Long-term remission after first-line single-agent treatment with arsenic trioxide of relapsed acute promyelocytic leukemia in an 8-year-old boy.


:Arsenic trioxide (ATO) has been proven to be highly effective in adults with newly diagnosed or relapsed acute promyelocytic leukemia (APL). Only very limited data are published on the use of ATO as a single agent for first-line therapy of relapsed APL. The authors present a case of a 8-year-old boy with a bone marrow relapse of APL 7 years after first diagnosis, who achieved durable molecular remission with ATO as single agent: induction therapy for 12 weeks, consolidation for 4 weeks, then 6 cycles of 10 days over a period of 6 months. In total, 140 doses of ATO (0.15 mg/kg/day) were given (21 mg/kg). Consecutive promyelocytic leukemia-retinoic acid receptor α (PML-RARα) RT-PCR analyses were negative with a follow-up of 48 months. Acute or late side effects of arsenic were not observed. At present, the boy is in complete remission 4 years after the diagnosis of the relapse.


Pediatr Hematol Oncol


Ebinger M,Schwarze CP,Feuchtinger T,Scheel-Walter HG,Lang P,Hildenbrand S,Gessler P,Handgretinger R




Has Abstract


2011-05-01 00:00:00












  • Nutritional vitamin B12 deficiency in hospitalized young children.

    abstract::The authors sought to determine prevalence, social, economic, and dietary patterns of young children (n = 20) identified as having vitamin B12 deficiency anemia after admission to their hospital in the last 3 years. The diagnosis of vitamin B12 deficiency was based on symptoms and clinical findings, findings on periph...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章


    authors: Cetinkaya F,Yildirmak Y,Kutluk G,Erdem E

    更新日期:2007-01-01 00:00:00

  • Unexplained menorrhagia and hematuria: a case report of Munchausen's syndrome by proxy.

    abstract::Unexplained menorrhagia and hematuria occurred in a 13-year-old female with a mild inherited platelet disorder who had never experienced prior bleeding as a result of this disorder. An intensive search revealed that this patient was receiving coumadin that was given by the mother. In addition, the mother drew large vo...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章


    authors: Souid AK,Korins K,Keith D,Dubansky S,Sadowitz PD

    更新日期:1993-07-01 00:00:00

  • Practice guidelines in pediatric hematooncology: implementation and survey. A possible way for medical quality assurance.

    abstract::The Hungarian Pediatric Oncology Working Group intended to change the practice of prescribing diagnostic tests as well as to examine the possibility of introducing indicators about the time factors of medical care. A nationwide accepted protocol was established for these tests. The examined time factors were the lengt...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章


    authors: Pásztélyi Z,Schuler D,Czvenits E

    更新日期:2000-12-01 00:00:00

  • Hematologic phenotype of the mutations IVS1-n6 (T-->C), IVS1-n110 (G-->A), and CD39 (C-->T) in carriers of beta-thalassemia in Greece.

    abstract::The hematologic phenotype was characterized in heterozygotes for three of the most common beta-thalassemia mutations in the Greek population. The study included 17 carriers of beta++ IVS1-n6 (T-->C), 21 carriers of beta+ IVS1-n110 (G-->A), and 17 carriers of beta 0 CD39 (C-->T). The 55 beta-thalassemia heterozygotes w...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章


    authors: Stefanis L,Kanavakis E,Traeger-Synodinos J,Tzetis M,Metaxotou-Mavromati A,Kattamis C

    更新日期:1994-09-01 00:00:00

  • The outcome of childhood adrenocortical carcinoma in Egypt: A model from developing countries.

    abstract::Adrenocortical carcinoma (ACC) is a rare, aggressive endocrine neoplasm. Complete surgical resection is the single most important treatment. Most available information has been learned from experience with its more frequent adult counterpart. In this study, we assessed the features and survival outcome of patients wit...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章


    authors: Zekri W,Hammad M,Rashed WM,Ahmed G,Elshafie M,Adly MH,Elborai Y,Abdalla B,Taha H,Elkinaae N,Refaat A,Younis A,Alfaar AS

    更新日期:2020-04-01 00:00:00

  • Allogeneic hemopoietic stem cell transplantation for childhood acute lymphoblastic leukemia in second complete remission-similar outcomes after matched related and unrelated donor transplant: a study of the Spanish Working Party for Blood and Marrow Trans

    abstract::The authors report the results of 58 children with ALL in 2CR after related (n = 31) or unrelated (n = 27) AHSCT. Characteristics at diagnosis and initial and after relapse antileukemic treatment were similar in the related donor (RD) and the unrelated donor (UD) groups. Conditioning consisted of TBI/CY +/- VP-16 for ...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章


    authors: Muñoz A,Diaz-Heredia C,Diaz MA,Badell I,Verdeguer A,Martinez A,Gomez P,Perez-Hurtado JM,Bureo E,Fernandez-Delgado R,Gonzalez-Valentin ME,Maldonado MS

