Complicated pulmonary aspergillosis with pneumothorax and pneumopericardium in a child with acute lymphoblastic leukemia.

Abstract:

:Invasive aspergillosis is a fungal infection that is being observed increasingly in immunocompromised patients due to the use of more aggressive chemotherapeutic regimens. To our knowledge, no case of pneumothorax and pneumopericardium associated with invasive pulmonary aspergillosis has been reported to date. High-dose amphotericin B (1 to 1.5 mg/kg/day) is the treatment of choice, although severe side effects, especially hypokalemia, are very common. Itraconazole is considered to be a therapeutic alternative for invasive pulmonary aspergillosis in immunocompromised patients. A rare combination of pneumothorax and pneumopericardium associated with systemic aspergillosis in a child with acute lymphoblastic leukemia is described. Treatment with low-dose amphotericin B and itraconazole achieved complete resolution of the foregoing complications.

journal_name

Pediatr Hematol Oncol

authors

Merino JM,Díaz MA,Ramírez M,Ruano D,Madero L

doi

10.3109/08880019509029555

subject

Has Abstract

pub_date

1995-03-01 00:00:00

pages

195-9

issue

2

eissn

0888-0018

issn

1521-0669

journal_volume

12

pub_type

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