Abstract:
:A high (18)F-fluorodeoxyglucose (FDG) uptake by positron emission tomography/computed tomography (PET/CT) imaging in sarcomas of adults has been reported. The current study aimed at defining the degree of (18)F-FDG uptake of pediatric sarcomas. This retrospective study included 29 patients (23 males, 6 females; mean age 14 ± 5 years) with soft tissue (n = 9) or bone (n = 20) sarcomas. Twenty-two patients (76%) underwent (18)F-FDG PET/CT and 7 (24%) had dedicated (18)F-FDG PET studies. Tumor (18)F-FDG uptake was quantified by standard uptake value (SUV)(max) and tumor-to-liver ratios (SUV ratios; tumor SUV(max)/liver SUV(mean)). Tumor SUV(max) and SUV ratios were correlated with tumor Ki-67 expression. SUV(max) ranged from 1.4 to 24 g/mL (median 2.5 g/mL) in soft tissue sarcomas and 1.6 to 20.4 g/mL (median 6.9 g/mL) in bone sarcomas (P = .03), and from 1.6 to 9.2 g/mL (median 3.9 g/mL) and 3.5 to 20.4 g/mL (median 12 g/mL) in Ewing sarcoma and osteosarcoma, respectively (P = .009). Tumor SUV ratios ranged from 0.8 to 8.7 (median 1.9) in soft tissue sarcomas and 1.4 to 8.9 (median 3.8) in bone sarcomas (P = .08). Ewing sarcoma had a significantly lower tumor SUV ratio than osteosarcoma (P = .01). Ki-67 expression correlated significantly with the (18)F-FDG uptake in bone but not in soft tissue sarcomas. All sarcomas were visualized by (18)F-FDG PET/CT imaging. A higher (18)F-FDG uptake was observed in osteosarcoma than in Ewing and soft tissue sarcomas. The results of this study suggest that the degree of tumor (18)F-FDG uptake is sufficient to allow for monitoring of therapeutic responses in pediatric sarcomas.
journal_name
Pediatr Hematol Oncoljournal_title
Pediatric hematology and oncologyauthors
Walter F,Federman N,Apichairuk W,Nelson S,Phelps ME,Allen-Auerbach M,Walter MA,Czernin Jdoi
10.3109/08880018.2011.602180subject
Has Abstractpub_date
2011-10-01 00:00:00pages
579-87issue
7eissn
0888-0018issn
1521-0669journal_volume
28pub_type
杂志文章abstract::Outlining the treatment for an unclassifiable lymphoid malignancy is often difficult. A highly undifferentiated lymphomatous mass that relapsed in spite of intense chemotherapy and autologous transplant is reported. At relapse, there was differentiation into myeloid lineage. Though remission was achieved with AML-type...
journal_title:Pediatric hematology and oncology
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journal_title:Pediatric hematology and oncology
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journal_title:Pediatric hematology and oncology
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journal_title:Pediatric hematology and oncology
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journal_title:Pediatric hematology and oncology
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journal_title:Pediatric hematology and oncology
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journal_title:Pediatric hematology and oncology
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journal_title:Pediatric hematology and oncology
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journal_title:Pediatric hematology and oncology
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journal_title:Pediatric hematology and oncology
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journal_title:Pediatric hematology and oncology
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journal_title:Pediatric hematology and oncology
pub_type: 临床试验,杂志文章
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更新日期:2002-04-01 00:00:00
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journal_title:Pediatric hematology and oncology
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journal_title:Pediatric hematology and oncology
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更新日期:1993-07-01 00:00:00
abstract::The malignant cells of childhood acute lymphoblastic leukemia (ALL) do not form a homogenous entity but a collection of differently maturated blasts. The most immature leukemia cells may be more resistant to therapy than the bulk of more differentiated blasts. We studied 42 patients with childhood ALL treated accordin...
journal_title:Pediatric hematology and oncology
pub_type: 临床试验,杂志文章
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更新日期:2014-05-01 00:00:00
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journal_title:Pediatric hematology and oncology
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journal_title:Pediatric hematology and oncology
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journal_title:Pediatric hematology and oncology
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journal_title:Pediatric hematology and oncology
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journal_title:Pediatric hematology and oncology
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journal_title:Pediatric hematology and oncology
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journal_title:Pediatric hematology and oncology
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journal_title:Pediatric hematology and oncology
pub_type: 临床试验,杂志文章
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journal_title:Pediatric hematology and oncology
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journal_title:Pediatric hematology and oncology
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