The effect of deferasirox on endocrine complications in children with thalassemia.

abstract：:Beta-thalassemia major is a severe, transfusion-dependent anemia that also causes infertility due to iron deposition to endocrine organs after overtransfusion. Very few pregnancies have been reported among such patients after modern therapies. In this study, 32 women with thalassemia who were admitted to Ali Asghar Ch...

journal_title：Pediatric hematology and oncology

authors： Ansari S,Azarkeivan A,Tabaroki A

更新日期：2006-01-01 00:00:00

abstract：:The clinical usefulness of the measurement of red cell zinc protoporphyrin (ZPP), an indicator of iron-deficient erythropoiesis, was assessed in a group of UK children undergoing investigation for red cell microcytosis. Of 213 children studied, 136 had increased ZPP values. Of these, 86 also had reduced iron stores as...

journal_title：Pediatric hematology and oncology

authors： Hinchliffe RF,Lilleyman JS,Steel GJ,Bellamy GJ

更新日期：1995-09-01 00:00:00

abstract：:Plexiform neurofibroma is a relatively common but potentially devastating manifestation of neurofibromatosis type 1 (NF 1). A substantial number of plexiform neurofibroma causes morbidity. Various treatment modalities are considered to decrease pain. In this paper a case with plexiform neurofibroma causing severe pain...

journal_title：Pediatric hematology and oncology

authors： Citak EC,Oguz A,Karadeniz C,Okur A,Memis L,Boyunaga O

更新日期：2008-09-01 00:00:00

abstract：:Neuroblastoma presenting with obstructive jaundice is a rare event. Management of this condition includes surgery, chemotherapy, radiotherapy, temporary cholecystostomy tube, endoscopic retrograde cholangiopancreatography (ERCP), and internal biliary drainage (IBD). We herein describe our experience with one infant af...

journal_title：Pediatric hematology and oncology

authors： Saettini F,Agazzi R,Giraldi E,Foglia C,Cavalleri L,Morali L,Fasolini G,Spotti A,Provenzi M

更新日期：2015-04-01 00:00:00

abstract：INTRODUCTION:Children with low von Willebrand factor (VWF) activity or type 1 von Willebrand disease (VWD) have increased risk of bleeding after adenotonsillar procedures and the optimal perioperative management to minimize bleeding is unknown. AIM:To report the effectiveness and safety of an institutional protocol in...

journal_title：Pediatric hematology and oncology

authors： Diaz R,Musso M,Mahoney D

更新日期：2020-08-17 00:00:00

abstract：:Bloodstream infections (BSI) represent one of the most serious complications in patients in the hematology-oncology unit. In this study, the prevalence, distribution, drug sensitivity profiles, and clinical outcome of BSI were analyzed in pediatric patients with hematological malignancies. Patients admitted to the ped...

journal_title：Pediatric hematology and oncology

authors： Chen S,Liu S,Yuan X,Mai H,Lin J,Wen F

更新日期：2019-11-01 00:00:00

abstract：:Both transplanted and leukemia patients are at high risk (HR) for invasive pulmonary aspergillosis (IPA). Methods for rapid diagnosis are crucial. Our objective was to investigate the impact of serial serum galactomannan assay (GMA) screening on IPA diagnosis in children. Between January 2010 and December 2011, all ch...

journal_title：Pediatric hematology and oncology

authors： Gefen A,Zaidman I,Shachor-Meyouhas Y,Avidor I,Hakim F,Weyl Ben-Arush M,Kassis I

更新日期：2015-03-01 00:00:00

abstract：:A case of a child with paroxysmal nocturnal hemoglobinuria (PNH) is characterized by an increased sensitivity of the erythrocyte to hemolytic action of complement. The widely used Ham test may not always be reliable. Recently, a panel of monoclonal antibodies has become available to detect various glycosylphosphatidyl...

journal_title：Pediatric hematology and oncology

authors： Kinugawa N,Shichishima T,Nishimura J,Kitani T

更新日期：1993-10-01 00:00:00

abstract：:Euthyroid sick syndrome is related to profound changes in thyroid metabolism induced by nonthyroidal diseases. To determine whether children with newly diagnosed Hodgkin disease might present thyroid abnormalities and to establish their predictive value, the authors performed regular thyroid function testing. Seven ch...

journal_title：Pediatric hematology and oncology

authors： Mohn A,Di Marzio A,Cerruto M,Angrilli F,Fioritoni C,Chiarelli F

更新日期：2001-04-01 00:00:00

abstract：:In an autopsy series of children with cancer, histopathologic myocardial changes caused by anthracyclines (A) were evaluated. The series comprised three groups: group A, 9 patients given A whose myocardial function had been evaluated before death; group B, 10 patients given A, but no lifetime echocardiographic evaluat...

