Abstract:
:Cardiac troponins (CTn) are the most sensitive and specific biochemical markers of myocardial injury and risk stratification. The assay for troponin T (cTnI) is standardized, and results obtained from different institutions are comparable. This is not the case with troponin I (cTnT), and clinicians should be aware that each institution must analyze and standardize its own results. Elevated cTn levels indicate cardiac injury, but do not define the mechanical injury. The differentiation of cTn elevation caused by coronary events from those not related to an acute coronary syndrome (ACS) is tiresome, at times vexing, and often costly. Elevation of cTn in non-ACS is a marker of increased cardiac and all-cause morbidity and mortality. The cause of these elevations may involve serious medical conditions that require meticulous diagnostic evaluation and aggressive therapy. At present, there are no guidelines to treat patients with elevated troponin levels and no coronary disease. The current strategy of treatment of patients with elevated troponin and non-ACS involves treating the underlying causes.
journal_name
Clin Cardioljournal_title
Clinical cardiologyauthors
Agzew Ydoi
10.1002/clc.20445subject
Has Abstractpub_date
2009-01-01 00:00:00pages
15-20issue
1eissn
0160-9289issn
1932-8737journal_volume
32pub_type
杂志文章,评审abstract::The purpose of the present study was to evaluate the effect of diltiazem on the left ventricular function in postinfarction patients. Twelve patients without cardiac decompensation at rest began diltiazem therapy beginning 3 months after an acute myocardial Q-wave infarction. Oral diltiazem was administered on the fir...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960111103
更新日期:1988-11-01 00:00:00
abstract:BACKGROUND:There are very sparse data on patient outcomes related to the use of extracorporeal membrane oxygenation (ECMO) prior to heart operation in children with congenital heart disease. This study was designed to evaluate this association using the Pediatric Health Information System (PHIS) database. HYPOTHESIS:W...
journal_title:Clinical cardiology
pub_type: 杂志文章,多中心研究
doi:10.1002/clc.22358
更新日期:2015-02-01 00:00:00
abstract:BACKGROUND:Late potentials (LP) on signal-averaged electrocardiography (SAECG), recorded 6 to 30 days after an acute myocardial infarction (AMI), identify patients at risk for late arrhythmic events. Angiotensin-converting enzyme (ACE) inhibitors have been shown to reduce ventricular remodeling and cardiovascular morta...
journal_title:Clinical cardiology
pub_type: 临床试验,杂志文章
doi:10.1002/clc.4960230206
更新日期:2000-02-01 00:00:00
abstract:BACKGROUND:Identifying vulnerable plaque is important for preventing an acute coronary event. The present study examined the relationship between the clinical presentation of coronary artery disease and the plaque characteristics of nonculprit segment assessed by virtual histology intravascular ultrasound (VH-IVUS). M...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.20471
更新日期:2009-08-01 00:00:00
abstract::Recently, it has been shown that nonischemic parts of the heart in myocardial infarction were separated from ischemic damaged ones by a sharp border zone. In this connection, the disturbance of contractile function of the myocardium of nonischemic parts is suggested to result from the infarction-concomitant emotional-...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960060403
更新日期:1983-04-01 00:00:00
abstract::Approaches to the treatment of supraventricular arrhythmias, including atrial fibrillation, atrial flutter, atrial tachycardia, atrioventricular (AV) reentrant tachycardia, and AV nodal reentrant tachycardia, continue to evolve. Within the past two decades, many new and effective treatments have become available. Thes...
journal_title:Clinical cardiology
pub_type: 杂志文章,评审
doi:10.1002/clc.4960171408
更新日期:1994-09-01 00:00:00
abstract:BACKGROUND:Current National Cholesterol Education Program (NCEP) guidelines recognize low-density lipoprotein cholesterol (LDL-C) below 100 mg/dl as an optimal level. Evidence supporting this is scant. Both LDL-C and C reactive protein (CRP) are known correlates of atherosclerosis progression. HYPOTHESIS:We examined t...
journal_title:Clinical cardiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/clc.4960270105
更新日期:2004-01-01 00:00:00
abstract::More women than men die each year of cardiovascular disease, which remains the leading cause of death in the United States. Sex-specific factors, including pregnancy-related disorders, should be considered when assessing cardiovascular (CV) risk in women. Hypertensive disorders of pregnancy have been associated with C...
