count, CNS involvement, and complete remission rate (88.9%), as compared to ot...

journal_title：Pediatric hematology and oncology

authors： Teyssier AC,Lapillonne H,Pasquet M,Ballerini P,Baruchel A,Ducassou S,Fenneteau O,Petit A,Cuccuini W,Ragu C,Preudhomme C,Mercher T,Sirvent N,Leverger G

更新日期：2017-11-01 00:00:00

abstract：:Factor X (FX) is the component of both extrinsic and intrinsic coagulation cascade and is the first enzyme of the common pathway which results in thrombus. Congenital FX deficiency (FXD) is an extremely rare coagulation defect. In this study, we aimed to investigate the clinical and laboratory data of the patients dia...

journal_title：Pediatric hematology and oncology

authors： Karabel M,Söker M,Yıldırım AT,Oymak Y,Kelekçi S,Karabel D

更新日期：2013-11-01 00:00:00

abstract：:At present, urinary vanillylmandelic acid (VMA) and/or homovanillic acid (HVA), metabolites of catecholamines, are the most sensitive diagnostic markers of neuroblastoma. They can be measured by the high-performance liquid chromatographic method, which has been used to screen for neuroblastoma in infants in Japan. Fro...

journal_title：Pediatric hematology and oncology

authors： Numata K,Kusui H,Kawakatsu H,Kizaki Z,Sawada T

更新日期：1997-11-01 00:00:00

abstract：:A 20-year-old female developed a relapse of B-precursor acute lymphoblastic leukemia (ALL) as a mass in her left breast after 6 years of maintained continuous complete remission. No leukemic lesions were identified in other sites such as the bone marrow or cerebrospinal fluid. The relapsed leukemic cells in the breast...

journal_title：Pediatric hematology and oncology

authors： Todo K,Morimoto A,Osone S,Nukina S,Ohtsuka T,Ishida H,Yoshihara T,Todo S

更新日期：2008-09-01 00:00:00

abstract：:Bloodstream infections (BSI) represent one of the most serious complications in patients in the hematology-oncology unit. In this study, the prevalence, distribution, drug sensitivity profiles, and clinical outcome of BSI were analyzed in pediatric patients with hematological malignancies. Patients admitted to the ped...

journal_title：Pediatric hematology and oncology

authors： Chen S,Liu S,Yuan X,Mai H,Lin J,Wen F

更新日期：2019-11-01 00:00:00

abstract：:The aim of this study was to evaluate children with lymphadenopathy and clinical approach to the suspicion of malignancy. The authors evaluated 457 patients with peripheral lymphadenopathy, less than 19 years of age, and referred to the Pediatric Oncology Department of Gazi University Medical School during the periods...

journal_title：Pediatric hematology and oncology

authors： Oguz A,Karadeniz C,Temel EA,Citak EC,Okur FV

更新日期：2006-10-01 00:00:00

abstract：:A recently isolated peptide hormone, hepcidin, is thought to be the principal regulator of iron homeostasis. Hepcidin acts by limiting intestinal iron absorption and promoting iron retention in reticuloendothelial cells. Its precursor peptide form is called pro-hepcidin. The aims of this study were to determine serum ...

journal_title：Pediatric hematology and oncology

authors： Tiker F,Celik B,Tarcan A,Kilicdag H,Ozbek N,Gurakan B

更新日期：2006-06-01 00:00:00

abstract：:A method is described to estimate MYCN (N-myc) oncogene amplification in neuroblastoma by the technique of differential polymerase chain reaction (PCR). The technique is quicker than conventional Southern blotting techniques and does not require radioactive materials. The ability to measure MYCN amplification from sma...

journal_title：Pediatric hematology and oncology

authors： Huddart SN,Mann JR,McGukin AG,Corbett R

更新日期：1993-01-01 00:00:00

abstract：:We report a patient who developed chronic myelogenous leukemia (CML) at 12 months of age. She was treated aggressively with stem cell transplant (SCT), interferon, donor lymphocytes and imatinib, with subsequent molecular progression. She received dasatinib, achieving a complete molecular response. Dasatinib was disco...

journal_title：Pediatric hematology and oncology

authors： Triche L,Yarbrough A,Roth M,Ying A,Wells R

更新日期：2020-08-01 00:00:00

abstract：:Primary CNS germ cell tumors (GCT) arise in the suprasellar and pineal regions. Suprasellar GCT may remain radiographically occult during the early symptomatic period. Although theoretically possible, it is more difficult to identify presymptomatic disease in the pineal region. Given the sensitivity of GCT to cytotoxi...

journal_title：Pediatric hematology and oncology

authors： MacDonald SM,Desai N,Heller G,Rolnitzky L,Allen JC

更新日期：2008-01-01 00:00:00

abstract：:A case of eosinophilic meningitis 2 months before the appearance of lymphoblasts in the cerebrospinal fluid is described in a child with acute lymphoblastic leukemia (ALL). The peripheral blood showed no simultaneous eosinophilia. The child was successfully treated for her CNS relapse, and complete remission was easil...

