Influence of angiotensin-converting enzyme gene polymorphism on development of athlete's heart.

Abstract:

BACKGROUND AND HYPOTHESIS:Genetic influence on development of athlete's heart is uncertain. This study investigated whether angiotensin-converting enzyme (ACE) gene polymorphism influenced development of athlete's heart. METHODS:Forty-three participants in a 100-km ultramarathon were classified on the basis of ACE gene polymorphism into a deletion group (n = 26) and an insertion group (n = 17). Echocardiograms were recorded to determine left ventricular end-diastolic and end-systolic diameters, interventricular septal thickness, left ventricular posterior wall thickness, left ventricular mass, and ejection fraction. RESULTS:Left ventricular end-diastolic diameter (65.5 +/- 4.0 mm) and left ventricular mass (369.5 +/- 73.9 g) were significantly larger in the subjects with deletion than in those with insertion (57.4 +/- 4.2 mm, 306.5 +/- 93.7 g). However, no significant differences in the other parameters were noted. CONCLUSIONS:In long-distance runners, ACE gene polymorphism of the D/D and D/I genotypes has a stronger influence on left ventricular hypertrophy than polymorphism of the I/I genotype.

journal_name

Clin Cardiol

journal_title

Clinical cardiology

authors

Nagashima J,Musha H,Takada H,Awaya T,Oba H,Mori N,Ohmiya K,Nobuoka S,Murayama M

doi

10.1002/clc.4960230814

subject

Has Abstract

pub_date

2000-08-01 00:00:00

pages

621-4

issue

8

eissn

0160-9289

issn

1932-8737

journal_volume

23

pub_type

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