journal_title:Clinical cardiology
pub_type: 杂志文章,评审
doi:10.1002/clc.21965
更新日期:2012-03-01 00:00:00
abstract::Natural history studies in heart failure have shown that increases in left ventricular (LV) volume and LV mass are directly related to future deterioration in LV performance and a less favorable clinical course. Despite the recognized importance of remodeling in heart failure, very little is known about the basic mech...
journal_title:Clinical cardiology
pub_type: 杂志文章,评审
doi:10.1002/clc.4960211304
更新日期:1998-12-01 00:00:00
abstract:BACKGROUND:The frequency of acute myocardial infarction (AMI) peaks on Mondays and in the mornings. However, the distribution of the types of acute coronary syndromes (ACS), including unstable angina (UA), has not been systematically evaluated. HYPOTHESIS:The distribution of the types of ACS and clinical presentations...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.22
更新日期:2006-12-01 00:00:00
abstract::In the last 15 years, intense interest has focused on various interventional, pharmacologic, and mechanical forms of therapy for the treatment of atherosclerotic coronary artery disease. Many techniques and devices (dilating balloons, perfusion catheters, thermal probes and balloons, lasers, atherectomy devices, stent...
journal_title:Clinical cardiology
pub_type: 杂志文章,评审
doi:10.1002/clc.4960150812
更新日期:1992-08-01 00:00:00
abstract:BACKGROUND:Chronic kidney disease (CKD) is associated with an increased risk of cardiovascular events following acute coronary syndrome (ACS). The underlying pathobiology and optimal treatments for this population continue to be evaluated. HYPOTHESIS:Patients with CKD will receive fewer evidence-based therapies and ex...
journal_title:Clinical cardiology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1002/clc.22253
更新日期:2014-06-01 00:00:00
abstract:INTRODUCTION:Health care demand is increasing due to greater longevity of patients with chronic comorbidities. This increasing demand is occurring in a setting of resource scarcity. To address these changes, high-value care initiatives, such as telemedicine, are valuable resource-preservation strategies. This study int...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.22586
更新日期:2016-11-01 00:00:00
abstract::His-bundle ablation is a very effective method to control drug-refractory supraventricular arrhythmias. We present a 69-year-old woman with paroxysmal atrial fibrillation, in whom several attempts of unipolar and bipolar His-bundle ablation were ineffective. Ultimately a stable 2/1 atrioventricular block was induced w...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960100516
更新日期:1987-05-01 00:00:00
abstract::Various types of pulmonary venous return abnormalities have been described in the literature. This report presents a case in which a 4-h-old neonate presented with cyanotic heart disease and respiratory distress. This neonate was subsequently shown to have complete absence of the pulmonary veins (CAPV), a previously u...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960110415
更新日期:1988-04-01 00:00:00
abstract:BACKGROUND AND HYPOTHESIS:Systemic hypertension is the leading cause of left ventricular (LV) hypertrophy. The present study aimed to investigate the mechanism of left atrial (LA) enlargement in patients with hypertensive heart disease during cardiac catheterization. METHODS:Data were obtained from eight control subje...
journal_title:Clinical cardiology
pub_type: 临床试验,杂志文章
doi:10.1002/clc.4960191211
更新日期:1996-12-01 00:00:00
abstract:BACKGROUND:Isolated left ventricular abnormal trabeculation (ILVAT) is defined as > 3 coarse trabeculations of the left ventricular wall, apically to the papillary muscles, in hearts without congenital malformations. HYPOTHESIS:The aims of the study were to assess by echocardiography the prevalence of ILVAT, to confir...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960220212
更新日期:1999-02-01 00:00:00
abstract::Recent clinical investigations have provided new insights into physiologic alterations taking place as heart failure progresses. As a result, new end points may be more relevant to monitor in patients, rather than the classical assessment of severity based on subjective evaluation of functional capacity. Structural ch...