journal_title：Pediatric hematology and oncology

authors： Behrendt H,de Korte D,van Gennip AH,van Leeuwen EF

更新日期：1987-01-01 00:00:00

abstract：:Six transfusion-dependent beta-thalassemia major patients were treated with allogeneic peripheral blood stem cell (PBSC) transplant. The donors were HLA identical siblings except one donor who was a father with one-antigen mismatch of HLA-B loci. The donors were mobilized with G-CSF and PBSC was infused without manipu...

journal_title：Pediatric hematology and oncology

authors： Fang J,Huang S,Chen C,Zhou D,Wu Y,Bao R

更新日期：2002-10-01 00:00:00

abstract：:Endothelial protein C receptor (EPCR) is primarily localized on the endothelial cells of large blood vessels and is very low or absent in the microvascular endothelium of most tissues. EPCR augments the thrombin/thrombomodulin-dependent activation of protein C by 5- to 20-fold. EPCR appears to be physiologically signi...

journal_title：Pediatric hematology and oncology

authors： Kendirli T,Ciftçi E,Ince E,Yurdakul E,Kansu A,Akar N

更新日期：2007-04-01 00:00:00

abstract：:A prospective, open-label, randomized, comparative study in pediatric cancer patients was conducted to evaluate the efficacy and safety of cefepime and meropenem in the empiric therapy of febrile neutropenic patients. Febrile episodes were classified as microbiologically documented infection, clinical documented infec...

journal_title：Pediatric hematology and oncology

authors： Oguz A,Karadeniz C,Citak EC,Cil V,Eldes N

更新日期：2006-04-01 00:00:00

abstract：AIM:To standardize diagnosis and treatment of childhood Wilms tumor (WT) in Turkey. METHODS AND PATIENTS:Between 1998 and 2006, WT patients were registered from 19 centers. Patients <16 years with unilateral WT whose treatment started in first postoperative 3 weeks were included. Treatments were stage I favorable (FH)...

journal_title：Pediatric hematology and oncology

authors： Akyüz C,Yalçin B,Yildiz I,Hazar V,Yörük A,Tokuç G,Akici F,Büyükpamukçu N,Kale G,Atahan L,Büyükünal C,Dervişoğlu S,Atkovar GA,Melikoğlu M,Karpuzoğlu G,Olgun N,Ayan I,Oğuz A,Yariş N,Dağdemir A,Darendeliler E,Sande

更新日期：2010-04-01 00:00:00

abstract：:This is a report of a case of acute respiratory failure following the administration of intrathecal methotrexate (MTX) for prophylaxis of central nervous system leukemia (CNS) in a 3-year-old girl with acute lymphoblastic leukemia. This could be attributed to acute metabolic or direct toxic effects of methotrexate to ...

journal_title：Pediatric hematology and oncology

authors： Martins da Cunha AC,Bartsch CH,Gadner H

更新日期：1990-01-01 00:00:00

abstract：:Focal nodular hyperplasia (FNH) of the liver is rare in children, and it is usually diagnosed through a biopsy of the liver or hepatectomy. The authors report a case of a 10-year-old girl with multiple focal nodular hyperplasia lesions of the liver after the completion of tumor therapy for advanced neuroblastoma, and ...

journal_title：Pediatric hematology and oncology

authors： Sugito K,Kusafuka T,Kawashima H,Uekusa S,Furuya T,Ohashi K,Inoue M,Ikeda T,Koshinaga T,Maebayashi T

更新日期：2010-04-01 00:00:00

abstract：:A case of angioimmunoblastic lymphadenopathy with dysproteinemia (AILD) in infancy is reported. The disease had a mild onset with generalized lymphadenopathy, hepatosplenomegaly, thrombocytopenia, polyclonal hypergammaglobulinemia, and T-cell deficiency. The AILD course lasted more than 100 months, alternating clinica...

journal_title：Pediatric hematology and oncology

authors： de Terlizzi M,Toma MG,Santostasi T,Colella R,Ceci A,De Benedictis G

更新日期：1989-01-01 00:00:00

abstract：:In this study, we aimed to determine serum adrenomedullin levels and compare them with levels of C-reactive protein (CRP) and procalcitonin (PCT). Cancer patients aged 0-18 years who experienced febrile neutropenia attacks were included in the study. Adrenomedullin, CRP, and PCT were analyzed at admission, day 3, and ...

journal_title：Pediatric hematology and oncology

authors： Demirkaya M,Tugcu D,Akcay A,Aydogan G,Akıcı F,Salcioglu Z,Ekmekci H,Sevinir B,Balci Ekmekci O

