Abstract:
BACKGROUND:Although suppression of premature ventricular contractions (PVCs) is not a predictor of mortality over the long term, the extent of PVC suppression is an important characteristic of any antiarrhythmic drug. HYPOTHESIS:This study was undertaken to determine whether intravenous (i.v.) dofetilide has the ability to suppress PVCs in patients who have frequent occurrences. METHODS:Subjects were men and women, aged 18 to 75 years, with > 30 PVCs/h on two consecutive 24-h Holter recordings while drug free, and > 50 PVCs/h during a 2-hour telemetric electrocardiogram. The study was randomized, double-blind, and placebo controlled. Subjects received a single-blind, i.v. infusion of placebo and were randomized (3:1) to receive a double-blind second infusion of placebo or an infusion of dofetilide (a 15-min loading infusion of 4 g/kg followed by a 60-min maintenance infusion of 3.5 g/kg, for a total dose of 7.5 g/kg). RESULTS:Dofetilide produced an 82.6% and placebo a 2.9% median reduction in PVCs. Drug responder rate, defined as 80% reduction in PVCs, was 50% in the dofetilide group and 0% in the placebo group. CONCLUSION:Intravenous dofetilide significantly reduced PVCs in patients who had > 30 PVCs/h at baseline, and it produced > or = 80% reduction in PVCs in 50% of all subjects.
journal_name
Clin Cardioljournal_title
Clinical cardiologyauthors
Pool PE,Singh SN,Friedrich Tdoi
10.1002/clc.4960230607subject
Has Abstractpub_date
2000-06-01 00:00:00pages
415-6issue
6eissn
0160-9289issn
1932-8737journal_volume
23pub_type
临床试验,杂志文章,随机对照试验abstract:BACKGROUND:Following successful cavotricuspid isthmus (CTI) ablation during typical atrial flutter (AFL), anticoagulation therapy is usually withdrawn. However, potential subsequent atrial fibrillation (AF) in these patients may increase embolic risk in the long term. Embolic rates in this setting have not been clearly...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.22538
更新日期:2016-06-01 00:00:00
abstract::The question of whether several attempts at transducer insertion increase the risk of performing transesophageal echocardiography (TEE) in patients with coronary artery disease (CAD) has not been addressed to date. In the course of performing TEE in 45 patients with CAD, two or more attempts to insert the transducer w...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960160807
更新日期:1993-08-01 00:00:00
abstract:BACKGROUND:Diabetic cardiomyopathy (DCMP) is a common complication of diabetes and is associated with increased mortality. It has been suggested that a poor R-wave progression in a resting electrocardiogram (ECG) could be a sign of cardiomyopathy. HYPOTHESIS:The aim of this study was primarily to analyze the relations...
journal_title:Clinical cardiology
pub_type: 杂志文章,随机对照试验
doi:10.1002/clc.20810
更新日期:2010-09-01 00:00:00
abstract::The renin-angiotensin system regulates blood pressure and sodium homeostasis through a series of coordinated substrate-enzyme interactions. These interactions result in the production of angiotensin II (AII), which exerts a number of diverse biologic effects mediated through AII cell-surface receptors. Dysregulation o...
journal_title:Clinical cardiology
pub_type: 杂志文章,评审
doi:10.1002/clc.4960200103
更新日期:1997-01-01 00:00:00
abstract:BACKGROUND:Vasovagal syncope (VVS) is a common cause of recurrent syncope. Nevertheless, the exact hemodynamic mechanism has not been elucidated. Pulse wave analysis (PWA) is widely used to evaluate vascular properties, as it reflects the condition of the entire arterial system. HYPOTHESIS:Cardiovascular autonomic mod...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.23380
更新日期:2020-07-01 00:00:00
abstract::The hemodynamic and myocardial energetic changes due to pulsus alternans were investigated by left and right heart catheterization and by oxygen consumption measurements in three patients with dilative cardiomyopathy. In all three patients, pulsus alternans developed after intravenous administration of the phosphodies...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960100506
更新日期:1987-05-01 00:00:00
abstract::Evidence is now accumulating which strongly suggests that prognosis of patients with painless myocardial ischemia determined either by ambulatory ECG monitoring or exercise testing may be no different than the prognosis of patients who have overt clinical manifestations of myocardial ischemia associated with transient...
