Avascular necrosis of femoral head as the initial manifestation of CML.

abstract：:Methotrexate (MTX) is an antimetabolite with a major role in the treatment of acute lymphoblastic leukaemia (ALL). The authors report the management of a 9-year-old boy who developed an anaphylactoid reaction to high-dose MTX infusion, after a first challenge with intrathecal administration, during induction therapy f...

journal_title：Pediatric hematology and oncology

authors： Caldeira T,Costa V,Silva I,Oliva T,Norton L

更新日期：2008-03-01 00:00:00

abstract：OBJECTIVES:Recent guidelines recommend to assess emotional distress in pediatric oncology during treatment and in after care. One tool used to do this is the distress thermometer (DT), a simple tool which has almost exclusively been studied in its screening abilities. Given its increased used as a measure of distress p...

journal_title：Pediatric hematology and oncology

authors： Pépin AJ,Lippé S,Krajinovic M,Laverdière C,Michon B,Sinnett D,Sultan S

更新日期：2017-04-01 00:00:00

abstract：:Ataxia-telangiectasia is an autosomal recessive disease characterized by progressive cerebellar ataxia, oculocutaneous telangiectasia, immunodeficiency, high incidence of cancer, and increased sensitivity to ionizing radiation. The authors report a case of dysgerminoma in a child with high alpha-fetoprotein, CA125 and...

journal_title：Pediatric hematology and oncology

authors： Koksal Y,Caliskan U,Ucar C,Yurtcu M,Artac H,Ilerisoy-Yakut Z,Reisli I

更新日期：2007-09-01 00:00:00

abstract：:Beta-thalassemia major is a severe, transfusion-dependent anemia that also causes infertility due to iron deposition to endocrine organs after overtransfusion. Very few pregnancies have been reported among such patients after modern therapies. In this study, 32 women with thalassemia who were admitted to Ali Asghar Ch...

journal_title：Pediatric hematology and oncology

authors： Ansari S,Azarkeivan A,Tabaroki A

更新日期：2006-01-01 00:00:00

abstract：:A discussion of a 5-year-old child with congenital hemolytic anemia and severe hypotonia caused by triosephosphate (TPI) deficiency is presented. The complexities in the diagnosis and management of this condition is discussed and the relevant literature is reviewed. ...

journal_title：Pediatric hematology and oncology

authors： Linarello RE,Shetty AK,Thomas T,Warrier RP

更新日期：1998-11-01 00:00:00

abstract：:The treatment of a child with a relapsed state acute leukemia after allogeneic stem cell transplantation (allo-SCT) is a challenge. The authors report about a child with an acute myelogenous leukemia (AML), which relapsed after allo-SCT despite immunological intervention. It was further treated with a second line chem...

journal_title：Pediatric hematology and oncology

authors： Hartwig M,Weigel S,Bernig T,Bader P,Dölken R,Beck J

更新日期：2007-03-01 00:00:00

abstract：:A 7-year-old boy with prolonged and marked leukopenia diagnosed at 6 months of age is described. The polymorphonuclear cells presented no hypersegmented nuclei or concentrated nuclear chromatin, although vacuolated myeloid cells appeared in bone marrow smears. Neutrophils reversed in response to administration of G-CS...

journal_title：Pediatric hematology and oncology

authors： Arai J,Wakiguchi H,Hisakawa H,Kubota H,Kurashige T

更新日期：2000-03-01 00:00:00

abstract：:Since 1981, the Children's Cancer and Leukemia Study Group (CCLSG) has developed a series of protocols for treatment of acute lymphoblastic leukemia (ALL) in childhood. In the first randomized controlled study of the 811 protocol (1981-1983) a comparison of conventional daily 6-mercaptopurine and methotrexate with a p...

journal_title：Pediatric hematology and oncology

authors： Koizumi S,Fujimoto T,Oka T,Watanabe S,Kikuta A,Tsuchiya T,Matsushita T,Asami K,Yanase T,Mimaya J,Ohta S,Miyake M,Nishikawa K,Furuyama T,Yamamura Y,Takaue Y,Ninomiya T,Shimokawa T,Iwai A,Ishida Y,Ariyoshi N,Kimur

更新日期：1997-01-01 00:00:00

abstract：:Blast cell chromosome abnormalities at presentation in childhood acute lymphoblastic leukemia (ALL) are common, and different patterns are known to be related to outcome. In contrast, the frequency and importance of further changes at the time of relapse remain unclear. Blast cell karyotype evolution was therefore stu...

journal_title：Pediatric hematology and oncology

authors： Vora AJ,Potter AM,Anderson LM,Lilleyman JS

更新日期：1994-07-01 00:00:00

abstract：:A high (18)F-fluorodeoxyglucose (FDG) uptake by positron emission tomography/computed tomography (PET/CT) imaging in sarcomas of adults has been reported. The current study aimed at defining the degree of (18)F-FDG uptake of pediatric sarcomas. This retrospective study included 29 patients (23 males, 6 females; mean a...