    更新日期:2008-06-01 00:00:00

  • Amputee skiers: lofty ambassadors in the rehabilitation of cancer.

    abstract::Adolescence is characterized by inter-related physiologic and emotional development. It is a particularly vulnerable period of life culminating into emergence as an adult. The majority of malignant bone tumors in pediatrics affect the adolescent patient. As a part of the treatment, amputation may be required for cure....

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章


    authors: Jaffe N,Zietz H

    更新日期:2004-09-01 00:00:00

  • Pleuropulmonary blastoma: an aggressive intrathoracic neoplasm of childhood.

    abstract::A case of a 4-year-old girl with pleuropulmonary blastoma is reported. Surgical resection of the tumor was performed and histologic examination revealed pleuropulmonary blastoma with rhabdomyosarcomatous differentiation. Postoperative chemotherapy was administered and 3 weeks after initiation of treatment protocol a s...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章


    authors: Perdikogianni C,Stiakaki E,Danilatou V,Delides G,Kalmanti M

    更新日期:2001-06-01 00:00:00

  • The influence of risk factors in promoting thrombosis during childhood: the role of acquired factors.

    abstract::Thrombo-embolism in childhood is a multifactorial disorder. The present study is a case-control study that investigated the role of genetic and acquired risk factors in 60 children with thrombosis and compared the results with the controls. Acquired and inherited risk factors precipitating thrombosis were present in 7...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章


    authors: Günes AM,Baytan B,Günay U

    更新日期:2006-07-01 00:00:00

  • Malignant rhabdoid tumor of the kidney presenting as intraocular metastasis.

    abstract::A newborn infant presented with intraocular tumor that was clinically diagnosed as retinoblastoma and treated by exenteration of the globe. Within a few weeks however, a large abdominal mass was noted, which was found to involve the left kidney and right lobe of liver. Pathologic evaluation of the intraocular mass as ...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章


    authors: Akhtar M,Ali MA,Sackey K,Bakry M,Johnson T

    更新日期:1991-01-01 00:00:00

  • Identification of novel genes with prognostic value in childhood leukemia using cDNA microarray and quantitative RT-PCR.

    abstract::The aim of this study was to identify genes distinctively expressed or suppressed in childhood leukemia with different prognoses, using cDNA microarray and quantitative reverse transcription-polymerase chain reaction (RT-PCR). The expression levels of the selected genes by cDNA microarray were quantified in primary le...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章


    authors: Hattori H,Matsuzaki A,Suminoe A,Koga Y,Tashiro K,Hara T

    更新日期:2006-03-01 00:00:00

  • α-Thalassemia frequency and mutations in children with hypochromic microcytic anemias and relation with β-thalassemia, iron deficiency anemia.

    abstract::The majority of the anemias during childhood are hypochromic and microcytic. The aim of the present study was to determine the status of α-thalassemia mutations and its association with other etiologies, such as iron deficiency anemia (IDA) and β-thalassemia trait, that are frequently seen hypochromic microcytic anemi...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章


    authors: Gulen H,Hanimeli O,Karaca O,Taneli F

    更新日期:2012-04-01 00:00:00

  • Increased expression of multidrug resistance gene (MDR1) at relapse in a child with acute lymphoblastic leukemia.

    abstract::Modern treatment protocols lead to complete remission in a high proportion of patients with childhood acute lymphoblastic leukemia (ALL). However, a large number of them show a relapse of the disease. Treatment failure in these patients is mainly attributable to de novo or acquired resistance to a wide variety of cyto...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章


    authors: Kourti M,Vavatsi N,Gombakis N,Tzimagiorgis G,Sidi V,Koliouskas D,Athanassiadou F

    更新日期:2006-09-01 00:00:00

  • Delayed Granulocyte Colony-Stimulating Factor (G-CSF) Administration after Chemotherapy Reduces Total G-CSF Doses without Affecting Neutrophil Recovery in a Randomized Clinical Study in Children with Solid Tumors.

