Changing pattern of treatment policies invalidates the use of C-reactive protein level and hyponatremia as indicators of sepsis in children with malignancies.

abstract：:An episode of transient encephalopathy after the first course of intravenous high-dose methotrexate (HD-MTX; 1000 mg/m2) was observed in a 4-year-old girl with acute lymphoblastic leukemia. The neurological abnormalities took place 5 days after HD-MTX therapy. She experienced complex partial seizure and left hemipares...

journal_title：Pediatric hematology and oncology

authors： Kubo M,Azuma E,Arai S,Komada Y,Ito M,Sakurai M

更新日期：1992-04-01 00:00:00

abstract：:Arsenic trioxide (ATO) has been proven to be highly effective in adults with newly diagnosed or relapsed acute promyelocytic leukemia (APL). Only very limited data are published on the use of ATO as a single agent for first-line therapy of relapsed APL. The authors present a case of a 8-year-old boy with a bone marrow...

journal_title：Pediatric hematology and oncology

authors： Ebinger M,Schwarze CP,Feuchtinger T,Scheel-Walter HG,Lang P,Hildenbrand S,Gessler P,Handgretinger R

更新日期：2011-05-01 00:00:00

abstract：:The aim of this study was to investigate the impact of therapy on long-term gonadal function of young people cured of childhood lymphomas and to assess whether a prepubertal state during the treatment protects the gonads from chemotherapy and/or radiotherapy late effects. Clinical evaluation, semen analysis, and endoc...

journal_title：Pediatric hematology and oncology

authors： Ben Arush MW,Solt I,Lightman A,Linn S,Kuten A

更新日期：2000-04-01 00:00:00

abstract：:During the last 5 years massive chemotherapy and autologous bone marrow transplantation have been increasingly explored in the treatment of pediatric solid tumors, mainly for neuroblastoma, Ewing's sarcoma, rhabdomyosarcoma, Wilms' tumor, germ cell tumors, osteosarcoma, and retinoblastoma. Although the disease course ...

journal_title：Pediatric hematology and oncology

authors： Yaniv I,Bouffet E,Irle C,Negrier S,Biron P,Favrot M,Philip I,Brunat-Mentigny M,Philip T

更新日期：1990-01-01 00:00:00

abstract：:The aim of this study was to identify genes distinctively expressed or suppressed in childhood leukemia with different prognoses, using cDNA microarray and quantitative reverse transcription-polymerase chain reaction (RT-PCR). The expression levels of the selected genes by cDNA microarray were quantified in primary le...

journal_title：Pediatric hematology and oncology

authors： Hattori H,Matsuzaki A,Suminoe A,Koga Y,Tashiro K,Hara T

更新日期：2006-03-01 00:00:00

abstract：:Thalassemic children are at a high risk of graft rejection in cord blood transplantation. To investigate this possible mechanism, the authors evaluated the effect of panel reactive antibody on the growth of CD34(+) cells in vitro. On semisolid medium, CD34(+) cells derived from cord blood were incubated with thalassem...

journal_title：Pediatric hematology and oncology

authors： Fang JP,Xu LH,Yang XG,Wu YF,Weng WJ,Xu HG

更新日期：2009-07-01 00:00:00

abstract：:This is a report of a case of acute respiratory failure following the administration of intrathecal methotrexate (MTX) for prophylaxis of central nervous system leukemia (CNS) in a 3-year-old girl with acute lymphoblastic leukemia. This could be attributed to acute metabolic or direct toxic effects of methotrexate to ...

journal_title：Pediatric hematology and oncology

authors： Martins da Cunha AC,Bartsch CH,Gadner H

更新日期：1990-01-01 00:00:00

abstract：:Treatment of Langerhans cell histiocytosis (LCH) is yet to be established. We treated seven patients with etoposide alone at a dose of 100 mg/m2/day for 3 days given every 3 to 4 weeks for six cycles. Three patients had received prior chemotherapy, two patients were less than 2 years of age, and two had liver dysfunct...

journal_title：Pediatric hematology and oncology

authors： Basade MM,Nair CN,Kurkure PA,Pai SK,Advani SH

更新日期：1996-03-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) seems to play a central role in angiogenesis-lymphangiogenesis in hematological malignancies. There are limited data related to childhood hematologic malignancies. The aim of the study was to evaluate soluble VEGF (sVEGF) levels in children with acute leukemia and malignant ly...

journal_title：Pediatric hematology and oncology

authors： Dincaslan HU,Yavuz G,Unal E,Tacyildiz N,Ikinciogullari A,Dogu F,Guloglu D,Yuksek N,Ertem U

更新日期：2010-10-01 00:00:00

abstract：:Ghosal-type hemato-diaphyseal dysplasia is a rare autosomal recessive disorder with distinctive diaphyseal and metaphyseal dysplasia of long bones and steroid-dependant anemia. The authors describe a 20-month-old girl who had had a severe transfusion-dependent anemia since late infancy and marked locomotion difficulti...

