Red blood cell distribution width is not a reliable biomarker for low iron stores in children with cystic fibrosis.

abstract：:The treatment of a child with a relapsed state acute leukemia after allogeneic stem cell transplantation (allo-SCT) is a challenge. The authors report about a child with an acute myelogenous leukemia (AML), which relapsed after allo-SCT despite immunological intervention. It was further treated with a second line chem...

journal_title：Pediatric hematology and oncology

authors： Hartwig M,Weigel S,Bernig T,Bader P,Dölken R,Beck J

更新日期：2007-03-01 00:00:00

abstract：:Adrenocortical carcinoma (ACC) is a rare, aggressive endocrine neoplasm. Complete surgical resection is the single most important treatment. Most available information has been learned from experience with its more frequent adult counterpart. In this study, we assessed the features and survival outcome of patients wit...

journal_title：Pediatric hematology and oncology

authors： Zekri W,Hammad M,Rashed WM,Ahmed G,Elshafie M,Adly MH,Elborai Y,Abdalla B,Taha H,Elkinaae N,Refaat A,Younis A,Alfaar AS

更新日期：2020-04-01 00:00:00

abstract：:Histone deacetylase inhibitors (HDACis) are epigenetic agents that display antitumor activities in experimental medulloblastoma (MB). Fingolimod (FTY720), an immunosuppressant agent currently used in the treatment of multiple sclerosis, also has anticancer actions and can act as an HDACi. Here we examined whether fing...

journal_title：Pediatric hematology and oncology

authors： Perla AS,Fratini L,Cardoso PS,de Farias CB,da Cunha Jaeger M,Roesler R

更新日期：2020-03-01 00:00:00

abstract：:Two children with inflammatory pseudotumor (IPT) of the lung are reported. Symptomless "cystic" lesions were present on routine chest x ray. Morphological study of these peculiar lesions included light microscopic, immunohistochemical, and ultrastructural analysis. Histologic appearance of the lesion varied from the f...

journal_title：Pediatric hematology and oncology

authors： Vujanić GM,Dojĉinov D

更新日期：1991-04-01 00:00:00

abstract：:Increased susceptibility to infection is reported in patients with beta-thalassemia major due to toxic effect of iron on neutrophil functions and reticuloendothelial system dysfunction. This study investigated the association between the neutrophil apoptosis and frequency of infection episodes, desferrioxamine treatme...

journal_title：Pediatric hematology and oncology

authors： Oren H,Sahin B,Irken G,Ateş H,Duman M,Yilmaz S,Türker M,Atabay B,Yaprak I

更新日期：2003-04-01 00:00:00

abstract：:The authors report on supernumerary nipples and various hematologic disorders in 7 patients [factor X deficiency (n = 1), factor XI deficiency (n = 2), acute lymphoblastic leukemia (n = 3), and acute myeloblastic leukemia (n = 1)]. They would like to draw attention to the association of supernumerary nipples with hema...

journal_title：Pediatric hematology and oncology

authors： Aslan D,Gürsel T,Kaya Z

更新日期：2004-07-01 00:00:00

abstract：:Immune thrombocytopenia (ITP) is an acute self-limited disease of childhood, mostly resolving within 6 months irrespective of whether therapy is given or not. Treatment options when indicated include corticosteroids, intravenous immune globulin (IVIG), and anti-RhD immunoglobulin. We reviewed our 32 years' experience ...

journal_title：Pediatric hematology and oncology

authors： Yildiz I,Ozdemir N,Celkan T,Soylu S,Karaman S,Canbolat A,Dogru O,Erginoz E,Apak H

更新日期：2015-01-01 00:00:00

abstract：:The FLT3 gene encodes a tyrosine kinase receptor that regulates proliferation and differentiation of hematopoietic cells. Recently, the internal duplication of FLT3 has been observed in hematological malignancies, suggesting the involvement of these mutations in leukemogenesis. The authors analyzed the expression of F...

journal_title：Pediatric hematology and oncology

authors： Ishii E,Zaitsu M,Ihara K,Hara T,Miyazaki S

更新日期：1999-09-01 00:00:00

abstract：:Absolute lymphocyte count (ALC) has been associated with overall survival (OS) and event-free survival, but we do not know if ALC is associated with minimal residual disease (MRD) at the end of induction (EOI) and whether it can be used as surrogate marker in resource limited settings. Immunological differences betwee...

journal_title：Pediatric hematology and oncology

authors： Pushpam D,Rajput N,Chopra A,Vishnubhatla S,Kumari M,Kumar R,Bakhshi S

更新日期：2019-04-01 00:00:00

abstract：:Immune thrombocytopenia (ITP) is a frequently encountered disease in childhood. Recent reports pointed to the benefit of high-dose steroid in ITP treatment since it resulted in a better outcome in a shorter time than IV immunoglobulin therapy. In the authors' clinic, mainly after 1984, megadose methyl prednisolone (MD...