journal_title：Pediatric hematology and oncology

authors： Pihkala J,Sariola H,Saarinen UM

更新日期：1994-05-01 00:00:00

abstract：BACKGROUND:Alterations in the tumor suppressor gene TP53 have been associated with poor outcome in adult hematological malignancies. We have earlier reported an increased expression of the TP53 encoded protein p53, in bone marrow samples from pediatric patients with aggressive leukemia. Our aim was now to evaluate p53 ...

journal_title：Pediatric hematology and oncology

authors： Honkaniemi E,Mattsson K,Barbany G,Sander B,Gustafsson B

更新日期：2014-05-01 00:00:00

abstract：:A method is described to estimate MYCN (N-myc) oncogene amplification in neuroblastoma by the technique of differential polymerase chain reaction (PCR). The technique is quicker than conventional Southern blotting techniques and does not require radioactive materials. The ability to measure MYCN amplification from sma...

journal_title：Pediatric hematology and oncology

authors： Huddart SN,Mann JR,McGukin AG,Corbett R

更新日期：1993-01-01 00:00:00

abstract：:Immune thrombocytopenia (ITP) is an acute self-limited disease of childhood, mostly resolving within 6 months irrespective of whether therapy is given or not. Treatment options when indicated include corticosteroids, intravenous immune globulin (IVIG), and anti-RhD immunoglobulin. We reviewed our 32 years' experience ...

journal_title：Pediatric hematology and oncology

authors： Yildiz I,Ozdemir N,Celkan T,Soylu S,Karaman S,Canbolat A,Dogru O,Erginoz E,Apak H

更新日期：2015-01-01 00:00:00

abstract：OBJECTIVE:Venous thrombotic events (VTE) are a well-recognized complication in pediatric cancer patients. Population-based data on the incidence and characteristics of VTE in all pediatric cancer patients are limited. This information is crucial to identify patients at high risk and design targeted interventions accord...

journal_title：Pediatric hematology and oncology

authors： Asyyed Z,MacDonald T,Digout C,Kulkarni K

更新日期：2017-03-01 00:00:00

abstract：:Invasive aspergillosis is a fungal infection that is being observed increasingly in immunocompromised patients due to the use of more aggressive chemotherapeutic regimens. To our knowledge, no case of pneumothorax and pneumopericardium associated with invasive pulmonary aspergillosis has been reported to date. High-do...

journal_title：Pediatric hematology and oncology

authors： Merino JM,Díaz MA,Ramírez M,Ruano D,Madero L

更新日期：1995-03-01 00:00:00

abstract：:The development of myeloid leukemias and myelodysplastic syndrome (MDS) is common in children with trisomy 8 mosaicism. However, the mechanisms by which the presence of an additional chromosome 8 translates to an increased risk of leukemias and MDS is currently unknown. The authors describe the analysis of stromal cel...

journal_title：Pediatric hematology and oncology

authors： Narendran A,Hawkins LM,Ganjavi H,Vanek W,Gee MF,Barlow JW,Johnson G,Malkin D,Freedman MH

更新日期：2004-04-01 00:00:00

abstract：:Thrombo-embolism in childhood is a multifactorial disorder. The present study is a case-control study that investigated the role of genetic and acquired risk factors in 60 children with thrombosis and compared the results with the controls. Acquired and inherited risk factors precipitating thrombosis were present in 7...

journal_title：Pediatric hematology and oncology

authors： Günes AM,Baytan B,Günay U

更新日期：2006-07-01 00:00:00

abstract：:Thalassemic children are at a high risk of graft rejection in cord blood transplantation. To investigate this possible mechanism, the authors evaluated the effect of panel reactive antibody on the growth of CD34(+) cells in vitro. On semisolid medium, CD34(+) cells derived from cord blood were incubated with thalassem...

journal_title：Pediatric hematology and oncology

authors： Fang JP,Xu LH,Yang XG,Wu YF,Weng WJ,Xu HG

更新日期：2009-07-01 00:00:00

abstract：:Modern treatment protocols lead to complete remission in a high proportion of patients with childhood acute lymphoblastic leukemia (ALL). However, a large number of them show a relapse of the disease. Treatment failure in these patients is mainly attributable to de novo or acquired resistance to a wide variety of cyto...

journal_title：Pediatric hematology and oncology

authors： Kourti M,Vavatsi N,Gombakis N,Tzimagiorgis G,Sidi V,Koliouskas D,Athanassiadou F

更新日期：2006-09-01 00:00:00

abstract：:Three cases of vitamin B12 deficiency that occurred during infancy are presented. These cases appeared to be the result of pre-existing maternal deficiency. All three infants demonstrated evidence of neurodevelopmental delay at presentation, and one had sustained loss of milestones and developed involuntary motor move...

journal_title：Pediatric hematology and oncology

authors： Doyle JJ,Langevin AM,Zipursky A

更新日期：1989-01-01 00:00:00

abstract：:The objective of this study was to ascertain the reactions and experiences of parents whose children were defined as false-positive cases in a research program of screening 6-month-old babies for neuroblastoma. Parents of seven of the eight infants falling into this category participated in the study. Parents of five ...