journal_title：Pediatric hematology and oncology

authors： Walter F,Federman N,Apichairuk W,Nelson S,Phelps ME,Allen-Auerbach M,Walter MA,Czernin J

更新日期：2011-10-01 00:00:00

abstract：:Ondansetron (Zofron, Glaxo) and tropisetron (Navoban, Sandoz) are selective serotonin (5HT3) antagonists that have proven very effective in the prevention of vomiting and nausea in adults and children receiving cancer chemotherapy. This study compared the efficacy of the two agents in the prevention of vomiting and na...

journal_title：Pediatric hematology and oncology

authors： Stiakaki E,Savvas S,Lydaki E,Bolonaki I,Kouvidi E,Dimitriou H,Kambourakis A,Kalmanti M

更新日期：1999-03-01 00:00:00

abstract：:The study assessed changes in cerebral blood flow and need for chronic blood transfusions in sickle cell disease children after splenectomy. A retrospective chart review of 40 children splenectomized between 1999 and 2014 was performed. The mean time-average maximum velocity before splenectomy was 129 cm/sec; which in...

journal_title：Pediatric hematology and oncology

authors： Siddiqui AH,Soh PB

更新日期：2015-05-01 00:00:00

abstract：:The hematologic phenotype was characterized in heterozygotes for three of the most common beta-thalassemia mutations in the Greek population. The study included 17 carriers of beta++ IVS1-n6 (T-->C), 21 carriers of beta+ IVS1-n110 (G-->A), and 17 carriers of beta 0 CD39 (C-->T). The 55 beta-thalassemia heterozygotes w...

journal_title：Pediatric hematology and oncology

authors： Stefanis L,Kanavakis E,Traeger-Synodinos J,Tzetis M,Metaxotou-Mavromati A,Kattamis C

更新日期：1994-09-01 00:00:00

abstract：:Outcomes in pediatric B-Non-Hodgkin Lymphoma (B NHL) have improved with intensive chemotherapy protocols, with long-term survival now over 80%. However, long-term adverse effects of therapy and poor outcomes for patients who relapse remain challenges. In this study, we aimed to evaluate the potential risks and benefit...

journal_title：Pediatric hematology and oncology

authors： Eissa HM,Allen CE,Kamdar K,Simko S,Goradia P,Dreyer Z,Steuber P,McClain KL,Guillerman RP,Bollard CM

更新日期：2014-04-01 00:00:00

abstract：:A case of a 4-year-old girl with pleuropulmonary blastoma is reported. Surgical resection of the tumor was performed and histologic examination revealed pleuropulmonary blastoma with rhabdomyosarcomatous differentiation. Postoperative chemotherapy was administered and 3 weeks after initiation of treatment protocol a s...

journal_title：Pediatric hematology and oncology

authors： Perdikogianni C,Stiakaki E,Danilatou V,Delides G,Kalmanti M

更新日期：2001-06-01 00:00:00

abstract：:Ghosal-type hemato-diaphyseal dysplasia is a rare autosomal recessive disorder with distinctive diaphyseal and metaphyseal dysplasia of long bones and steroid-dependant anemia. The authors describe a 20-month-old girl who had had a severe transfusion-dependent anemia since late infancy and marked locomotion difficulti...

journal_title：Pediatric hematology and oncology

authors： Alebouyeh M,Vossough P,Tabarrok F

更新日期：2003-07-01 00:00:00

abstract：:The purpose of this study was to retrospectively analyze the clinical presentation, treatment, and outcomes of children with Wilms tumor (WT) and intravascular extension who were treated at a single institution. A retrospective review was conducted of medical records of all children with Wilms tumor and intravascular ...

journal_title：Pediatric hematology and oncology

authors： Aspiazu D,Fernandez-Pineda I,Cabello R,Ramirez G,Alvarez-Madrid A,De Agustin JC

更新日期：2012-02-01 00:00:00

abstract：:Ewing's sarcoma is one of the most common malignant tumors of the skeletal system in children and young adults. It most frequently stems from the long bones of the extremities. However, though uncommon, extraosseous localization can be seen. Epidural extraosseous presentations are extremely rare. In this case, the aut...

journal_title：Pediatric hematology and oncology

authors： Erkutlu I,Buyukhatipoglu H,Alptekin M,Ozsarac C,Buyukbese I,Gok A

更新日期：2007-10-01 00:00:00

abstract：:In recent years erythropoietic agents have become important tools in the management of anemia in cancer patients, improving hemoglobin (Hb) concentrations, reducing the need for transfusion, and enhancing quality of life. In this prospective and historically controlled study, the effects of epoetin beta on Hb concentr...

journal_title：Pediatric hematology and oncology

authors： Corapcioglu F,Aksu G,Basar EZ,Demirel A,Oncel S,Mutlu A

更新日期：2008-09-01 00:00:00

abstract：:The aim of this study was to investigate the impact of therapy on long-term gonadal function of young people cured of childhood lymphomas and to assess whether a prepubertal state during the treatment protects the gonads from chemotherapy and/or radiotherapy late effects. Clinical evaluation, semen analysis, and endoc...