journal_title：Pediatric hematology and oncology

authors： Alebouyeh M,Vossough P,Tabarrok F

更新日期：2003-07-01 00:00:00

abstract：:A firm, painless tumor of the temporal region was excised in a 3-year-old girl. The diagnosis of nonossifying fibromyxoid tumor was established on pathologic examination, which showed that most of the cells formed cords and tubulelike structures in a myxoid background. Bone and osteoid were lacking. The child is free ...

journal_title：Pediatric hematology and oncology

authors： Leray V,Gosseye S,Sempoux C,Ninane J,Vanwijck R

更新日期：1994-07-01 00:00:00

abstract：:Euthyroid sick syndrome is related to profound changes in thyroid metabolism induced by nonthyroidal diseases. To determine whether children with newly diagnosed Hodgkin disease might present thyroid abnormalities and to establish their predictive value, the authors performed regular thyroid function testing. Seven ch...

journal_title：Pediatric hematology and oncology

authors： Mohn A,Di Marzio A,Cerruto M,Angrilli F,Fioritoni C,Chiarelli F

更新日期：2001-04-01 00:00:00

abstract：:The majority of the anemias during childhood are hypochromic and microcytic. The aim of the present study was to determine the status of α-thalassemia mutations and its association with other etiologies, such as iron deficiency anemia (IDA) and β-thalassemia trait, that are frequently seen hypochromic microcytic anemi...

journal_title：Pediatric hematology and oncology

authors： Gulen H,Hanimeli O,Karaca O,Taneli F

更新日期：2012-04-01 00:00:00

abstract：:The clinical usefulness of the measurement of red cell zinc protoporphyrin (ZPP), an indicator of iron-deficient erythropoiesis, was assessed in a group of UK children undergoing investigation for red cell microcytosis. Of 213 children studied, 136 had increased ZPP values. Of these, 86 also had reduced iron stores as...

journal_title：Pediatric hematology and oncology

authors： Hinchliffe RF,Lilleyman JS,Steel GJ,Bellamy GJ

更新日期：1995-09-01 00:00:00

abstract：:This is a pilot study performed to determine the maximum tolerated number of courses of high-dose thiotepa and carboplatin with autologous peripheral blood progenitor cell (PBPC) transplantation in poor-risk pediatric central nervous system (CNS) tumor patients. Twelve patients were enrolled and a total of 24 PBPC tra...

journal_title：Pediatric hematology and oncology

authors： Ozkaynak MF,Sandoval C,Levendoglu-Tugal O,Jayabose S

更新日期：2004-10-01 00:00:00

abstract：AIM:In recent years, survival rates of childhood cancers have significantly increased, and occurrence of long-term adverse late effects (eg, insulin resistance, diabetes mellitus, metabolic syndrome, hypertension) has become increasingly important. Early diagnosis of obesity/hypertension in childhood is essential to av...

journal_title：Pediatric hematology and oncology

authors： Guler E,Col N,Buyukcelik M,Balat A

更新日期：2018-02-01 00:00:00

abstract：:Endocrine system dysfunctions are the significant complications of excessive iron overload in beta thalassemia patients. The aim of this study was to evaluate the long-term effect of chelation with deferasirox on endocrine complications. The study group consisted of children with beta thalassemia who had been evaluate...

journal_title：Pediatric hematology and oncology

authors： Bilgin BK,Yozgat AK,Isik P,Çulha V,Kacar D,Kara A,Ozbek NY,Yarali N

更新日期：2020-09-01 00:00:00

abstract：:To determine treatment outcome using ceftazidime-aminoglycosides in febrile neutropenic children with cancer, the authors conducted a prospective cohort study in 216 episodes. Early and complete responses to antibiotics were 108/216 (50.0%) and 133/216 (61.6%) episodes, respectively. Death, a modification of antibioti...

journal_title：Pediatric hematology and oncology

authors： Laoprasopwattana K,Pruekprasert P,Laosombat V,Wongchanchailert M

更新日期：2007-12-01 00:00:00

abstract：:Background: Preclinical studies show that TLR9 agonists can eradicate leukemia by induction of immune responses in vivo against AML and ALL. These studies demonstrated that TLR9 agonists induce an immediate NK response followed by adaptive T and B cells responses resulting in long term anti-leukemia immunity. Methods:...

journal_title：Pediatric hematology and oncology

authors： Ronsley R,Kariminia A,Ng B,Mostafavi S,Reid G,Subrt P,Hijiya N,Schultz KR

更新日期：2019-11-01 00:00:00

abstract：:Maternal education might be an important factor for the neuroblastoma risk in children, but it was conflicting. This meta-analysis was performed to evaluate the relationship between maternal education and neuroblastoma susceptibility and to explore whether maternal education was an important indicator to be associated...

journal_title：Pediatric hematology and oncology

authors： Wang P,Liao N,Liao XH,Liang B,Huang CX,Li W

更新日期：2013-02-01 00:00:00

abstract：:Between 1983 and 2008, prenatal diagnostic procedures for identifying hemoglobinopathies were performed in 947 at-risk fetuses. Seventy-six percent of the fetuses were at risk for β-thalassemia major and 16% for sickle cell anemia; only a small percentage (7%) were at risk for compound heterozygosity of β-thalassemia ...

