Monocyte chemoattractant protein-1 and coronary artery disease.

Abstract:

:The designation of atherosclerosis as a chronic inflammatory process represents an exciting and logical paradigm shift for cardiologists. Monocyte chemoattractant protein-1 (MCP-1) plays an important role in the recruitment and activation of monocytes and thus in the development of atherosclerosis. Enhanced MCP-1 expression has been detected in macrophages, endothelial cells, and vascular smooth muscle cells in the atheromatous plaque. Activation of macrophages by MCP-1 also appears to be involved in the vulnerability of the plaque. Indeed, circulating MCP-1 levels are elevated in patients with acute myocardial infarction and in those with unstable angina, but not in patients with stable angina. Production of MCP-1 and macrophage accumulation are also observed after coronary angioplasty or grafting, indicating that MCP-1 expression may be related not only to instability of atheromatous plaques, but also to the formation of restenotic lesions. The development of therapeutic drugs for atherosclerosis targeted specially against MCP-1 may be useful in the prevention of plaque formation and future myocardial infarction.

journal_name

Clin Cardiol

journal_title

Clinical cardiology

authors

Ikeda U,Matsui K,Murakami Y,Shimada K

doi

10.1002/clc.4960250403

subject

Has Abstract

pub_date

2002-04-01 00:00:00

pages

143-7

issue

4

eissn

0160-9289

issn

1932-8737

journal_volume

25

pub_type

杂志文章,评审
  • Effects of acute exercise on hemorheological, endothelial, and platelet markers in patients with chronic heart failure in sinus rhythm.

    abstract:BACKGROUND:Chronic heart failure (CHF) is associated with an increased risk of thrombosis and thromboembolic events, including stroke and venous thromboembolism. which may be related to a prothrombotic or hypercoagulable state. Acute vigorous exercise has been associated with activation of hemostasis, and this risk may...

    journal_title:Clinical cardiology

    pub_type: 杂志文章

    doi:10.1002/clc.4960241107

    authors: Gibbs CR,Blann AD,Edmunds E,Watson RD,Lip GY

    更新日期:2001-11-01 00:00:00

  • Transient biventricular apical ballooning: a unique presentation of the "broken heart".

    abstract::Transient left ventricular (LV) apical ballooning and normal epicardial coronary arteries are the hallmarks of Takotsubo cardiomyopathy. The syndrome is often triggered by emotional or physiologic stress, and its pathogenesis is poorly understood. Current proposals focus on elevated cathecolamines in association with ...

    journal_title:Clinical cardiology

    pub_type: 杂志文章

    doi:10.1002/clc.20065

    authors: Novak G,Kross K,Follmer K,Brofferio A,Shirani J

    更新日期:2007-07-01 00:00:00

  • Left atrial activation and asymmetric anatomical remodeling in patients with atrial fibrillation: The relation between anatomy and function.

    abstract:BACKGROUND:Identifying patients with advanced left atrial (LA) remodeling before catheter ablation (CA) of atrial fibrillation (AF) is crucial. HYPOTHESIS:This study aimed to identify echocardiographic parameters associated with changes in anatomy and conduction properties of the left atrium (LA). METHODS:We examined...

    journal_title:Clinical cardiology

    pub_type: 杂志文章

    doi:10.1002/clc.23515

    authors: Nedios S,Löbe S,Knopp H,Seewöster T,Heijman J,Crijns HJGM,Arya A,Bollmann A,Hindricks G,Dinov B

    更新日期:2021-01-01 00:00:00

  • Diagnosis of aortic pseudoaneurysm by echocardiography.

    abstract::The diagnosis of pseudoaneurysm of the ascending aorta is of paramount importance because of its propensity to rupture. As the frequency of surgical procedures involving the aortic root and valve increases, an increase in the incidence of aortic pseudoaneurysm may be anticipated. We recently studied a patient who deve...

    journal_title:Clinical cardiology

    pub_type: 杂志文章

    doi:10.1002/clc.4960151017

    authors: Lasorda DM,Power TP,Dianzumba SB,Incorvati RL

    更新日期:1992-10-01 00:00:00

  • Sudden death and its risk factors after atrioventricular junction ablation and pacemaker implantation in patients with atrial fibrillation.

