Nutritional vitamin B12 deficiency in infancy: three case reports and a review of the literature.

Abstract:

:Three cases of vitamin B12 deficiency that occurred during infancy are presented. These cases appeared to be the result of pre-existing maternal deficiency. All three infants demonstrated evidence of neurodevelopmental delay at presentation, and one had sustained loss of milestones and developed involuntary motor movements. Prior to the initiation of therapy, all three infants were anemic: one was thrombocytopenic and one pancytopenic. In all three cases the hematologic and neurologic abnormalities were corrected with vitamin B12 therapy. The literature is reviewed and discussed with respect to the mechanism of the infants' vitamin B12 deficiency and neurodevelopmental manifestations.

journal_name

Pediatr Hematol Oncol

authors

Doyle JJ,Langevin AM,Zipursky A

doi

10.3109/08880018909034282

subject

Has Abstract

pub_date

1989-01-01 00:00:00

pages

161-72

issue

2

eissn

0888-0018

issn

1521-0669

journal_volume

6

pub_type

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