Abstract:
:A total of 231 patients suffering from a first acute myocardial infarction were randomly allocated within 4 hours following the onset of symptoms either to anistreplase or anisoylated plasminogen streptokinase activator complex (APSAC), 30 U over 5 minutes, or to conventional heparin therapy, 5000 IU in bolus injection. Heparin was reintroduced in both groups 4 h after initial therapy at a dosage of 500 IU/kg per day. A total of 112 patients received anistreplase and 119 received heparin within a mean period of 188 +/- 62 min following the onset of symptoms. Infarct size was estimated from single photon emission computerized tomography and expressed in percentage of the total myocardial volume. The patency rate of the infarct-related artery was 77% in the anistreplase group and 36% in the heparin group (p less than 0.001). Left ventricular ejection fraction determined from contrast angiography was significantly higher in the anistreplase group than in the heparin group (6 absolute percentage point difference). A significant 31% reduction in infarct size was found in the anistreplase group (33% for the anterior wall infarction subgroup [p less than 0.05] and 16% for the inferior wall infarction subgroup, NS). A close inverse relation was found between the values of left ventricular ejection fraction and infarct size (r = -.73, p less than 0.01). In conclusion, early infusion of anistreplase in acute myocardial infarction produced a high early patency rate, a significant limitation of infarct size, and a significant preservation of left ventricular systolic function, mainly in the anterior wall infarctions.
journal_name
Clin Cardioljournal_title
Clinical cardiologyauthors
Bassand JP,Bernard Y,Lusson JR,Machecourt J,Cassagnes J,Borel Edoi
10.1002/clc.4960131310subject
Has Abstractpub_date
1990-03-01 00:00:00pages
V39-44; discussion V67-72eissn
0160-9289issn
1932-8737journal_volume
Suppl 5pub_type
临床试验,杂志文章,随机对照试验,评审abstract:BACKGROUND:Sex-based differences in acute coronary syndrome (ACS) mortality may attenuate with age due to better symptom recognition and prompt care. HYPOTHESIS:Age is a modifier of temporal trends in sex-based differences in ACS care. METHODS:Among 104 817 eligible patients with ACS enrolled in the AHA Get With the ...
journal_title:Clinical cardiology
pub_type: 杂志文章,多中心研究
doi:10.1002/clc.22938
更新日期:2018-06-01 00:00:00
abstract:BACKGROUND:The Reduction in ENdpoints with the Angiotensin Antagonist Losartan (RENAAL) study reported that losartan delayed the progression of renal disease in patients with type 2 diabetes and nephropathy. Diabetic or renally impaired patients are at high cardiovascular risk, a risk potentially increased in patients ...
journal_title:Clinical cardiology
pub_type: 临床试验,杂志文章
doi:10.1002/clc.4960280307
更新日期:2005-03-01 00:00:00
abstract:BACKGROUND:Therapeutic hypothermia improves survival for selected patients who remain comatose after cardiac arrest. Hypothermia triggers changes in electrocardiographic (ECG) parameters; however, the association of these changes to in-hospital mortality remains unclear. HYPOTHESIS:QT interval changes induced by thera...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.22224
更新日期:2014-02-01 00:00:00
abstract::At a recent Transcatheter Therapeutics meeting in San Francisco the PROSPECT Trial was presented by Dr. Greg Stone. Prospect stands for Providing Regional Observations to Study Predictors of Events in the Coronary Tree. This was a natural history study of atherosclerosis using multi-modality intracoronary imaging to p...
journal_title:Clinical cardiology
pub_type: 社论
doi:10.1002/clc.20809
更新日期:2010-06-01 00:00:00
abstract::Nonpharmacologic therapies for patients with sustained ventricular tachycardia have been necessitated by the low frequency of drug-responsive patients. These nonpharmacologic therapies include antitachycardia pacemakers, low-energy cardioverters, defibrillators, surgery and, for the present, catheter ablation. Antitac...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:
更新日期:1988-03-01 00:00:00
abstract:BACKGROUND:ST-segment depression during exercise testing is frequently observed in the absence of restenosis after percutaneous transluminal coronary angioplasty (PTCA). HYPOTHESIS:With the goal of improving the prediction of restenosis after PTCA, we evaluated the usefulness of ST-segment depression plus QT dispersio...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960220608
更新日期:1999-06-01 00:00:00
abstract::Hypertrophic cardiomyopathy predisposes patients to atrial fibrillation and the development of systemic embolization. We describe a rare case of bilateral renal artery thrombosis which presented as acute renal failure requiring dialysis. The patient was successfully treated with a selective, continuous infusion of uro...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960171114
更新日期:1994-11-01 00:00:00
abstract::The usual normal S-T segment of the surface electrocardiogram (ECG) contributes little to the diagnostic procedure. When the S-T segment is too long or too short, or when it is displaced upward or downward, it is commonly abnormal. Under such circumstances, an S-T segment abnormality usually contributes considerable d...
