Specific deficit analyses in motor performance and quality of life of pediatric cancer patients--a cross-sectional pilot study.


:Although survival rates in childhood cancer have distinctly improved, pediatric cancer patients often experience various disease- and treatment-related side effects with long-term consequences. Despite current studies investigating inactivity and limitations in physical functioning and quality of life in pediatric cancer patients, only little information regarding specific deficits in physical functioning and quality of life has been available until now. No study has yet analyzed these parameters from a global perspective and then identified specific deficits in a mixed childhood cancer population. Within this cross-sectional pilot study, motor performance and quality of life of 26 pediatric cancer patients were assessed after inpatient medical treatment, using standardized motor test batteries (MOT 4-6; DMT 6-18) and a quality of life questionnaire (KINDL®). Reference data have been mainly provided by the German "Children and Young People Health Survey" (KiGGS). Patients achieved lower motor performance scores (p = .000) (more than 27% below the average of healthy peers). Specific deficits were identified in motor speed and motor control (4-6 years), as well as in endurance, strength and coordination under time pressure (6-17 years). In terms of quality of life, no significant differences were examined compared to healthy children of the same age. The results of this study confirm that children with oncological diseases frequently have specific motor problems. Future research in pediatric oncology must investigate the impact of targeted, individualized exercise interventions addressing these specific deficits.


Pediatr Hematol Oncol


Beulertz J,Bloch W,Prokop A,Baumann FT




Has Abstract


2013-05-01 00:00:00












  • Efficacy of recombinant human granulocyte colony-stimulating factor and recombinant human granulocyte-macrophage colony-stimulating factor in neutropenic children with malignancies.

    abstract::The difference between the effects of administration of recombinant human granulocyte colony-stimulating factor (rhG-CSF) and recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF) was studied in 39 children with neutropenia secondary to chemotherapy (absolute neutrophil count (ANC) less than 1,...

    journal_title:Pediatric hematology and oncology

    pub_type: 临床试验,杂志文章


    authors: Lydaki E,Bolonaki E,Stiakaki E,Dimitriou H,Kalmantis T,Kalmanti M

    更新日期:1995-11-01 00:00:00

  • Allogeneic peripheral blood stem cell transplantation in beta-thalassemia.

    abstract::Six transfusion-dependent beta-thalassemia major patients were treated with allogeneic peripheral blood stem cell (PBSC) transplant. The donors were HLA identical siblings except one donor who was a father with one-antigen mismatch of HLA-B loci. The donors were mobilized with G-CSF and PBSC was infused without manipu...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章


    authors: Fang J,Huang S,Chen C,Zhou D,Wu Y,Bao R

    更新日期:2002-10-01 00:00:00

  • Efficacy and safety of human umbilical cord derived mesenchymal stem cell therapy in children with severe aplastic anemia following allogeneic hematopoietic stem cell transplantation: a retrospective case series of 37 patients.

    abstract::The treatment of pediatric severe aplastic anemia (SAA) with allogeneic hematopoietic stem cell transplantation (allo-HSCT), presents major challenges including the risks of graft failure, septic complications, and graft-versus-host disease (GVHD). Additive infusions of human umbilical cord derived mesenchymal stem ce...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章


    authors: Si Y,Yang K,Qin M,Zhang C,Du Z,Zhang X,Liu Y,Yue Y,Feng Z

    更新日期:2014-02-01 00:00:00

  • Low vitamin D levels are associated with both iron deficiency and anemia in children and adolescents.

    abstract:BACKGROUND:We aimed to examine the association between vitamin D deficiency and anemia in a nationally representative sample of Korean children and adolescents. METHODS:Cross-sectional data on 2526 children and adolescents aged 10-20 years from the Korea National Health and Nutrition Examination Survey-V (2010-2012) w...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章,多中心研究


    authors: Lee JA,Hwang JS,Hwang IT,Kim DH,Seo JH,Lim JS

    更新日期:2015-03-01 00:00:00

  • A pilot trial of tandem autologous peripheral blood progenitor cell transplantation following high-dose thiotepa and carboplatin in children with poor-risk central nervous system tumors.

    abstract::This is a pilot study performed to determine the maximum tolerated number of courses of high-dose thiotepa and carboplatin with autologous peripheral blood progenitor cell (PBPC) transplantation in poor-risk pediatric central nervous system (CNS) tumor patients. Twelve patients were enrolled and a total of 24 PBPC tra...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章


    authors: Ozkaynak MF,Sandoval C,Levendoglu-Tugal O,Jayabose S

    更新日期:2004-10-01 00:00:00

  • Relationship between modified CT severity index and clinical features of L-asparaginase-associated pancreatitis in pediatric acute lymphoblastic leukemia.