    abstract::The use of G-CSF after myelotoxic chemotherapy accelerates neutrophil recovery reducing the risk of febrile neutropenia. Current guidelines recommend initiating G-CSF 24 hours after myelotoxic chemotherapy. However, the optimal timing of post-chemotherapy G-CSF administration has not been elucidated. Our previous work...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章


    authors: Yankelevich M,Hoogstra DJ,Abrams J,Chu R,Bhambhani K,Taub JW

    更新日期:2020-11-01 00:00:00

  • Primary spinal epidural extraosseous Ewing's sarcoma mimicking a spinal abscess.

    abstract::Ewing's sarcoma is one of the most common malignant tumors of the skeletal system in children and young adults. It most frequently stems from the long bones of the extremities. However, though uncommon, extraosseous localization can be seen. Epidural extraosseous presentations are extremely rare. In this case, the aut...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章


    authors: Erkutlu I,Buyukhatipoglu H,Alptekin M,Ozsarac C,Buyukbese I,Gok A

    更新日期:2007-10-01 00:00:00

  • Fever and neutropenia hospital discharges in children with cancer: A 2012 update.

    abstract::Fever and neutropenia (FN) is a common precipitant for hospitalization among children with cancer, but hospital utilization trends are not well described. This study describes national trends for hospital discharges for FN among children with cancer for the year 2012, compared with the authors' previous analysis from ...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章,多中心研究


    authors: Mueller EL,Croop J,Carroll AE

    更新日期:2016-02-01 00:00:00

  • Unexpected result in the etiological approaching to an anemic case: a leech infestation.

    abstract::One of the causes of the childhood anemia is gastrointestinal system bleeding, which rarely results from parasites. The authors report on a 3-year-old boy with severe anemia and a history of hematemesis. While they were investigating the cause of the anemia and the hematemesis, a leech showing itself in the nasal pass...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章


    authors: Demirören K,Calişkan U

    更新日期:2003-10-01 00:00:00

  • Definition of response and remission in children over one year of age with advanced neuroblastoma: proposition for a scoring system.

    abstract::A two-step evaluation system is proposed to analyze the results of therapy for stage IV neuroblastoma in children over 1 year of age. Since most protocols consist of first-line chemotherapy followed by surgery and often high-dose chemotherapy with bone marrow rescue, "response" should assess the effect of chemotherapy...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章


    authors: Philip T,Helson L,Bernard JL,Zucker JM,Kremens B,Favrot M,Hartmann O

    更新日期:1987-01-01 00:00:00

  • Characterization of the coagulation profile in children with liver disease and extrahepatic portal vein obstruction or shunt.

    abstract:INTRODUCTION:Chronic liver disease causes a disruption of procoagulant and anticoagulant factors, resulting in a fragile state, prone to increased rates of both bleeding and thrombosis. Currently, there is limited literature describing the changes observed in pediatric liver disease and extrahepatic portal vein obstruc...

    journal_title:Pediatric hematology and oncology

    pub_type: 临床试验,杂志文章


    authors: Beattie W,Magnusson M,Hardikar W,Monagle P,Ignjatovic V

    更新日期:2017-03-01 00:00:00

  • Relationship between modified CT severity index and clinical features of L-asparaginase-associated pancreatitis in pediatric acute lymphoblastic leukemia.

    abstract:PURPOSE:To describe clinical and CT features of L-asparaginase-associated pancreatitis (L-AP) and to correlate CT grades with clinical parameters. METHODS:A total of 16 children (M:F = 9:7; mean age, 8.1 years) who developed L-AP after L-asparaginase (L-asp) treatment and underwent abdominal CT scan were included. We ...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章


    authors: Oh HJ,Im SA,Lee JW,Chung NG,Cho B

    更新日期:2014-10-01 00:00:00

  • High expression but no internal tandem duplication of FLT3 in normal hematopoietic cells.

    abstract::The FLT3 gene encodes a tyrosine kinase receptor that regulates proliferation and differentiation of hematopoietic cells. Recently, the internal duplication of FLT3 has been observed in hematological malignancies, suggesting the involvement of these mutations in leukemogenesis. The authors analyzed the expression of F...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章


    authors: Ishii E,Zaitsu M,Ihara K,Hara T,Miyazaki S

    更新日期:1999-09-01 00:00:00

  • Elevated p53 protein expression; a predictor of relapse in rare chronic myeloid malignancies in children?

    abstract:BACKGROUND:Alterations in the tumor suppressor gene TP53 have been associated with poor outcome in adult hematological malignancies. We have earlier reported an increased expression of the TP53 encoded protein p53, in bone marrow samples from pediatric patients with aggressive leukemia. Our aim was now to evaluate p53 ...