journal_title:Clinical cardiology
pub_type: 杂志文章,评审
doi:10.1002/clc.4960200602
更新日期:1997-06-01 00:00:00
abstract:BACKGROUND:The reproducibility of left ventricular (LV) mass measurement by two-dimensional (2-D) echocardiography is inadequate for individual assessments. HYPOTHESIS:This study was undertaken to evaluate the potential of LV mass determination with a new three-dimensional (3-D) echocardiographic method compared with ...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960201111
更新日期:1997-11-01 00:00:00
abstract:BACKGROUND:Heart failure (HF) is a major problem in developed countries. However, its relationship with obesity remains unclear, especially in low-risk populations. The objective of the study was to analyze the relationship between obesity and HF in a low-risk Mediterranean population. HYPOTHESIS:Obesity is an indepen...
journal_title:Clinical cardiology
pub_type: 杂志文章,多中心研究
doi:10.1002/clc.20837
更新日期:2010-12-01 00:00:00
abstract:BACKGROUND:Heart failure is a significant cause of morbidity and mortality, yet patient risk stratification may be difficult. Prevention or treatment of atrial fibrillation (AF) may be an important strategy in these patients that could positively affect their outcome. It has been demonstrated that in patients with syst...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.22736
更新日期:2017-10-01 00:00:00
abstract:BACKGROUND:Randomized controlled trials showed the nonvitamin K oral anticoagulant (NOAC) edoxaban was effective and safe for stroke and systemic embolism prevention in nonvalvular atrial fibrillation (AF) and for the prevention and treatment of venous thromboembolism (VTE; including pulmonary embolism and deep vein th...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.23279
更新日期:2019-12-01 00:00:00
abstract::More women than men die each year of cardiovascular disease, which remains the leading cause of death in the United States. Sex-specific factors, including pregnancy-related disorders, should be considered when assessing cardiovascular (CV) risk in women. Hypertensive disorders of pregnancy have been associated with C...
journal_title:Clinical cardiology
pub_type: 杂志文章,评审
doi:10.1002/clc.21965
更新日期:2012-03-01 00:00:00
abstract::After reviewing these published studies, I think one can conclude that in the patient population with chronic and/or paroxysmal atrial fibrillation, warfarin is beneficial and the benefits outweigh the risks. However, it is important to point out that patients at high risk for embolic disease, for example, dilated car...
journal_title:Clinical cardiology
pub_type: 社论
doi:10.1002/clc.4960160703
更新日期:1993-07-01 00:00:00
abstract::This manuscript was written in an effort to emphasize the points made by Porter et al. (Clin Cardiol 1997; 20:971-973). Right ventricular infarction may be erroneously interpreted as an anteroseptal infarction because of elevation of the S-T segments in leads V1-V4. The two can be separated when, using the Grant metho...
journal_title:Clinical cardiology
pub_type: 杂志文章,评审
doi:10.1002/clc.4960210411
更新日期:1998-04-01 00:00:00
abstract:BACKGROUND:Cardiac troponin T elevation after coronary intervention has been demonstrated to be associated with the prognosis of coronary artery disease (CAD). However, there were few studies about comprehensive risk factors analysis of troponin T elevation after elective drug-eluting stent (DES) implantation. HYPOTHE...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.20973
更新日期:2011-12-01 00:00:00
abstract::Physical quantities and equations are used to define the laws of natural and engineering sciences. Clarity has been brought in equal measure into the the theory of physical quantities and the SI-system of units due to the basic work of Wallot and that of national and international institutions. For practical use in th...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960020410
更新日期:1979-08-01 00:00:00
abstract::Hyponatremia is common and is increasingly recognized as an independent prognostic marker that adversely affects morbidity and mortality in various disease states, including heart failure. In acute decompensated heart failure (ADHF), the degree of hyponatremia often parallels the severity of cardiac dysfunction and is...