    abstract:PURPOSE:To describe clinical and CT features of L-asparaginase-associated pancreatitis (L-AP) and to correlate CT grades with clinical parameters. METHODS:A total of 16 children (M:F = 9:7; mean age, 8.1 years) who developed L-AP after L-asparaginase (L-asp) treatment and underwent abdominal CT scan were included. We ...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章


    authors: Oh HJ,Im SA,Lee JW,Chung NG,Cho B

    更新日期:2014-10-01 00:00:00

  • Vincristine and irinotecan in children with relapsed hepatoblastoma: a single-institution experience.

    abstract:PURPOSE:This study was to determine the efficacy of vincristine and irinotecan in children with relapsed hepatoblastoma (HB). METHODS:A total of 10 patients with relapsed HB were enrolled. Three patients were excluded. Patients received irinotecan 50 mg/m(2)/day, day 1-5 and vincristine 1.5 mg/m(2)/day, day 1, repeate...

    journal_title:Pediatric hematology and oncology

    pub_type: 临床试验,杂志文章


    authors: Zhang YT,Feng LH,Zhong XD,Wang LZ,Chang J

    更新日期:2015-02-01 00:00:00

  • Hodgkin's disease in association with Down syndrome: a case report.

    abstract::The increased incidence of malignancies, especially acute leukemia, in Down syndrome has been clearly established. The association of Hodgkin's disease with Down syndrome has not been extensively documented, and only a few cases have been reported. We present here a case report of Hodgkin's disease in an 11-year-old f...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章


    authors: Kusumakumary P,Jyothirmayi R,Chellam VG,Krishnan NM

    更新日期:1996-09-01 00:00:00

  • Percutaneous transhepatic biliary drainage in an infant with obstructive jaundice caused by neuroblastoma.

    abstract::Neuroblastoma presenting with obstructive jaundice is a rare event. Management of this condition includes surgery, chemotherapy, radiotherapy, temporary cholecystostomy tube, endoscopic retrograde cholangiopancreatography (ERCP), and internal biliary drainage (IBD). We herein describe our experience with one infant af...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章


    authors: Saettini F,Agazzi R,Giraldi E,Foglia C,Cavalleri L,Morali L,Fasolini G,Spotti A,Provenzi M

    更新日期:2015-04-01 00:00:00

  • Wiskott-Aldrich syndrome: Two case reports with a novel mutation.

    abstract:BACKGROUND:The Wiskott-Aldrich syndrome (WAS) is X-linked recessive disorder associated with microplatelet thrombocytopenia, eczema, infections, and an increased risk of autoimmunity and lymphoid neoplasia. The originally described features of WAS include susceptibility to infections, microthrombocytopenia, and eczema....

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章


    authors: Kamuran K,Çetin M,Geylan H,Karaman S,Demir N,Yurekturk E,Yavuz İ,Yavuz G,Tuncer O

    更新日期:2017-08-01 00:00:00

  • Olfactory neuroblastoma in children: results of multimodality treatment in 2 patients.

    abstract::Olfactory neuroblastoma, a rare malignancy of the olfactory epithelium, is an uncommon tumor in children. It occurs mostly in older individuals and the treatment strategies are based on the experience with adults. In this report, clinical characteristics and treatment results of 2 patients with olfactory neuroblastoma...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章


    authors: Küpeli S,Yalçin B,Büyükpamukçu M

    更新日期:2011-02-01 00:00:00

  • Cerebrospinal fluid and plasma methotrexate levels following high-dose regimen given as a 3-hour intravenous infusion in children with nonHodgkin's lymphoma.

    abstract::In the French nonHodgkin's lymphoma protocols, central nervous system prophylaxis is provided by high-dose methotrexate (HD-MTX), given as a 3-hour IV infusion of 3 g/m2 MTX along with intrathecal MTX injection. The incidence of CNS relapse is less than 3%. We designed a study to evaluate the MTX transfer across the b...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章


    authors: Vassal G,Valteau D,Bonnay M,Patte C,Aubier F,Lemerle J

    更新日期:1990-01-01 00:00:00

  • Usefulness of red cell zinc protoporphyrin concentration in the investigation of microcytosis in children.

    abstract::The clinical usefulness of the measurement of red cell zinc protoporphyrin (ZPP), an indicator of iron-deficient erythropoiesis, was assessed in a group of UK children undergoing investigation for red cell microcytosis. Of 213 children studied, 136 had increased ZPP values. Of these, 86 also had reduced iron stores as...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章


    authors: Hinchliffe RF,Lilleyman JS,Steel GJ,Bellamy GJ

    更新日期:1995-09-01 00:00:00

  • Homozygous 23-bp insertion of endothelial protein c receptor gene in a child with fatal sepsis.