journal_title：Pediatric hematology and oncology

authors： Yetgin S,Yenicesu IC,Ersoy F

更新日期：2005-07-01 00:00:00

abstract：:We investigated bone marrow (BM) recovery of hematopoietic stem cells (HSC) and hematopoietic microenvironment after chemotherapy in childhood acute lymphoblastic leukemia (ALL). Twenty-nine de novo childhood ALL patients were enrolled and BM biopsy sections at diagnosis (BM0), after induction (BM1), consolidation (BM...

journal_title：Pediatric hematology and oncology

authors： Park SH,Lee MJ,Park CJ,Jang S,Seo EJ,Im HJ,Seo JJ

更新日期：2019-05-01 00:00:00

abstract：:Li-Fraumeni syndrome (LFS) is one of the familial cancers characterized by different tumors and hereditary TP53 mutations. The adrenocortical carcinoma (ACC) association with acute leukemia is unusual in childhood, even in LFS. The authors here present a family with pR337P mutation in TP53 gene who had a child with ac...

journal_title：Pediatric hematology and oncology

authors： Karakas Z,Tugcu D,Unuvar A,Atay D,Akcay A,Gedik H,Kayserili H,Dogan O,Anak S,Devecioglu O

更新日期：2010-05-01 00:00:00

abstract：:The development of myeloid leukemias and myelodysplastic syndrome (MDS) is common in children with trisomy 8 mosaicism. However, the mechanisms by which the presence of an additional chromosome 8 translates to an increased risk of leukemias and MDS is currently unknown. The authors describe the analysis of stromal cel...

journal_title：Pediatric hematology and oncology

authors： Narendran A,Hawkins LM,Ganjavi H,Vanek W,Gee MF,Barlow JW,Johnson G,Malkin D,Freedman MH

更新日期：2004-04-01 00:00:00

abstract：:To determine treatment outcome using ceftazidime-aminoglycosides in febrile neutropenic children with cancer, the authors conducted a prospective cohort study in 216 episodes. Early and complete responses to antibiotics were 108/216 (50.0%) and 133/216 (61.6%) episodes, respectively. Death, a modification of antibioti...

journal_title：Pediatric hematology and oncology

authors： Laoprasopwattana K,Pruekprasert P,Laosombat V,Wongchanchailert M

更新日期：2007-12-01 00:00:00

abstract：:Hyperleukocytosis in patients with leukemia is associated with early mortality, especially due to the pulmonary and neurological complications of leukostasis. The prompt use of leukapheresis may improve patients' survival in the initial treatment period. The medical records of all previously untreated acute leukemia p...

journal_title：Pediatric hematology and oncology

authors： Yilmaz D,Karapinar B,Karadaş N,Duyu M,Yazici P,Ay Y,Balkan C,Aydinok Y,Kavakli K

更新日期：2014-05-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) seems to play a central role in angiogenesis-lymphangiogenesis in hematological malignancies. There are limited data related to childhood hematologic malignancies. The aim of the study was to evaluate soluble VEGF (sVEGF) levels in children with acute leukemia and malignant ly...

journal_title：Pediatric hematology and oncology

authors： Dincaslan HU,Yavuz G,Unal E,Tacyildiz N,Ikinciogullari A,Dogu F,Guloglu D,Yuksek N,Ertem U

更新日期：2010-10-01 00:00:00

abstract：:Factor X (FX) is the component of both extrinsic and intrinsic coagulation cascade and is the first enzyme of the common pathway which results in thrombus. Congenital FX deficiency (FXD) is an extremely rare coagulation defect. In this study, we aimed to investigate the clinical and laboratory data of the patients dia...

journal_title：Pediatric hematology and oncology

authors： Karabel M,Söker M,Yıldırım AT,Oymak Y,Kelekçi S,Karabel D

更新日期：2013-11-01 00:00:00

abstract：:We present the management challenge provided by a patient with kaposiform hemangioendothelioma associated with Kasabach-Merritt phenomenon. A female child presented at 14 months of age with an ecchymotic swelling of her right upper arm and axilla. Subsequently, she developed profound thrombocytopenia and hypofibrinoge...

journal_title：Pediatric hematology and oncology

authors： Blei F,Karp N,Rofsky N,Rosen R,Greco MA

更新日期：1998-07-01 00:00:00

abstract：:Primary CNS germ cell tumors (GCT) arise in the suprasellar and pineal regions. Suprasellar GCT may remain radiographically occult during the early symptomatic period. Although theoretically possible, it is more difficult to identify presymptomatic disease in the pineal region. Given the sensitivity of GCT to cytotoxi...

journal_title：Pediatric hematology and oncology

authors： MacDonald SM,Desai N,Heller G,Rolnitzky L,Allen JC

更新日期：2008-01-01 00:00:00

abstract：:The effectiveness of the different pharmacological agents and different doses of systemic corticosteroids was analyzed. A total of 1109 patients (median age 8 months; F/M: 2.3) with hemangioma, followed up in our unit for 23 years, were evaluated retrospectively. Forty-five of them received systemic corticosteroids. T...