journal_title:Clinical cardiology
pub_type: 杂志文章,评审
doi:10.1002/clc.4960181603
更新日期:1995-09-01 00:00:00
abstract::A case of systemic hypotension with volume depletion not responding to intravenous fluids was found to have features of cardiac tamponade on two-dimensional (2-D) echocardiography. Intracardiac pressures were normal on cardiac catheterization. An interesting observation was the presence of left ventricular (LV) collap...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960210318
更新日期:1998-03-01 00:00:00
abstract::This study analyzes the prevalence of coronary artery disease (CAD) among patients with rheumatic valvular heart disease (VHD) in Chile. Coronary angiography was performed in all patients referred to cardiac catheterization with VHD who were over age 50 years and who had angina or ECG signs of ischemia. A total of 100...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960060709
更新日期:1983-07-01 00:00:00
abstract::Type 2 diabetes mellitus (T2DM) is a major independent risk factor for cardiovascular disease, and diabetic dyslipidemia is a major contributor to cardiovascular risk in these patients. Here we report the rationale and design of a phase 3, double-blind study specifically designed to evaluate the lipid-lowering efficac...
journal_title:Clinical cardiology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1002/clc.23018
更新日期:2018-09-01 00:00:00
abstract::The case of a 73-year-old man with right heart failure and systolic and diastolic murmur at the fourth left intercostal space is described. There was a history of rheumatic fever. Two-dimensional echocardiography showed rheumatic change of the tricuspid valve with giant right atrium and ventricle, which was confirmed ...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960090710
更新日期:1986-07-01 00:00:00
abstract::Embolism of a fragment of a central venous catheter is a serious clinical complication, especially when the fragment cannot be made visible by radiological methods. We report a case where such a fragment could only be localized by transesophageal echocardiography (TEE). With combined use of x-rays and TEE, the cathete...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960110614
更新日期:1988-06-01 00:00:00
abstract::Patients with acute coronary syndrome (ACS) usually receive acetylsalicylic acid plus an adenosine diphosphate (ADP) receptor inhibitor to reduce the long-term risk of recurrent events. However, patients receiving standard antiplatelet prophylaxis still face a substantial risk of recurrent events. Strategies involving...
journal_title:Clinical cardiology
pub_type: 杂志文章,评审
doi:10.1002/clc.22233
更新日期:2014-03-01 00:00:00
abstract:BACKGROUND:Nonalcoholic fatty liver disease, insulin resistance (IR), and obesity frequently coexist with type 2 diabetes mellitus (DM), but it is uncertain whether these risk factors for vascular disease contribute to a change in atherosclerosis over time, independently of DM status. HYPOTHESIS:We hypothesized that t...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.22529
更新日期:2016-06-01 00:00:00
abstract::Type II heparin-induced thrombocytopenia (HIT) is a potentially severe adverse effect of heparin treatment triggered by an immune response. Although most cases occur in patients receiving unfractioned heparin, HIT can also arise after low-molecular-weight heparin (LMWH). We report a case of HIT in a postoperative orth...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.20546
更新日期:2010-02-01 00:00:00
abstract::This review describes 23 patients with aortic valve stenosis who underwent balloon valvuloplasty during life and had subsequent valve tissue examined at the time of aortic valve replacement or at necropsy. Of 23 stenotic aortic valves, 17 were examined within 30 days (early) after balloon dilation. Of these 94% had no...
journal_title:Clinical cardiology
pub_type: 杂志文章,评审
doi:10.1002/clc.4960141113
更新日期:1991-11-01 00:00:00
abstract:BACKGROUND:Cardiac contractility modulation (CCM) is an electrical-device therapy for patients with heart failure with reduced ejection fraction (HFrEF). Patients with left ventricular ejection fraction (LVEF) ≤35% also have indication for an implantable cardioverter-defibrillator (ICD), and in some cases subcutaneous ...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.22919
更新日期:2018-04-01 00:00:00
abstract::Warfarin and other 4-hydroxycoumarins are effective antithrombotic agents. They affect four blood coagulation proteins that act sequentially to produce thrombin. Coumarin therapy decreases the biological activity of these proteins, and therefore decreases the rate at which blood clots. As the mechanism by which these ...
journal_title:Clinical cardiology
pub_type: 杂志文章,评审
doi:
更新日期:1990-04-01 00:00:00
abstract::Physicians previously perceived heart disease to be a man's disease; yet, since 1984, more women have died of ischemic heart disease. Because women who develop obstructive coronary heart disease and heart failure tend to do so 10 years later than men, cardiology clinical trials that use arbitrary age cutoffs or exclus...
journal_title:Clinical cardiology
pub_type: 杂志文章,评审
doi:10.1002/clc.22907
更新日期:2018-02-01 00:00:00