    abstract::Endothelial protein C receptor (EPCR) is primarily localized on the endothelial cells of large blood vessels and is very low or absent in the microvascular endothelium of most tissues. EPCR augments the thrombin/thrombomodulin-dependent activation of protein C by 5- to 20-fold. EPCR appears to be physiologically signi...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章


    authors: Kendirli T,Ciftçi E,Ince E,Yurdakul E,Kansu A,Akar N

    更新日期:2007-04-01 00:00:00

  • Relationships of cytokine (GM-CSF) serum concentration to blood cell count and the inflammatory parameters in children with malignant diseases.

    abstract::This study examined both the endogenous and exogenous (therapy-related) pharmacokinetics of the cytokine granulocyte-macrophage colony-stimulating factor (GM-CSF) in neutropenic children with solid and systemic malignancies. The daily endogenous GM-CSF serum concentration before application was 29 pg/mL. During the 10...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章


    authors: Müller CE,Mukodzi S,Reddemann H

    更新日期:1999-11-01 00:00:00

  • Unexpected result in the etiological approaching to an anemic case: a leech infestation.

    abstract::One of the causes of the childhood anemia is gastrointestinal system bleeding, which rarely results from parasites. The authors report on a 3-year-old boy with severe anemia and a history of hematemesis. While they were investigating the cause of the anemia and the hematemesis, a leech showing itself in the nasal pass...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章


    authors: Demirören K,Calişkan U

    更新日期:2003-10-01 00:00:00

  • Therapy response correlates with ALDH activity in ALDH low-positive childhood acute lymphoblastic leukemias.

    abstract::The malignant cells of childhood acute lymphoblastic leukemia (ALL) do not form a homogenous entity but a collection of differently maturated blasts. The most immature leukemia cells may be more resistant to therapy than the bulk of more differentiated blasts. We studied 42 patients with childhood ALL treated accordin...

    journal_title:Pediatric hematology and oncology

    pub_type: 临床试验,杂志文章


    authors: Ahlers J,Witte KE,Schwarze CP,Lang P,Handgretinger R,Ebinger M

    更新日期:2014-05-01 00:00:00

  • MYCN amplification by differential PCR.

    abstract::A method is described to estimate MYCN (N-myc) oncogene amplification in neuroblastoma by the technique of differential polymerase chain reaction (PCR). The technique is quicker than conventional Southern blotting techniques and does not require radioactive materials. The ability to measure MYCN amplification from sma...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章


    authors: Huddart SN,Mann JR,McGukin AG,Corbett R

    更新日期:1993-01-01 00:00:00

  • 18F-fluorodeoxyglucose uptake of bone and soft tissue sarcomas in pediatric patients.

    abstract::A high (18)F-fluorodeoxyglucose (FDG) uptake by positron emission tomography/computed tomography (PET/CT) imaging in sarcomas of adults has been reported. The current study aimed at defining the degree of (18)F-FDG uptake of pediatric sarcomas. This retrospective study included 29 patients (23 males, 6 females; mean a...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章


    authors: Walter F,Federman N,Apichairuk W,Nelson S,Phelps ME,Allen-Auerbach M,Walter MA,Czernin J

    更新日期:2011-10-01 00:00:00

  • Advanced nasopharyngeal carcinoma in the young: The Northern Israel Oncology Center experience, 1973-1991.

    abstract::Between 1973 and 1991, 10 patients with locally advanced [stages III and IV] nasopharyngeal carcinoma were treated at the Northern Israel Oncology Center. All patients were treated with wide-field irradiation to the primary tumor, including the base of skull, neck, and supraclavicular region. After 1984, 6 patients al...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章


    authors: Arush MW,Stein ME,Rosenblatt E,Lavie R,Kuten A

    更新日期:1995-05-01 00:00:00

  • Angioimmunoblastic lymphadenopathy with dysproteinemia: report of a case in infancy with review of literature.

    abstract::A case of angioimmunoblastic lymphadenopathy with dysproteinemia (AILD) in infancy is reported. The disease had a mild onset with generalized lymphadenopathy, hepatosplenomegaly, thrombocytopenia, polyclonal hypergammaglobulinemia, and T-cell deficiency. The AILD course lasted more than 100 months, alternating clinica...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章,评审


    authors: de Terlizzi M,Toma MG,Santostasi T,Colella R,Ceci A,De Benedictis G

    更新日期:1989-01-01 00:00:00

  • Does D-dimer predict cerebral sinovenous thrombosis in the newborn?

    abstract::Sinovenous thrombosis describes thrombosis in one or more of the cerebral venous sinuses. The incidence of SVT in childhood appears to be highest during the neonatal period. Although plasma level of D-dimer has been shown to be sensitive for the diagnosis of deep vein thrombosis and pulmonary embolism in adult patient...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章


    authors: Karagöl BS,Erdeve O,Fítöz S,Uysal Z,Atasay B,Arsan S

    更新日期:2007-07-01 00:00:00

  • Dysgerminoma in a child with ataxia-telangiectasia.