    abstract:BACKGROUND:Although sudden death (SD) is a rare complication after atrioventricular junction (AVJ) ablation and permanent pacemaker implantation, the risk factors leading to this SD remain unknown. The purpose of this study was to investigate SD and its risk factors after ablate-and-pace strategy for rate control in at...

    journal_title:Clinical cardiology

    pub_type: 杂志文章

    doi:10.1002/clc.22600

    authors: Wang RX,Lee HC,Li JP,Hodge DO,Cha YM,Friedman PA,Munger TM,Srivathsan K,Pavri BB,Shen WK

    更新日期:2017-01-01 00:00:00

  • Stroke and Systemic Embolism After Successful Ablation of Typical Atrial Flutter.

    abstract:BACKGROUND:Following successful cavotricuspid isthmus (CTI) ablation during typical atrial flutter (AFL), anticoagulation therapy is usually withdrawn. However, potential subsequent atrial fibrillation (AF) in these patients may increase embolic risk in the long term. Embolic rates in this setting have not been clearly...

    journal_title:Clinical cardiology

    pub_type: 杂志文章

    doi:10.1002/clc.22538

    authors: Expósito V,Rodríguez-Entem F,González-Enríquez S,Veiga G,Olavarri I,Olalla JJ

    更新日期:2016-06-01 00:00:00

  • The epidemiology of triglyceride as a coronary artery disease risk factor.

    abstract::Triglyceride (TG) has long been associated as a risk factor for coronary artery disease. A recent meta-analysis of various epidemiologic studies has confirmed this link. An important issue is to assess further the appropriate cutpoints to classify desirable TG because recent data indicate that levels < 200 mg/dl confe...

    journal_title:Clinical cardiology

    pub_type: 杂志文章,评审

    doi:10.1002/clc.4960221402

    authors: Miller M

    更新日期:1999-06-01 00:00:00

  • Expanding the understanding of the treatment of chronic angina: a 21st century approach-part II.

    abstract::Three randomized, clinical trials of the drug ranolazine relate to patients with symptomatic myocardial ischemia. A fourth randomized, controlled, clinical trial compares optimal medical therapy with percutaneous coronary intervention (PCI) plus medical therapy. ...

    journal_title:Clinical cardiology

    pub_type: 社论

    doi:10.1002/clc.20406

    authors: Conti CR

    更新日期:2008-07-01 00:00:00

  • Hypertrophic cardiomyopathy: two-dimensional echocardiographic score versus clinical and electrocardiographic findings.

    abstract::The severity and site of hypertrophy is important in determining the clinical picture and the natural history of hypertrophic cardiomyopathy (HCM). We evaluated left ventricular hypertrophy by means of two-dimensional echocardiographic score and score index, and correlated these findings with symptoms, electrovector-c...

    journal_title:Clinical cardiology

    pub_type: 杂志文章

    doi:10.1002/clc.4960120809

    authors: Melacini P,Fasoli G,Canciani B,Buja G,Mammola C,Volta SD

    更新日期:1989-08-01 00:00:00

  • Dynamic assessment of myocardial involvement in patients with end-stage renal disease by ultrasonic tissue characterization and serum markers of collagen metabolism.

    abstract:BACKGROUND:Congestive heart failure is the most common cause of mortality in patients with end-stage renal disease (ESRD). However, noninvasive assessment for cardiac involvement in ESRD has not been established. HYPOTHESIS:Assessment of ultrasonic tissue characterization and serum markers of collagen degradation is u...

    journal_title:Clinical cardiology

    pub_type: 杂志文章

    doi:10.1002/clc.4960270412

    authors: Fatema K,Hirono O,Masakane I,Nitobe J,Kaneko K,Zhang X,Takeishi Y,Kubota I

    更新日期:2004-04-01 00:00:00

  • Acute effects of alcohol on left ventricular dynamics during isometric exercise in normal subjects.

    abstract::The aim of this study was to assess whether drinking social amounts of alcohol impairs myocardial contractility in normal humans. To that end, 17 healthy volunteers performed isometric handgrip exercise before and 60 minutes after an intake of 1 g/kg body weight of ethanol within 60 minutes. Left ventricular M-mode ec...