journal_title：Pediatric hematology and oncology

authors： Beksac MS,Gumruk F,Gurgey A,Cakar N,Mumusoglu S,Ozyuncu O,Altay C

更新日期：2011-02-01 00:00:00

abstract：:Overall survival from cancer has greatly improved, although it still remains the second leading cause of mortality in the world. This result was achieved through the use of chemotherapy and radiotherapy, which are severely toxic to normal tissues. In the long-term follow-up of cancer patients, the development of secon...

journal_title：Pediatric hematology and oncology

authors： Varan A,Kebudi R

更新日期：2011-08-01 00:00:00

abstract：:Factor XIII deficiency is a very rare bleeding disorder. We report here on the clinical outcome of a young child with intracranial bleeding due to factor XIII deficiency. Clinicians should bear in mind that severe factor XIII deficiency is associated with a significant risk of unexpected intracranial hemorrhage (ICH)....

journal_title：Pediatric hematology and oncology

authors： Bay A,Sirikci A,Dogan A,Leblebisatan G,Yilmaz F

更新日期：2013-11-01 00:00:00

abstract：:A 12-year-old female is reported who presented with right hip pain for 6 months. With massive splenohepatomegaly and leukocytosis, CML was suspected and confirmed on bone-marrow examination and cytogenetics. Further investigations confirmed avascular necrosis (AVN) of the right femoral head. CML was treated by hydroxy...

journal_title：Pediatric hematology and oncology

authors： Kumar S,Bansal D,Prakash M,Sharma P

更新日期：2014-09-01 00:00:00

abstract：:Primary diffuse leptomeningeal glioneuronal tumors (DLGNT) are rare tumors, recently recognized as a unique entity based on their unique pathologic and clinical characteristics. We report three cases of DLGNT and compare their clinical characteristics and presentation with other reported cases, and with primary leptom...

journal_title：Pediatric hematology and oncology

authors： Abongwa C,Cotter J,Tamrazi B,Dhall G,Davidson T,Margol A

更新日期：2020-04-01 00:00:00

abstract：:The authors report the results of 58 children with ALL in 2CR after related (n = 31) or unrelated (n = 27) AHSCT. Characteristics at diagnosis and initial and after relapse antileukemic treatment were similar in the related donor (RD) and the unrelated donor (UD) groups. Conditioning consisted of TBI/CY +/- VP-16 for ...

journal_title：Pediatric hematology and oncology

authors： Muñoz A,Diaz-Heredia C,Diaz MA,Badell I,Verdeguer A,Martinez A,Gomez P,Perez-Hurtado JM,Bureo E,Fernandez-Delgado R,Gonzalez-Valentin ME,Maldonado MS

更新日期：2008-06-01 00:00:00

abstract：OBJECTIVES:Recent guidelines recommend to assess emotional distress in pediatric oncology during treatment and in after care. One tool used to do this is the distress thermometer (DT), a simple tool which has almost exclusively been studied in its screening abilities. Given its increased used as a measure of distress p...

journal_title：Pediatric hematology and oncology

authors： Pépin AJ,Lippé S,Krajinovic M,Laverdière C,Michon B,Sinnett D,Sultan S

更新日期：2017-04-01 00:00:00

abstract：:Down syndrome (DS) is an important risk factor associated with acute leukemia (AL). The presence of polymorphisms that reduce 5,10-methylenetetrahydrofolate reductase (MTHFR) activity has been linked to the multifactorial leukemogenic process. The authors have conducted a study to test whether 677C-->T and/or 1298A-->...

journal_title：Pediatric hematology and oncology

authors： Amorim MR,Zanrosso CW,Magalhães IQ,Pereira SC,Figueiredo A,Emerenciano M,Pinheiro VR,d'Andréa ML,Orioli IM,Koifman S,Pombo-de-Oliveira MS

更新日期：2008-12-01 00:00:00

abstract：:A two-step evaluation system is proposed to analyze the results of therapy for stage IV neuroblastoma in children over 1 year of age. Since most protocols consist of first-line chemotherapy followed by surgery and often high-dose chemotherapy with bone marrow rescue, "response" should assess the effect of chemotherapy...

journal_title：Pediatric hematology and oncology

authors： Philip T,Helson L,Bernard JL,Zucker JM,Kremens B,Favrot M,Hartmann O

更新日期：1987-01-01 00:00:00

abstract：:Hemophagocytic lymphohistiocytosis (HLH) is a rare and fatal hematological syndrome that causes a disturbance of the immune system. Overall mortality of HLH is greater than 50% and the majority of patients who die do so within the first 8 weeks of chemotherapy treatment. To find clinical parameters relating to high-ri...

journal_title：Pediatric hematology and oncology

authors： Dao AT,Luong VT,Nguyen TT,Huynh QT,Phan TT,Lam MT,Ngoma AM,Koriyama C

更新日期：2014-04-01 00:00:00