Abstract:
BACKGROUND AND HYPOTHESIS:Genetic influence on development of athlete's heart is uncertain. This study investigated whether angiotensin-converting enzyme (ACE) gene polymorphism influenced development of athlete's heart. METHODS:Forty-three participants in a 100-km ultramarathon were classified on the basis of ACE gene polymorphism into a deletion group (n = 26) and an insertion group (n = 17). Echocardiograms were recorded to determine left ventricular end-diastolic and end-systolic diameters, interventricular septal thickness, left ventricular posterior wall thickness, left ventricular mass, and ejection fraction. RESULTS:Left ventricular end-diastolic diameter (65.5 +/- 4.0 mm) and left ventricular mass (369.5 +/- 73.9 g) were significantly larger in the subjects with deletion than in those with insertion (57.4 +/- 4.2 mm, 306.5 +/- 93.7 g). However, no significant differences in the other parameters were noted. CONCLUSIONS:In long-distance runners, ACE gene polymorphism of the D/D and D/I genotypes has a stronger influence on left ventricular hypertrophy than polymorphism of the I/I genotype.
journal_name
Clin Cardioljournal_title
Clinical cardiologyauthors
Nagashima J,Musha H,Takada H,Awaya T,Oba H,Mori N,Ohmiya K,Nobuoka S,Murayama Mdoi
10.1002/clc.4960230814subject
Has Abstractpub_date
2000-08-01 00:00:00pages
621-4issue
8eissn
0160-9289issn
1932-8737journal_volume
23pub_type
杂志文章abstract:BACKGROUND:Myocardial infarction in the absence of obstructive coronary artery disease (MINOCA) accounts for approximately 5% - 6% of acute myocardial infarction (AMI) patients. Anxiety symptoms are common in patients with coronary artery disease (CAD), and are associated with a poor prognosis. However, the association...
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pub_type: 临床试验,杂志文章,多中心研究
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