    journal_title:Clinical cardiology

    pub_type: 杂志文章

    doi:10.1002/clc.4960060302

    authors: Kupari M,Heikkilä J,Ylikahri R

    更新日期:1983-03-01 00:00:00

  • Echocardiography of the coronary sinus in adults.

    abstract::The coronary sinus (CS) is a small tubular structure just above the posterior left atrioventricular junction. The CS can be imaged in several different echocardiographic views. Using zoom M-mode recordings of the CS in apical two-chamber view, CS caliber can be sharply imaged and easily measured during different phase...

    journal_title:Clinical cardiology

    pub_type: 杂志文章,评审

    doi:10.1002/clc.4960230304

    authors: D'Cruz IA,Shala MB,Johns C

    更新日期:2000-03-01 00:00:00

  • Mechanism of left atrial enlargement related to ventricular diastolic impairment in hypertension.

    abstract:BACKGROUND AND HYPOTHESIS:Systemic hypertension is the leading cause of left ventricular (LV) hypertrophy. The present study aimed to investigate the mechanism of left atrial (LA) enlargement in patients with hypertensive heart disease during cardiac catheterization. METHODS:Data were obtained from eight control subje...

    journal_title:Clinical cardiology

    pub_type: 临床试验,杂志文章

    doi:10.1002/clc.4960191211

    authors: Matsuda M,Matsuda Y

    更新日期:1996-12-01 00:00:00

  • Evaluation of left ventricular diastolic function profile in patients with pulmonary hypertension due to heart failure with preserved ejection fraction.

    abstract:BACKGROUND:Echocardiography plays an important role in the diagnostic work up of heart failure with preserved ejection fraction (HFpEF). We sought to determine the left ventricular (LV) diastolic profile by echocardiography in patients diagnosed with pulmonary hypertension (PH) due to PH-HFpEF. HYPOTHESIS:The study of...

    journal_title:Clinical cardiology

    pub_type: 杂志文章

    doi:10.1002/clc.22664

    authors: Raeisi-Giglou P,Lam L,Tamarappoo BK,Newman J,Dweik RA,Tonelli AR

    更新日期:2017-06-01 00:00:00

  • INVEST: results of combined strategies to control blood pressure.

    abstract::The treatment of hypertension continues to be challenging due to the lack of understanding regarding underlying modulators of blood pressure as well as co-existing conditions such as atherosclerosis and diabetes. This has led to uncertainty regarding treatment strategy and intensity. The INternational VErapamil SR/tra...

    journal_title:Clinical cardiology

    pub_type: 杂志文章

    doi:10.1002/clc.4960241705

    authors: Kolloch RE

    更新日期:2001-11-01 00:00:00

  • Heart Rhythm Society: expert consensus statements-part 1.

    abstract::One of the most important roles for professional societies in medicine is assembling multiple stakeholders and experts to develop documents that can help guide and define policies and strategies for best medical care. Each year the Heart Rhythm Society (HRS) develops several consensus documents that address critical c...

    journal_title:Clinical cardiology

    pub_type: 杂志文章,评审

    doi:10.1002/clc.22666

    authors: Sennhauser S,Anand R,Kusumoto F,Goldschlager N

    更新日期:2017-03-01 00:00:00

  • Cutting balloon coronary angioplasty--initial clinical experience.

    abstract::The success of percutaneous transluminal coronary angioplasty is limited by acute occlusion and late restenosis. In 25 patients (20 men, 5 women, age range 36-81 years) coronary angioplasty was performed using a new cutting balloon into which 3-4 longitudinally orientated blades are incorporated so as to reduce the ra...

    journal_title:Clinical cardiology

    pub_type: 杂志文章

    doi:10.1002/clc.4960160907

    authors: Unterberg C,Buchwald AB,Barath P,Schmidt T,Kreuzer H,Wiegand V

    更新日期:1993-09-01 00:00:00

  • Left ventricular dysfunction in Rocky Mountain spotted fever.

