Acute hemodynamic and arrhythmogenic effects of high-dose intravenous salbutamol in patients with chronic left ventricular dysfunction.

Abstract:

:The short-term hemodynamic and possible arrhythmogenic effects of intravenous salbutamol at a dose of 30 or 60 micrograms/min were evaluated in 14 patients with severe chronic left ventricular dysfunction using equilibrium radionuclide angiocardiography and electrocardiographic monitoring. Salbutamol infusions at a dose of 30 micrograms/min did not cause significant hemodynamic changes; however, at a dose of 60 micrograms/min there was a significant increase in stroke volume, cardiac output, and left ventricular ejection fraction. Heart rate increased significantly while systemic peripheral resistance decreased significantly. Two patients developed ventricular premature beats and another two supraventricular tachycardia, but none were associated with adverse consequences. Thus, high-dose intravenous salbutamol is effective and safe, and may be used in the acute management of patients with poor left ventricular function.

journal_name

Clin Cardiol

journal_title

Clinical cardiology

authors

Rotstein Z,Battler A,Rath S,Perek J,Eldar M

doi

10.1002/clc.4960130708

subject

Has Abstract

pub_date

1990-07-01 00:00:00

pages

468-72

issue

7

eissn

0160-9289

issn

1932-8737

journal_volume

13

pub_type

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