更新日期：2015-01-01 00:00:00

abstract：:In patients undergoing bone marrow transplantation cryptococcosis is rarely encountered. We report a fatal case of Cryptococcus meningitis in a 12-year-old girl with acute lymphoblastic leukemia (ALL) in second remission who had a transplant from a human leukocyte antigen (HLA)-identical unrelated bone marrow donor. T...

journal_title：Pediatric hematology and oncology

authors： Miniero R,Nesi F,Vai S,De Intinis G,Papalia F,Targhetta R,Busca A,Vassallo E,Giacchino M

更新日期：1997-09-01 00:00:00

abstract：:In five patients under the age of 15 with hemophilia and inhibitors, due to frequent joint bleedings, 13 joints were treated with synoviorthesis (intra-articular injection of radioactive gold). The patients received high doses of factor VIII/IX for 2-4 days or were treated simultaneously with tolerance induction accor...

journal_title：Pediatric hematology and oncology

authors： Löfqvist T,Petersson C

更新日期：1992-04-01 00:00:00

abstract：:Twenty-eight children with HSP and 79 healthy children were entered into study. Activities of protein C, free-protein S and antithrombin, activated protein C resistance, levels of fibrinogen. D-dimer, thrombin-antithrombin complex (TAT), prothrombin fragments 1 + 2 (PF(1+2)), and von Willebrand factor antigen (vWAg) a...

journal_title：Pediatric hematology and oncology

authors： Yilmaz D,Kavakli K,Ozkayin N

更新日期：2005-01-01 00:00:00

abstract：:The aim of this study was to establish reference values and factors associated with serum AFP elevation in infants. Five hundred twenty-four samples collected from infants up to the age of 2 years at the University Hospital Düsseldorf (Germany) were analyzed. At birth mean serum AFP levels were 41,687 ng/ml in 256 ter...

journal_title：Pediatric hematology and oncology

authors： Blohm ME,Vesterling-Hörner D,Calaminus G,Göbel U

更新日期：1998-03-01 00:00:00

abstract：:The increased incidence of malignancies, especially acute leukemia, in Down syndrome has been clearly established. The association of Hodgkin's disease with Down syndrome has not been extensively documented, and only a few cases have been reported. We present here a case report of Hodgkin's disease in an 11-year-old f...

journal_title：Pediatric hematology and oncology

authors： Kusumakumary P,Jyothirmayi R,Chellam VG,Krishnan NM

更新日期：1996-09-01 00:00:00

abstract：:To determine treatment outcome using ceftazidime-aminoglycosides in febrile neutropenic children with cancer, the authors conducted a prospective cohort study in 216 episodes. Early and complete responses to antibiotics were 108/216 (50.0%) and 133/216 (61.6%) episodes, respectively. Death, a modification of antibioti...

journal_title：Pediatric hematology and oncology

authors： Laoprasopwattana K,Pruekprasert P,Laosombat V,Wongchanchailert M

更新日期：2007-12-01 00:00:00

abstract：:Between 1973 and 1991, 10 patients with locally advanced [stages III and IV] nasopharyngeal carcinoma were treated at the Northern Israel Oncology Center. All patients were treated with wide-field irradiation to the primary tumor, including the base of skull, neck, and supraclavicular region. After 1984, 6 patients al...

journal_title：Pediatric hematology and oncology

authors： Arush MW,Stein ME,Rosenblatt E,Lavie R,Kuten A

更新日期：1995-05-01 00:00:00

abstract：:All pediatric osteosarcomas treated in our hospital between 1985 and 1995 were reviewed. There were 26 patients, 15 males and 11 females, aged 20 or less at diagnosis. All had limb primaries. Nineteen patients had localized disease and seven presented with metastases. Intensive multiagent chemotherapy was given both p...

journal_title：Pediatric hematology and oncology

authors： Kwong DL,Ha SY,Chau KY,Choi PH,Chan GC,Kwong PW,Lau YL

更新日期：1998-05-01 00:00:00

abstract：:Twelve cases of neuroblastoma (NB) (7 boys and 5 girls) and 4 cases of primitive peripheral neuroectodermal tumor (PNET) (3 boys and 1 girl) were investigated for the presence of apoptosis and retinoic acid receptor (RAR) by immunhistochemical method. The apoptotic index in NB was zero or 1% in 8 children and relative...

journal_title：Pediatric hematology and oncology

authors： Farid P,Babosa M,Hauser P,Schuler D,Szende B

更新日期：2000-06-01 00:00:00

abstract：:A 9-year-old girl presented at the Pediatric Emergency Department with an acute onset of gastrointestinal symptoms due to hypercalcemia. Despite the absence of circulating blast, bone marrow biopsy was diagnostic of acute lymphoblastic leukemia. The hypercalcemia was initially treated with intravenous hydration and fu...

journal_title：Pediatric hematology and oncology

authors： Buonuomo PS,Ruggiero A,Piastra M,Riccardi R,Polidori G,Chiaretti A

更新日期：2004-09-01 00:00:00