    abstract::Rocky Mountain spotted fever is a serious infectious disease that continues to occur with increasing incidence in various areas of the United States. A high case-fatality ratio (11%) persists in spite of availability of adequate chemotherapeutic agents, and the cardiac involvement may play an important role in the fin...

    journal_title:Clinical cardiology

    pub_type: 杂志文章

    doi:10.1002/clc.4960061006

    authors: Marin-Garcia J

    更新日期:1983-10-01 00:00:00

  • The resting cardiokymogram: distribution of morphologies in normal patients and in patients with coronary heart disease.

    abstract::The cardiokymograph, a relatively new noninvasive device capable of recording anterior left ventricular segmental wall motion, was used to evaluate the frequency and type of wall motion abnormalities in 25 normal patients and in 109 patients with ischemic heart disease. Of the 25 patients with normal coronary arteries...

    journal_title:Clinical cardiology

    pub_type: 杂志文章

    doi:10.1002/clc.4960030605

    authors: Tzivoni D,Diamond GA,Vas R,Silverberg RA,Forrester JS

    更新日期:1980-12-01 00:00:00

  • Acoustic appearance of atrial septal aneurysm.

    abstract::Atrial septal aneurysm in the otherwise normal heart is a very rare and usually asymptomatic condition. A midsystolic click was described as the only clinical manifestation so far. A low-pitched early-to-midsystolic acoustic phenomenon in a 39-year-old woman corresponding with maximal leftward motion of the aneurysmat...

    journal_title:Clinical cardiology

    pub_type: 杂志文章

    doi:10.1002/clc.4960150713

    authors: Kautzner J,Bĕlohlávek M,Holm FV,Munclinger MJ

    更新日期:1992-07-01 00:00:00

  • Long-term use of K-strophanthin in advanced congestive heart failure due to dilated cardiomyopathy: a double-blind crossover evaluation versus digoxin.

    abstract::K-strophanthin or digoxin were added to diuretics (all cases) and vasodilators (most cases) for treating advanced congestive heart failure in 22 patients with dilated cardiomyopathy and sinus rhythm. K-strophanthin (0.125 mg intravenously) or digoxin (0.25 mg orally) were administered daily in two 3-month periods, dur...

    journal_title:Clinical cardiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1002/clc.4960171005

    authors: Agostoni PG,Doria E,Berti M,Guazzi MD

    更新日期:1994-10-01 00:00:00

  • Diagnostic accuracy of 2-D echocardiography for detection of exercise-induced wall motion abnormalities in patients with coronary artery disease: comparison to biplane cineventriculography.

    abstract::To determine the accuracy of two-dimensional echocardiography (2-D echo) for assessment of exercise-induced wall motion abnormalities in patients with coronary artery disease, the results of stress echocardiography were compared with exercise cineventriculography. In 56 consecutive patients, biplane cineventriculograp...

    journal_title:Clinical cardiology

    pub_type: 杂志文章

    doi:10.1002/clc.4960110808

    authors: Voelker W,Jacksch R,Dittmann H,Karsch KR

    更新日期:1988-08-01 00:00:00

  • The role of prolonged thrombolytic infusions and transesophageal echocardiography in thrombosed prosthetic heart valves: case report and review of the literature.

    abstract::Thrombolytic therapy for prosthetic heart valve thrombosis has recently been receiving increased attention and is now frequently used an alternative to high-risk surgery. A case is presented describing a novel thrombolytic therapy regimen with emphasis on the role of transesophageal echocardiography in diagnosis and m...

    journal_title:Clinical cardiology

    pub_type: 杂志文章,评审

    doi:10.1002/clc.4960181117

    authors: Puleo JA,Fontanet HL,Schocken DD

    更新日期:1995-11-01 00:00:00

  • Percutaneous mitral commissurotomy using the metallic valvulotome technique in a critically ill adult.

    abstract::A 25-year-old man presented with cardiogenic shock secondary to rheumatic mitral stenosis. Despite aggressive medical treatment he continued to deteriorate. This report describes the successful use of the metallic valvulotome technique for mitral commissurotomy in the context of a critically ill patient. ...

