Abstract:
:The designation of atherosclerosis as a chronic inflammatory process represents an exciting and logical paradigm shift for cardiologists. Monocyte chemoattractant protein-1 (MCP-1) plays an important role in the recruitment and activation of monocytes and thus in the development of atherosclerosis. Enhanced MCP-1 expression has been detected in macrophages, endothelial cells, and vascular smooth muscle cells in the atheromatous plaque. Activation of macrophages by MCP-1 also appears to be involved in the vulnerability of the plaque. Indeed, circulating MCP-1 levels are elevated in patients with acute myocardial infarction and in those with unstable angina, but not in patients with stable angina. Production of MCP-1 and macrophage accumulation are also observed after coronary angioplasty or grafting, indicating that MCP-1 expression may be related not only to instability of atheromatous plaques, but also to the formation of restenotic lesions. The development of therapeutic drugs for atherosclerosis targeted specially against MCP-1 may be useful in the prevention of plaque formation and future myocardial infarction.
journal_name
Clin Cardioljournal_title
Clinical cardiologyauthors
Ikeda U,Matsui K,Murakami Y,Shimada Kdoi
10.1002/clc.4960250403subject
Has Abstractpub_date
2002-04-01 00:00:00pages
143-7issue
4eissn
0160-9289issn
1932-8737journal_volume
25pub_type
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journal_title:Clinical cardiology
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更新日期:2004-04-01 00:00:00
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pub_type: 临床试验,杂志文章
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更新日期:2017-06-01 00:00:00
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更新日期:2001-11-01 00:00:00
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更新日期:2017-03-01 00:00:00
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journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960160907
更新日期:1993-09-01 00:00:00
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journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960061006
更新日期:1983-10-01 00:00:00
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pub_type: 杂志文章
doi:10.1002/clc.4960030605
更新日期:1980-12-01 00:00:00
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更新日期:1992-07-01 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2004-06-01 00:00:00
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更新日期:2020-07-01 00:00:00