    abstract::Ataxia-telangiectasia is an autosomal recessive disease characterized by progressive cerebellar ataxia, oculocutaneous telangiectasia, immunodeficiency, high incidence of cancer, and increased sensitivity to ionizing radiation. The authors report a case of dysgerminoma in a child with high alpha-fetoprotein, CA125 and...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章,评审


    authors: Koksal Y,Caliskan U,Ucar C,Yurtcu M,Artac H,Ilerisoy-Yakut Z,Reisli I

    更新日期:2007-09-01 00:00:00

  • Long-term remission after first-line single-agent treatment with arsenic trioxide of relapsed acute promyelocytic leukemia in an 8-year-old boy.

    abstract::Arsenic trioxide (ATO) has been proven to be highly effective in adults with newly diagnosed or relapsed acute promyelocytic leukemia (APL). Only very limited data are published on the use of ATO as a single agent for first-line therapy of relapsed APL. The authors present a case of a 8-year-old boy with a bone marrow...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章


    authors: Ebinger M,Schwarze CP,Feuchtinger T,Scheel-Walter HG,Lang P,Hildenbrand S,Gessler P,Handgretinger R

    更新日期:2011-05-01 00:00:00

  • How to interpret high levels of distress when using the Distress Thermometer in the long-term follow-up clinic? A study with Acute Lymphoblastic Leukemia survivors.

    abstract:OBJECTIVES:Recent guidelines recommend to assess emotional distress in pediatric oncology during treatment and in after care. One tool used to do this is the distress thermometer (DT), a simple tool which has almost exclusively been studied in its screening abilities. Given its increased used as a measure of distress p...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章


    authors: Pépin AJ,Lippé S,Krajinovic M,Laverdière C,Michon B,Sinnett D,Sultan S

    更新日期:2017-04-01 00:00:00

  • Causes for hospitalization and death in Iranian patients with β-thalassemia major.

    abstract::There are limited studies that have focused on the causes for hospitalization as an indicator of morbidity in patients with β-thalassemia major (BTM). A cross-sectional study was conducted to determine the main causes for hospitalization and death in hospitalized BTM patients in a referral hospital in Shiraz, southern...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章


    authors: Bazrgar M,Peiravian F,Abedpour F,Karimi M

    更新日期:2011-03-01 00:00:00

  • Tumor lysis syndrome complicating treatment of widespread metastatic abdominal rhabdomyosarcoma.

    abstract::In this paper we describe a 9-year-old girl with abdominal embryonal rhabdomyosarcoma. She had ascites and widespread metastatic disease at presentation and was oliguric but had a normal creatinine. Following the start of chemotherapy she developed acute renal failure secondary to the tumor lysis syndrome, requiring h...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章


    authors: Khan J,Broadbent VA

    更新日期:1993-04-01 00:00:00

  • Sustained molecular response following a failed attempt of tyrosine kinase inhibitor discontinuation & the effects on growth in a child with chronic myeloid leukemia: not always a short story.

    abstract::We report a patient who developed chronic myelogenous leukemia (CML) at 12 months of age. She was treated aggressively with stem cell transplant (SCT), interferon, donor lymphocytes and imatinib, with subsequent molecular progression. She received dasatinib, achieving a complete molecular response. Dasatinib was disco...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章


    authors: Triche L,Yarbrough A,Roth M,Ying A,Wells R

    更新日期:2020-08-01 00:00:00

  • Serum galactomannan screening for diagnosis of invasive pulmonary aspergillosis in children after stem cell transplantation or with high-risk leukemia.

    abstract::Both transplanted and leukemia patients are at high risk (HR) for invasive pulmonary aspergillosis (IPA). Methods for rapid diagnosis are crucial. Our objective was to investigate the impact of serial serum galactomannan assay (GMA) screening on IPA diagnosis in children. Between January 2010 and December 2011, all ch...

    journal_title:Pediatric hematology and oncology

    pub_type: 临床试验,杂志文章


    authors: Gefen A,Zaidman I,Shachor-Meyouhas Y,Avidor I,Hakim F,Weyl Ben-Arush M,Kassis I

    更新日期:2015-03-01 00:00:00

  • Acute monoblastic leukemia as a second malignancy following chemotherapy for osteogenic sarcoma: a case report.

    abstract::A patient with well-differentiated monoblastic leukemia (ANLL FAB-M5b) is described in whom acute leukemia was diagnosed 25 months after having completed postoperative adjuvant chemotherapy for osteogenic sarcoma of the femur. All analyzed metaphases showed 48xy, dup 1(q12), +3, +9. ...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章


    authors: Orazi A,Sozzi G,Delia D,Morandi F,Rottoli L,Cattoretti G

    更新日期:1988-01-01 00:00:00