    journal_title:Clinical cardiology

    pub_type: 杂志文章

    doi:10.1002/clc.4960270616

    authors: Ward DE,Tanner MA

    更新日期:2004-06-01 00:00:00

  • Elevated serum cardiac troponin in non-acute coronary syndrome.

    abstract::Cardiac troponins (CTn) are the most sensitive and specific biochemical markers of myocardial injury and risk stratification. The assay for troponin T (cTnI) is standardized, and results obtained from different institutions are comparable. This is not the case with troponin I (cTnT), and clinicians should be aware tha...

    journal_title:Clinical cardiology

    pub_type: 杂志文章,评审

    doi:10.1002/clc.20445

    authors: Agzew Y

    更新日期:2009-01-01 00:00:00

  • New antithrombotics for secondary prevention of acute coronary syndrome.

    abstract::Patients with acute coronary syndrome (ACS) usually receive acetylsalicylic acid plus an adenosine diphosphate (ADP) receptor inhibitor to reduce the long-term risk of recurrent events. However, patients receiving standard antiplatelet prophylaxis still face a substantial risk of recurrent events. Strategies involving...

    journal_title:Clinical cardiology

    pub_type: 杂志文章,评审

    doi:10.1002/clc.22233

    authors: Goto S,Tomita A

    更新日期:2014-03-01 00:00:00

  • Hemodynamic-guided heart-failure management using a wireless implantable sensor: Infrastructure, methods, and results in a community heart failure disease-management program.

    abstract:BACKGROUND:The real-world impact of remote pulmonary artery pressure (PAP) monitoring on New York Heart Association (NYHA) class improvement and heart failure (HF) hospitalization rate is presented here from a single center. HYPOTHESIS:METHODS: Seventy-seven previously hospitalized outpatients with NYHA class III HF w...

    journal_title:Clinical cardiology

    pub_type: 杂志文章

    doi:10.1002/clc.22643

    authors: Jermyn R,Alam A,Kvasic J,Saeed O,Jorde U

    更新日期:2017-03-01 00:00:00

  • Hypercholesterolemia paradox in relation to mortality in acute coronary syndrome.

    abstract:BACKGROUND:Hypercholesterolemia is a risk factor for coronary artery disease, yet is associated with lower risk of adverse outcomes in patients with acute coronary syndromes (ACS). HYPOTHESIS:We explored this paradox in 84,429 patients with non-ST-segment elevation ACS in the Can Rapid Risk Stratification of Unstable ...

    journal_title:Clinical cardiology

    pub_type: 杂志文章

    doi:10.1002/clc.20518

    authors: Wang TY,Newby LK,Chen AY,Mulgund J,Roe MT,Sonel AF,Bhatt DL,DeLong ER,Ohman EM,Gibler WB,Peterson ED

    更新日期:2009-09-01 00:00:00

  • Pulmonary hypertension: newer concepts in diagnosis and management.

    abstract::Pulmonary hypertension comprises a family of disorders occurring as a primary disease or as a complication of a large number of respiratory and cardiac diseases. Pulmonary hypertension is present when pulmonary artery pressure or mean pressure exceeds 30 mmHg or 20 mmHg, respectively. Underlying the hemodynamic change...

    journal_title:Clinical cardiology

    pub_type: 杂志文章,评审

    doi:10.1002/clc.4960200804

    authors: Moraes D,Loscalzo J

    更新日期:1997-08-01 00:00:00

  • An analysis of vascular properties using pulse wave analysis in patients with vasovagal syncope.

    abstract:BACKGROUND:Vasovagal syncope (VVS) is a common cause of recurrent syncope. Nevertheless, the exact hemodynamic mechanism has not been elucidated. Pulse wave analysis (PWA) is widely used to evaluate vascular properties, as it reflects the condition of the entire arterial system. HYPOTHESIS:Cardiovascular autonomic mod...

    journal_title:Clinical cardiology

    pub_type: 杂志文章

    doi:10.1002/clc.23380

    authors: Jang JH,Park JH,Ko KY,Baek YS,Kwon SW,Park SD,Shin SH,Woo SI,Kwan J,Kim DH

    更新日期:2020-07-01 00:00:00