    journal_title:Pediatric hematology and oncology

    pub_type: 临床试验,杂志文章


    authors: Honkaniemi E,Mattsson K,Barbany G,Sander B,Gustafsson B

    更新日期:2014-05-01 00:00:00

  • Osteosarcoma as a second malignancy after treatment for neuroblastoma.

    abstract::A 4-month old girl was diagnosed as having stage IV neuroblastoma of the right adrenal gland. Preoperative chemotherapy was given, followed by local surgical excision. Postoperatively, irradiation of the tumor bed and adjuvant chemotherapy was given for 11 months. Nine years after cessation of chemotherapy, the patien...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章


    authors: Iwata A,Hirota T,Konno K,Fujimoto T,Sumida S,Sato K,Hara K

    更新日期:2001-10-01 00:00:00

  • Supernumerary nipples in children with hematologic disorders.

    abstract::The authors report on supernumerary nipples and various hematologic disorders in 7 patients [factor X deficiency (n = 1), factor XI deficiency (n = 2), acute lymphoblastic leukemia (n = 3), and acute myeloblastic leukemia (n = 1)]. They would like to draw attention to the association of supernumerary nipples with hema...

    journal_title:Pediatric hematology and oncology

    pub_type: 信件


    authors: Aslan D,Gürsel T,Kaya Z

    更新日期:2004-07-01 00:00:00

  • Clinical value of RAG1 expression and IKZF1 deletions in Philadelphia negative pediatric B cell precursor acute lymphoblastic leukemia.

    abstract::This study aimed to address the clinical impact of recombination-activating gene (RAG1) expression and tumor suppressor IKZF1 gene deletions in Philadelphia negative B-cell precursor acute lymphoblastic leukemia (B-ALL) patients. Fifty newly diagnosed pediatric Philadelphia negative B-ALL patients were included in thi...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章


    authors: Aref S,Khaled N,Menshawy NE,Sabry M,Agder MA

    更新日期:2020-08-01 00:00:00

  • Clinical outcome of febrile neutropenia in children with cancer using ceftazidime and aminoglycosides.

    abstract::To determine treatment outcome using ceftazidime-aminoglycosides in febrile neutropenic children with cancer, the authors conducted a prospective cohort study in 216 episodes. Early and complete responses to antibiotics were 108/216 (50.0%) and 133/216 (61.6%) episodes, respectively. Death, a modification of antibioti...

    journal_title:Pediatric hematology and oncology

    pub_type: 临床试验,杂志文章


    authors: Laoprasopwattana K,Pruekprasert P,Laosombat V,Wongchanchailert M

    更新日期:2007-12-01 00:00:00

  • Evaluation of patients with intracranial tumors and central diabetes insipidus.

    abstract::The aim of the study is to evaluate the etiologic and clinical characteristics, treatment regimens, and outcome of the patients with intracranial tumors presenting with central diabetes insipidus (DI). Sixty-nine patients with intracranial tumors presenting with central DI between 1972 and 2012 were retrospectively ev...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章


    authors: Varan A,Atas E,Aydın B,Yalçın B,Akyüz C,Kutluk T,Büyükpamukçu M

    更新日期:2013-10-01 00:00:00

  • Acute monoblastic leukemia as a second malignancy following chemotherapy for osteogenic sarcoma: a case report.

    abstract::A patient with well-differentiated monoblastic leukemia (ANLL FAB-M5b) is described in whom acute leukemia was diagnosed 25 months after having completed postoperative adjuvant chemotherapy for osteogenic sarcoma of the femur. All analyzed metaphases showed 48xy, dup 1(q12), +3, +9. ...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章


    authors: Orazi A,Sozzi G,Delia D,Morandi F,Rottoli L,Cattoretti G

    更新日期:1988-01-01 00:00:00

  • Clinical versus laboratory tumor lysis syndrome in children with acute leukemia.

    abstract::Renal and metabolic complications of tumor lysis syndrome (TLS) were recognized frequently in the 1960s and 1970s. Strategies were designed to prevent TLS. We conducted a retrospective chart review study to identify the current TLS risk in children with acute leukemia. Children were considered to have "laboratory tumo...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章


    authors: Kedar A,Grow W,Neiberger RE

    更新日期:1995-03-01 00:00:00

  • Secondary malignant neoplasms after childhood cancer.

    abstract::Overall survival from cancer has greatly improved, although it still remains the second leading cause of mortality in the world. This result was achieved through the use of chemotherapy and radiotherapy, which are severely toxic to normal tissues. In the long-term follow-up of cancer patients, the development of secon...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章,评审


    authors: Varan A,Kebudi R

    更新日期:2011-08-01 00:00:00