journal_title:Clinical cardiology
pub_type: 杂志文章,评审
doi:10.1002/clc.20822
更新日期:2010-11-01 00:00:00
abstract::Antihypertensive drug therapy can lower blood pressure and prolong life, but many hypertensive patients continue to develop further risk factors and to die prematurely of heart disease. Antihypertensive drugs can also interfere with the patient's quality of life, and many are not compatible with the concomitant medica...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960181506
更新日期:1995-06-01 00:00:00
abstract::Nicardipine a second-generation dihidropyridine calcium antagonist, has been approved in oral formulation for use in the United States, and is under review for parenteral use. Nicardipine is the most vascular-selective agent of this class currently approved and should, on theoretical grounds, be ideal for combination ...
journal_title:Clinical cardiology
pub_type: 杂志文章,评审
doi:10.1002/clc.4960150403
更新日期:1992-04-01 00:00:00
abstract::In order to assess the diagnostic value of dipyridamole (D) testing, we studied the responses of 34 patients with chest pain and 10 normal subjects. Blood pressure and 12-lead ECG were recorded during and after intravenous infusion of 0.6 mg/kg dipyridamole for 10 minutes. Coronary arteriography and maximal or symptom...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960050402
更新日期:1982-04-01 00:00:00
abstract::Type II heparin-induced thrombocytopenia (HIT) is a potentially severe adverse effect of heparin treatment triggered by an immune response. Although most cases occur in patients receiving unfractioned heparin, HIT can also arise after low-molecular-weight heparin (LMWH). We report a case of HIT in a postoperative orth...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.20546
更新日期:2010-02-01 00:00:00
abstract::A patient is presented who has mitral valve prolapse and syndactyly of the hands. This combination of findings has not been previously reported, but is consistent with one theory of the development of mitral valve prolapse. ...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960050306
更新日期:1982-03-01 00:00:00
abstract:BACKGROUND:The effect of body fat distribution on left ventricular (LV) mass and geometry has been recently recognized. However, data regarding circulating inflammatory markers in relation to regional visceral fat deposits, which are metabolically active tissues that can impact cardiac structural remodeling, remain spa...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.22242
更新日期:2014-03-01 00:00:00
abstract:BACKGROUND:Although the outcome of patients with angiographically insignificantly narrowed coronary arteries (INCA) is not clearly defined, such lesions can progress or rupture, thus causing cardiovascular morbidity. Preventive therapy with aspirin and lipid-lowering drugs therefore seems warranted in these patients. ...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960270605
更新日期:2004-06-01 00:00:00
abstract::Malignant lymphoma commonly involves the heart. Previous studies have found cardiac metastases in up to 20% of patients dying with lymphoma. Cardiac signs and symptoms of lymphoma are relatively rare, however, and in most cases, the diagnosis is made either postmortem or too late to affect the clinical course. This re...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960190326
更新日期:1996-03-01 00:00:00
abstract:BACKGROUND:Limited information is available regarding outcome of very elderly patients referred for percutaneous coronary intervention (PCI). PURPOSE:This study aimed to assess acute and intermediate term clinical outcomes among nonagenarians. METHODS:The study included 32 consecutive nonagenarian patients undergoing...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.20596
更新日期:2009-12-01 00:00:00
abstract::The purpose of this paper is to review the history of the clinico-pathologic investigations performed at the University of Padua on an old morbid entity ("parchment heart"), which, in the 1960s, led to the clinical description of the disease, in the 1980s to the revival of the scientific interest, and in the mid 1990s...
journal_title:Clinical cardiology
pub_type: 历史文章,杂志文章
doi:10.1002/clc.4960200406
更新日期:1997-04-01 00:00:00
abstract:BACKGROUND:There are no studies in the literature related to the effect of beta blockers (BB) on changes in C-reactive protein (CRP) levels after percutaneous coronary intervention (PCI). HYPOTHESIS:We designed a prospective randomized study to investigate the impact of BB therapy on CRP in patients who underwent elec...
journal_title:Clinical cardiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/clc.4960280509
更新日期:2005-05-01 00:00:00
abstract::Until recently, instrumenting the pericardium was possible only when a pericardial effusion is present or by surgical exposure of the pericardium. Techniques are now being developed to instrument the normal pericardium. This development will allow clinicians and investigators to study pericardial fluid in health and i...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960221304
更新日期:1999-01-01 00:00:00