journal_title：Pediatric hematology and oncology

authors： Ben Arush MW,Solt I,Lightman A,Linn S,Kuten A

更新日期：2000-04-01 00:00:00

abstract：:The effectiveness of the different pharmacological agents and different doses of systemic corticosteroids was analyzed. A total of 1109 patients (median age 8 months; F/M: 2.3) with hemangioma, followed up in our unit for 23 years, were evaluated retrospectively. Forty-five of them received systemic corticosteroids. T...

journal_title：Pediatric hematology and oncology

authors： Akyüz C,Yariş N,Kutluk MT,Büyükpamukçu M

更新日期：2001-01-01 00:00:00

abstract：:In 33 children, 23 with acute lymphoblastic leukemia (ALL) and 10 with solid tumors, the phenotype of the enzyme adenosine deaminase (ADA) was detected in the erythrocytes by electrophoresis in cellulose acetate. In all children the ADA enzyme activity was also determined in the plasma by spectrophotometry at the onse...

journal_title：Pediatric hematology and oncology

authors： Hatzistilianou M,Athanassiadou F,Catriu D,Makedou A,Hitoglou S,Papaeconomou A

更新日期：1996-07-01 00:00:00

abstract：:Primary erythrocytosis diagnosed in a 10-month-old female and followed for 12 years is described. The erythrocytosis was associated with an abnormally elevated set point of erythropoietin production in which the sensitivity fluctuated independently, but corresponded to the alterations in the oxygen-carrying capacity o...

journal_title：Pediatric hematology and oncology

authors： Kalmantis T,Kalmanti M

更新日期：1991-07-01 00:00:00

abstract：:Hyperleukocytosis in patients with leukemia is associated with early mortality, especially due to the pulmonary and neurological complications of leukostasis. The prompt use of leukapheresis may improve patients' survival in the initial treatment period. The medical records of all previously untreated acute leukemia p...

journal_title：Pediatric hematology and oncology

authors： Yilmaz D,Karapinar B,Karadaş N,Duyu M,Yazici P,Ay Y,Balkan C,Aydinok Y,Kavakli K

更新日期：2014-05-01 00:00:00

abstract：:To investigate the possible clinical application of the hypothesis that insufficient induction of 3,4-dihydroxyphenylalanine decarboxylase (DDC) causes accumulation and secretion of 3,4-dihydroxyphenylalanine (DOPA) in unfavorable neuroblastomas, we measured plasma DOPA in 28 neuroblastoma patients. Abnormally high le...

journal_title：Pediatric hematology and oncology

authors： Ikeda H,Suzuki N,Takahashi A,Kuroiwa M,Matsuyama S

更新日期：1996-01-01 00:00:00

abstract：:We evaluated serum C-reactive protein (CRP) level and serum sodium concentration as early indicators of bacteremia in neutropenic children in two different series in 1983-1984 (49 bacteremias) and 1989-1990 (29 bacteremias). During the earlier period, the goal was to avoid unnecessary antimicrobial therapy. Currently ...

journal_title：Pediatric hematology and oncology

authors： Riikonen P,Saarinen UM,Perkkiö M,Hovi L,Siimes MA

更新日期：1992-10-01 00:00:00

abstract：:Nesiritide is a recombinant formulation of B-type natriuretic peptide used most commonly in the treatment of adults with decompensated congestive heart failure. The physiologic effects of BNP include natriuresis, diuresis, and smooth muscle relaxation. These physiologic effects result in its beneficial therapeutic eff...

journal_title：Pediatric hematology and oncology

authors： Wheeler AD,Tobias JD

更新日期：2005-06-01 00:00:00

abstract：:Breastfeeding is well-known to have a protective effect against infection in infants. It has been suggested that breast milk may play a role in the prevention of certain childhood cancer. We investigated this issue in a case-control study comprising 300 patients with childhood cancer. There was 73 patients (24.3%) wit...

journal_title：Pediatric hematology and oncology

authors： Küçükçongar A,Oğuz A,Pınarlı FG,Karadeniz C,Okur A,Kaya Z,Çelik B

更新日期：2015-01-01 00:00:00

abstract：:Bloodstream infections (BSI) represent one of the most serious complications in patients in the hematology-oncology unit. In this study, the prevalence, distribution, drug sensitivity profiles, and clinical outcome of BSI were analyzed in pediatric patients with hematological malignancies. Patients admitted to the ped...

journal_title：Pediatric hematology and oncology

authors： Chen S,Liu S,Yuan X,Mai H,Lin J,Wen F

更新日期：2019-11-01 00:00:00

abstract：:Overall survival from cancer has greatly improved, although it still remains the second leading cause of mortality in the world. This result was achieved through the use of chemotherapy and radiotherapy, which are severely toxic to normal tissues. In the long-term follow-up of cancer patients, the development of secon...

journal_title：Pediatric hematology and oncology

authors： Varan A,Kebudi R

更新日期：2011-08-01 00:00:00