Angiotensin-II-receptors: new targets for antihypertensive therapy.

Abstract:

:The renin-angiotensin system regulates blood pressure and sodium homeostasis through a series of coordinated substrate-enzyme interactions. These interactions result in the production of angiotensin II (AII), which exerts a number of diverse biologic effects mediated through AII cell-surface receptors. Dysregulation of this system is implicated in the pathogenesis of various forms of hypertension. Traditional therapy for hypertension has included angiotensin-converting enzyme inhibitors, which block the production of AII. However, a new class of drugs, AT1-receptor blockers, now offers a number of benefits by specifically blocking the effects of AII at its physiologically relevant receptor.

journal_name

Clin Cardiol

journal_title

Clinical cardiology

authors

Oliverio MI,Coffman TM

doi

10.1002/clc.4960200103

subject

Has Abstract

pub_date

1997-01-01 00:00:00

pages

3-6

issue

1

eissn

0160-9289

issn

1932-8737

journal_volume

20

pub_type

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