journal_title:Clinical cardiology
pub_type: 杂志文章,评审
doi:10.1002/clc.4960111202
更新日期:1988-12-01 00:00:00
abstract::During the last several years dilating balloons have been applied in the treatment of stenotic cardiac valves. This interest has been extended to stenotic porcine bioprosthetic valves. Part I of this review discusses the pathologic changes producing stenotic porcine prosthetic valves. Part II of this review describes ...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960140912
更新日期:1991-09-01 00:00:00
abstract::In a family affected by arrhythmogenic right ventricular cardiomyopathy (ARVC) the familial occurrence was investigated. All 14 members of two generations were investigated carefully, and only 2 (father and one son) members were affected. Both subjects had a massive form of the disease with relevant ventricular arrhyt...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960150314
更新日期:1992-03-01 00:00:00
abstract:BACKGROUND:Although women typically develop coronary artery disease several years after men, once they have symptomatic disease their thromboembolic complications are worse than in men. The mechanism mediating this gender difference in outcome after thromboembolic events is unknown. We previously studied platelet funct...
journal_title:Clinical cardiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/clc.4960191106
更新日期:1996-11-01 00:00:00
abstract:BACKGROUND:Heart failure (HF) is a major problem in developed countries. However, its relationship with obesity remains unclear, especially in low-risk populations. The objective of the study was to analyze the relationship between obesity and HF in a low-risk Mediterranean population. HYPOTHESIS:Obesity is an indepen...
journal_title:Clinical cardiology
pub_type: 杂志文章,多中心研究
doi:10.1002/clc.20837
更新日期:2010-12-01 00:00:00
abstract::Constrictive pericarditis is a fibrotic process involving both layers of the pericardium and is known to give rise to obstruction to blood flow in the right heart. We report a patient with constrictive pericarditis who had echocardiographic features of mitral stenosis caused by a fibrocalcific mass lesion involving th...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960190615
更新日期:1996-06-01 00:00:00
abstract::Three randomized, clinical trials of the drug ranolazine relate to patients with symptomatic myocardial ischemia. A fourth randomized, controlled, clinical trial compares optimal medical therapy with percutaneous coronary intervention (PCI) plus medical therapy. ...
journal_title:Clinical cardiology
pub_type: 社论
doi:10.1002/clc.20406
更新日期:2008-07-01 00:00:00
abstract:BACKGROUND:The majority of coronary cameral fistulas (CCFs) are congenital in origin. On the other hand, acquired coronary cameral fistulas, having various etiopathogenic origins, are increasingly recognized. HYPOTHESIS:The aim of this study was to assess the possible involvement of coronary atherosclerosis in the pat...
journal_title:Clinical cardiology
pub_type: 杂志文章,评审
doi:10.1002/clc.4960220409
更新日期:1999-04-01 00:00:00
abstract::Despite a totality of evidence indicating clear benefits of statin therapy in secondary and primary prevention of cardiovascular disease (CVD), a large number of additional trials are currently planned or in progress to help us better understand, treat, and prevent CVD. Both monotherapy and combination statin regimens...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960240707
更新日期:2001-01-01 00:00:00
abstract::Many patients with coronary artery disease treated by percutaneous transluminal coronary angioplasty (PTCA) have a history of previous myocardial injury resulting in a reduced left ventricular ejection fraction (EF). The effects of successful PTCA on myocardial perfusion and left ventricular function in these patients...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960120504
更新日期:1989-05-01 00:00:00
abstract::The effects of monotherapy with atenolol or diltiazem-SR on blood pressure, 24-h blood pressure (BP) load, and exercise capacity were tested in patients with mild to moderate (stages I and II) essential hypertension. After 3-week single-blind placebo therapy, patients with sitting diastolic blood pressure (SDBP) of 94...
journal_title:Clinical cardiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/clc.4960171209
更新日期:1994-12-01 00:00:00
abstract::In this editorial, I would like to share some thoughts about clinical studies, including value and limitations using as an example a recently published randomized clinical trial. Randomized and non-randomized clinical trials, epidemiologic studies, and registries guide our clinical practice. They are good but not perf...
