Abstract:
:The purpose of the present study was to evaluate the effect of diltiazem on the left ventricular function in postinfarction patients. Twelve patients without cardiac decompensation at rest began diltiazem therapy beginning 3 months after an acute myocardial Q-wave infarction. Oral diltiazem was administered on the first day in a single dose (120 mg) and the following 2 weeks in a 60 mg three times a day (tid) regimen. The therapeutic effect was studied by isotope angiocardiography at rest using equilibrium measurements with technetium-99m. Acute as well as continuous treatment improved left ventricular function in terms of increased synergy of the contraction (decreased phase deviation from a median of 20.0 degrees to median of 12.4 degrees and 13.0 degrees, respectively, p less than 0.01) and increased ejection fraction from a median of 46% to a median of 50% and 51%, respectively, p less than 0.05. It is suggested that the improvement of left ventricular function may be due in part to decreased pressure rate product. This improved left ventricular function during diltiazem treatment may explain the improved prognosis induced by diltiazem in postinfarction patients.
journal_name
Clin Cardioljournal_title
Clinical cardiologyauthors
Boström PA,Lilja B,Johansson BW,Meier Kdoi
10.1002/clc.4960111103subject
Has Abstractpub_date
1988-11-01 00:00:00pages
739-42issue
11eissn
0160-9289issn
1932-8737journal_volume
11pub_type
杂志文章abstract::Ranolazine utilization in the management of refractory angina has been established by multiple randomized clinical studies. However, there is growing evidence showing an evolving role in the field of cardiac arrhythmias. Multiple experimental and clinical studies have evaluated the role of ranolazine in prevention and...
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journal_title:Clinical cardiology
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更新日期:2012-09-01 00:00:00
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pub_type: 社论
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更新日期:1993-07-01 00:00:00
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doi:10.1002/clc.4960120608
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pub_type: 临床试验,杂志文章
doi:10.1002/clc.4960210907
更新日期:1998-09-01 00:00:00
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journal_title:Clinical cardiology
pub_type: 临床试验,杂志文章
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更新日期:1996-12-01 00:00:00
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pub_type: 杂志文章,多中心研究,随机对照试验
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1002/clc.4960090608
更新日期:1986-06-01 00:00:00