journal_title：Pediatric hematology and oncology

authors： Bell S,Parker L,Cole M,Craft AW

更新日期：1994-03-01 00:00:00

abstract：:A 4-month old girl was diagnosed as having stage IV neuroblastoma of the right adrenal gland. Preoperative chemotherapy was given, followed by local surgical excision. Postoperatively, irradiation of the tumor bed and adjuvant chemotherapy was given for 11 months. Nine years after cessation of chemotherapy, the patien...

journal_title：Pediatric hematology and oncology

authors： Iwata A,Hirota T,Konno K,Fujimoto T,Sumida S,Sato K,Hara K

更新日期：2001-10-01 00:00:00

abstract：:Maternal education might be an important factor for the neuroblastoma risk in children, but it was conflicting. This meta-analysis was performed to evaluate the relationship between maternal education and neuroblastoma susceptibility and to explore whether maternal education was an important indicator to be associated...

journal_title：Pediatric hematology and oncology

authors： Wang P,Liao N,Liao XH,Liang B,Huang CX,Li W

更新日期：2013-02-01 00:00:00

abstract：PURPOSE:This study was to determine the efficacy of vincristine and irinotecan in children with relapsed hepatoblastoma (HB). METHODS:A total of 10 patients with relapsed HB were enrolled. Three patients were excluded. Patients received irinotecan 50 mg/m(2)/day, day 1-5 and vincristine 1.5 mg/m(2)/day, day 1, repeate...

journal_title：Pediatric hematology and oncology

authors： Zhang YT,Feng LH,Zhong XD,Wang LZ,Chang J

更新日期：2015-02-01 00:00:00

abstract：:The acquired form of pure red cell aplasia (PRCA) presents either as an acute self-limited disease, predominantly seen in children, or as a chronic illness more frequently seen in adults with rare spontaneous remissions. A 14-year-old boy presented with pallor, without hepatosplenomegaly, jaundice, lymphadenopathy, pe...

journal_title：Pediatric hematology and oncology

authors： Khalil A,Elhasid R,Ben Barak A,Ben Arush MW

更新日期：2010-10-01 00:00:00

abstract：:Parvovirus B19 (PVB19) is the causative agent of infectious erythema. In healthy children the virus causes transient erythroid aplasia, whereas in children with chronic hemolytic anemias it can cause severe aplastic crises, and in immunodeficient individuals it can produce chronic red cell aplasia. If contracted durin...

journal_title：Pediatric hematology and oncology

authors： Miniero R,Dalponte S,Linari A,Saracco P,Testa A,Musiani M

更新日期：1996-11-01 00:00:00

abstract：:Arsenic trioxide (ATO) has been proven to be highly effective in adults with newly diagnosed or relapsed acute promyelocytic leukemia (APL). Only very limited data are published on the use of ATO as a single agent for first-line therapy of relapsed APL. The authors present a case of a 8-year-old boy with a bone marrow...

journal_title：Pediatric hematology and oncology

authors： Ebinger M,Schwarze CP,Feuchtinger T,Scheel-Walter HG,Lang P,Hildenbrand S,Gessler P,Handgretinger R

更新日期：2011-05-01 00:00:00

abstract：:Histone deacetylase inhibitors (HDACis) are epigenetic agents that display antitumor activities in experimental medulloblastoma (MB). Fingolimod (FTY720), an immunosuppressant agent currently used in the treatment of multiple sclerosis, also has anticancer actions and can act as an HDACi. Here we examined whether fing...

journal_title：Pediatric hematology and oncology

authors： Perla AS,Fratini L,Cardoso PS,de Farias CB,da Cunha Jaeger M,Roesler R

更新日期：2020-03-01 00:00:00

abstract：:Autologous blood-derived stem cells were used for stem-cell rescue in a 5-year-old boy with chemotherapy-resistant B-Non-Hodgkin's lymphoma (B-NHL) involving bone marrow. The high dose chemoradiotherapy was carried out 5 months after initial diagnosis during partial remission. The preparative regimen consisted of 12 G...

journal_title：Pediatric hematology and oncology

authors： Emminger W,Emminger-Schmidmeier W,Ambros P,Gadner H,Höcker P,Radaszkiewicz T,Hinterberger W

更新日期：1990-01-01 00:00:00

abstract：:Hepatoblastoma, the commonest primary malignant liver tumor in infants and children, is usually associated with elevated serum alpha-fetoprotein (AFP) levels. The authors sought to determine if AFP levels can be used to modify treatment, thereby avoiding the wait for formal imaging studies and prolonged suboptimal tre...

journal_title：Pediatric hematology and oncology

authors： Sayar D,Yaniv I,Goshen Y,Cohen IJ

更新日期：2001-12-01 00:00:00