journal_title：Pediatric hematology and oncology

authors： Akyüz C,Yariş N,Kutluk MT,Büyükpamukçu M

更新日期：2001-01-01 00:00:00

abstract：:To determine the effect of recombinant human granulocyte-colony stimulation factor (rhG-CSF) on the immune system, serum immunoglobulins, lymphocyte subsets, and serum cytokines were analyzed in eight pediatric patients with aplastic anemia (AA) during 8-week rhG-CSF therapy. The rhG-CSF was administered either subcut...

journal_title：Pediatric hematology and oncology

authors： Hibi S,Yoshihara T,Nakajima F,Misu H,Mabuchi O,Imashuku S

更新日期：1994-05-01 00:00:00

abstract：:Unexplained menorrhagia and hematuria occurred in a 13-year-old female with a mild inherited platelet disorder who had never experienced prior bleeding as a result of this disorder. An intensive search revealed that this patient was receiving coumadin that was given by the mother. In addition, the mother drew large vo...

journal_title：Pediatric hematology and oncology

authors： Souid AK,Korins K,Keith D,Dubansky S,Sadowitz PD

更新日期：1993-07-01 00:00:00

abstract：:The authors aimed to investigate the efficacy of epoetin-alpha on hemoglobin levels and red cell transfusion requirement in children with both hematologic malignancy (HM, n = 27) and solid tumors (ST, n = 14). Epoetin-alpha was given (150 U/kg or 250 U/kg, thrice weekly) for 12 weeks. Epoetin alpha significantly incre...

journal_title：Pediatric hematology and oncology

authors： Yilmaz D,Cetingül N,Kantar M,Oniz H,Kansoy S,Kavakli K

更新日期：2004-01-01 00:00:00

abstract：:Ataxia-telangiectasia is an autosomal recessive disease characterized by progressive cerebellar ataxia, oculocutaneous telangiectasia, immunodeficiency, high incidence of cancer, and increased sensitivity to ionizing radiation. The authors report a case of dysgerminoma in a child with high alpha-fetoprotein, CA125 and...

journal_title：Pediatric hematology and oncology

authors： Koksal Y,Caliskan U,Ucar C,Yurtcu M,Artac H,Ilerisoy-Yakut Z,Reisli I

更新日期：2007-09-01 00:00:00

abstract：:Twenty-eight children with HSP and 79 healthy children were entered into study. Activities of protein C, free-protein S and antithrombin, activated protein C resistance, levels of fibrinogen. D-dimer, thrombin-antithrombin complex (TAT), prothrombin fragments 1 + 2 (PF(1+2)), and von Willebrand factor antigen (vWAg) a...

journal_title：Pediatric hematology and oncology

authors： Yilmaz D,Kavakli K,Ozkayin N

更新日期：2005-01-01 00:00:00

abstract：:In patients undergoing bone marrow transplantation cryptococcosis is rarely encountered. We report a fatal case of Cryptococcus meningitis in a 12-year-old girl with acute lymphoblastic leukemia (ALL) in second remission who had a transplant from a human leukocyte antigen (HLA)-identical unrelated bone marrow donor. T...

journal_title：Pediatric hematology and oncology

authors： Miniero R,Nesi F,Vai S,De Intinis G,Papalia F,Targhetta R,Busca A,Vassallo E,Giacchino M

更新日期：1997-09-01 00:00:00

abstract：:Neutropenic enterocolitis is an acute, life-threatening inflammation of the small and large bowel, often seen in children with malignancies during periods of prolonged or severe neutropenia. During the period 1990-1995, 180 children were treated at the authors' center for acute lymphoblastic leukemia using a standard ...

journal_title：Pediatric hematology and oncology

authors： Jain Y,Arya LS,Kataria R

更新日期：2000-01-01 00:00:00

abstract：:Since the mid-1960s intrathecal chemotherapy (methotrexate [MTX], cytarabine [Ara-C], or both, plus hydrocortisone) has constituted the standard approach to prophylaxis and treatment of central nervous system (CNS) leukemia and lymphoma. Intrathecal chemotherapy-related neurotoxicity has been described in a variable p...

journal_title：Pediatric hematology and oncology

authors： García-Tena J,López-Andreu JA,Ferrís J,Menor F,Mulas F,Millet E,Verdeguer A

更新日期：1995-07-01 00:00:00

abstract：:The difference between the effects of administration of recombinant human granulocyte colony-stimulating factor (rhG-CSF) and recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF) was studied in 39 children with neutropenia secondary to chemotherapy (absolute neutrophil count (ANC) less than 1,...

journal_title：Pediatric hematology and oncology

authors： Lydaki E,Bolonaki E,Stiakaki E,Dimitriou H,Kalmantis T,Kalmanti M

更新日期：1995-11-01 00:00:00

abstract：:A prospective, open-label, randomized, comparative study in pediatric cancer patients was conducted to evaluate the efficacy and safety of cefepime and meropenem in the empiric therapy of febrile neutropenic patients. Febrile episodes were classified as microbiologically documented infection, clinical documented infec...

journal_title：Pediatric hematology and oncology

authors： Oguz A,Karadeniz C,Citak EC,Cil V,Eldes N

更新日期：2006-04-01 00:00:00