Abstract:
BACKGROUND:The relationship between eicosapentaenoic acid (EPA) therapy and coronary plaque stability assessed by optical frequency domain imaging (OFDI) has not been thoroughly described. HYPOTHESIS:EPA therapy is associated with decreased plaque instability in patients undergoing percutaneous coronary intervention (PCI) using OFDI. METHODS:Data on coronary artery plaques from 121 patients who consecutively underwent PCI between October 2015 and July 2018 were retrospectively analyzed. Of these patients, 109 were untreated (no-EPA group), whereas 12 were treated with EPA (EPA group). Each plaque's morphological characteristics were analyzed using OFDI. RESULTS:We used 1:4 propensity score matching for patients who received or did not receive EPA therapy before PCI. Baseline characteristics were balanced between both groups (age, sex, body mass index, diabetes mellitus, hypertension, dyslipidemia, chronic kidney disease, smoking, previous PCI or coronary artery bypass grafting, previous myocardial infarction, prior statin use, acute coronary syndrome, hemoglobin A1c level, low-density lipoprotein cholesterol concentration, triglyceride concentration, and high-density lipoprotein cholesterol concentration). OFDI data from 60 patients were analyzed in this study. The EPA group had significantly lower mean lipid index (818 ± 806 vs 1574 ± 891) and macrophage grade (13.5 ± 5.9 vs 19.3 ± 7.4) but higher mean minimum fibrous cap thickness (109.2 ± 55.7 vs 81.6 ± 36.4 μm) than the no-EPA group (P = 0.010, 0.019, and 0.040, respectively). Multiple logistic regression analyses showed that prior EPA use was independently associated with lower lipid index and macrophage grade (P = 0.043 and 0.024, respectively). CONCLUSION:This OFDI analysis suggests that EPA therapy is associated with decreased plaque instability in patients undergoing PCI.
journal_name
Clin Cardioljournal_title
Clinical cardiologyauthors
Konishi T,Sunaga D,Funayama N,Yamamoto T,Murakami H,Hotta D,Nojima M,Tanaka Sdoi
10.1002/clc.23185subject
Has Abstractpub_date
2019-06-01 00:00:00pages
618-628issue
6eissn
0160-9289issn
1932-8737journal_volume
42pub_type
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journal_title:Clinical cardiology
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doi:10.1002/clc.4960130311
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1994-10-01 00:00:00
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journal_title:Clinical cardiology
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更新日期:2018-03-01 00:00:00
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更新日期:2017-10-01 00:00:00
abstract::Subaortic stenosis has been described with increasing frequency as an ominous feature of atrioventricular septal defect (AVSD), especially following surgical correction of the anomaly in non-Down's syndrome patients. In order to study the surgical anatomy of the left ventricular outflow tract in this malformation, 48 ...
journal_title:Clinical cardiology
pub_type: 杂志文章,评审
doi:10.1002/clc.4960140611
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更新日期:1987-04-01 00:00:00
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更新日期:2017-03-01 00:00:00