journal_title:Clinical cardiology
pub_type: 社论
doi:10.1002/clc.20598
更新日期:2009-04-01 00:00:00
abstract::We report a patient with controlled atrial fibrillation-flutter (AFF) and mitral stenosis who developed a marked increase in atrioventricular conduction during an infusion of low dose dopamine with development of hemodynamic compromise. This side effect has not been previously described in humans. Dopamine infusion sh...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960101114
更新日期:1987-11-01 00:00:00
abstract:BACKGROUND:Recent studies have suggested that immunoassay of cardiac troponin T (cTnT) provides a more sensitive measurement of myocardial necrosis than creatine kinase MB (CK-MB) mass concentration. HYPOTHESIS:The purpose of this study was to compare the release of cTnT and CK-MB isoenzyme in patients undergoing perc...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960191005
更新日期:1996-10-01 00:00:00
abstract:BACKGROUND:Small heart syndrome has previously been reported as neurocirculatory asthenia, associated with a small heart shadow on a chest roentgenogram. This is characterized as weakness or fatigue even after ordinary exertion, palpitation, dyspnea, and fainting, resembling patients with chronic fatigue syndrome (CFS)...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.20227
更新日期:2008-07-01 00:00:00
abstract:INTRODUCTION:Health care demand is increasing due to greater longevity of patients with chronic comorbidities. This increasing demand is occurring in a setting of resource scarcity. To address these changes, high-value care initiatives, such as telemedicine, are valuable resource-preservation strategies. This study int...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.22586
更新日期:2016-11-01 00:00:00
abstract::A total of 231 patients suffering from a first acute myocardial infarction were randomly allocated within 4 hours following the onset of symptoms either to anistreplase or anisoylated plasminogen streptokinase activator complex (APSAC), 30 U over 5 minutes, or to conventional heparin therapy, 5000 IU in bolus injectio...
journal_title:Clinical cardiology
pub_type: 临床试验,杂志文章,随机对照试验,评审
doi:10.1002/clc.4960131310
更新日期:1990-03-01 00:00:00
abstract::The purpose of this study was to investigate the efficacy of the patient-based coronary heart disease (CHD) risk management strategy in general practice by analyzing patients who were sent to a specialized center as refractory to conventional treatment. Of the 452 patients studied, 152 were excluded because of seconda...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960170305
更新日期:1994-03-01 00:00:00
abstract::Rising costs have reached a point at which physicians must assume a major role in dealing with the cost of medicine. Little information is available regarding actual practice at the community hospital level. In order to develop some insight on this issue, a survey of cardiovascular specialists was conducted regarding ...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960140104
更新日期:1991-01-01 00:00:00
abstract:BACKGROUND:Syndrome X is defined as typical angina pectoris, positive treadmill exercise test, negative intravenous ergonovine test, and angiographically normal coronary arteries. HYPOTHESIS:In the present study, we investigated the anti-ischemic and antianginal effects of nisoldipine and ramipril in patients with syn...
journal_title:Clinical cardiology
pub_type: 临床试验,杂志文章
doi:10.1002/clc.4960220513
更新日期:1999-05-01 00:00:00
abstract:BACKGROUND:A significantly lower perioperative mortality has established the nonthoracotomy approach as the preferred technique in implantable cardioverter defibrillation (ICD) implantation. With the currently available transvenous endocardial leads in combination with the expanded use of biphasic ICD devices, the need...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960200207
更新日期:1997-02-01 00:00:00
abstract:BACKGROUND:Atrial fibrillation (AF) is a complex cardiac arrhythmia in clinical practice with increasing incidence. However, the effects of statins on patients with AF are not quite clear. HYPOTHESIS:To investigate the protective effect of calcium channel blocker (CCB) and valsartan combined fluvastatin on hypertensio...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.23487
更新日期:2020-12-01 00:00:00
abstract::Patients with coronary artery disease have a variety of treatment options available to them. These include medications to control anginal episodes and, when appropriate, revascularization interventions in the form of coronary artery bypass graft and angioplasty. Despite advances in the treatment of angina, a substanti...
journal_title:Clinical cardiology
pub_type: 杂志文章,评审
doi:10.1002/clc.4960251407
更新日期:2002-12-01 00:00:00
abstract::As I advanced through medical school at Johns Hopkins, and throughout my subsequent training, I was constantly reminded of the contributions made to medicine by our predecessors. Many of whom were at Johns Hopkins, but many were not. As I continue active involvement in the education of medical students and physicians,...
journal_title:Clinical cardiology
pub_type: 社论,历史文章
doi:10.1002/clc.20392
更新日期:2008-04-01 00:00:00